BARRY TROST

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. pmc Cyclic 1,2-diketones as core building blocks: a strategy for the total synthesis of (-)-terpestacin
    Barry M Trost
    Department of Chemistry, Stanford University, Stanford, California 94305 5080, USA
    Chemistry 16:6265-77. 2010
  2. pmc Access to a welwitindolinone core using sequential cycloadditions
    Barry M Trost
    Department of Chemistry, Stanford University, Stanford, California 94305 5080, USA
    Org Lett 11:3782-5. 2009
  3. doi request reprint Direct N-carbamoylation of 3-monosubstituted oxindoles with alkyl imidazole carboxylates
    Barry M Trost
    Department of Chemistry, Stanford University, 337 Campus Drive, Stanford, California 94305 5080, USA
    J Org Chem 74:5115-7. 2009
  4. pmc Tandem ruthenium-catalyzed redox isomerization--O-conjugate addition: an atom-economic synthesis of cyclic ethers
    Barry M Trost
    Department of Chemistry, Stanford University, Stanford, California 94305 5080, USA
    Org Lett 11:2539-42. 2009
  5. pmc Asymmetric synthesis of bicyclo[4.3.1]decadienes and bicyclo[3.3.2]decadienes via [6 + 3] trimethylenemethane cycloaddition with tropones
    Barry M Trost
    Department of Chemistry, Stanford University, Stanford, California 94305 5080, USA
    J Am Chem Soc 130:14960-1. 2008
  6. ncbi request reprint Dinuclear asymmetric Zn aldol additions: formal asymmetric synthesis of fostriecin
    Barry M Trost
    Department of Chemistry, Stanford University, Stanford, California, 94305 5080, USA
    J Am Chem Soc 127:3666-7. 2005
  7. pmc Asymmetric synthesis of diamine derivatives via sequential palladium and rhodium catalysis
    Barry M Trost
    Department of Chemistry, Stanford University, Stanford, California 94305 5080, USA
    J Am Chem Soc 131:4190-1. 2009
  8. ncbi request reprint Desymmetrization of meso 1,3- and 1,4-diols with a dinuclear zinc asymmetric catalyst
    Barry M Trost
    Department of Chemistry, Stanford University, Stanford, CA 94305 5080, USA
    J Am Chem Soc 125:2410-1. 2003
  9. pmc Stereoselective, dual-mode ruthenium-catalyzed ring expansion of alkynylcyclopropanols
    Barry M Trost
    Department of Chemistry, Stanford University, Stanford, California 94305 5080, USA
    J Am Chem Soc 130:17258-9. 2008
  10. ncbi request reprint Ruthenium-catalyzed alkyne-propargyl alcohol addition. An asymmetric total synthesis of (+)-alpha-kainic acid
    Barry M Trost
    Department of Chemistry, Stanford University, Stanford, CA 94305 5080, USA
    Org Lett 5:1467-70. 2003

Detail Information

Publications160 found, 100 shown here

  1. pmc Cyclic 1,2-diketones as core building blocks: a strategy for the total synthesis of (-)-terpestacin
    Barry M Trost
    Department of Chemistry, Stanford University, Stanford, California 94305 5080, USA
    Chemistry 16:6265-77. 2010
    ..During our exploration many interesting chemoselectivity issues have been addressed, such as a highly selective ring-closing metathesis and a challenging oxidation of a disubstituted olefin in the presence of three trisubstituted ones...
  2. pmc Access to a welwitindolinone core using sequential cycloadditions
    Barry M Trost
    Department of Chemistry, Stanford University, Stanford, California 94305 5080, USA
    Org Lett 11:3782-5. 2009
    ..3.1]decadiene. Subsequent modifications to the cycloadduct allowed for an intramolecular [4 + 2] cycloaddition to generate the oxindole and complete the core of the natural product family...
  3. doi request reprint Direct N-carbamoylation of 3-monosubstituted oxindoles with alkyl imidazole carboxylates
    Barry M Trost
    Department of Chemistry, Stanford University, 337 Campus Drive, Stanford, California 94305 5080, USA
    J Org Chem 74:5115-7. 2009
    ..Regioselective N-carbamoylation of oxindoles was achieved through the use of imidazole carboxylate reagents. This reaction provides ready access to N-carbamoyl-3-monosubstituted oxindoles...
  4. pmc Tandem ruthenium-catalyzed redox isomerization--O-conjugate addition: an atom-economic synthesis of cyclic ethers
    Barry M Trost
    Department of Chemistry, Stanford University, Stanford, California 94305 5080, USA
    Org Lett 11:2539-42. 2009
    ..Enones and enals derived from the [IndRu(PPh(3))(2)Cl]-catalyzed redox isomerization of primary and secondary propargyl alcohols undergo a subsequent intramolecular conjugate addition to provide cyclic ethers in excellent yields...
  5. pmc Asymmetric synthesis of bicyclo[4.3.1]decadienes and bicyclo[3.3.2]decadienes via [6 + 3] trimethylenemethane cycloaddition with tropones
    Barry M Trost
    Department of Chemistry, Stanford University, Stanford, California 94305 5080, USA
    J Am Chem Soc 130:14960-1. 2008
    ..3.1]decadienes in excellent regio-, diastereo-, and enantioselectivity. Products of the Pd-TMM [6 + 3] cycloaddition participate in a thermal [3,3] sigmatropic rearrangement to yield bicyclo[3.3.2]decadienes in good yield...
  6. ncbi request reprint Dinuclear asymmetric Zn aldol additions: formal asymmetric synthesis of fostriecin
    Barry M Trost
    Department of Chemistry, Stanford University, Stanford, California, 94305 5080, USA
    J Am Chem Soc 127:3666-7. 2005
    ..5% overall yield...
  7. pmc Asymmetric synthesis of diamine derivatives via sequential palladium and rhodium catalysis
    Barry M Trost
    Department of Chemistry, Stanford University, Stanford, California 94305 5080, USA
    J Am Chem Soc 131:4190-1. 2009
    ..Further elaboration of these materials affords complex, stereodefined polyamine architectures, thus demonstrating the power of these combined methods for simplifying asymmetric C-N bond construction...
  8. ncbi request reprint Desymmetrization of meso 1,3- and 1,4-diols with a dinuclear zinc asymmetric catalyst
    Barry M Trost
    Department of Chemistry, Stanford University, Stanford, CA 94305 5080, USA
    J Am Chem Soc 125:2410-1. 2003
    ..A model to rationalize the results is presented...
  9. pmc Stereoselective, dual-mode ruthenium-catalyzed ring expansion of alkynylcyclopropanols
    Barry M Trost
    Department of Chemistry, Stanford University, Stanford, California 94305 5080, USA
    J Am Chem Soc 130:17258-9. 2008
    ....
  10. ncbi request reprint Ruthenium-catalyzed alkyne-propargyl alcohol addition. An asymmetric total synthesis of (+)-alpha-kainic acid
    Barry M Trost
    Department of Chemistry, Stanford University, Stanford, CA 94305 5080, USA
    Org Lett 5:1467-70. 2003
    ..A single stereocenter introduced by an asymmetric reduction of a ketone sets the stage for all the other stereocenters. A novel 1,6-addition of silyl cuprate serves to install a hydroxyl group at the diene termines. [reaction: see text]..
  11. pmc Total synthesis of bryostatin 16 using atom-economical and chemoselective approaches
    Barry M Trost
    Department of Chemistry, Stanford University, Stanford, California 94305 5080, USA
    Nature 456:485-8. 2008
    ..Analogues of bryostatin that do not exist in nature could be readily made by following this route, which might allow the biological activity of bryostatins to be fine-tuned...
  12. ncbi request reprint Ruthenium-catalyzed vinylsilane synthesis and cross-coupling as a selective approach to alkenes: benzyldimethylsilyl as a robust vinylmetal functionality
    Barry M Trost
    Department of Chemistry, Stanford University, Stanford, California 94305, USA
    Org Lett 5:1895-8. 2003
    ..The BDMS-vinylsilanes are further elaborated through mild palladium-catalyzed cross coupling and show significant stability to intervening synthetic operations, including silyl ether deprotection...
  13. pmc Exploiting orthogonally reactive functionality: synthesis and stereochemical assignment of (-)-ushikulide A
    Barry M Trost
    Department of Chemistry, Stanford University, Stanford, California 94305 5080, USA
    J Am Chem Soc 130:16190-2. 2008
    ..This approach has the dual effect of minimizing the number of steps and protecting groups required for our synthetic route. This strategy culminated in the efficient synthesis and stereochemical assignment of ushikulide A...
  14. ncbi request reprint Migratory hydroamination: a facile enantioselective synthesis of benzomorphans
    Barry M Trost
    Department of Chemistry, Stanford University, Stanford, California 94305 5080, USA
    J Am Chem Soc 125:8744-5. 2003
    ..The strategy outlined here for the enantioselective synthesis of three contiguous stereogenic centers and the novel cycloisomerization should have many applications in alkaloid synthesis...
  15. ncbi request reprint Synthesis of substituted 1,3-diene synthetic equivalents by a Ru-catalyzed diyne hydrative cyclization
    Barry M Trost
    Department of Chemistry, Stanford University, Stanford, CA 94305 5080, USA
    Chem Asian J 1:469-78. 2006
    ..The utility of this method was demonstrated by both sulfur dioxide extrusion of the 3-sulfolenes to afford 1,3-dienes and subsequent inter- or intramolecular Diels-Alder reactions...
  16. ncbi request reprint A formal synthesis of (-)-mycalamide A
    Barry M Trost
    Department of Chemistry, Stanford University, Stanford, California 94305 5080, USA
    J Am Chem Soc 126:48-9. 2004
    ..The first one is chemoselective, while the second one is highly diastereoselective. Three additional steps would be required to complete a total synthesis of (-)-mycalamide A...
  17. pmc Direct asymmetric Zn-aldol reaction of methyl vinyl ketone and its synthetic applications
    Barry M Trost
    Department of Chemistry, Stanford University, Stanford, California 94305 5080, USA
    J Am Chem Soc 127:8602-3. 2005
    ..For example, convergent fragment coupling methods have been demonstrated via highly diastereoselective cycloaddition of nitrile oxide after reduction into 1,3-diol or via cross-metathesis reaction...
  18. pmc Sequential Ru-Pd catalysis: a two-catalyst one-pot protocol for the synthesis of N- and O-heterocycles
    Barry M Trost
    Department of Chemistry, Stanford University, Stanford, California 94305, USA
    J Am Chem Soc 128:6745-54. 2006
    ..Finally, the utility of these heterocyclic products in total synthesis is demonstrated through concise syntheses of a kainoid intermediate, a constituent of oil of rose, and the ring B portion of bryostatin, a potent chemotherapeutic...
  19. ncbi request reprint A flexible approach toward trans-fused polycyclic tetrahydropyrans. A synthesis of prymnesin and yessotoxin units
    Barry M Trost
    Department of Chemistry, Stanford University, Stanford, California 94305 5080, USA
    Org Lett 6:4311-3. 2004
    ..Ru-catalyzed cycloisomerization and oxidative cyclization of bis-homopropargylic alcohols provide a rapid iterative approach to structural units of the ladder toxins...
  20. ncbi request reprint Total synthesis of (+)-amphidinolide A. Assembly of the fragments
    Barry M Trost
    Department of Chemistry, Stanford University, Stanford, California 94305 5080, USA
    J Am Chem Soc 127:13589-97. 2005
    ..Diastereomers of 6 and 7 were easily prepared by modification of the synthetic routes to allow access to multiple diastereomers of 1 for structural determination...
  21. ncbi request reprint Palladium-catalyzed regio- and enantioselective allylic alkylation of bis allylic carbonates derived from Morita-Baylis-Hillman adducts
    Barry M Trost
    Department of Chemistry, Stanford University, Stanford, California 94305, USA
    Org Lett 9:3961-4. 2007
    ..Morita-Baylis-Hillman diene adducts are used as substrates in the palladium-catalyzed asymmetric allylic alkylation reaction with oxygen and carbon nucleophiles in good regio- and enantioselectivity...
  22. ncbi request reprint Highly stereoselective synthesis of α-alkyl-α-hydroxycarboxylic acid derivatives catalyzed by a dinuclear zinc complex
    Barry M Trost
    Department of Chemistry, Stanford University, Stanford, CA 94305 5080, USA
    Angew Chem Int Ed Engl 51:6480-3. 2012
    ..This work highlights the utility of the ProPhenol family of ligands. The modular nature of these ligands proved crucial in the optimization of reaction conditions to achieve excellent stereoselectivities...
  23. pmc Total synthesis of laulimalide: assembly of the fragments and completion of the synthesis of the natural product and a potent analogue
    Barry M Trost
    Department of Chemistry, Stanford University, Stanford, California 94305 5080, USA
    Chemistry 18:2961-71. 2012
    ..We also report a second generation route that provides a more concise synthesis of the natural product...
  24. ncbi request reprint 4-Aryloxybutenolides as "chiral aldehyde" equivalents: an efficient enantioselective synthesis of (+)-brefeldin a
    Barry M Trost
    Department of Chemistry, Stanford University, California 94305 5080, USA
    J Am Chem Soc 124:9328-9. 2002
    ..This synthesis also highlights the Pd-catalyzed DYKAT of crotyl carbonate to create the remote stereocenter. A new two-step method to convert aldehydes to delta-hydroxy-E-alpha,beta-enoates is also outlined...
  25. pmc Palladium-catalyzed allylic alkylation of carboxylic Acid derivatives: N-acyloxazolinones as ester enolate equivalents
    Barry M Trost
    Department of Chemistry, Stanford University, Stanford, CA 94305 5080 USA http www stanford edu group bmtrost
    Angew Chem Int Ed Engl 51:204-8. 2012
    ..The imide products were readily converted into a series of carboxylic acid derivatives without loss of enantiopurity...
  26. ncbi request reprint Synthesis of novel quaternary amino acids using molybdenum-catalyzed asymmetric allylic alkylation
    Barry M Trost
    Department of Chemistry, Stanford University, Stanford, California 94305 5080, USA
    J Am Chem Soc 124:7256-7. 2002
    ..The reactions complements the Pd AAA wherein the cinnamyl substrate leads to only the product of attack at the primary terminus of the allyl moiety...
  27. ncbi request reprint Chemo-, regio-, and enantioselective Pd-catalyzed allylic alkylation of indolocarbazole pro-aglycons
    Barry M Trost
    Department of Chemistry, Stanford University, Stanford, California 94305 5080, USA
    Org Lett 4:2005-8. 2002
    ..Chemoselective allylation of (bis)indole lactam pro-aglycon 3 allows access to N-distally substituted indolopyrrolocarbazole derivatives; glyoxamide precursor 14 provides entry into N-proximally substituted derivatives...
  28. ncbi request reprint Enantioselective synthesis of (-)-codeine and (-)-morphine
    Barry M Trost
    Department of Chemistry, Stanford University, Stanford, California 94305 5080, USA
    J Am Chem Soc 124:14542-3. 2002
    ..The final ring formation involves a novel visible light-promoted hydroamination. Thus, six steps are required to convert the pivotal tricyclic intermediate into codeine, which has been demethylated in high yield to morphine...
  29. doi request reprint Exploring the unique reactivity of diazoesters: an efficient approach to chiral β-amino acids
    Barry M Trost
    Department of Chemistry, Stanford University, Stanford, California 94305 5080, USA
    Org Lett 15:440-3. 2013
    ..This transformation enables access to optically enriched β-amido-α-diazoesters. These products are transformed to β-amino acids not readily accessible using known methods...
  30. ncbi request reprint An enantioselective biomimetic total synthesis of (-)-siccanin
    Barry M Trost
    Department of Chemistry, Stanford University, Stanford, CA 94305 5080, USA
    Angew Chem Int Ed Engl 42:3943-7. 2003
  31. ncbi request reprint Palladium-catalyzed DYKAT of vinyl epoxides: enantioselective total synthesis and assignment of the configuration of (+)-Broussonetine G
    Barry M Trost
    Department of Chemistry, Stanford University, Stanford, CA 94305 5080, USA
    Angew Chem Int Ed Engl 42:5987-90. 2003
  32. doi request reprint Tandem Palladium(0) and Palladium(II)-Catalyzed Allylic Alkylation Through Complementary Redox Cycles
    Barry M Trost
    Department of Chemistry, Stanford University, Stanford CA 94305 5080 USA http www stanford edu group bmtrost
    Angew Chem Int Ed Engl 51:11522-6. 2012
    ..This allows for the selective introduction of otherwise indistinguishable allyl groups...
  33. ncbi request reprint Atom economy. Palladium-catalyzed formation of coumarins by addition of phenols and alkynoates via a net C-H insertion
    Barry M Trost
    Department of Chemistry, Stanford University, Stanford, CA 94305 5080, USA
    J Am Chem Soc 125:4518-26. 2003
    ..A novel mechanism involving a palladium phenoxide formed from a hydridopalladium carboxylate and phenol is invoked to rationalize the results...
  34. pmc Enantioselective synthesis of 2,2-disubstituted tetrahydrofurans: palladium-catalyzed [3+2] cycloadditions of trimethylenemethane with ketones
    Barry M Trost
    Department of Chemistry, Stanford University, Stanford, CA 94305 5080 USA
    Angew Chem Int Ed Engl 52:4466-9. 2013
    ..The reaction is catalyzed by palladium in the presence of L1, which possesses a stereogenic phosphorus atom, and only a single epimer at the phosphorus atom yields the active catalyst. Cp=cyclopentadiene, TMS=trimethylsilyl...
  35. ncbi request reprint On the diastereoselectivity of ru-catalyzed [5 + 2] cycloadditions
    Barry M Trost
    Department of Chemistry, Stanford University, Stanford, California 94305 5080, USA
    Org Lett 5:4149-51. 2003
    ..reaction: see text]. Ru-catalyzed cycloisomerization of cyclopropylenynes proceeds with good to high diastereoselectivities to form hexahydroazulenes...
  36. pmc Palladium-catalyzed regio-, diastereo-, and enantioselective benzylic allylation of 2-substituted pyridines
    Barry M Trost
    Department of Chemistry, Stanford University, Stanford, California 94305 5080, USA
    J Am Chem Soc 131:12056-7. 2009
    ....
  37. ncbi request reprint Pd-catalyzed carbonylative lactamization: a novel synthetic approach to FR900482
    Barry M Trost
    Department of Chemistry, Stanford University, Stanford, CA 94305 5080, USA
    Org Lett 6:1745-8. 2004
    ..reaction--see text]..
  38. pmc Evaluating transition-metal-catalyzed transformations for the synthesis of laulimalide
    Barry M Trost
    Department of Chemistry, Stanford University, Stanford, California 94305 5080, USA
    J Am Chem Soc 131:17087-9. 2009
    ..The designed synthetic route also allowed us to prepare an analogue of the natural product that possesses significant cytotoxic activity...
  39. pmc Metal vinylidenes as catalytic species in organic reactions
    Barry M Trost
    Department of Chemistry, Stanford University, Stanford, CA 94305, USA
    Chem Asian J 3:164-94. 2008
    ..This Focus Review addresses the reactions and applications of metal vinylidenes in organic synthesis...
  40. ncbi request reprint A short and concise asymmetric synthesis of hamigeran B
    Barry M Trost
    Department of Chemistry, Stanford University, Stanford, CA 94305 5080, USA
    Chemistry 11:951-9. 2005
    ..The successful route consists of 15 steps from 2-methylcyclopentanone and dimethylorcinol illustrating the efficiency of the route based upon the Pd AAA...
  41. pmc Dinuclear Zn-catalyzed asymmetric alkynylation of unsaturated aldehydes
    Barry M Trost
    Department of Chemistry, Stanford University, Stanford, CA 94305 8080, USA
    J Am Chem Soc 128:8-9. 2006
    ..Herein, we report a practical and general alkynylation of aromatic and alpha,beta-unsaturated aldehydes using our zinc catalyst system...
  42. ncbi request reprint Stereocontrolled total synthesis of (+)-streptazolin by a palladium-catalyzed reductive diyne cyclization
    Barry M Trost
    Department of Chemistry, Stanford University, Stanford, CA 94305 5080, USA
    Angew Chem Int Ed Engl 43:4327-9. 2004
  43. pmc Synthesis of a ring-expanded bryostatin analogue
    Barry M Trost
    Department of Chemistry, Stanford University, Stanford, California 94305, USA
    J Am Chem Soc 129:2206-7. 2007
  44. pmc Palladium-catalyzed asymmetric allylic alkylation of 3-aryloxindoles with allylidene dipivalate: a useful enol pivalate product
    Barry M Trost
    Department of Chemistry, Stanford University, Stanford CA 94305 4401 USA http www stanford edu group bmtrost
    Angew Chem Int Ed Engl 52:2260-4. 2013
    ..This reaction affords stable, synthetically useful enol pivalates in high yield and with excellent regio- and enantioselectivity. A broad range of substrates is tolerated, including unprotected and 3-heteroaryl nucleophiles...
  45. pmc Vanadium-catalyzed addition of propargyl alcohols and imines
    Barry M Trost
    Department of Chemistry, Stanford University, Stanford, California 94305 5080, USA
    J Am Chem Soc 128:10358-9. 2006
    ..The strategy described herein provides an atom-economical access to beta-aryl-substituted Z-enones with an allylic amino functional group, which are not readily accessible with other methods...
  46. ncbi request reprint A "chiral aldehyde" equivalent as a building block towards biologically active targets
    Barry M Trost
    Department of Chemistry, Stanford University, Stanford, CA 94305 5080, USA
    Chemistry 10:2237-52. 2004
    ..The route to (+)-brefeldin A lends itself to analogue syntheses and was completed in 18 steps in 6 % overall yield...
  47. pmc Palladium-catalyzed asymmetric construction of vicinal all-carbon quaternary stereocenters and its application to the synthesis of cyclotryptamine alkaloids
    Barry M Trost
    Department of Chemistry, Stanford University, Stanford, CA 94305 5580 USA
    Angew Chem Int Ed Engl 52:9176-81. 2013
    ..The twofold Pd-catalyzed transformation proceeds through an initial matched allylation followed by a second mismatched allylation to deliver the desired product. ..
  48. ncbi request reprint A stereospecific ruthenium-catalyzed allylic alkylation
    Barry M Trost
    Department of Chemistry, Stanford University, Stanford, CA 94305 5080, USA
    Angew Chem Int Ed Engl 41:1059-61. 2002
  49. ncbi request reprint A chemoselective reduction of alkynes to (E)-alkenes
    Barry M Trost
    Department of Chemistry, Stanford University, Stanford, California 94305 5080, USA
    J Am Chem Soc 124:7922-3. 2002
    ..The reaction is compatible with many sensitive functional groups and provides a general trans-alkyne reduction not possible by other means...
  50. ncbi request reprint Formation of vinyl halides via a ruthenium-catalyzed three-component coupling
    Barry M Trost
    Department of Chemistry, Stanford University, Stanford, California 94305, USA
    J Am Chem Soc 124:7376-89. 2002
    ..The vinyl halides have been shown to be precursors to alpha-hydroxy ketones and cyclopentenones, and as coupling partners in Suzuki-type reactions...
  51. pmc Asymmetric synthesis of methylenetetrahydrofurans by palladium-catalyzed [3 + 2] cycloaddition of trimethylenemethane with aldehydes--a novel ligand design
    Barry M Trost
    Department of Chemistry, Stanford University, Stanford, California 94305 5080, USA
    J Am Chem Soc 133:7664-7. 2011
    ..The method allows for the formation of chiral disubstituted tetrahydrofurans in good yields and enantioselectivities...
  52. ncbi request reprint A mechanistic dichotomy in ruthenium-catalyzed propargyl alcohol reactivity: a novel hydrative diyne cyclization
    Barry M Trost
    Department of Chemistry, Stanford University, Stanford, California 94305 5080, USA
    J Am Chem Soc 125:11516-7. 2003
    ..Strong mechanistic evidence suggests two reaction manifolds indeed operate, depending upon the presence of propargyl alcohols and the degree of substitution on the hydroxyl-bearing carbon...
  53. pmc Exercising regiocontrol in palladium-catalyzed asymmetric prenylations and geranylation: unifying strategy toward flustramines A and B
    Barry M Trost
    Department of Chemistry, Stanford University, Stanford, California 94305 5080, USA
    J Am Chem Soc 133:7328-31. 2011
    ..The resulting prenylated and reverse-prenylated products were transformed into ent-flustramides and ent-flustramines A and B. Additionally, control of the regio- and diastereoselectivity was obtained using π-geranylpalladium complexes...
  54. doi request reprint Structure and reactivity of late transition metal η³-benzyl complexes
    Barry M Trost
    Stanford University, Department of Chemistry, Stanford, CA 94305 5080 USA
    Angew Chem Int Ed Engl 53:2826-51. 2014
    ..In this Review we discuss the synthesis and characterization of these complexes with late transition metals and the subsequent development of catalytic benzylic functionalization methods, including asymmetric variants...
  55. doi request reprint Ligand-accelerated enantioselective propargylation of aldehydes via allenylzinc reagents
    Barry M Trost
    Department of Chemistry, Stanford University, Stanford, California 94305, USA
    Org Lett 13:1900-3. 2011
    ..A wide range of aldehydes can be propargylated to afford valuable and versatile homopropargyl alcohols in good to excellent yields with high levels of enantiopurity...
  56. ncbi request reprint Enantioselective construction of highly substituted pyrrolidines by palladium-catalyzed asymmetric [3+2] cycloaddition of trimethylenemethane with ketimines
    Barry M Trost
    Department of Chemistry, Stanford University, Stanford, California 94305 5080, USA
    J Am Chem Soc 132:8238-40. 2010
    ..The corresponding pyrrolidines were obtained in excellent yields and selectivities making use of our novel phosphoramidite ligands L2-L3...
  57. ncbi request reprint Palladium-catalyzed asymmetric allylic alkylations of polynitrogen-containing aromatic heterocycles
    Barry M Trost
    Department of Chemistry, Stanford University, Stanford, California 94305 5080, United States
    J Am Chem Soc 133:12439-41. 2011
    ....
  58. ncbi request reprint Asymmetric allylic alkylation of cyclic vinylogous esters and thioesters by Pd-catalyzed decarboxylation of enol carbonate and beta-ketoester substrates
    Barry M Trost
    Department of Chemistry, Stanford University, Stanford, CA 94305 5080, USA
    Angew Chem Int Ed Engl 45:3109-12. 2006
  59. pmc New class of nucleophiles for palladium-catalyzed asymmetric allylic alkylation. Total synthesis of agelastatin A
    Barry M Trost
    Department of Chemistry, Stanford University, Stanford, California 94305 5080, USA
    J Am Chem Soc 128:6054-5. 2006
    ..The feasibility of accessing (-)-agelastatin A from the same enantiomer of the chiral catalyst from the other regioisomeric piperazinone is indicated...
  60. pmc Palladium asymmetric allylic alkylation of prochiral nucleophiles: horsfiline
    Barry M Trost
    Department of Chemistry, Stanford University, California 94305, USA
    Org Lett 8:2027-30. 2006
    ..reaction; see text] The asymmetric synthesis of the oxindole alkaloid horsfiline is described. A palladium-catalyzed asymmetric allylic alkylation (AAA) is used to set the spiro(pyrrolidine-oxindole) stereogenic center...
  61. ncbi request reprint DYKAT of vinyl aziridines: total synthesis of (+)-pseudodistomin D
    Barry M Trost
    Department of Chemistry, Stanford University, Stanford, CA 94305 5080, USA
    Org Lett 7:823-6. 2005
    ..The piperidine core was constructed through a silver(I)-catalyzed hydroamination of an alkyne and subsequent diastereo- and regioselective reduction. [reaction: see text]..
  62. pmc Palladium-catalyzed dynamic kinetic asymmetric transformations of vinyl aziridines with nitrogen heterocycles: rapid access to biologically active pyrroles and indoles
    Barry M Trost
    Department of Chemistry, Stanford University, Stanford, California 94305 5080, United States
    J Am Chem Soc 132:15800-7. 2010
    ....
  63. doi request reprint Atom-economical synthesis of functionalized cycloalkanes via catalytic redox cycloisomerization of propargyl alcohols
    Barry M Trost
    Department of Chemistry, Stanford University, Stanford, California 94305 5080, USA
    Org Lett 14:1708-11. 2012
    ..Furthermore, an asymmetric variant of this protocol realized by the aid of a chiral nonracemic diamine catalyst, which provides the cyclization products in up to 97% ee, is presented...
  64. pmc Total syntheses of bryostatins: synthesis of two ring-expanded bryostatin analogues and the development of a new-generation strategy to access the C7-C27 fragment
    Barry M Trost
    Department of Chemistry, Stanford University, Stanford, CA 94305, USA
    Chemistry 17:9789-805. 2011
    ..Given the difficulty in forming the C16-C17 olefin at a late stage, we also describe our development of a new-generation strategy to access the C7-C27 fragment, containing both the ring B and C subunits...
  65. ncbi request reprint Strategy for employing unstabilized nucleophiles in palladium-catalyzed asymmetric allylic alkylations
    Barry M Trost
    Department of Chemistry, Stanford University, Stanford, California 94305 5080, USA
    J Am Chem Soc 130:14092-3. 2008
    ....
  66. ncbi request reprint Dinuclear zinc-catalyzed enantioselective Aza-Henry reaction
    Barry M Trost
    Department of Chemistry, Stanford University, Stanford, CA 94305 8080, USA
    Org Lett 9:2023-6. 2007
    ..alpha,beta-Unsaturated imines proved to be a particularly useful class of substrate routinely giving the alpha-nitro amine products in high enantiomeric excess...
  67. ncbi request reprint Palladium-catalyzed diastereo- and enantioselective Wagner-Meerwein shift: control of absolute stereochemistry in the C-C bond migration event
    Barry M Trost
    Department of Chemistry, Stanford University, Stanford, California 94305, USA
    J Am Chem Soc 130:6231-42. 2008
    ..The method provides an efficient way to synthesize highly substituted cyclopentanones with an alpha-chiral O-tertiary center which has various synthetic applications...
  68. pmc Total synthesis of (-)-pseudolaric acid B
    Barry M Trost
    Department of Chemistry, Stanford University, Stanford, California 94305 5080, USA
    J Am Chem Soc 129:14556-7. 2007
    ....
  69. pmc Synthesis of (-)-Delta9-trans-tetrahydrocannabinol: stereocontrol via Mo-catalyzed asymmetric allylic alkylation reaction
    Barry M Trost
    Department of Chemistry, Stanford University, Stanford, California 94305, USA
    Org Lett 9:861-3. 2007
    ....
  70. pmc Asymmetric catalysis: an enabling science
    Barry M Trost
    Department of Chemistry, Stanford University, Stanford, CA 94305 5080, USA
    Proc Natl Acad Sci U S A 101:5348-55. 2004
    ..General themes for designing catalysts to effect asymmetric induction are helping to make this strategy more useful, in general, with the resultant effect of a marked enhancement of synthetic efficiency...
  71. ncbi request reprint Palladium-catalyzed asymmetric addition of pronucleophiles to allenes
    Barry M Trost
    Department of Chemistry, Stanford University, Stanford, CA 94305 5080, USA
    J Am Chem Soc 125:4438-9. 2003
    ..Thus, a new approach for asymmetric allylic alkylations of carbon pronucleophiles by simple additions provides a very efficient, more atom economic strategy for asymmetric C-C bond formation...
  72. ncbi request reprint DYKAT of Baylis-Hillman adducts: concise total synthesis of furaquinocin E
    Barry M Trost
    Department of Chemistry, Stanford University, Stanford, CA 94305 5080, USA
    J Am Chem Soc 124:11616-7. 2002
    ..This new approach is successfully applied to the synthesis of furaquinocin E and an analogue...
  73. ncbi request reprint Unusual effects in the pd-catalyzed asymmetric allylic alkylations: synthesis of chiral chromans
    Barry M Trost
    Department of Chemistry, Stanford Univeristy, Stanford, California 94305 5080, USA
    J Am Chem Soc 125:9276-7. 2003
    ..A synthesis of (+)-clusifoliol, a constituent of a folk medicine for treatment of malignant tumors, which also assigns the absolute configuration, illustrates the utility of the method...
  74. ncbi request reprint Utilization of molybdenum- and palladium-catayzed dynamic kinetic asymmetric transformations for the preparation of tertiary and quaternary stereogenic centers: a concise synthesis of tipranavir
    Barry M Trost
    Department of Chemistry, Stanford University, Stanford, California 94305 5080, USA
    J Am Chem Soc 124:14320-1. 2002
    ....
  75. ncbi request reprint Direct asymmetric aldol reactions of acetone using bimetallic zinc catalysts
    B M Trost
    Department of Chemistry, Stanford University, Stanford, CA 94305 5080, USA
    Org Lett 3:2497-500. 2001
    ..reaction: see text] The enantioselective aldol reaction using a novel binuclear zinc catalyst of acetone with several aldehydes gave products in good yields (62-89%) with a high level of enantioselectivity (ee = 76-92%)...
  76. doi request reprint Regio- and enantioselective synthesis of pyrrolidines bearing a quaternary center by palladium-catalyzed asymmetric [3 + 2] cycloaddition of trimethylenemethanes
    Barry M Trost
    Department of Chemistry, Stanford University, Stanford, California 94305 5080, USA
    J Am Chem Soc 135:2459-61. 2013
    ....
  77. doi request reprint Palladium-Catalyzed Enantioselective Allylic Alkylations through C-H Activation
    Barry M Trost
    Department of Chemistry, Stanford University, Stanford CA 94305 5080 USA http www stanford edu group bmtrost
    Angew Chem Int Ed Engl 52:1523-6. 2013
    ..This is a conceptually and mechanistically distinct strategy from traditional methods for the synthesis of enantioenriched allylic substitution products. 2,6-DMBQ=2,6-dimethylbenzoquinone...
  78. pmc Diastereoselective formation of tetrahydrofurans via Pd-catalyzed asymmetric allylic alkylation: synthesis of the C13-C29 subunit of amphidinolide N
    Barry M Trost
    Department of Chemistry, Stanford University, Stanford, California 94305 5080, USA
    Org Lett 14:5632-5. 2012
    ..The C19 hydroxyl-bearing stereocenter was introduced using a chelation-controlled allylation which led exclusively to a single diastereoisomer...
  79. pmc Total synthesis of aeruginosin 98B
    Barry M Trost
    Department of Chemistry, Stanford University, Stanford, California 94305 5080, USA
    J Am Chem Soc 134:18944-7. 2012
    ..The key step is a highly diastereoselective Pd-catalyzed intramolecular asymmetric allylic alkylation reaction of a diastereomeric mixture of allylic carbonates that is enabled by the use of racemic phosphine ligand L1...
  80. pmc Asymmetric catalytic synthesis of the proposed structure of trocheliophorolide B
    Barry M Trost
    Department of Chemistry, Stanford University, Stanford, California 94305 5080, USA
    Org Lett 14:4698-700. 2012
    ..Comparison with the reported data suggests a misassignment of the natural product structure...
  81. doi request reprint Synthesis of α-allylated α,β-unsaturated carbonyl compounds using vanadium/palladium contemporaneous dual catalysis
    Barry M Trost
    Department of Chemistry, Stanford University, Stanford, California, USA
    Nat Protoc 7:1497-501. 2012
    ..0 h for isolation and purification. This chemistry has been applied to obtain a wide range of α-allylated α,β-unsaturated ketones, esters and amides, which are highly valuable building blocks in organic synthesis...
  82. pmc Palladium-catalyzed asymmetric allylic alkylation of electron-deficient pyrroles with meso electrophiles
    Barry M Trost
    Department of Chemistry, Stanford University, Stanford, California 94305, United States
    Org Lett 14:2254-7. 2012
    ..A nitropyrrole-containing nucleoside analogue was synthesized in seven steps to demonstrate the synthetic utility of this transformation...
  83. pmc Total synthesis of laulimalide: synthesis of the northern and southern fragments
    Barry M Trost
    Department of Chemistry, Stanford University, Stanford, California 94305 5080, USA
    Chemistry 18:2948-60. 2012
    ..This reaction proved to be selective for the formation of a six-membered ring, over a seven. The use of an electron-deficient bidentate phosphine allowed for the reaction to proceed with a reduced catalyst loading...
  84. pmc Enantioselective palladium-catalyzed [3 + 2] cycloadditions of trimethylenemethane with nitroalkenes
    Barry M Trost
    Department of Chemistry, Stanford University, Stanford, California 94305 5080, USA
    Org Lett 14:234-7. 2012
    ..Furthermore, the products thus formed are highly versatile synthetic intermediates and provide convenient access to both cyclopentylamines and cyclopentenones...
  85. ncbi request reprint Palladium-catalyzed asymmetric benzylation of 3-aryl oxindoles
    Barry M Trost
    Department of Chemistry, Stanford University, Stanford, California 94305 5080, USA
    J Am Chem Soc 132:15534-6. 2010
    ..This methodology represents a novel asymmetric carbon-carbon bond formation between a benzyl group and a prochiral nucleophile to generate a quaternary center...
  86. ncbi request reprint Regioselective hydrosilylation of propargylic alcohols: an aldol surrogate
    Barry M Trost
    Department of Chemistry, Stanford University, Stanford, CA 94305 5080, USA
    Angew Chem Int Ed Engl 42:3415-8. 2003
  87. ncbi request reprint An efficient one-pot enantio- and diastereoselective synthesis of heterocycles
    Barry M Trost
    Department of Chemistry, Stanford University, Stanford, CA 94305 5080, USA
    Angew Chem Int Ed Engl 41:4693-7. 2002
  88. ncbi request reprint Pd-catalyzed asymmetric allylic alkylation. A short route to the cyclopentyl core of viridenomycin
    Barry M Trost
    Department of Chemistry, Stanford University, Stanford, CA 94305 5080, USA
    Org Lett 5:1563-5. 2003
    ..reaction: see text]..
  89. ncbi request reprint Callipeltoside A: assignment of absolute and relative configuration by total synthesis
    Barry M Trost
    Department of Chemistry, Stanford University, Stanford, CA 94305 5080, USA
    Angew Chem Int Ed Engl 41:841-3. 2002
  90. pmc The direct catalytic asymmetric aldol reaction
    Barry M Trost
    Department of Chemistry, Stanford University, Stanford, CA 94305 5080, USA
    Chem Soc Rev 39:1600-32. 2010
    ..New methods have improved the reactivity, selectivity and substrate scope of the direct aldol reaction and enabled the synthesis of complex molecular targets (357 references)...
  91. pmc Total synthesis of bryostatin 16 using a Pd-catalyzed diyne coupling as macrocyclization method and synthesis of C20-epi-bryostatin 7 as a potent anticancer agent
    Barry M Trost
    Department of Chemistry, Stanford University, Stanford, California 94305 5080, United States
    J Am Chem Soc 132:16403-16. 2010
    ..Preliminary biological studies indicated that this new analogue exhibits nanomolar anti-cancer activity against several cancer cell lines...
  92. pmc An atom-economic synthesis of nitrogen heterocycles from alkynes
    Barry M Trost
    Department of Chemistry, Stanford University, Stanford, California 94305 5080, United States
    J Am Chem Soc 133:740-3. 2011
    ..Control over the reaction conditions provides ready access to isopyrroles, 2,3,4-trisubstituted pyrroles, and 3-substituted pyrollidin-2-ones...
  93. doi request reprint An atom-economical access to β-heteroarylated ketones from propargylic alcohols via tandem ruthenium/indium catalysis
    Barry M Trost
    Department of Chemistry, Stanford University, Stanford, California 94305, USA
    Org Lett 13:398-401. 2011
    ..Both electron-rich and neutral heteroarenes, such as furans and indoles, efficiently undergo the redox isomerization/conjugate addition (RICA) sequence to provide the corresponding adducts in yields of up to 97%...
  94. ncbi request reprint A three-component coupling approach to cyclopentanoids
    B M Trost
    Department of Chemistry, Stanford University, Stanford, California 94305, USA
    J Org Chem 66:7714-22. 2001
    ..Further applicability of this strategy is shown in the total syntheses of tetrahydrodicranenone B, rosaprostol, and a selective COX-2 inhibitor...
  95. ncbi request reprint Application of the AAA reaction to the synthesis of the furanoside of C-2-epi-hygromycin A: a total synthesis of C-2-epi-hygromycin A
    Barry M Trost
    Department of Chemistry, Stanford University, CA 94305 5080, USA
    Chemistry 8:259-68. 2002
    ..The utility of a phenol as a nucleophile in the Pd catalyzed glycosylation is demonstrated. From this strategy emerged a short, practical synthesis of C-2-epi-hygromycin A...
  96. ncbi request reprint An efficient enantioselective synthesis of (-)-galanthamine
    Barry M Trost
    Department of Chemistry, Stanford University, Stanford, CA 94305 5080, USA
    Angew Chem Int Ed Engl 41:2795-7. 2002
  97. ncbi request reprint Palladium-catalyzed asymmetric allylic alkylation of alpha-aryl ketones
    Barry M Trost
    Department of Chemistry, Stanford University, Stanford, CA 94305 5080, USA
    Angew Chem Int Ed Engl 41:3492-5. 2002
  98. pmc The palladium catalyzed asymmetric addition of oxindoles and allenes: an atom-economical versatile method for the construction of chiral indole alkaloids
    Barry M Trost
    Department of Chemistry, Stanford University, Stanford, California 94305 5080, USA
    J Am Chem Soc 133:20611-22. 2011
    ....
  99. ncbi request reprint Intramolecular palladium-catalyzed allylic alkylation: enantio- and diastereoselective synthesis of [2.2.2] bicycles
    Barry M Trost
    Department of Chemistry, Stanford University, Stanford, CA 94305 5080, USA
    Org Lett 4:3427-30. 2002
    ..Pd-catalyzed asymmetric allylic alkylation provides both enantio- and diastereoselectivity in formation of bicyclo [2.2.2] octan-2,3-diones and quinuclidin-2-ones, the latter potential precursors to quinine alkaloids. [reaction: see text]..
  100. ncbi request reprint Stereocontrolled synthesis of (+)-boronolide
    Barry M Trost
    Department of Chemistry, Stanford University, Stanford, CA 94305 5080, USA
    Org Lett 4:3513-6. 2002
    ..Ring closing metathesis provides the lactone ring. The synthesis requires 12 steps and proceeds in 26% overall yield. [reaction: see text]..
  101. pmc Acetoxy Meldrum's acid: a versatile acyl anion equivalent in the Pd-catalyzed asymmetric allylic alkylation
    Barry M Trost
    Department of Chemistry, Stanford University, Stanford, California 94305 5080, USA
    Org Lett 13:3222-5. 2011
    ..These scaffolds were used to complete formal syntheses of the anti-HIV drugs carbovir, abacavir, and the antibiotic aristeromycin...

Research Grants37

  1. NOVEL APPROACHES TO ANTITUMOR AND ANTIVIRAL AGENTS
    BARRY TROST; Fiscal Year: 2004
    ..By accessing a very diverse range of structural types, the best opportunities to discover new therapeutic agents arise. ..
  2. SYNTHESIS OF MACROCYCLES STEROIDS CYCLOPENTANOIDS ETC
    BARRY TROST; Fiscal Year: 2001
    ..Ring expansion methods may convert these cores into the taxoid skeleton with appropriate functionality at key points for analog development. ..
  3. Synthesis of Macrolides. Steroids, Cyclopentanoids, etc
    BARRY TROST; Fiscal Year: 2005
    ..This new concept sets the stage for solutions to a long standing problem, the ion channel blockers, the grayanotoxins. as well as the more recently discovered rameswaralide, a potent antiinflamatory. ..
  4. Synthesis of Macrolides, Steroids, Cyclopentanoids, etc.
    BARRY TROST; Fiscal Year: 2006
    ..These new synthetic methods apply to many structural types beyond those illustrated and constitutes a significant to gain access to complex molecular targets more easily. [unreadable] [unreadable] [unreadable]..
  5. Synthesis of Macrolides, Steroids, Cyclopentanoids, etc.
    BARRY TROST; Fiscal Year: 2007
    ..These new synthetic methods apply to many structural types beyond those illustrated and constitutes a significant to gain access to complex molecular targets more easily. ..
  6. NOVEL APPROACHES TO ANTITUMOR AND ANTIVIRAL AGENTS
    BARRY TROST; Fiscal Year: 1993
    ..The diversity of the challenges posed by antiviral and antitumor agents represent highly meaningful tests of their use...
  7. SYNTHESIS OF MACROCYCLES STEROIDS CYCLOPENTANOIDS ETC
    BARRY TROST; Fiscal Year: 1999
    ..Ring expansion methods may convert these cores into the taxoid skeleton with appropriate functionality at key points for analog development. ..
  8. Synthesis of Macrolides, Steroids, Cyclopentanoids, etc.
    BARRY TROST; Fiscal Year: 2007
    ..These new synthetic methods apply to many structural types beyond those illustrated and constitutes a significant to gain access to complex molecular targets more easily. ..
  9. Synthesis of Macrolides, Steroids, Cyclopentanoids, etc.
    BARRY TROST; Fiscal Year: 2008
    ..These new synthetic methods apply to many structural types beyond those illustrated and constitutes a significant to gain access to complex molecular targets more easily. ..
  10. NOVEL APPROACHES TO ANTITUMOR AND ANTIVIRAL AGENTS
    BARRY TROST; Fiscal Year: 2005
    ..By expediting access to very diverse arrays of structural types, the best opportunities to discover new therapeutic agents arise. ..
  11. Synthesis of Macrolides. Steroids, Cyclopentanoids, etc
    BARRY TROST; Fiscal Year: 2002
    ..This new concept sets the stage for solutions to a long standing problem, the ion channel blockers, the grayanotoxins. as well as the more recently discovered rameswaralide, a potent antiinflamatory. ..
  12. NOVEL SYNTHETIC APPROACHES TO ANTITUMOR COMPOUNDS
    BARRY TROST; Fiscal Year: 1992
    ..A strategy to one family of tumor promoters represented by teleocidin explores the concept of chemical chameleons. In most cases, the strategy also considers the problem of absolute stereochemistry...
  13. NOVEL APPROACHES TO ANTITUMOR AND ANTIVIRAL AGENTS
    BARRY TROST; Fiscal Year: 1999
    ..Equally important, new avenues to vary structure around these cores in order to establish structure-activity relationships with the aim to create better therapeutic agents become available. ..
  14. NOVEL SYNTHETIC APPROACHES TO ANTITUMOR COMPOUNDS
    BARRY TROST; Fiscal Year: 1990
    ..A strategy to one family of tumor promoters represented by teleocidin explores the concept of chemical chameleons. In most cases, the strategy also considers the problem of absolute stereochemistry...
  15. Synthesis of Macrolides. Steroids, Cyclopentanoids, etc
    BARRY TROST; Fiscal Year: 2003
    ..This new concept sets the stage for solutions to a long standing problem, the ion channel blockers, the grayanotoxins. as well as the more recently discovered rameswaralide, a potent antiinflamatory. ..
  16. NOVEL APPROACHES TO ANTITUMOR AND ANTIVIRAL AGENTS
    BARRY TROST; Fiscal Year: 2002
    ..By accessing a very diverse range of structural types, the best opportunities to discover new therapeutic agents arise. ..
  17. Synthesis of Macrolides. Steroids, Cyclopentanoids, etc
    BARRY TROST; Fiscal Year: 2004
    ..This new concept sets the stage for solutions to a long standing problem, the ion channel blockers, the grayanotoxins. as well as the more recently discovered rameswaralide, a potent antiinflamatory. ..
  18. NOVEL APPROACHES TO ANTITUMOR AND ANTIVIRAL AGENTS
    BARRY TROST; Fiscal Year: 2008
    ..By expediting access to very diverse arrays of structural types, the best opportunities to discover new therapeutic agents arise. ..
  19. SYNTHESIS OF MACROCYCLES STEROIDS CYCLOPENTANOIDS ETC
    BARRY TROST; Fiscal Year: 2000
    ..Ring expansion methods may convert these cores into the taxoid skeleton with appropriate functionality at key points for analog development. ..
  20. Novel Approaches for Antitumor and Antiviral Agents
    BARRY TROST; Fiscal Year: 2009
    ..This proposal helps to address this key challenge by developing the underlying initial technology within classes of compounds having demonstrably antitumor or antiviral activities. ..
  21. Synthesis of Macrolides, Steroids, Cyclopentanoids, etc.
    BARRY TROST; Fiscal Year: 2009
    ..These new synthetic methods apply to many structural types beyond those illustrated and constitutes a significant to gain access to complex molecular targets more easily. ..
  22. NOVEL APPROACHES TO ANTITUMOR AND ANTIVIRAL AGENTS
    BARRY TROST; Fiscal Year: 2007
    ..By expediting access to very diverse arrays of structural types, the best opportunities to discover new therapeutic agents arise. ..
  23. NOVEL SYNTHETIC APPROACHES TO ANTITUMOR COMPOUNDS
    BARRY TROST; Fiscal Year: 1991
    ..A strategy to one family of tumor promoters represented by teleocidin explores the concept of chemical chameleons. In most cases, the strategy also considers the problem of absolute stereochemistry...
  24. NOVEL APPROACHES TO ANTITUMOR AND ANTIVIRAL AGENTS
    BARRY TROST; Fiscal Year: 2006
    ..By expediting access to very diverse arrays of structural types, the best opportunities to discover new therapeutic agents arise. ..
  25. NOVEL APPROACHES TO ANTITUMOR AND ANTIVIRAL AGENTS
    BARRY TROST; Fiscal Year: 2000
    ..Equally important, new avenues to vary structure around these cores in order to establish structure-activity relationships with the aim to create better therapeutic agents become available. ..
  26. NOVEL APPROACHES TO ANTITUMOR AND ANTIVIRAL AGENTS
    BARRY TROST; Fiscal Year: 2001
    ..By accessing a very diverse range of structural types, the best opportunities to discover new therapeutic agents arise. ..
  27. NOVEL APPROACHES TO ANTITUMOR AND ANTIVIRAL AGENTS
    BARRY TROST; Fiscal Year: 2003
    ..By accessing a very diverse range of structural types, the best opportunities to discover new therapeutic agents arise. ..
  28. Novel Approaches for Antitumor and Antiviral Agents
    Barry M Trost; Fiscal Year: 2010
    ..This proposal helps to address this key challenge by developing the underlying initial technology within classes of compounds having demonstrably antitumor or antiviral activities. ..