Rabindra Tirouvanziam

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. pmc Profound functional and signaling changes in viable inflammatory neutrophils homing to cystic fibrosis airways
    Rabindra Tirouvanziam
    Departments of Pediatrics, Genetics, and Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 105:4335-9. 2008
  2. pmc High-dose oral N-acetylcysteine, a glutathione prodrug, modulates inflammation in cystic fibrosis
    Rabindra Tirouvanziam
    Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 103:4628-33. 2006
  3. ncbi request reprint Neutrophilic inflammation as a major determinant in the progression of cystic fibrosis
    Rabindra Tirouvanziam
    Herzenberg Laboratory, Department of Genetics, Stanford University, Stanford, California 94305, USA
    Drug News Perspect 19:609-14. 2006
  4. doi request reprint Blood basophils from cystic fibrosis patients with allergic bronchopulmonary aspergillosis are primed and hyper-responsive to stimulation by aspergillus allergens
    Yael Gernez
    Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA
    J Cyst Fibros 11:502-10. 2012
  5. doi request reprint Modulation of mTOR effector phosphoproteins in blood basophils from allergic patients
    Yael Gernez
    Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Clin Immunol 32:565-73. 2012
  6. pmc Activation of critical, host-induced, metabolic and stress pathways marks neutrophil entry into cystic fibrosis lungs
    Megha Makam
    Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 106:5779-83. 2009
  7. pmc Functional evolution of the vertebrate Myb gene family: B-Myb, but neither A-Myb nor c-Myb, complements Drosophila Myb in hemocytes
    Colin J Davidson
    Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA
    Genetics 169:215-29. 2005
  8. pmc Basophil CD203c levels are increased at baseline and can be used to monitor omalizumab treatment in subjects with nut allergy
    Yael Gernez
    Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305, USA
    Int Arch Allergy Immunol 154:318-27. 2011
  9. doi request reprint Immunophenotyping of peripheral eosinophils demonstrates activation in eosinophilic esophagitis
    Tammie Nguyen
    Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Pediatr Gastroenterol Nutr 53:40-7. 2011
  10. doi request reprint A randomized controlled pilot trial of oral N-acetylcysteine in children with autism
    Antonio Y Hardan
    Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, California 94305, USA
    Biol Psychiatry 71:956-61. 2012

Collaborators

Detail Information

Publications15

  1. pmc Profound functional and signaling changes in viable inflammatory neutrophils homing to cystic fibrosis airways
    Rabindra Tirouvanziam
    Departments of Pediatrics, Genetics, and Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 105:4335-9. 2008
    ..Thus, we identified a subset of neutrophils within CF airways with a viable but dysfunctional phenotype. This subset provides a possible therapeutic target and indicates a need to revisit current paradigms of CF airway disease...
  2. pmc High-dose oral N-acetylcysteine, a glutathione prodrug, modulates inflammation in cystic fibrosis
    Rabindra Tirouvanziam
    Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 103:4628-33. 2006
    ..032). Thus, high-dose oral N-acetylcysteine has the potential to counter the intertwined redox and inflammatory imbalances in CF...
  3. ncbi request reprint Neutrophilic inflammation as a major determinant in the progression of cystic fibrosis
    Rabindra Tirouvanziam
    Herzenberg Laboratory, Department of Genetics, Stanford University, Stanford, California 94305, USA
    Drug News Perspect 19:609-14. 2006
    ..Thus, researchers and clinicians need to view the pathophysiological importance of neutrophils in a new light, to the ultimate benefit of patients...
  4. doi request reprint Blood basophils from cystic fibrosis patients with allergic bronchopulmonary aspergillosis are primed and hyper-responsive to stimulation by aspergillus allergens
    Yael Gernez
    Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA
    J Cyst Fibros 11:502-10. 2012
    ..Since basophils play a key role in allergy, we hypothesized that they would display alterations in CF-ABPA patients compared to CF-AC or patients without Af colonization (CF)...
  5. doi request reprint Modulation of mTOR effector phosphoproteins in blood basophils from allergic patients
    Yael Gernez
    Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Clin Immunol 32:565-73. 2012
    ..Thus, basophil responses to offending allergens are associated with modulation of mTOR effector phosphoproteins...
  6. pmc Activation of critical, host-induced, metabolic and stress pathways marks neutrophil entry into cystic fibrosis lungs
    Megha Makam
    Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 106:5779-83. 2009
    ..Taken together, our data demonstrate an early and sustained activation of host-responsive metabolic and stress pathways upon neutrophil entry into CF airways, suggesting potential targets for therapeutic modulation...
  7. pmc Functional evolution of the vertebrate Myb gene family: B-Myb, but neither A-Myb nor c-Myb, complements Drosophila Myb in hemocytes
    Colin J Davidson
    Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA
    Genetics 169:215-29. 2005
    ..Finally, these experiments demonstrate the utility of genetic complementation in Drosophila to explore the functional evolution of duplicated genes in vertebrates...
  8. pmc Basophil CD203c levels are increased at baseline and can be used to monitor omalizumab treatment in subjects with nut allergy
    Yael Gernez
    Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305, USA
    Int Arch Allergy Immunol 154:318-27. 2011
    ..Basophils contribute to anaphylaxis and allergies. We examined the utility of assessing basophil-associated surface antigens (CD11b/CD63/CD123/CD203c/CD294) in characterizing and monitoring subjects with nut allergy...
  9. doi request reprint Immunophenotyping of peripheral eosinophils demonstrates activation in eosinophilic esophagitis
    Tammie Nguyen
    Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Pediatr Gastroenterol Nutr 53:40-7. 2011
    ..The aim of the study was to assess whether any surface molecules or transcription factors are activated in peripheral eosinophils in subjects with EoE...
  10. doi request reprint A randomized controlled pilot trial of oral N-acetylcysteine in children with autism
    Antonio Y Hardan
    Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, California 94305, USA
    Biol Psychiatry 71:956-61. 2012
    ..The goal of this pilot study was to assess the feasibility of using oral N-acetylcysteine (NAC), a glutamatergic modulator and an antioxidant, in the treatment of behavioral disturbance in children with autism...
  11. doi request reprint Distinct plasma profile of polar neutral amino acids, leucine, and glutamate in children with Autism Spectrum Disorders
    Rabindra Tirouvanziam
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Autism Dev Disord 42:827-36. 2012
    ..Findings from this limited prospective study warrant further examination of plasma AA levels in larger cross-sectional and longitudinal cohorts to adequately assess for relationships with developmental and clinical features of ASD...
  12. pmc Altered phosphorylated signal transducer and activator of transcription profile of CD4+CD161+ T cells in asthma: modulation by allergic status and oral corticosteroids
    Yael Gernez
    Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA
    J Allergy Clin Immunol 120:1441-8. 2007
    ..Asthma is a complex immunologic disorder linked to altered cytokine signaling...
  13. doi request reprint The long-term impact of early adversity on late-life psychiatric disorders
    ANDA GERSHON
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 401 Quarry Road, Stanford, CA 94305 5717, USA
    Curr Psychiatry Rep 15:352. 2013
    ..We conclude with clinical implications, methodological challenges and suggestions for future research...
  14. pmc Fluorescence-activated cell sorting (FACS) of Drosophila hemocytes reveals important functional similarities to mammalian leukocytes
    Rabindra Tirouvanziam
    Herzenberg Laboratory, Department of Genetics, Stanford University School of Medicine, Beckman Center B007, Stanford, CA 94305 5318, USA
    Proc Natl Acad Sci U S A 101:2912-7. 2004
    ....
  15. ncbi request reprint Primary inflammation in human cystic fibrosis small airways
    Rabindra Tirouvanziam
    Institut National de la Santé et de la Recherche Médicale U506, 94807 Villejuif, France
    Am J Physiol Lung Cell Mol Physiol 283:L445-51. 2002
    ..This model of mature human small airways provides the first clear-cut evidence that, in CF, inflammation may arise at least partly from a primary defect in the regulation of neutrophil recruitment, independently of infection...