S Strober

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. ncbi request reprint Mixed chimerism and immunosuppressive drug withdrawal after HLA-mismatched kidney and hematopoietic progenitor transplantation
    Maria T Millan
    Department of Surgery, Division of Transplantation, Stanford University School of Medicine, Stanford, CA 94305, USA
    Transplantation 73:1386-91. 2002
  2. ncbi request reprint CD4+CD25+ regulatory T cells preserve graft-versus-tumor activity while inhibiting graft-versus-host disease after bone marrow transplantation
    Matthias Edinger
    Division of Bone Marrow Transplantation, Department of Medicine, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, California 94305, USA
    Nat Med 9:1144-50. 2003
  3. ncbi request reprint Suppression of graft-versus-host disease by naturally occurring regulatory T cells
    Defu Zeng
    Division of Rheumatology and Immunology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
    Transplantation 77:S9-S11. 2004
  4. ncbi request reprint Short tandem repeat analysis to monitor chimerism in macaca fascicularis
    Macy Lau
    Transplantation Immunology Laboratory, Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA, USA
    Am J Transplant 4:1543-8. 2004
  5. ncbi request reprint Expression of CD161 (NKR-P1A) defines subsets of human CD4 and CD8 T cells with different functional activities
    Tsuyoshi Takahashi
    Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Immunol 176:211-6. 2006
  6. ncbi request reprint Path to clinical transplantation tolerance and prevention of graft-versus-host disease
    Samuel Strober
    Division of Immunology and Rheumatology, Stanford University School of Medicine, CCSR Building, Room 2215 C, 269 Campus Drive, Stanford, CA, 94305 5166, USA
    Immunol Res 58:240-8. 2014
  7. pmc Donor-type CD4(+)CD25(+) regulatory T cells suppress lethal acute graft-versus-host disease after allogeneic bone marrow transplantation
    Petra Hoffmann
    Division of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, CA 94305, USA
    J Exp Med 196:389-99. 2002
  8. ncbi request reprint Early defect prethymic in bone marrow T cell progenitors in athymic nu/nu mice
    Devavani Chatterjea-Matthes
    Department of Medicine, Stanford University, Stanford, CA 94305, USA
    J Immunol 171:1207-15. 2003
  9. ncbi request reprint Approaches to transplantation tolerance in humans
    Samuel Strober
    Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305 5166, USA
    Transplantation 77:932-6. 2004
  10. ncbi request reprint Natural killer 1.1(+) T cells and "natural suppressor" T cells in the bone marrow
    S Strober
    Department of Medicine, Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA, USA
    J Allergy Clin Immunol 106:S113-4. 2000

Research Grants

  1. CD4/CD8/ALPHA BETA T CELLS IN AUTOIMMUNE MICE
    Samuel Strober; Fiscal Year: 2001
  2. MOBILIZED BLOOD STEM CELL TRANSPLANTATION WITHOUT GVHD
    Samuel Strober; Fiscal Year: 2007
  3. Lupus Glomenulonephritis and NK T cells
    Samuel Strober; Fiscal Year: 2010
  4. CD4(-) and CD8(-) T Cells in Autoimmune & Normal Mice
    Samuel Strober; Fiscal Year: 2005
  5. MOBILIZED BLOOD STEM CELL TRANSPLANTATION WITHOUT GVHD
    Samuel Strober; Fiscal Year: 2005
  6. Lymphoma Therapy Using Mixed Progenitor Transplants
    Samuel Strober; Fiscal Year: 2004
  7. DONOR CELL FACILITATION OF TOLERANCE
    Samuel Strober; Fiscal Year: 2004
  8. CD4(-) and CD8(-) T Cells in Autoimmune & Normal Mice
    Samuel Strober; Fiscal Year: 2004
  9. MOBILIZED BLOOD STEM CELL TRANSPLANTATION WITHOUT GVHD
    Samuel Strober; Fiscal Year: 2004
  10. Lymphoma Therapy Using Mixed Progenitor Transplants
    Samuel Strober; Fiscal Year: 2003

Collaborators

Detail Information

Publications49

  1. ncbi request reprint Mixed chimerism and immunosuppressive drug withdrawal after HLA-mismatched kidney and hematopoietic progenitor transplantation
    Maria T Millan
    Department of Surgery, Division of Transplantation, Stanford University School of Medicine, Stanford, CA 94305, USA
    Transplantation 73:1386-91. 2002
    ....
  2. ncbi request reprint CD4+CD25+ regulatory T cells preserve graft-versus-tumor activity while inhibiting graft-versus-host disease after bone marrow transplantation
    Matthias Edinger
    Division of Bone Marrow Transplantation, Department of Medicine, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, California 94305, USA
    Nat Med 9:1144-50. 2003
    ..Thus, CD4+CD25+ T cells are potent regulatory cells that can separate GVHD from GVT activity mediated by conventional donor T cells...
  3. ncbi request reprint Suppression of graft-versus-host disease by naturally occurring regulatory T cells
    Defu Zeng
    Division of Rheumatology and Immunology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
    Transplantation 77:S9-S11. 2004
    ..The balance of subsets in the graft determines disease severity. The authors' work on the nature of the regulatory-suppressor T cells and their mechanisms of action is summarized in this article...
  4. ncbi request reprint Short tandem repeat analysis to monitor chimerism in macaca fascicularis
    Macy Lau
    Transplantation Immunology Laboratory, Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA, USA
    Am J Transplant 4:1543-8. 2004
    ..The successful adaptation of human STR reagents to monitor chimerism in transplanted cynos will facilitate the use of this species in preclinical tolerance studies...
  5. ncbi request reprint Expression of CD161 (NKR-P1A) defines subsets of human CD4 and CD8 T cells with different functional activities
    Tsuyoshi Takahashi
    Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Immunol 176:211-6. 2006
    ..Unexpectedly, the CD8+CD161+ cells contained an anergic CD8alpha+CD8betalow/-CD161high T cell subset that failed to proliferate, secrete cytokines, or mediate NK lytic activity...
  6. ncbi request reprint Path to clinical transplantation tolerance and prevention of graft-versus-host disease
    Samuel Strober
    Division of Immunology and Rheumatology, Stanford University School of Medicine, CCSR Building, Room 2215 C, 269 Campus Drive, Stanford, CA, 94305 5166, USA
    Immunol Res 58:240-8. 2014
    ....
  7. pmc Donor-type CD4(+)CD25(+) regulatory T cells suppress lethal acute graft-versus-host disease after allogeneic bone marrow transplantation
    Petra Hoffmann
    Division of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, CA 94305, USA
    J Exp Med 196:389-99. 2002
    ..Our results demonstrate that the balance of donor-type CD4(+)CD25(+) T(reg) and conventional CD4(+)CD25(-) T cells can determine the outcome of aGVHD...
  8. ncbi request reprint Early defect prethymic in bone marrow T cell progenitors in athymic nu/nu mice
    Devavani Chatterjea-Matthes
    Department of Medicine, Stanford University, Stanford, CA 94305, USA
    J Immunol 171:1207-15. 2003
    ..We show that defects in bone marrow prethymic T cell development can also contribute to T cell deficiency in nu/nu mice...
  9. ncbi request reprint Approaches to transplantation tolerance in humans
    Samuel Strober
    Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305 5166, USA
    Transplantation 77:932-6. 2004
    ..Preclinical and clinical studies of the use of total lymphoid irradiation for the induction of chimeric and nonchimeric tolerance are summarized here...
  10. ncbi request reprint Natural killer 1.1(+) T cells and "natural suppressor" T cells in the bone marrow
    S Strober
    Department of Medicine, Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA, USA
    J Allergy Clin Immunol 106:S113-4. 2000
    ..1(+) T cells is dependent on their rapid secretion of high levels of IL-4. This unique cytokine secretion is not observed in conventional NK1. 1(-) T cells and can downregulate the function of the latter cells...
  11. ncbi request reprint Protective conditioning against GVHD and graft rejection after combined organ and hematopoietic cell transplantation
    Samuel Strober
    Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305 5166, USA
    Blood Cells Mol Dis 40:48-54. 2008
    ..Thus, conditioning with TLI based regimens can simultaneously protect against organ graft rejection and GVHD. Levels of chimerism are dependent upon the content of donor T cells in the hematopoietic graft...
  12. ncbi request reprint Predominance of NK1.1+TCR alpha beta+ or DX5+TCR alpha beta+ T cells in mice conditioned with fractionated lymphoid irradiation protects against graft-versus-host disease: "natural suppressor" cells
    F Lan
    Department of Medicine, Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Immunol 167:2087-96. 2001
    ..1+ and DX5+asialo-GM1+ T cells derived from either donors or hosts conditioned with lymphoid irradiation is dependent on their secretion of high levels of IL-4...
  13. ncbi request reprint Allogeneic bone marrow cells that facilitate complete chimerism and eliminate tumor cells express both CD8 and T-cell antigen receptor-alphabeta
    F Lan
    Department of Medicine, Division of Immunology and Rheumatology, Stanford University School of Medicine, 300 Pasteur Dr, Stanford, CA 94305, USA
    Blood 97:3458-65. 2001
    ..Thus, the resident allogeneic bone marrow CD8(+) TCRalphabeta+ T cells had the unique capacity to eliminate the host lymphohematopoietic cells without nonlymphohematopoietic tissue injury. (Blood. 2001;97:3458-3465)..
  14. ncbi request reprint Heterogeneity of NK1.1+ T cells in the bone marrow: divergence from the thymus
    D Zeng
    Division of Immunology and Rheumatology, Department of Medicine, Stanford Medical School, CA 94305, USA
    J Immunol 163:5338-45. 1999
    ..In conclusion, the large majority of NK1.1+ T cells in the bone marrow are CD1 dependent. Marrow NK1.1+ T cells include CD8+, Valpha14-Jalpha281-, and beta2m-independent subsets that are not clearly detected in the thymus...
  15. pmc Clonable progenitors committed to the T lymphocyte lineage in the mouse bone marrow; use of an extrathymic pathway
    S Dejbakhsh-Jones
    Department of Medicine, Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 98:7455-60. 2001
    ..Progenitors were capable of rapidly reconstituting athymic hosts. In conclusion, the clonable bone marrow progenitors were capable of T cell reconstitution predominantly by means of an extrathymic pathway...
  16. pmc The changed balance of regulatory and naive T cells promotes tolerance after TLI and anti-T-cell antibody conditioning
    R G Nador
    Division of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA
    Am J Transplant 10:262-72. 2010
    ..In conclusion, tolerance induction after conditioning in this model depends upon the ability of naturally occurring regulatory NKT and Treg cells to suppress the residual alloreactive T cells that are capable of rejecting grafts...
  17. pmc Tolerance and withdrawal of immunosuppressive drugs in patients given kidney and hematopoietic cell transplants
    J D Scandling
    Department of Medicine Nephrology, Stanford University School of Medicine, Stanford, CA, USA
    Am J Transplant 12:1133-45. 2012
    ..All 16 patients had excellent graft function at the last observation point with or without maintenance drugs...
  18. ncbi request reprint Stepwise development of committed progenitors in the bone marrow that generate functional T cells in the absence of the thymus
    Marcos E Garcia-Ojeda
    Department of Medicine, Stanford University School of Medicine, CA 94305, USA
    J Immunol 175:4363-73. 2005
    ..In conclusion, CTPs in wild-type bone marrow can generate functional T cells via an extrathymic pathway in athymic nu/nu mice...
  19. ncbi request reprint Different subsets of T cells in the adult mouse bone marrow and spleen induce or suppress acute graft-versus-host disease
    V Palathumpat
    Department of Medicine, Stanford University School of Medicine, CA 94305
    J Immunol 149:808-17. 1992
    ..Purified populations of the latter cells suppressed GVHD. Recipients given unfractionated C57BL/Ka spleen cells and protected with low-density bone marrow or spleen cells were chimeras...
  20. ncbi request reprint Favorable treatment outcome in non-Hodgkin's lymphoma patients with "poor" mobilization of peripheral blood progenitor cells
    K E Stockerl-Goldstein
    Divisions of Bone Marrow Transplantation, Stanford University School of Medicine, California 94305 5623, USA
    Biol Blood Marrow Transplant 6:506-12. 2000
    ..However, there is no significant difference in relapse, event-free survival, or overall survival for such patients compared with those who mobilize PBPCs easily...
  21. ncbi request reprint Alloantigen recognition is critical for CD8 T cell-mediated graft anti-tumor activity against murine BCL1 lymphoma after myeloablative bone marrow transplantation
    A Pillai
    Division of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305 5166, USA
    Bone Marrow Transplant 40:487-97. 2007
    ..We conclude that CD8(+) T cells from unimmunized normal donor mice require alloantigen recognition to mediate their anti-tumor activity following allogeneic BMT...
  22. ncbi request reprint Host conditioning with total lymphoid irradiation and antithymocyte globulin prevents graft-versus-host disease: the role of CD1-reactive natural killer T cells
    Fengshuo Lan
    Department of Medicine, Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford Medical Center, 300 Pasteur Drive, Stanford, CA 94305 5166, USA
    Biol Blood Marrow Transplant 9:355-63. 2003
    ..In conclusion, the TLI and ATG/anti-thymocyte serum conditioning regimen protects against GVHD in rats and mice, and regulatory natural killer T cells are required for protection...
  23. ncbi request reprint Immune tolerance to combined organ and bone marrow transplants after fractionated lymphoid irradiation involves regulatory NK T cells and clonal deletion
    Masanori Higuchi
    Division of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, Center for Clinical Science Research Building, 300 Pasteur Drive, Stanford, CA 94305, USA
    J Immunol 169:5564-70. 2002
    ..We conclude that immune tolerance to bone marrow transplants involves clonal deletion, and tolerance to heart allografts in this model also involves regulatory CD1-reactive NK T cells...
  24. ncbi request reprint CD1 expression defines subsets of follicular and marginal zone B cells in the spleen: beta 2-microglobulin-dependent and independent forms
    M Amano
    Department of Medicine, Stanford University School of Medicine, CA 94305 5111, USA
    J Immunol 161:1710-7. 1998
    ..They further suggest that a beta 2m-independent form of CD1 is expressed on B cells that can stimulate T cells; however, this form is not easily visualized with the anti-CD1 mAb used here...
  25. ncbi request reprint Unique patterns of surface receptors, cytokine secretion, and immune functions distinguish T cells in the bone marrow from those in the periphery: impact on allogeneic bone marrow transplantation
    Defu Zeng
    Department of Medicine, Division of Immunology and Rheumatology, Stanford University School of Medicine, CA 94305 5166, USA
    Blood 99:1449-57. 2002
    ..Because neither the purified marrow CD4(+) or CD8(+) T cells induced GVH disease, their unique features are desirable for inclusion in allogeneic bone marrow or hematopoietic progenitor transplants...
  26. ncbi request reprint Host NKT cells can prevent graft-versus-host disease and permit graft antitumor activity after bone marrow transplantation
    Asha B Pillai
    Division of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, CA 94305 5166, USA
    J Immunol 178:6242-51. 2007
    ..In conclusion, after TLI/ATS host conditioning and allogeneic bone marrow transplantation, host NKT cells can separate the proinflammatory and tumor cytolytic functions of donor T cells...
  27. ncbi request reprint A technique of bone marrow collection from vertebral bodies of cynomolgus macaques for transplant studies
    Mona G Flores
    Transplantation Immunology Laboratory, Department of Cardiothoracic Surgery, Falk Cardiovascular Research Center, Stanford University School of Medicine, Stanford, CA 94305 5407, USA
    J Surg Res 124:280-8. 2005
    ..We report here a procedure to isolate and characterize large numbers of bone marrow cells (BMCs) from cynomolgus monkeys (cynos) that can then successfully be transplanted into conditioned recipients...
  28. ncbi request reprint Liver allografts are toleragenic in rats conditioned with posttransplant total lymphoid irradiation
    Kazuhito Nagasaki
    Department of Surgery, Division of Transplantation, Stanford University School of Medicine, Stanford, CA, USA
    Transplantation 84:619-28. 2007
    ..Posttransplant total lymphoid irradiation (TLI) treatment has been applied to tolerance induction protocols in heart and kidney transplantation models...
  29. ncbi request reprint Long-term followup of patients treated with total lymphoid irradiation for lupus nephritis
    Mark C Genovese
    Division of Immunology and Rheumatology, Stanford University Medical Center, Palo Alto, California 94304, USA
    Arthritis Rheum 46:1014-8. 2002
    ..To describe the long-term survival, renal condition, and morbidity outcomes in patients who received total lymphoid irradiation (TLI) for the treatment of lupus nephritis...
  30. doi request reprint Tolerance and chimerism after renal and hematopoietic-cell transplantation
    John D Scandling
    Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
    N Engl J Med 358:362-8. 2008
    ..Adverse events requiring hospitalization were limited to a 2-day episode of fever with neutropenia. The patient has had neither rejection episodes nor clinical manifestations of graft-versus-host disease...
  31. doi request reprint Simultaneous protection against allograft rejection and graft-versus-host disease after total lymphoid irradiation: role of natural killer T cells
    Yin Ping Liu
    Division of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305 5166, USA
    Transplantation 85:607-14. 2008
    ..We determined whether total lymphoid irradiation can simultaneously protect against graft-versus-host disease while facilitating tolerance...
  32. ncbi request reprint Protective conditioning for acute graft-versus-host disease
    Robert Lowsky
    Department of Medicine, Stanford University School of Medicine, Stanford, Calif, USA
    N Engl J Med 353:1321-31. 2005
    ..Conditioning with total lymphoid irradiation plus antithymocyte serum protects mice against acute graft-versus-host disease (GVHD) after hematopoietic-cell transplantation. We tested this strategy in humans...
  33. ncbi request reprint Rapid engraftment after allogeneic transplantation of density-enriched peripheral blood CD34+ cells in patients with advanced hematologic malignancies
    T M Cao
    Department of Medicine, Division of Bone Marrow Transplantation, Stanford University Medical Center, Stanford, California 94305-5623, USA
    Cancer 91:2205-13. 2001
    ..However, the low-density selected cells still resulted in GVHD, and there was a high treatment-related mortality...
  34. pmc TLI and ATG conditioning with low risk of graft-versus-host disease retains antitumor reactions after allogeneic hematopoietic cell transplantation from related and unrelated donors
    Holbrook E Kohrt
    Department of Medicine, Stanford University School of Medicine, CA 94305, USA
    Blood 114:1099-109. 2009
    ..Active trial registration currently at clinicaltrials.gov under IDs of NCT00185640 and NCT00186615...
  35. ncbi request reprint Depletion of host Langerhans cells before transplantation of donor alloreactive T cells prevents skin graft-versus-host disease
    Miriam Merad
    Department of Pathology, Stanford University School of Medicine, Palo Alto, California 94304, USA
    Nat Med 10:510-7. 2004
    ....
  36. ncbi request reprint Only the CD62L+ subpopulation of CD4+CD25+ regulatory T cells protects from lethal acute GVHD
    Joerg Ermann
    Division of Immunology and Rheumatology, The Department of Medicine, Stanford University School of Medicine, CCSR Bldg, Rm 2215 C, 300 Pasteur Dr, Stanford, CA 94305 5166, USA
    Blood 105:2220-6. 2005
    ..The ability of Treg cells to efficiently enter the priming sites of pathogenic allo-reactive T cells appears to be a prerequisite for their protective function in aGVHD...
  37. pmc Differences in Bcl-2 expression by T-cell subsets alter their balance after in vivo irradiation to favor CD4+Bcl-2hi NKT cells
    Zhenyu Yao
    Department of Medicine, Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA 94305 5166, USA
    Eur J Immunol 39:763-75. 2009
    ..In conclusion, differential expression of Bcl-2 contributes to the changes in T-cell subsets and immune function after irradiation...
  38. pmc Ineffective vaccination against solid tumors can be enhanced by hematopoietic cell transplantation
    Alexander Filatenkov
    Division of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Immunol 183:7196-203. 2009
    ..In conclusion, these findings show that otherwise ineffective vaccination to solid nonhematologic tumors can be dramatically enhanced by HCT...
  39. pmc Beta-galactosylceramide alters invariant natural killer T cell function and is effective treatment for lupus
    Sufi R Morshed
    Department of Medicine, Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Clin Immunol 132:321-33. 2009
    ..In conclusion, beta-galactosylceramide, a glycolipid that reduces the cytokine secretion induced by a potent NKT cell agonist ameliorates lupus in NZB/W mice...
  40. pmc Host natural killer T cells induce an interleukin-4-dependent expansion of donor CD4+CD25+Foxp3+ T regulatory cells that protects against graft-versus-host disease
    Asha B Pillai
    Department of Medicine, Division of Immunology and Rheumatology, Stanford University School of Medicine, CA 38105, USA
    Blood 113:4458-67. 2009
    ....
  41. ncbi request reprint Interferon-alpha-inducible proteins are novel autoantigens in murine lupus
    Wolfgang Hueber
    Stanford University School of Medicine, Stanford, California, 94305, USA
    Arthritis Rheum 50:3239-49. 2004
    ..To investigate the spectrum of B cell autoimmunity in the recently described anti-CD1-autoreactive T cell receptor (TCR)-transgenic murine lupus-like (CD1 lupus-like) model...
  42. pmc NKT cells, Treg, and their interactions in bone marrow transplantation
    Holbrook E Kohrt
    Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA
    Eur J Immunol 40:1862-9. 2010
    ..In addition, we also examine the interactions between NKT cells and Treg in the context of BMT, and integrate the data from murine experimental models with the observations made in humans...
  43. ncbi request reprint Naive and memory T cells induce different types of graft-versus-host disease
    Suparna Dutt
    Department of Medicine, Stanford University School of Medicine, CA 94305, USA
    J Immunol 179:6547-54. 2007
    ..Nevertheless, the expected increase in potency as compared with naive T cells was not observed due to differences in the pattern and kinetics of tissue injury...
  44. ncbi request reprint Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis
    Christopher Lock
    Department of Neurology and Neurological Sciences, Beckman Center, Stanford University, Stanford, California, USA
    Nat Med 8:500-8. 2002
    ..These results in EAE corroborate the microarray studies on MS lesions. Large-scale analysis of transcripts in MS lesions elucidates new aspects of pathology and opens possibilities for therapy...
  45. pmc Induced tolerance to rat liver allografts involves the apoptosis of intragraft T cells and the generation of CD4(+)CD25(+)FoxP3(+) T regulatory cells
    Masato Fujiki
    Division of Transplantation, Department of Surgery, Stanford University, Stanford, CA 94305 5492, USA
    Liver Transpl 16:147-54. 2010
    ....
  46. pmc Natural killer T cells and innate immune B cells from lupus-prone NZB/W mice interact to generate IgM and IgG autoantibodies
    Tsuyoshi Takahashi
    Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305 5166, USA
    Eur J Immunol 38:156-65. 2008
    ..In conclusion, direct interactions between innate immune T and B cells form a pathway for the development of IgM and IgG lupus autoantibody secretion in NZB/W mice...
  47. ncbi request reprint Characterization of novel antigens recognized by serum autoantibodies from anti-CD1 TCR-transgenic lupus mice
    Wolfgang Hueber
    Department of Medicine, Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Eur J Immunol 34:1654-62. 2004
    ..Serological and biochemical characterization suggested that p105 was distinct from known lupus autoantigens of similar molecular masses, indicating that p105 represents a novel autoantigen in lupus...
  48. pmc L-selectin and beta7 integrin on donor CD4 T cells are required for the early migration to host mesenteric lymph nodes and acute colitis of graft-versus-host disease
    Suparna Dutt
    Department of Medicine, Stanford University School of Medicine, CCSR Building, Room 2215 C, Pasteur Drive, Stanford, CA 94305 5166, USA
    Blood 106:4009-15. 2005
    ..In conclusion, the combination of CD62L and beta7 integrin is required to induce acute colitis and facilitate entry of CD4+ donor T cells in the mesenteric nodes associated with lethal GVHD in allogeneic hosts...
  49. ncbi request reprint Donor CD4+ T and B cells in transplants induce chronic graft-versus-host disease with autoimmune manifestations
    Chunyan Zhang
    The Beckman Research Institute, Gonda Building, R2017, City of Hope National Medical Center, 1500 East Duarte Rd, Duarte, CA 91010, USA
    Blood 107:2993-3001. 2006
    ....

Research Grants43

  1. CD4/CD8/ALPHA BETA T CELLS IN AUTOIMMUNE MICE
    Samuel Strober; Fiscal Year: 2001
    ..The possible role of CD1 molecules as an autoantigen in heredity mouse models of lipus (NZB/NZW) will be explored also by attempting to block spontaneous autoantibody secretion in vitro and in vivo with anti-CD1 antibodies. ..
  2. MOBILIZED BLOOD STEM CELL TRANSPLANTATION WITHOUT GVHD
    Samuel Strober; Fiscal Year: 2007
    ..abstract_text> ..
  3. Lupus Glomenulonephritis and NK T cells
    Samuel Strober; Fiscal Year: 2010
    ..proposed research studies the interactions between the NK T cells and B cells in the immune tissues and inflamed kidneys that cause autoantibody formation, and studies ways to inhibit the interactions and ameliorate the kidney disease ..
  4. CD4(-) and CD8(-) T Cells in Autoimmune & Normal Mice
    Samuel Strober; Fiscal Year: 2005
    ..The latter cells will be transferred to non-transgenic NZB/NZW hosts to determine their contribution to IgG autoantibody secretion. ..
  5. MOBILIZED BLOOD STEM CELL TRANSPLANTATION WITHOUT GVHD
    Samuel Strober; Fiscal Year: 2005
    ..abstract_text> ..
  6. Lymphoma Therapy Using Mixed Progenitor Transplants
    Samuel Strober; Fiscal Year: 2004
    ..GVHD will be monitored by clinical signs, survival, and histopathology. ..
  7. DONOR CELL FACILITATION OF TOLERANCE
    Samuel Strober; Fiscal Year: 2004
    ..They will also study GVHD using similar hypotheses and models. Mice tolerant of their allografts will be observed for evidence of immune deviation, clonal anergy or deletion, chimerism, and allograft expression of cytokine mRNA. ..
  8. CD4(-) and CD8(-) T Cells in Autoimmune & Normal Mice
    Samuel Strober; Fiscal Year: 2004
    ..The latter cells will be transferred to non-transgenic NZB/NZW hosts to determine their contribution to IgG autoantibody secretion. ..
  9. MOBILIZED BLOOD STEM CELL TRANSPLANTATION WITHOUT GVHD
    Samuel Strober; Fiscal Year: 2004
    ..abstract_text> ..
  10. Lymphoma Therapy Using Mixed Progenitor Transplants
    Samuel Strober; Fiscal Year: 2003
    ..GVHD will be monitored by clinical signs, survival, and histopathology. ..
  11. DONOR CELL FACILITATION OF TOLERANCE
    Samuel Strober; Fiscal Year: 2003
    ..They will also study GVHD using similar hypotheses and models. Mice tolerant of their allografts will be observed for evidence of immune deviation, clonal anergy or deletion, chimerism, and allograft expression of cytokine mRNA. ..
  12. MOBILIZED BLOOD STEM CELL TRANSPLANTATION WITHOUT GVHD
    Samuel Strober; Fiscal Year: 2006
    ..abstract_text> ..
  13. CD4(-) and CD8(-) T Cells in Autoimmune & Normal Mice
    Samuel Strober; Fiscal Year: 2006
    ..The latter cells will be transferred to non-transgenic NZB/NZW hosts to determine their contribution to IgG autoantibody secretion. ..
  14. DONOR CELL FACILITATION OF TOLERANCE
    Samuel Strober; Fiscal Year: 2009
    ..However, the differential resistance is lost in p53"'" mice and in Bcl-2 transgenic mice. We will determine whether the ability to induce tolerance and prevent GVHD is also lost in the latter genetically altered mice. ..
  15. DONOR CELL FACILITATION OF TOLERANCE
    Samuel Strober; Fiscal Year: 2010
    ..However, the differential resistance is lost in p53"'" mice and in Bcl-2 transgenic mice. We will determine whether the ability to induce tolerance and prevent GVHD is also lost in the latter genetically altered mice. ..
  16. Lupus Glomenulonephritis and NK T cells
    Samuel Strober; Fiscal Year: 2009
    ..proposed research studies the interactions between the NK T cells and B cells in the immune tissues and inflamed kidneys that cause autoantibody formation, and studies ways to inhibit the interactions and ameliorate the kidney disease ..
  17. DONOR CELL FACILITATION OF TOLERANCE
    Samuel Strober; Fiscal Year: 2009
    ..However, the differential resistance is lost in p53"'" mice and in Bcl-2 transgenic mice. We will determine whether the ability to induce tolerance and prevent GVHD is also lost in the latter genetically altered mice. ..
  18. DONOR CELL FACILITATION OF TOLERANCE
    Samuel Strober; Fiscal Year: 2007
    ..However, the differential resistance is lost in p53"'" mice and in Bcl-2 transgenic mice. We will determine whether the ability to induce tolerance and prevent GVHD is also lost in the latter genetically altered mice. ..
  19. DONOR CELL FACILITATION OF TOLERANCE
    Samuel Strober; Fiscal Year: 2007
    ..However, the differential resistance is lost in p53"'" mice and in Bcl-2 transgenic mice. We will determine whether the ability to induce tolerance and prevent GVHD is also lost in the latter genetically altered mice. ..
  20. CD4(-) and CD8(-) T Cells in Autoimmune & Normal Mice
    Samuel Strober; Fiscal Year: 2003
    ..The latter cells will be transferred to non-transgenic NZB/NZW hosts to determine their contribution to IgG autoantibody secretion. ..
  21. DONOR CELL FACILITATION OF TOLERANCE
    Samuel Strober; Fiscal Year: 2002
    ..They will also study GVHD using similar hypotheses and models. Mice tolerant of their allografts will be observed for evidence of immune deviation, clonal anergy or deletion, chimerism, and allograft expression of cytokine mRNA. ..
  22. MOBILIZED BLOOD STEM CELL TRANSPLANTATION WITHOUT GVHD
    Samuel Strober; Fiscal Year: 1999
    ..Results of this study should help the design of clinical protocols of allogeneic marrow or mobilized blood cell transplantation in attempts to reduce the risks of graft-versus-host disease and recurrent malignancy. ..
  23. DONOR CELL FACILITATION OF TOLERANCE
    Samuel Strober; Fiscal Year: 1999
    ..Finally, the subsets of donor cells which induce tolerance, and subsets of recipient cells which maintain tolerance will be identified in adoptive transfer studies. ..
  24. CD4/CD8/ALPHA BETA T CELLS IN AUTOIMMUNE MICE
    Samuel Strober; Fiscal Year: 1999
    ..The possible role of CD1 molecules as an autoantigen in heredity mouse models of lipus (NZB/NZW) will be explored also by attempting to block spontaneous autoantibody secretion in vitro and in vivo with anti-CD1 antibodies. ..
  25. Lymphoma Therapy Using Mixed Progenitor Transplants
    Samuel Strober; Fiscal Year: 2002
    ..GVHD will be monitored by clinical signs, survival, and histopathology. ..
  26. DONOR CELL FACILITATION OF TOLERANCE
    Samuel Strober; Fiscal Year: 2001
    ..They will also study GVHD using similar hypotheses and models. Mice tolerant of their allografts will be observed for evidence of immune deviation, clonal anergy or deletion, chimerism, and allograft expression of cytokine mRNA. ..
  27. Lymphoma Therapy Using Mixed Progenitor Transplants
    Samuel Strober; Fiscal Year: 2001
    ..GVHD will be monitored by clinical signs, survival, and histopathology. ..
  28. MOBILIZED BLOOD STEM CELL TRANSPLANTATION WITHOUT GVHD
    Samuel Strober; Fiscal Year: 2001
    ..Results of this study should help the design of clinical protocols of allogeneic marrow or mobilized blood cell transplantation in attempts to reduce the risks of graft-versus-host disease and recurrent malignancy. ..
  29. CD4/CD8/ALPHA BETA T CELLS IN AUTOIMMUNE MICE
    Samuel Strober; Fiscal Year: 2000
    ..The possible role of CD1 molecules as an autoantigen in heredity mouse models of lipus (NZB/NZW) will be explored also by attempting to block spontaneous autoantibody secretion in vitro and in vivo with anti-CD1 antibodies. ..
  30. MOBILIZED BLOOD STEM CELL TRANSPLANTATION WITHOUT GVHD
    Samuel Strober; Fiscal Year: 2000
    ..Results of this study should help the design of clinical protocols of allogeneic marrow or mobilized blood cell transplantation in attempts to reduce the risks of graft-versus-host disease and recurrent malignancy. ..
  31. DONOR CELL FACILITATION OF TOLERANCE
    Samuel Strober; Fiscal Year: 2000
    ..They will also study GVHD using similar hypotheses and models. Mice tolerant of their allografts will be observed for evidence of immune deviation, clonal anergy or deletion, chimerism, and allograft expression of cytokine mRNA. ..
  32. Gene and Cytokine Expression in Tolerance and GVHD
    Samuel Strober; Fiscal Year: 2009
    ..In addition to providing information about guidance of drug withdrawal, the studies are designed to provide further insight into the cellular and molecular immune mechanisms of tolerance and GVHD protection. ..