James Trudell


Affiliation: Stanford University
Country: USA


  1. request reprint
    Trudell J. Unique assignment of inter-subunit association in GABA(A) alpha 1 beta 3 gamma 2 receptors determined by molecular modeling. Biochim Biophys Acta. 2002;1565:91-6 pubmed
    ..In addition to predicting the most likely inter-subunit arrangement, the model predicts which residues form the GABA and benzodiazepine binding sites. ..
  2. Trudell J, Yue M, Bertaccini E, Jenkins A, Harrison N. Molecular modeling and mutagenesis reveals a tetradentate binding site for Zn2+ in GABA(A) alphabeta receptors and provides a structural basis for the modulating effect of the gamma subunit. J Chem Inf Model. 2008;48:344-9 pubmed publisher
    ..Sensitivity to Zn2+ was restored in the double mutant receptor, alpha1beta2gamma2 (I282H; K285E), in which the competition with lysine was removed and a more favorable Zn2+ binding site was formed. ..