Genomes and Genes
Thomas C Sudhof
Affiliation: Stanford University
- Sando R, Jiang X, Sudhof T. Latrophilin GPCRs direct synapse specificity by coincident binding of FLRTs and teneurins. Science. 2019;363: pubmed publisher..Thus, postsynaptic latrophilins promote excitatory synapse formation by simultaneous binding of two unrelated presynaptic ligands, which is required for formation of synaptic inputs at specific dendritic localizations. ..
- Wu X, Morishita W, Riley A, Hale W, Sudhof T, Malenka R. Neuroligin-1 Signaling Controls LTP and NMDA Receptors by Distinct Molecular Pathways. Neuron. 2019;: pubmed publisher..Our data suggest that neuroligin-1 performs two mechanistically distinct signaling functions and that neurolign-1-mediated trans-synaptic cell adhesion signaling critically regulates LTP. ..
- ..Among others, this hypothesis implies that synapse formation can be understood in terms of inter- and intracellular signaling, and that neuropsychiatric disorders involve an impairment in such signaling. ..
- Zhou M, Liu Z, Melin M, Ng Y, Xu W, Sudhof T. A central amygdala to zona incerta projection is required for acquisition and remote recall of conditioned fear memory. Nat Neurosci. 2018;: pubmed publisher..Thus, the amygdala inhibitory input to parvalbumin-positive neurons in the zona incerta, a nucleus not previously implicated in fear memory, is an essential component of the fear memory circuitry. ..
- Seigneur E, Polepalli J, Sudhof T. Cbln2 and Cbln4 are expressed in distinct medial habenula-interpeduncular projections and contribute to different behavioral outputs. Proc Natl Acad Sci U S A. 2018;115:E10235-E10244 pubmed publisher..Thus, Cbln2 and Cbln4 are expressed in distinct MHb neurons that contribute to different behaviors. ..
- Li J, Shalev Benami M, Sando R, Jiang X, Kibrom A, Wang J, et al. Structural Basis for Teneurin Function in Circuit-Wiring: A Toxin Motif at the Synapse. Cell. 2018;173:735-748.e15 pubmed publisher..These results highlight the unusual structural organization of TENs giving rise to their multifarious functions. ..
- Chanda S, Ang C, Davila J, Pak C, Mall M, Lee Q, et al. Generation of induced neuronal cells by the single reprogramming factor ASCL1. Stem Cell Reports. 2014;3:282-96 pubmed publisher..Surprisingly, ASCL1-induced iN cells were predominantly excitatory, demonstrating that ASCL1 is permissive but alone not deterministic for the inhibitory neuronal lineage. ..
- Seigneur E, Sudhof T. Genetic Ablation of All Cerebellins Reveals Synapse Organizer Functions in Multiple Regions Throughout the Brain. J Neurosci. 2018;38:4774-4790 pubmed publisher..We also show that cerebellins are not initially required for synapse formation, but rather for specification and long-term synapse maintenance and demonstrate that all cerebellins, not just Cbln1, contribute to brain function. ..
- ..Moreover, this complex mediates short- and long-term plasticity in response to bursts of action potentials, thus critically contributing to the computational power of a synapse. ..
- Huang Y, Zhou B, Wernig M, Sudhof T. ApoE2, ApoE3, and ApoE4 Differentially Stimulate APP Transcription and A? Secretion. Cell. 2017;168:427-441.e21 pubmed publisher..Our data describe a novel signal transduction pathway in neurons whereby ApoE activates a non-canonical MAP kinase cascade that enhances APP transcription and amyloid-? synthesis. ..
- Anderson G, Maxeiner S, Sando R, Tsetsenis T, Malenka R, SÃ¼dhof T. Postsynaptic adhesion GPCR latrophilin-2 mediates target recognition in entorhinal-hippocampal synapse assembly. J Cell Biol. 2017;216:3831-3846 pubmed publisher..Thus, Lphn2 appears to control synapse numbers in the entorhinal cortex/CA1 region circuit by acting as a domain-specific postsynaptic target-recognition molecule. ..
- Luo F, Sudhof T. Synaptotagmin-7-Mediated Asynchronous Release Boosts High-Fidelity Synchronous Transmission at a Central Synapse. Neuron. 2017;94:826-839.e3 pubmed publisher..Thus, asynchronous release surprisingly functions, at least at some synapses, to sustain high-fidelity neurotransmission driven by synchronous release during high-frequency stimulus trains. ..
- Chen L, Jiang M, Zhang B, Gokce O, SÃ¼dhof T. Conditional Deletion of All Neurexins Defines Diversity of Essential Synaptic Organizer Functions for Neurexins. Neuron. 2017;94:611-625.e4 pubmed publisher..Thus, neurexins function primarily as context-dependent specifiers of synapses. ..
- Acuna C, Liu X, Sudhof T. How to Make an Active Zone: Unexpected Universal Functional Redundancy between RIMs and RIM-BPs. Neuron. 2016;91:792-807 pubmed publisher..Thus, RBPs perform unexpectedly broad roles at the active zone that together with those of RIMs are essential for all active zone functions. ..
- Gokce O, Stanley G, Treutlein B, Neff N, Camp J, Malenka R, et al. Cellular Taxonomy of the Mouse Striatum as Revealed by Single-Cell RNA-Seq. Cell Rep. 2016;16:1126-1137 pubmed publisher..Our findings suggest that functional diversity within a complex tissue arises from a small number of discrete cell types, which can exist in a continuous spectrum of functional states. ..
- Zhang B, Chen L, Liu X, Maxeiner S, Lee S, Gokce O, et al. Neuroligins Sculpt Cerebellar Purkinje-Cell Circuits by Differential Control of Distinct Classes of Synapses. Neuron. 2015;87:781-96 pubmed publisher..Using systematic analyses of all neuroligins in a defined neural circuit, our data thus show that neuroligins differentially contribute to various Purkinje-cell synapses in the cerebellum inÂ vivo. ..
- Liu Z, Chen Z, Shang C, Yan F, Shi Y, Zhang J, et al. IGF1-Dependent Synaptic Plasticity of Mitral Cells in Olfactory Memory during Social Learning. Neuron. 2017;95:106-122.e5 pubmed publisher..Thus, our data reveal a synaptic substrate for a socially conditioned long-term memory that operates at the level of the initial processing of sensory information. ..
- Sudhof T. Neurotransmitter release: the last millisecond in the life of a synaptic vesicle. Neuron. 2013;80:675-90 pubmed publisher..This architecture allows direct flow of Ca(2+) ions from Ca(2+) channels to synaptotagmin, which then triggers fusion, thus mediating tight millisecond coupling of an action potential to neurotransmitter release. ..
- Yi F, Danko T, Botelho S, Patzke C, Pak C, Wernig M, et al. Autism-associated SHANK3 haploinsufficiency causes Ih channelopathy in human neurons. Science. 2016;352:aaf2669 pubmed publisher..Our data suggest that SHANK3 mutations predispose to autism, at least partially, by inducing an Ih channelopathy that may be amenable to pharmacological intervention. ..
- Acuna C, Liu X, Gonzalez A, SÃ¼dhof T. RIM-BPs Mediate Tight Coupling of Action Potentials to Ca(2+)-Triggered Neurotransmitter Release. Neuron. 2015;87:1234-47 pubmed publisher..Thus, RIM-BPs ensure optimal organization of the machinery for fast release in mammalian synapses without being a central component of the machinery itself. ..
- Sudhof T, Rizo J. Synaptic vesicle exocytosis. Cold Spring Harb Perspect Biol. 2011;3: pubmed publisher..The synaptic membrane-fusion machinery is controlled by synaptotagmin, and additionally regulated by a presynaptic protein matrix (the "active zone") that includes Munc13 and RIM proteins as central components. ..
- Sudhof T. Neuroligins and neurexins link synaptic function to cognitive disease. Nature. 2008;455:903-11 pubmed publisher..In humans, alterations in genes encoding neurexins or neuroligins have recently been implicated in autism and other cognitive diseases, linking synaptic cell adhesion to cognition and its disorders. ..