EDITH VIONI SULLIVAN

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. ncbi Effect of vision, touch and stance on cerebellar vermian-related sway and tremor: a quantitative physiological and MRI study
    Edith V Sullivan
    Department of Psychiatry and Behavioral Sciences and Neuroscience Program, Stanford University School of Medicine, Stanford, CA 94305, USA
    Cereb Cortex 16:1077-86. 2006
  2. ncbi In vivo quantification of ethanol kinetics in rat brain
    Elfar Adalsteinsson
    Harvard-MIT Division of Health Sciences and Technology, MIT, Cambridge, MA, USA
    Neuropsychopharmacology 31:2683-91. 2006
  3. ncbi Diffusion tensor imaging and aging
    Edith V Sullivan
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 401 Quarry Road, Stanford, CA 94305, USA
    Neurosci Biobehav Rev 30:749-61. 2006
  4. ncbi Neurocircuitry in alcoholism: a substrate of disruption and repair
    Edith V Sullivan
    Department of Psychiatry and Behavioral Sciences and Neuroscience Program, Stanford University School of Medicine, Stanford, CA 94305 5723, USA
    Psychopharmacology (Berl) 180:583-94. 2005
  5. ncbi Effects of alcohol dependence comorbidity and antipsychotic medication on volumes of the thalamus and pons in schizophrenia
    Edith V Sullivan
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305 5723, USA
    Am J Psychiatry 160:1110-6. 2003
  6. ncbi Neuroimaging of the Wernicke-Korsakoff syndrome
    Edith V Sullivan
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA
    Alcohol Alcohol 44:155-65. 2009
  7. ncbi Neuroinflammation as a neurotoxic mechanism in alcoholism: commentary on "Increased MCP-1 and microglia in various regions of human alcoholic brain"
    Edith V Sullivan
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 401 Quarry Road, Stanford, CA 94305, USA
    Exp Neurol 213:10-7. 2008
  8. ncbi Compromised pontocerebellar and cerebellothalamocortical systems: speculations on their contributions to cognitive and motor impairment in nonamnesic alcoholism
    Edith V Sullivan
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, California 94305 5723, USA
    Alcohol Clin Exp Res 27:1409-19. 2003
  9. ncbi Quantitative fiber tracking of lateral and interhemispheric white matter systems in normal aging: relations to timed performance
    Edith V Sullivan
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine MC5723, 401 Quarry Road, Stanford, CA 94305 5723, United States
    Neurobiol Aging 31:464-81. 2010
  10. ncbi Hippocampal volume deficits in alcoholic Korsakoff's syndrome
    Edith V Sullivan
    Department of Psychiatry and Behavioral Sciences and Neuroscience Program, Stanford University School of Medicine, Stanford, CA 94305 5723, USA
    Neurology 61:1716-9. 2003

Research Grants

  1. CEREBELLAR STRUCTURE AND FUNCTION IN ALCOHOLISM
    Edith Sullivan; Fiscal Year: 2007
  2. NORMAL AGING OF BRAIN STRUCTURE AND FUNCTION
    EDITH VIONI SULLIVAN; Fiscal Year: 2010
  3. NORMAL AGING OF BRAIN STRUCTURE AND FUNCTION
    Edith Sullivan; Fiscal Year: 2007
  4. NORMAL AGING OF BRAIN STRUCTURE AND FUNCTION
    Edith Sullivan; Fiscal Year: 2009
  5. NORMAL AGING OF BRAIN STRUCTURE AND FUNCTION
    Edith Sullivan; Fiscal Year: 2004
  6. CEREBELLAR STRUCTURE AND FUNCTION IN ALCOHOLISM
    Edith Sullivan; Fiscal Year: 2003

Detail Information

Publications95

  1. ncbi Effect of vision, touch and stance on cerebellar vermian-related sway and tremor: a quantitative physiological and MRI study
    Edith V Sullivan
    Department of Psychiatry and Behavioral Sciences and Neuroscience Program, Stanford University School of Medicine, Stanford, CA 94305, USA
    Cereb Cortex 16:1077-86. 2006
    ....
  2. ncbi In vivo quantification of ethanol kinetics in rat brain
    Elfar Adalsteinsson
    Harvard-MIT Division of Health Sciences and Technology, MIT, Cambridge, MA, USA
    Neuropsychopharmacology 31:2683-91. 2006
    ..Serial proton spectroscopy measurements provide a valid in vivo method for quantifying brain alcohol uptake and elimination kinetics in real time...
  3. ncbi Diffusion tensor imaging and aging
    Edith V Sullivan
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 401 Quarry Road, Stanford, CA 94305, USA
    Neurosci Biobehav Rev 30:749-61. 2006
    ..These hypotheses are not mutually exclusive but establish a basis for posing testable questions about brain systems recruited when those used in youth are altered by aging...
  4. ncbi Neurocircuitry in alcoholism: a substrate of disruption and repair
    Edith V Sullivan
    Department of Psychiatry and Behavioral Sciences and Neuroscience Program, Stanford University School of Medicine, Stanford, CA 94305 5723, USA
    Psychopharmacology (Berl) 180:583-94. 2005
    ....
  5. ncbi Effects of alcohol dependence comorbidity and antipsychotic medication on volumes of the thalamus and pons in schizophrenia
    Edith V Sullivan
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305 5723, USA
    Am J Psychiatry 160:1110-6. 2003
    ..The authors sought to determine whether patients with both schizophrenia and alcohol dependence would manifest exaggerated volume deficits in either structure...
  6. ncbi Neuroimaging of the Wernicke-Korsakoff syndrome
    Edith V Sullivan
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA
    Alcohol Alcohol 44:155-65. 2009
    ....
  7. ncbi Neuroinflammation as a neurotoxic mechanism in alcoholism: commentary on "Increased MCP-1 and microglia in various regions of human alcoholic brain"
    Edith V Sullivan
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 401 Quarry Road, Stanford, CA 94305, USA
    Exp Neurol 213:10-7. 2008
  8. ncbi Compromised pontocerebellar and cerebellothalamocortical systems: speculations on their contributions to cognitive and motor impairment in nonamnesic alcoholism
    Edith V Sullivan
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, California 94305 5723, USA
    Alcohol Clin Exp Res 27:1409-19. 2003
    ....
  9. ncbi Quantitative fiber tracking of lateral and interhemispheric white matter systems in normal aging: relations to timed performance
    Edith V Sullivan
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine MC5723, 401 Quarry Road, Stanford, CA 94305 5723, United States
    Neurobiol Aging 31:464-81. 2010
    ....
  10. ncbi Hippocampal volume deficits in alcoholic Korsakoff's syndrome
    Edith V Sullivan
    Department of Psychiatry and Behavioral Sciences and Neuroscience Program, Stanford University School of Medicine, Stanford, CA 94305 5723, USA
    Neurology 61:1716-9. 2003
    ..To examine whether the amnesic syndrome of alcoholic Korsakoff's syndrome (KS) originates from pathology of the hippocampus and not solely the diencephalon...
  11. ncbi Effects of age and sex on volumes of the thalamus, pons, and cortex
    Edith V Sullivan
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, USA
    Neurobiol Aging 25:185-92. 2004
    ..Both pontine and cortical white matter volumes remained stable across the age span in both men and women...
  12. ncbi Postural sway reduction in aging men and women: relation to brain structure, cognitive status, and stabilizing factors
    Edith V Sullivan
    Department of Psychiatry and Behavioral Sciences and Neuroscience Program, Stanford University School of Medicine, 401 Quarry Road, Stanford, CA 94305 5723, United States
    Neurobiol Aging 30:793-807. 2009
    ..Thus, aging men and women were shown to have diminished postural control, associated with cognitive and brain structural involution, in unstable stance conditions and with diminished sensory input...
  13. ncbi Alcohol and drug dependence: brain mechanisms and behavioral impact
    Edith V Sullivan
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine (MC5723, 401 Quarry Road, Stanford, CA 94305-5723, USA
    Neuropsychol Rev 17:235-8. 2007
  14. ncbi Balance and gait deficits in schizophrenia compounded by the comorbidity of alcoholism
    Edith V Sullivan
    Department of Psychiatry and Behavoiral Sciences, Stanford University School of Medicine, CA 94305 5723, USA
    Am J Psychiatry 161:751-5. 2004
    ..Alcoholism carries a liability of balance and gait instability that persists with sobriety. Such deficits are less well documented in schizophrenia and may be compounded by comorbidity with alcoholism, which is prevalent in schizophrenia...
  15. ncbi Neuroimaging of rodent and primate models of alcoholism: initial reports from the integrative neuroscience initiative on alcoholism
    Edith V Sullivan
    Department of Psychiatry and Behavioral Sciences and Neuroscience Program, Stanford University School of Medicine, Stanford, California 94305 5723, USA
    Alcohol Clin Exp Res 29:287-94. 2005
    ....
  16. ncbi Preservation of hippocampal volume throughout adulthood in healthy men and women
    Edith V Sullivan
    Department of Psychiatry and Behavioral Sciences and Neuroscience Program, Stanford University School of Medicine, 401 Quarry Road, Stanford, CA 94305 5723, USA
    Neurobiol Aging 26:1093-8. 2005
    ..Absence of hippocampus age relationships endured when restricting analyses to older individuals (> or =50 years) and considering menopause and hormone replacement therapy...
  17. ncbi Selective age-related degradation of anterior callosal fiber bundles quantified in vivo with fiber tracking
    Edith V Sullivan
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA
    Cereb Cortex 16:1030-9. 2006
    ....
  18. ncbi Striatal and forebrain nuclei volumes: contribution to motor function and working memory deficits in alcoholism
    Edith V Sullivan
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305 5723, USA
    Biol Psychiatry 57:768-76. 2005
    ..Basal forebrain structures hold cholinergic mechanisms influencing memory formation, vulnerable to chronic alcoholism; however, alcoholism's effect on volumes of these structures has seldom been considered with in vivo measurement...
  19. ncbi Physiological and focal cerebellar substrates of abnormal postural sway and tremor in alcoholic women
    Edith V Sullivan
    Departments of Psychiatry and Behavioral Sciences and Neuroscience Program, Stanford University School of Medicine, Stanford, California 94305 5723, USA
    Biol Psychiatry 67:44-51. 2010
    ....
  20. ncbi Pontocerebellar volume deficits and ataxia in alcoholic men and women: no evidence for "telescoping"
    Edith V Sullivan
    Department of Psychiatry and Behavioral Sciences, School of Medicine, Stanford University, 401 Quarry Road, Stanford, CA 94305 5723, USA
    Psychopharmacology (Berl) 208:279-90. 2010
    ....
  21. ncbi Differential rates of regional brain change in callosal and ventricular size: a 4-year longitudinal MRI study of elderly men
    E V Sullivan
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA
    Cereb Cortex 12:438-45. 2002
    ....
  22. ncbi A profile of neuropsychological deficits in alcoholic women
    Edith V Sullivan
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, California 94305 5723, USA
    Neuropsychology 16:74-83. 2002
    ..The alcohol-related deficits in working memory, visuospatial, and balance implicate disruption of prefrontal, superior parietal, and cerebellar brain systems...
  23. ncbi Heritability of hippocampal size in elderly twin men: equivalent influence from genes and environment
    E V Sullivan
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, California 94305 5723, USA
    Hippocampus 11:754-62. 2001
    ..Considering the potential of environmental modification of this structure suggested by lower heritability, the hippocampus appears well-suited to support the dynamic processes of encoding and consolidation of new, declarataive memories...
  24. ncbi Magnetic resonance relaxometry reveals central pontine abnormalities in clinically asymptomatic alcoholic men
    E V Sullivan
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California 94305 5723, USA
    Alcohol Clin Exp Res 25:1206-12. 2001
    ....
  25. ncbi Motor sequencing deficits in schizophrenia: a comparison with Parkinson's disease
    E V Sullivan
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, California 94305 5723, USA
    Neuropsychology 15:342-50. 2001
    ....
  26. ncbi Sex differences in corpus callosum size: relationship to age and intracranial size
    E V Sullivan
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, USA
    Neurobiol Aging 22:603-11. 2001
    ..Sexual dimorphism in the corpus callosum is not a simple artifact of sex differences in brain size and may reflect differences in connectivity necessitated by differences in brain size...
  27. ncbi Contribution of alcohol abuse to cerebellar volume deficits in men with schizophrenia
    E V Sullivan
    Department of Psychiatry and Behavioral Sciences 5717, Stanford University School of Medicine, 401 Quarry Rd, Stanford, CA 94305 5717, USA
    Arch Gen Psychiatry 57:894-902. 2000
    ..Complicating such investigations is the high incidence of alcoholism comorbidity in patients with schizophrenia that itself can contribute to cerebellar abnormalities...
  28. ncbi Cerebellar volume decline in normal aging, alcoholism, and Korsakoff's syndrome: relation to ataxia
    E V Sullivan
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, California 94305 5717, USA
    Neuropsychology 14:341-52. 2000
    ..Regional distribution but not severity of cerebellar volume deficits is similar in alcoholic individuals whether or not complicated by KS and relates to ataxia...
  29. ncbi Pattern of motor and cognitive deficits in detoxified alcoholic men
    E V Sullivan
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, California 94305 5717, USA
    Alcohol Clin Exp Res 24:611-21. 2000
    ....
  30. ncbi Pontocerebellar contribution to postural instability and psychomotor slowing in HIV infection without dementia
    Edith V Sullivan
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 401 Quarry Road, Stanford, CA 94305 5723, USA
    Brain Imaging Behav 5:12-24. 2011
    ..Postural stability and psychomotor speed were impaired and attributable, at least in part, to compromised infratentorial brain systems...
  31. ncbi Speed and efficiency but not accuracy or timing deficits of limb movements in alcoholic men and women
    Edith V Sullivan
    Department of Psychiatry, Stanford University School of Medicine, California 94305 5723, USA
    Alcohol Clin Exp Res 26:705-13. 2002
    ..Whether evidence for such dysfunction lingers in patients with uncomplicated alcoholism, which is known to affect cerebellar structural integrity, is controversial...
  32. ncbi Mechanisms of postural control in alcoholic men and women: biomechanical analysis of musculoskeletal coordination during quiet standing
    Edith V Sullivan
    Department of Psychiatry and Behavioral Sciences and Neuroscience Program, Stanford University School of Medicine, Stanford, California 94305 5723, USA
    Alcohol Clin Exp Res 34:528-37. 2010
    ..Whether alcoholic men and women who have remained abstinent from alcohol for weeks to months differ from each other in the degree of residual postural instability and biomechanical control mechanisms has not been directly tested...
  33. ncbi Fiber tracking functionally distinct components of the internal capsule
    Edith V Sullivan
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305 5723, USA
    Neuropsychologia 48:4155-63. 2010
    ....
  34. ncbi Longitudinal study of callosal microstructure in the normal adult aging brain using quantitative DTI fiber tracking
    Edith V Sullivan
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California 94305 5723, USA
    Dev Neuropsychol 35:233-56. 2010
    ....
  35. ncbi Dual tasking and working memory in alcoholism: relation to frontocerebellar circuitry
    Sandra Chanraud
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305 5723, USA
    Neuropsychopharmacology 35:1868-78. 2010
    ....
  36. ncbi Development and resolution of brain lesions caused by pyrithiamine- and dietary-induced thiamine deficiency and alcohol exposure in the alcohol-preferring rat: a longitudinal magnetic resonance imaging and spectroscopy study
    Adolf Pfefferbaum
    Neuroscience Program, SRI International, Menlo Park, CA, USA
    Neuropsychopharmacology 32:1159-77. 2007
    ....
  37. ncbi Low striatal glutamate levels underlie cognitive decline in the elderly: evidence from in vivo molecular spectroscopy
    Natalie M Zahr
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 401 Quarry Road, Stanford, CA 94305 5723, USA
    Cereb Cortex 18:2241-50. 2008
    ..The selective relations between performance and striatal Glu provide initial and novel, human in vivo support for age-related modification of Glu levels as contributing to cognitive decline in normal aging...
  38. ncbi Recovery of short-term memory and psychomotor speed but not postural stability with long-term sobriety in alcoholic women
    Margaret J Rosenbloom
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA
    Neuropsychology 18:589-97. 2004
    ..By Year 4, 13 of 14 returners had maintained sobriety for more than 30 months; as a group, these women had returned to normal levels on tests of memory and psychomotor speed but remained impaired in standing balance...
  39. ncbi Brain injury and recovery following binge ethanol: evidence from in vivo magnetic resonance spectroscopy
    Natalie M Zahr
    Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California 94305, USA
    Biol Psychiatry 67:846-54. 2010
    ..The current in vivo magnetic resonance (MR) imaging and spectroscopy study was conducted to test the hypothesis that binge EtOH exposure would injure but not cause the death of neurons as previously ascertained postmortem...
  40. ncbi In vivo glutamate decline associated with kainic acid-induced status epilepticus
    Natalie M Zahr
    Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 401 Quarry Rd, Stanford, CA 94305, USA
    Brain Res 1300:65-78. 2009
    ..Taken together, these results support the conclusion that seizure activity following KA infusion causes loss of glutamatergic neurons...
  41. ncbi Working and episodic memory in HIV infection, alcoholism, and their comorbidity: baseline and 1-year follow-up examinations
    Rosemary Fama
    Neuroscience Program, SRI International, Menlo Park, California 94305 5723, USA
    Alcohol Clin Exp Res 33:1815-24. 2009
    ....
  42. ncbi Diffusion tensor imaging with quantitative fibre tracking in HIV infection and alcoholism comorbidity: synergistic white matter damage
    Adolf Pfefferbaum
    Neuroscience Program, SRI International Stanford University School of Medicine, Stanford, CA 94305 5723, USA
    Brain 130:48-64. 2007
    ....
  43. ncbi Local-global interference is modulated by age, sex and anterior corpus callosum size
    Eva M Müller-Oehring
    Department of Psychiatry and Behavioral Sciences MC 5723, Stanford University School of Medicine, 401 Quarry Road, Stanford, CA 94305 5723, USA
    Brain Res 1142:189-205. 2007
    ....
  44. ncbi Improvement in memory and static balance with abstinence in alcoholic men and women: selective relations with change in brain structure
    Margaret J Rosenbloom
    Department of Psychiatry and Behavioral Science, Stanford University School of Medicine, 401 Quarry Road, Stanford, CA 94305 5723, USA
    Psychiatry Res 155:91-102. 2007
    ..Both memory and ataxia can improve with sustained sobriety, and brain-behavior associations suggest selective brain structural substrates for the changes observed...
  45. ncbi Callosal microstructural abnormalities in Alzheimer's disease and alcoholism: same phenotype, different mechanisms
    Anne Lise Pitel
    Department of Psychiatry and Behavioral Sciences and Neuroscience Program, Stanford University School of Medicine, Stanford, CA 94305, USA
    Psychiatry Res 184:49-56. 2010
    ..Conversely, in alcoholism, disruption of callosal microstructural integrity was related to shrinkage of the corpus callosum itself...
  46. ncbi Preliminary evidence of reduced cognitive inhibition in methamphetamine-dependent individuals
    Ruth Salo
    Department of Psychiatry, UC Davis Medical Center, 2230 Stockton Blvd, Sacramento, CA 95817, USA
    Psychiatry Res 111:65-74. 2002
    ..Furthermore, the dissociation between explicit attentional performance and priming effects suggests that some attentional functions are not as affected by long-term methamphetamine use as others...
  47. ncbi Differential effect of HIV infection and alcoholism on conflict processing, attentional allocation, and perceptual load: evidence from a Stroop Match-to-Sample task
    Tilman Schulte
    Neuroscience Program, SRI International, Menlo Park, CA, USA
    Biol Psychiatry 57:67-75. 2005
    ..Although HIV alone did not demonstrate detectable impairment in performance, HIV conferred liability on attentional processes when combined with alcohol abuse...
  48. ncbi Disruption of brain white matter microstructure by excessive intracellular and extracellular fluid in alcoholism: evidence from diffusion tensor imaging
    Adolf Pfefferbaum
    Neuroscience Program, SRI International, Stanford University School of Medicine, CA, USA
    Neuropsychopharmacology 30:423-32. 2005
    ....
  49. ncbi Persistent cognitive deficits in community-treated alcoholic men and women volunteering for research: limited contribution from psychiatric comorbidity
    Margaret J Rosenbloom
    Department of Psychiatry and Behavioral Science, Stanford University School of Medicine, Stanford, CA 94025, USA
    J Stud Alcohol 66:254-65. 2005
    ..While unexpected, this finding suggests that, in this sample, poorer cognitive performance was more a function of alcoholism per se than nonalcoholic comorbidity...
  50. ncbi Global-local interference is related to callosal compromise in alcoholism: a behavior-DTI association study
    Eva M Müller-Oehring
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California 94305 5723, USA
    Alcohol Clin Exp Res 33:477-89. 2009
    ....
  51. ncbi Compounded brain volume deficits in schizophrenia-alcoholism comorbidity
    Daniel H Mathalon
    Department of Psychiatry, Yale University School of Medicine Veterans Affairs Connecticut Healthcare System, West Haven 06516, USA
    Arch Gen Psychiatry 60:245-52. 2003
    ..Schizophrenia and alcoholism are characterized by brain volume abnormalities. Despite the frequent comorbidity of these conditions, the potentially compounded effects of comorbidity on brain structure have seldom been rigorously assessed...
  52. ncbi Callosal degradation in HIV-1 infection predicts hierarchical perception: a DTI study
    Eva M Müller-Oehring
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 401 Quarry Road, Stanford, CA 94305, USA
    Neuropsychologia 48:1133-43. 2010
    ..We conclude that component processes of visuospatial perception are compromised in HIV-1 infection attributable, at least in part, to degraded callosal microstructural integrity relevant for local-global feature integration...
  53. ncbi Disruption of frontocerebellar circuitry and function in alcoholism
    Edith V Sullivan
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305 5723, USA
    Alcohol Clin Exp Res 27:301-9. 2003
    ..Martin and Mitchell H. Parks; and Functional reorganization of the brain in alcoholism: neuroimaging evidence, by John E. Desmond, S.H. Annabel Chen, Michelle R. Pryor, Eve De Rosa, Adolf Pfefferbaum, and Edith V. Sullivan...
  54. ncbi Enhanced release from proactive interference in nonamnesic alcoholic individuals: implications for impaired associative binding
    Eve De Rosa
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, USA
    Neuropsychology 17:469-81. 2003
    ..The absence of PI in alcoholic participants may reflect impaired configural binding of paired-associate stimuli while sparing the elemental ability to process each stimulus component...
  55. ncbi Measurement of serum, liver, and brain cytokine induction, thiamine levels, and hepatopathology in rats exposed to a 4-day alcohol binge protocol
    Natalie M Zahr
    Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 401 Quarry Rd, Stanford, CA 94305, USA
    Alcohol Clin Exp Res 34:1858-70. 2010
    ....
  56. ncbi In vivo evidence for alcohol-induced neurochemical changes in rat brain without protracted withdrawal, pronounced thiamine deficiency, or severe liver damage
    Natalie M Zahr
    Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305 5723, USA
    Neuropsychopharmacology 34:1427-42. 2009
    ..Thus, we provide novel in vivo evidence for alcohol exposure as causing changes in brain chemistry in the absence of protracted withdrawal, pronounced thiamine deficiency, or severe liver damage...
  57. ncbi Reproducibility study of whole-brain 1H spectroscopic imaging with automated quantification
    Meng Gu
    Department of Electrical Engineering, Stanford University, Stanford, California 94305 5488, USA
    Magn Reson Med 60:542-7. 2008
    ..The results demonstrate that reproducible whole-brain (1)H-MRSI data can be robustly obtained with the proposed methods...
  58. ncbi Longitudinal brain magnetic resonance imaging study of the alcohol-preferring rat. Part I: adult brain growth
    Edith V Sullivan
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California, USA
    Alcohol Clin Exp Res 30:1234-47. 2006
    ....
  59. ncbi Increased frontocerebellar activation in alcoholics during verbal working memory: an fMRI study
    John E Desmond
    Department of Radiology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Neuroimage 19:1510-20. 2003
    ....
  60. ncbi Diffusion tensor imaging in normal aging and neuropsychiatric disorders
    Edith V Sullivan
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA
    Eur J Radiol 45:244-55. 2003
    ..Investigations comparing diagnoses hold promise for contribution to differential diagnosis. Correlations with cognitive and motor performance provide evidence for functional ramifications of these diffusion measures...
  61. ncbi In vivo metabolite differences between the basal ganglia and cerebellum of the rat brain detected with proton MRS at 3T
    Dirk Mayer
    Radiology Department Lucas MRS I Center Stanford University, 1201 Welch Road, P 273, Stanford, California 94305 5488, USA
    Psychiatry Res 154:267-73. 2007
    ....
  62. ncbi Volumetric cerebral perfusion imaging in healthy adults: regional distribution, laterality, and repeatability of pulsed continuous arterial spin labeling (PCASL)
    Adolf Pfefferbaum
    Neuroscience Program, SRI International, Menlo Park, CA, USA
    Psychiatry Res 182:266-73. 2010
    ..High CBF in the posterior cingulate and posterior and central precuneus cortices in this task-free acquisition suggests high activity in these principal nodes of the "default mode network."..
  63. ncbi In vivo fiber tracking in the rat brain on a clinical 3T MRI system using a high strength insert gradient coil
    Dirk Mayer
    Department of Radiology, Stanford University School of Medicine, Stanford, CA, USA
    Neuroimage 35:1077-85. 2007
    ..An additional benefit of scanning at lower field strength, such as 3 T, is the reduction of artifacts due to main field inhomogeneity relative to higher field animal systems...
  64. ncbi The human basal forebrain integrates the old and the new
    Eve De Rosa
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305 USA
    Neuron 41:825-37. 2004
    ..These results provide evidence for parallel neural systems, each with the potential to resolve interference in the face of competing information...
  65. ncbi Low N-acetyl-aspartate and high choline in the anterior cingulum of recently abstinent methamphetamine-dependent subjects: a preliminary proton MRS study. Magnetic resonance spectroscopy
    Thomas E Nordahl
    Department of Psychiatry and Behavioral Sciences, University of California, Davis, CA, USA
    Psychiatry Res 116:43-52. 2002
    ..The neuronal compromise that these changes reflect may contribute to the attentional deficits and dampened reward system in MD...
  66. ncbi Gray matter N-acetyl aspartate deficits in secondary progressive but not relapsing-remitting multiple sclerosis
    Elfar Adalsteinsson
    Department of Radiology, Stanford University School of Medicine, Stanford, CA, USA
    AJNR Am J Neuroradiol 24:1941-5. 2003
    ....
  67. ncbi Problem solving, working memory, and motor correlates of association and commissural fiber bundles in normal aging: a quantitative fiber tracking study
    Natalie M Zahr
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305 5723, USA
    Neuroimage 44:1050-62. 2009
    ....
  68. ncbi Subject-matched templates for spatial normalization
    Torsten Rohlfing
    Neuroscience Program, SRI International, Menlo Park, CA, USA
    Med Image Comput Comput Assist Interv 12:224-31. 2009
    ..We demonstrate that such an approach is technically feasible and significantly improves spatial normalization accuracy over using a single template...
  69. ncbi Using magnetic resonance imaging and diffusion tensor imaging to assess brain damage in alcoholics
    Margaret Rosenbloom
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California, USA
    Alcohol Res Health 27:146-52. 2003
    ..Ultimately DTI may be useful in elucidating the mechanisms that underlie macrostructural and functional brain changes seen with abstinence and relapse...
  70. ncbi MR diffusion tensor imaging: a window into white matter integrity of the working brain
    Sandra Chanraud
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine MC5723, 401 Quarry Road, Stanford, CA 94305 5723, USA
    Neuropsychol Rev 20:209-25. 2010
    ..Here we present an overview of the principles of diffusion tensor imaging (DTI) and its contribution to progress in our current understanding of normal and pathological brain function...
  71. ncbi Regional striatal volume abnormalities in schizophrenia: effects of comorbidity for alcoholism, recency of alcoholic drinking, and antipsychotic medication type
    Anjali Deshmukh
    Neuroscience Program, SRI International, Menlo Park, California, USA
    Schizophr Res 79:189-200. 2005
    ..Further, these cross-sectional data provide indirect support for at least partial recovery of nucleus accumbens volume with sobriety in alcoholics, regardless of schizophrenia comorbidity...
  72. ncbi Cortical NAA deficits in HIV infection without dementia: influence of alcoholism comorbidity
    Adolf Pfefferbaum
    Neuroscience Program, SRI International, Menlo Park, CA 94025, USA
    Neuropsychopharmacology 30:1392-9. 2005
    ..Further, the use of absolute measures revealed deficits in NAA and Cr that would have gone undetected if these metabolites were expressed as a ratio...
  73. ncbi Dysmorphology and microstructural degradation of the corpus callosum: Interaction of age and alcoholism
    Adolf Pfefferbaum
    Neuroscience Program, SRI International, 333 Ravenswood Avenue, Menlo Park, CA 94025, USA
    Neurobiol Aging 27:994-1009. 2006
    ..Thus, despite abstinence from alcohol, the interaction of age and recent alcoholism history exerted a compounded untoward effect on callosal macrostructure and microstructure...
  74. ncbi Alcoholic neurobiology: changes in dependence and recovery
    Fulton T Crews
    Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill 27599 7178, USA
    Alcohol Clin Exp Res 29:1504-13. 2005
    ....
  75. ncbi Corpus callosum, pons, and cortical white matter in alcoholic women
    Adolf Pfefferbaum
    Neuroscience Program, SRI International, 333 Ravenswood Avenue, Menlo Park, CA 94025, USA
    Alcohol Clin Exp Res 26:400-6. 2002
    ..To measure the effect of alcohol abuse on white matter brain macrostructure in women with alcoholism and to determine whether observed abnormalities interact with age...
  76. ncbi Motor sequencing in Parkinson's disease: relationship to executive function and motor rigidity
    Rosemary Fama
    Neuroscience Program, SRI International
    Cortex 38:753-67. 2002
    ..The results further suggest that the more complex the motor sequencing task, the more susceptible it is to influence from generalized cognitive sequencing ability...
  77. ncbi Supratentorial profile of white matter microstructural integrity in recovering alcoholic men and women
    Adolf Pfefferbaum
    Neuroscience Program, SRI International, Menlo Park, CA 94025
    Biol Psychiatry 59:364-72. 2006
    ..The full extent of the white matter involvement in uncomplicated alcoholism, however, is unknown, yet knowledge of the distribution of white matter degradation might provide clues to mechanisms underlying the pathology...
  78. ncbi The effects of alcoholism on auditory evoked potentials during sleep
    Christian L Nicholas
    Department of Psychology, University of Melbourne, Melbourne, Australia
    J Sleep Res 11:247-53. 2002
    ..The finding also suggests that the evoked K-complex may be a relatively simple measure of the effect of alcoholism on EEG during sleep...
  79. ncbi A dissociation in attentional control: evidence from methamphetamine dependence
    Ruth Salo
    Department of Psychiatry and Behavioral Sciences and the Imaging Research Center, University of California Davis 95817, USA
    Biol Psychiatry 57:310-3. 2005
    ..The goal of this study was to test whether task-shifting, selective inhibition, or both processes were impaired in long-term but currently abstinent methamphetamine-dependent individuals...
  80. ncbi Clinical signs of cerebellar dysfunction in schizophrenia, alcoholism, and their comorbidity
    Anjali Deshmukh
    Neuroscience Program, SRI International, Menlo Park, CA 94025, USA
    Schizophr Res 57:281-91. 2002
    ..By contrast, clinical signs of cerebellar dysfunction of gait and stance in patients with schizophrenia may be secondary to the effects of alcohol on the cerebellum...
  81. ncbi Frontal circuitry degradation marks healthy adult aging: Evidence from diffusion tensor imaging
    Adolf Pfefferbaum
    Neuroscience Program, SRI International, USA
    Neuroimage 26:891-9. 2005
    ..The selective decline of anterior anisotropy with advancing age provides evidence for the potential of a microstructural white matter mechanism for the commonly observed decline in frontally-based functions...
  82. ncbi Increased brain white matter diffusivity in normal adult aging: relationship to anisotropy and partial voluming
    Adolf Pfefferbaum
    Neuroscience Program, SRI International, Menlo Park, California 94025, USA
    Magn Reson Med 49:953-61. 2003
    ..25 in healthy adults may reflect partial voluming rather than actual changes in white matter coherence...
  83. ncbi Dissociation of remote and anterograde memory impairment and neural correlates in alcoholic Korsakoff syndrome
    Rosemary Fama
    Neuroscience Program, SRI International, Menlo Park, California, USA
    J Int Neuropsychol Soc 10:427-41. 2004
    ....
  84. ncbi Component cognitive and motor processes of the digit symbol test: differential deficits in alcoholism, HIV infection, and their comorbidity
    Stephanie A Sassoon
    Neuroscience Program, SRI International, Menlo Park, California, USA
    Alcohol Clin Exp Res 31:1315-24. 2007
    ....
  85. ncbi Postmortem MR imaging of formalin-fixed human brain
    Adolf Pfefferbaum
    Neuroscience Program, SRI International, Menlo Park, CA 94025, USA
    Neuroimage 21:1585-95. 2004
    ..Examples of high-resolution images and results from attempts at diffusion imaging are presented...
  86. ncbi Interaction of thiamine deficiency and voluntary alcohol consumption disrupts rat corpus callosum ultrastructure
    Xiaohua He
    Department of Pathology D06, University of Sydney, Sydney, NSW 2006, Australia
    Neuropsychopharmacology 32:2207-16. 2007
    ....
  87. ncbi Morphological changes in aging brain structures are differentially affected by time-linked environmental influences despite strong genetic stability
    Adolf Pfefferbaum
    Neuroscience Program, SRI International, Center for Health Sciences BN 115, 333 Ravenswood Street, Menlo Park, CA 94025, USA
    Neurobiol Aging 25:175-83. 2004
    ..Genetic stability was present even in old age when brain and other morphological changes can be rapid and highly variable across individuals, inconsistent with an hypothesis that random DNA damage is the cause of aging...
  88. ncbi Alcoholism, HIV infection, and their comorbidity: factors affecting self-rated health-related quality of life
    Margaret J Rosenbloom
    Neuroscience Program, Center for Health Sciences, SRI International, 333 Ravenswood Avenue, Menlo Park, California 94025, USA
    J Stud Alcohol Drugs 68:115-25. 2007
    ..We sought to determine whether comorbidity for both disorders further reduced HRQOL and what factors exacerbated or mitigated their effect...
  89. ncbi Perceptual learning in detoxified alcoholic men: contributions from explicit memory, executive function, and age
    Rosemary Fama
    Neuroscience Program, SRI International, Menlo Park, California, USA
    Alcohol Clin Exp Res 28:1657-65. 2004
    ..e., frontal executive systems) to perform the same task at normal levels. Use of more demanding cognitive systems by the alcoholics may be less efficient and more costly to processing capacity than those invoked by controls...
  90. ncbi Contribution of alcoholism to brain dysmorphology in HIV infection: effects on the ventricles and corpus callosum
    Adolf Pfefferbaum
    Neuroscience Program, SRI International, CA 94025, USA
    Neuroimage 33:239-51. 2006
    ....
  91. ncbi Longitudinal brain magnetic resonance imaging study of the alcohol-preferring rat. Part II: effects of voluntary chronic alcohol consumption
    Adolf Pfefferbaum
    Neuroscience Program, SRI International, Menlo Park, California, USA
    Alcohol Clin Exp Res 30:1248-61. 2006
    ..CONCLUSION: The P rats showed an age-alcohol interaction different from humans, in that normal growth in selective brain regions that continues in adult rats was retarded...
  92. ncbi Visuoperceptual learning in alcoholic Korsakoff syndrome
    Rosemary Fama
    Neuroscience Program, SRI International, Menlo Park, California, USA
    Alcohol Clin Exp Res 30:680-7. 2006
    ..This process is likely mediated by posterior cortical networks relatively unaffected in KS and that are independent of the hippocampal-diencephalic declarative memory system...
  93. ncbi Deformation-based brain morphometry to track the course of alcoholism: differences between intra-subject and inter-subject analysis
    Torsten Rohlfing
    Neuroscience Program, SRI International, 333 Ravenswood Avenue, Menlo Park, CA 94025 3943, USA
    Psychiatry Res 146:157-70. 2006
    ..This discrepancy in results underscores the importance of distinguishing between volume differences and volume changes in morphometric analyses...
  94. ncbi Alcoholic men endorse more DSM-IV withdrawal symptoms than alcoholic women matched in drinking history
    Anjali Deshmukh
    Neuroscience Program, SR International, Menlo Park, California, USA
    J Stud Alcohol 64:375-9. 2003
    ..Despite this similarity, the DSM criteria were sensitive to gender differences, which can now be challenged with rigorous testing...
  95. ncbi Upper and lower limb motor impairments in alcoholism, HIV infection, and their comorbidity
    Rosemary Fama
    Neuroscience Program, SRI International, Menlo Park, California, USA
    Alcohol Clin Exp Res 31:1038-44. 2007
    ....

Research Grants26

  1. CEREBELLAR STRUCTURE AND FUNCTION IN ALCOHOLISM
    Edith Sullivan; Fiscal Year: 2007
    ..systems in excess of those recruited by controls, and this would have the untoward outcome of reducing processing capacity available for simultaneous performance of other tasks, including maintenance of postural stability ..
  2. NORMAL AGING OF BRAIN STRUCTURE AND FUNCTION
    EDITH VIONI SULLIVAN; Fiscal Year: 2010
    ..Initiate longitudinal 4-year follow-up data collection to test hypotheses regarding selective accelerated deterioration of frontally-based brain systems in normal aging. ..
  3. NORMAL AGING OF BRAIN STRUCTURE AND FUNCTION
    Edith Sullivan; Fiscal Year: 2007
    ..Initiate longitudinal 4-year follow-up data collection to test hypotheses regarding selective accelerated deterioration of frontally-based brain systems in normal aging. ..
  4. NORMAL AGING OF BRAIN STRUCTURE AND FUNCTION
    Edith Sullivan; Fiscal Year: 2009
    ..Initiate longitudinal 4-year follow-up data collection to test hypotheses regarding selective accelerated deterioration of frontally-based brain systems in normal aging. ..
  5. NORMAL AGING OF BRAIN STRUCTURE AND FUNCTION
    Edith Sullivan; Fiscal Year: 2004
    ....
  6. CEREBELLAR STRUCTURE AND FUNCTION IN ALCOHOLISM
    Edith Sullivan; Fiscal Year: 2003
    ..abstract_text> ..