David Stevenson

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. ncbi request reprint American Pediatric Society Presidential Address 2006: science on the edge with life in the balance
    David K Stevenson
    Divison of Neonatal and Developmental Medicine, Department of Pediatrics, Stanford University School of Medicine, Stanford, California 94306, USA
    Pediatr Res 60:630-5. 2006
  2. pmc Transdisciplinary translational science and the case of preterm birth
    D K Stevenson
    Stanford University School of Medicine, Palo Alto, CA 94304, USA
    J Perinatol 33:251-8. 2013
  3. doi request reprint Bilirubin production and the risk of bilirubin neurotoxicity
    David K Stevenson
    Department of Pediatrics, Division of Neonatal and Developmental Medicine, Stanford University School of Medicine, Stanford, CA 94305 5208, USA
    Semin Perinatol 35:121-6. 2011
  4. ncbi request reprint Beware of the weaker sex: don't get too close to your twin brother
    David K Stevenson
    Division of Neonatal and Developmental Medicine, Department of Pediatrics, Stanford University School of Medicine, 750 Welch Rd, Suite 315, Palo Alto, CA 94306, USA
    Pediatrics 120:638-9. 2007
  5. pmc Metalloporphyrins in the management of neonatal hyperbilirubinemia
    David K Stevenson
    Department of Pediatrics, Stanford University School of Medicine, Palo Alto, CA 94304, USA
    Semin Fetal Neonatal Med 15:164-8. 2010
  6. ncbi request reprint Ethical considerations in neuroimaging and its impact on decision-making for neonates
    David K Stevenson
    Department of Pediatrics, Stanford University School of Medicine, 750 Welch Road, Suite 315, Palo Alto, CA 94304, USA
    Brain Cogn 50:449-54. 2002
  7. ncbi request reprint The jaundiced newborn. Understanding and managing transitional hyperbilirubinemia
    D K Stevenson
    Division of Neonatal, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA
    Minerva Pediatr 54:373-82. 2002
  8. pmc Sex differences in outcomes of very low birthweight infants: the newborn male disadvantage
    D K Stevenson
    Department of Pediatrics, Stanford University, Palo Alto, CA 94305 5119, USA
    Arch Dis Child Fetal Neonatal Ed 83:F182-5. 2000
  9. ncbi request reprint Carbon monoxide and bilirubin production in neonates
    D K Stevenson
    Department of Pediatrics, Stanford University School of Medicine, CA 94304 1510, USA
    Semin Perinatol 25:85-93. 2001
  10. pmc Carbon monoxide detection and biological investigations
    D K Stevenson
    Department of Pediatrics, Stanford University School of Medicine, CA 94305 5208, USA
    Trans Am Clin Climatol Assoc 111:61-75. 2000

Research Grants

Detail Information

Publications90

  1. ncbi request reprint American Pediatric Society Presidential Address 2006: science on the edge with life in the balance
    David K Stevenson
    Divison of Neonatal and Developmental Medicine, Department of Pediatrics, Stanford University School of Medicine, Stanford, California 94306, USA
    Pediatr Res 60:630-5. 2006
  2. pmc Transdisciplinary translational science and the case of preterm birth
    D K Stevenson
    Stanford University School of Medicine, Palo Alto, CA 94304, USA
    J Perinatol 33:251-8. 2013
    ..Forming a more integrated (or 'constructionist'), problem-based science reflective of transdisciplinary research requires the adoption of novel practices to overcome these obstacles...
  3. doi request reprint Bilirubin production and the risk of bilirubin neurotoxicity
    David K Stevenson
    Department of Pediatrics, Division of Neonatal and Developmental Medicine, Stanford University School of Medicine, Stanford, CA 94305 5208, USA
    Semin Perinatol 35:121-6. 2011
    ....
  4. ncbi request reprint Beware of the weaker sex: don't get too close to your twin brother
    David K Stevenson
    Division of Neonatal and Developmental Medicine, Department of Pediatrics, Stanford University School of Medicine, 750 Welch Rd, Suite 315, Palo Alto, CA 94306, USA
    Pediatrics 120:638-9. 2007
  5. pmc Metalloporphyrins in the management of neonatal hyperbilirubinemia
    David K Stevenson
    Department of Pediatrics, Stanford University School of Medicine, Palo Alto, CA 94304, USA
    Semin Fetal Neonatal Med 15:164-8. 2010
    ....
  6. ncbi request reprint Ethical considerations in neuroimaging and its impact on decision-making for neonates
    David K Stevenson
    Department of Pediatrics, Stanford University School of Medicine, 750 Welch Road, Suite 315, Palo Alto, CA 94304, USA
    Brain Cogn 50:449-54. 2002
    ..Once this is appreciated, the boundary between the technical and the ethical will be less often disputed...
  7. ncbi request reprint The jaundiced newborn. Understanding and managing transitional hyperbilirubinemia
    D K Stevenson
    Division of Neonatal, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA
    Minerva Pediatr 54:373-82. 2002
    ..In this review, we will discuss the various risk factors associated with hyperbilirubinemia and describe strategies for the diagnosis and management of transitional hyperbilirubinemia...
  8. pmc Sex differences in outcomes of very low birthweight infants: the newborn male disadvantage
    D K Stevenson
    Department of Pediatrics, Stanford University, Palo Alto, CA 94305 5119, USA
    Arch Dis Child Fetal Neonatal Ed 83:F182-5. 2000
    ..To determine the differences in short term outcome of very low birthweight infants attributable to sex...
  9. ncbi request reprint Carbon monoxide and bilirubin production in neonates
    D K Stevenson
    Department of Pediatrics, Stanford University School of Medicine, CA 94304 1510, USA
    Semin Perinatol 25:85-93. 2001
    ..This report provides a brief overview of these interrelationships in the hope that it may provide insight into the central role this pathway plays in the existence of most organisms...
  10. pmc Carbon monoxide detection and biological investigations
    D K Stevenson
    Department of Pediatrics, Stanford University School of Medicine, CA 94305 5208, USA
    Trans Am Clin Climatol Assoc 111:61-75. 2000
    ..It may be shown that the integrity of the heme catabolic pathway, which is ever present and plays a role in every tissue, is central to the existence of most complex organisms...
  11. pmc Synchronized nasal intermittent positive-pressure ventilation and neonatal outcomes
    Vineet Bhandari
    Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut 06520 8064, USA
    Pediatrics 124:517-26. 2009
    ..Limited information is available on the outcomes of infants managed with SNIPPV...
  12. pmc Dermal carbon monoxide excretion in neonatal rats during light exposure
    Hendrik J Vreman
    Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305, USA
    Pediatr Res 66:66-9. 2009
    ..We conclude that light-induced elevations in total body CO excretion may be caused by transdermally excreted CO, which is most likely produced through endogenous photosensitizer-mediated photooxidation of dermal biomolecules...
  13. pmc Antenatal consent in the SUPPORT trial: challenges, costs, and representative enrollment
    Wade D Rich
    Department of Pediatrics, School of Medicine, University of California, San Diego, California, USA
    Pediatrics 126:e215-21. 2010
    ....
  14. ncbi request reprint The effectiveness of oral tin mesoporphyrin prophylaxis in reducing bilirubin production after an oral heme load in a transgenic mouse model
    Glenn H DeSandre
    Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94306, USA
    Biol Neonate 89:139-46. 2006
    ..The use of tin mesoporphyrin (SnMP) has been proposed for interdicting the development of severe hyperbilirubinemia in a variety of conditions...
  15. ncbi request reprint Determination of carbon monoxide (CO) in rodent tissue: effect of heme administration and environmental CO exposure
    Hendrik J Vreman
    Department of Pediatrics, Division of Neonatal and Developmental Medicine, Stanford University School of Medicine, Stanford, CA 94305 5208, USA
    Anal Biochem 341:280-9. 2005
    ..Intestine, lung, testes, and brain contained the lowest CO concentrations...
  16. ncbi request reprint Phototherapy: current methods and future directions
    Hendrik J Vreman
    Department of Pediatrics, Division of Neonatal and Developmental Medicine, Stanford University School of Medicine, Stanford, CA 94305 5208, USA
    Semin Perinatol 28:326-33. 2004
    ....
  17. ncbi request reprint Monitoring age-related susceptibility of young mice to oral Salmonella enterica serovar Typhimurium infection using an in vivo murine model
    Stacy M Burns-Guydish
    Division of Neonatal and Developmental Medicine, Department of Pediatrics, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA
    Pediatr Res 58:153-8. 2005
    ..Thus, this model of age-related susceptibility to S. typhimurium using BLI can be used to advance our understanding of the mechanisms involved in newborn susceptibility to infection...
  18. doi request reprint Readmission for neonatal jaundice in California, 1991-2000: trends and implications
    Anthony E Burgos
    Department of Pediatrics, Stanford University, Stanford, California, USA
    Pediatrics 121:e864-9. 2008
    ..We sought to describe population-based trends, potential risk factors, and hospital costs of readmission for jaundice for term and late preterm infants...
  19. ncbi request reprint Regulation of maternal and fetal hemodynamics by heme oxygenase in mice
    Hui Zhao
    Department of Pediatrics, Stanford University School of Medicine, Stanford, California 94305 5208, USA
    Biol Reprod 78:744-51. 2008
    ....
  20. ncbi request reprint Concentration of carbon monoxide (CO) in postmortem human tissues: effect of environmental CO exposure
    Hendrik J Vreman
    Department of Pediatrics, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305 5208, USA
    J Forensic Sci 51:1182-90. 2006
    ..2%, and 69.1% of total hemoglobin, respectively. We conclude that measurements of CO concentration in a variety of tissues can be used as markers for the degree of exogenous CO exposure and the identification of possible causes of death...
  21. pmc Interobserver reliability and accuracy of cranial ultrasound scanning interpretation in premature infants
    Susan R Hintz
    Division of Neonatal and Developmental Medicine, Stanford University School of Medicine, Palo Alto, CA 94304, USA
    J Pediatr 150:592-6, 596.e1-5. 2007
    ..To assess interobserver reliability between 2 central readers of cranial ultrasound scanning (CUS) and accuracy of local, compared with central, interpretations...
  22. ncbi request reprint Neonatal microstructural development of the internal capsule on diffusion tensor imaging correlates with severity of gait and motor deficits
    Jessica Rose
    Department of Orthopaedic Surgery, Stanford University School of Medicine, Stanford, CA, USA
    Dev Med Child Neurol 49:745-50. 2007
    ..This preliminary study suggests neonatal DTI may be an important predictor of the severity of future gait and motor deficits...
  23. ncbi request reprint Systemic effects of orally-administered zinc and tin (IV) metalloporphyrins on heme oxygenase expression in mice
    Ichiro Morioka
    Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305 5208, USA
    Pediatr Res 59:667-72. 2006
    ..We conclude that the three Mps are absorbed at different rates in the mouse and affect bilirubin production and HO-1 expression in a tissue- and time-dependent manner...
  24. ncbi request reprint Expression and regulation of heme oxygenase isozymes in the developing mouse cortex
    Hui Zhao
    Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305 5208, USA
    Pediatr Res 60:518-23. 2006
    ..Therefore, we conclude that HO-1 gene expression in the cortex is developmentally-regulated and that methylation of the HO-1 CpG island is not associated with the down-regulation of the gene...
  25. pmc Neurodevelopmental outcomes of premature infants with severe respiratory failure enrolled in a randomized controlled trial of inhaled nitric oxide
    Susan R Hintz
    NICHD Neonatal Research Network
    J Pediatr 151:16-22, 22.e1-3. 2007
    ....
  26. ncbi request reprint The potential Salmonella aroA- vaccine strain is safe and effective in young BALB/c mice
    Stacy M Burns-Guydish
    Division of Neonatal and Developmental Medicine, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305 5208, USA
    Neonatology 91:114-20. 2007
    ..Due to the increased susceptibility of neonates to pathogens including those with mutations, the use of live vaccine strategies in the human population may present a potential risk to the young...
  27. pmc Inhaled nitric oxide for preterm premature rupture of membranes, oligohydramnios, and pulmonary hypoplasia
    Valerie Y Chock
    Division of Neonatology, Stanford University, Stanford, California, USA
    Am J Perinatol 26:317-22. 2009
    ..However, the small sample size precludes definitive conclusions. Further studies are required to determine if iNO is of benefit in this specific patient population...
  28. pmc Predicting time to hospital discharge for extremely preterm infants
    Susan R Hintz
    Department of Pediatrics, Division of Neonatology, Stanford University School of Medicine and Lucile Packard Children s Hospital, Palo Alto, CA 94304, USA
    Pediatrics 125:e146-54. 2010
    ..Accurate models for predicting time to hospital discharge could aid in resource planning, family counseling, and stimulate quality-improvement initiatives...
  29. pmc Early-childhood neurodevelopmental outcomes are not improving for infants born at <25 weeks' gestational age
    Susan R Hintz
    Division of Neonatal and Developmental Medicine, Department of Pediatrics, Stanford University School of Medicine, 750 Welch Rd, Suite 315, Palo Alto, CA 94304, USA
    Pediatrics 127:62-70. 2011
    ..We compared neurodevelopmental outcomes at 18 to 22 months' corrected age of infants born with extremely low birth weight at an estimated gestational age of <25 weeks during 2 periods: 1999-2001 (epoch 1) and 2002-2004 (epoch 2)...
  30. doi request reprint Neonatal brain structure on MRI and diffusion tensor imaging, sex, and neurodevelopment in very-low-birthweight preterm children
    Jessica Rose
    Department of Orthopaedic Surgery, Stanford University School of Medicine, Stanford, CA, USA
    Dev Med Child Neurol 51:526-35. 2009
    ..Results indicate that the higher incidence of abnormal neurodevelopment in preterm males relates to greater incidence and severity of brain abnormalities, including reduced PLIC and splenium development...
  31. ncbi request reprint Transcutaneous bilirubinometry: a noninvasive tool for studying newborn jaundiced rats before and after exposure to light
    Hendrik J Vreman
    Department of Pediatrics, Stanford University School of Medicine, CA 94305, USA
    Pediatr Res 59:203-9. 2006
    ..Thus, in addition to being a useful tool for evaluating jaundice in human neonates, TcB methodology can be used successfully for the noninvasive monitoring of jaundice in neonatal Gunn rats pre- and postlight exposure...
  32. ncbi request reprint Inhaled nitric oxide for premature infants with severe respiratory failure
    Krisa P Van Meurs
    Division of Neonatal and Developmental Medicine, Department of Pediatrics, Stanford University School of Medicine, Palo Alto, Calif 94304, USA
    N Engl J Med 353:13-22. 2005
    ..We conducted a multicenter, randomized, blinded, controlled trial to determine whether inhaled nitric oxide reduced the rate of death or bronchopulmonary dysplasia in such infants...
  33. doi request reprint Inhibition of heme oxygenase activity in newborn mice by azalanstat
    Takeshi Morisawa
    Department of Pediatrics, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA
    Can J Physiol Pharmacol 86:651-9. 2008
    ..Therefore, other imidazole-dioxolanes should be evaluated to determine whether they are more potent than AZA for use in treating neonatal jaundice...
  34. ncbi request reprint Selection of potential therapeutics based on in vivo spatiotemporal transcription patterns of heme oxygenase-1
    Weisheng Zhang
    Division of Neonatal and Developmental Medicine, Department of Pediatrics, Stanford University Medical Center, Stanford University, Stanford, CA 94305 5208, USA
    J Mol Med (Berl) 80:655-64. 2002
    ..Among the known inhibitors of HO enzyme activity that were evaluated in this study, ZnBG did not significantly affect HO-1 transcription and therefore may be well suited for the prevention of neonatal jaundice...
  35. pmc Stability of neuromotor outcomes at 18 and 30 months of age after extremely low birth weight status
    Myriam Peralta-Carcelen
    Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Pediatrics 123:e887-95. 2009
    ..Extremely low birth weight (< or =1000 g) children have increased rates of cerebral palsy and other abnormal neurologic findings...
  36. ncbi request reprint Continuous, noninvasive, and localized microvascular tissue oximetry using visible light spectroscopy
    David A Benaron
    Biomedical Optics Laboratory, and Department of Pediatrics, Stanford Hospital and Livermore Veterans Affairs Medical Center, Palo Alto, California 94305, USA
    Anesthesiology 100:1469-75. 2004
    ..Unlike near-infrared spectroscopy or pulse oximetry (SpO2), VLS tissue oximetry uses shallow-penetrating visible light to measure microvascular hemoglobin oxygen saturation (StO2) in small, thin tissue volumes...
  37. ncbi request reprint Cesarean delivery rates and neonatal morbidity in a low-risk population
    Jeffrey B Gould
    Division of Neonatal and Developmental Medicine, Stanford University, Stanford, California 94304, USA
    Obstet Gynecol 104:11-9. 2004
    ..To estimate the relationship between case-mix adjusted cesarean delivery rates and neonatal morbidity and mortality in infants born to low-risk mothers...
  38. doi request reprint Quantitating carbon monoxide production from heme by vascular plant preparations in vitro
    Hendrik J Vreman
    Department of Pediatrics, Division of Neonatal and Developmental Medicine, Stanford University School of Medicine, 300 Pasteur Dr, Stanford, CA 94305 5208, USA
    Plant Physiol Biochem 49:61-8. 2011
    ..We conclude that gas chromatography is uniquely suited for the determination of CO production in pigmented, heterogeneous plant tissue preparations...
  39. ncbi request reprint Promoting antenatal steroid use for fetal maturation: results from the California Perinatal Quality Care Collaborative
    David D Wirtschafter
    California Perinatal Quality Care Collaborative, Palo Alto, California, USA
    J Pediatr 148:606-612. 2006
    ..We hypothesized that mean performance would improve and the number of centers performing below the lowest quartile of the baseline year would decrease...
  40. pmc Predictors of death or bronchopulmonary dysplasia in preterm infants with respiratory failure
    N Ambalavanan
    Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35249, USA
    J Perinatol 28:420-6. 2008
    ..To identify the variables that predict death/physiologic bronchopulmonary dysplasia (BPD) in preterm infants with severe respiratory failure...
  41. ncbi request reprint Parenteral glutamine supplementation does not reduce the risk of mortality or late-onset sepsis in extremely low birth weight infants
    Brenda B Poindexter
    Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Pediatrics 113:1209-15. 2004
    ..Whether glutamine supplementation would provide a similar benefit to extremely low birth weight (ELBW) infants is not known...
  42. pmc Very low birth weight preterm infants with surgical short bowel syndrome: incidence, morbidity and mortality, and growth outcomes at 18 to 22 months
    Conrad R Cole
    Emory University School of Medicine, Division of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, 2015 Uppergate Dr, Atlanta, GA 30322, USA
    Pediatrics 122:e573-82. 2008
    ....
  43. ncbi request reprint Gestational pattern of heme oxygenase expression in the rat
    Doron Kreiser
    Department of Pediatrics, Stanford University School of Medicine, 750 Welch Rd, 315, Palo Alto, CA 94304, U S A
    Pediatr Res 54:172-8. 2003
    ..We conclude that there is a clear uterine and placental gestational pattern of HO expression in the rat. This pattern is comparable to that of vascular endothelial growth factor and leptin...
  44. pmc Community supports after surviving extremely low-birth-weight, extremely preterm birth: special outpatient services in early childhood
    Susan R Hintz
    Division of Neonatal and Developmental Medicine, Department of Pediatrics, Stanford University School of Medicine, Palo Alto, California 94304, USA
    Arch Pediatr Adolesc Med 162:748-55. 2008
    ..To determine special outpatient services (SOS) use, need, associated factors, and neurodevelopmental and functional outcomes among extremely preterm infants at 18 to 22 months' corrected age...
  45. ncbi request reprint Statin treatment increases formation of carbon monoxide and bilirubin in mice: a novel mechanism of in vivo antioxidant protection
    Lucie Muchova
    Department of Pediatrics, Stanford University School of Medicine, 300 Pasteur Drive, Rm S230, Stanford, CA 94305 5208, USA
    Can J Physiol Pharmacol 85:800-10. 2007
    ..These findings suggest that the induction of HO and the production of its products, CO and bilirubin, may be a mechanism by which statins exert antioxidant actions and confer cardioprotection in vivo...
  46. pmc Outcome of term infants using apgar scores at 10 minutes following hypoxic-ischemic encephalopathy
    Abbot R Laptook
    Department of Pediatrics, Women and Infants Hospital of Rhode Island, Providence, Rhode Island 02906, USA
    Pediatrics 124:1619-26. 2009
    ..The objective of this study was to determine whether Apgar scores at 10 minutes are associated with death or disability in early childhood after perinatal hypoxic-ischemic encephalopathy...
  47. doi request reprint Understanding neonatal jaundice: a perspective on causation
    Ronald S Cohen
    Department of Pediatrics, Stanford University School of Medicine, Stanford, California 94305, USA
    Pediatr neonatol 51:143-8. 2010
    ..Information on the level of bilirubin production and its rate of elimination may help to guide the clinical management of neonatal jaundice...
  48. pmc Outcomes of safety and effectiveness in a multicenter randomized, controlled trial of whole-body hypothermia for neonatal hypoxic-ischemic encephalopathy
    Seetha Shankaran
    Department of Pediatrics, Wayne State University School of Medicine, Detroit, Michigan, USA
    Pediatrics 122:e791-8. 2008
    ..Whole-body hypothermia reduced the frequency of death or moderate/severe disabilities in neonates with hypoxic-ischemic encephalopathy in a randomized, controlled multicenter trial...
  49. pmc Cytokines associated with bronchopulmonary dysplasia or death in extremely low birth weight infants
    Namasivayam Ambalavanan
    Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35249, USA
    Pediatrics 123:1132-41. 2009
    ..The goal was to develop multivariate logistic regression models for the outcome of bronchopulmonary dysplasia and/or death at postmenstrual age of 36 weeks by using clinical and cytokine data from the first 28 days...
  50. ncbi request reprint Late-onset sepsis in very low birth weight neonates: the experience of the NICHD Neonatal Research Network
    Barbara J Stoll
    Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Pediatrics 110:285-91. 2002
    ....
  51. ncbi request reprint Apigenin decreases hemin-mediated heme oxygenase-1 induction
    Aida Abate
    Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305, USA
    Free Radic Biol Med 39:711-8. 2005
    ..These results suggest that hemin-induced HO-1 expression can be attenuated by flavonoids, such as APG...
  52. ncbi request reprint Transcutaneous bilirubin measurements and serum total bilirubin levels in indigenous African infants
    Tina M Slusher
    Department of Pediatrics, West Virginia University School of Medicine, Morgantown, West Virginia 26506, USA
    Pediatrics 113:1636-41. 2004
    ....
  53. ncbi request reprint End tidal carbon monoxide levels are lower in women with gestational hypertension and pre-eclampsia
    Doron Kreiser
    Department of Gynecology and Obstetrics, Stanford University School of Medicine, Stanford, CA, USA
    J Perinatol 24:213-7. 2004
    ..The aim of this study was to compare end tidal breath CO (ETCO) levels in women with gestational hypertension (GH) or pre-eclampsia to the levels in healthy pregnant and nonpregnant women...
  54. ncbi request reprint Effects of metalloporphyrins on heme oxygenase-1 transcription: correlative cell culture assays guide in vivo imaging
    Monica Hajdena-Dawson
    Stanford University School of Medicine, USA
    Mol Imaging 2:138-49. 2003
    ..Thus, this study serves as a model for understanding the effects of specific compounds in relation to defined targets using an integrated approach...
  55. pmc Reduction in red blood cell transfusions among preterm infants: results of a randomized trial with an in-line blood gas and chemistry monitor
    John A Widness
    Department of Pediatrics, College of Medicine, University of Iowa, Iowa City, Iowa, USA
    Pediatrics 115:1299-306. 2005
    ..To date, researchers have had only limited success in finding ways to reduce transfusions significantly in this patient population...
  56. pmc The role of Bach1 in the induction of heme oxygenase by tin mesoporphyrin
    Aida Abate
    Department of Pediatrics, Stanford University School of Medicine, 300 Pasteur Drive, Rm S 230, Stanford, CA 94305, USA
    Biochem Biophys Res Commun 354:757-63. 2007
    ..In conclusion, SnMP induces HO-1 expression not only by de-repressing the HO-1 promoter by binding Bach1, but also by accelerating Bach1 degradation...
  57. pmc Maternal age, multiple birth, and extremely low birth weight infants
    Betty R Vohr
    Department of Pediatrics, The Warren Alpert Medical School of Brown University, Providence, RI, USA
    J Pediatr 154:498-503.e2. 2009
    ..To compare the rates of adverse neurodevelopmental outcome or death at 18 to 22 months among extremely low birth weight (ELBW) infants born to mothers >or=4 0 years to the corresponding rates among infants of younger mothers...
  58. pmc Prolonged duration of initial empirical antibiotic treatment is associated with increased rates of necrotizing enterocolitis and death for extremely low birth weight infants
    C Michael Cotten
    Department of Pediatrics, Duke University, Durham, NC 27710, USA
    Pediatrics 123:58-66. 2009
    ....
  59. ncbi request reprint Failure to detect elevated levels of carboxyhemoglobin in infants dying from SIDS
    Robert G Meny
    Department of Pediatrics, University of Maryland, Baltimore 21201, USA
    J Forensic Sci 47:660-2. 2002
    ..83%); 48 age-matched controls (0.53+/-0.38%); and three individuals who died from fire related causes (41+/-20%). No statistical differences in COHb levels were detected between blood from SIDS and control infants (p = 0.43)...
  60. pmc Neonatal candidiasis: epidemiology, risk factors, and clinical judgment
    Daniel K Benjamin
    Department of Pediatrics, Duke University, Duke Clinical Research Institute, 2400 Pratt St, Durham, NC 27705, USA
    Pediatrics 126:e865-73. 2010
    ..We quantified risk factors that predict infection in premature infants at high risk and compared clinical judgment with a prediction model of invasive candidiasis...
  61. pmc Impact of timing of birth and resident duty-hour restrictions on outcomes for small preterm infants
    Edward F Bell
    Department of Pediatrics, University of Iowa, Iowa City, IA 52242, USA
    Pediatrics 126:222-31. 2010
    ....
  62. ncbi request reprint Changes in pathogens causing early-onset sepsis in very-low-birth-weight infants
    Barbara J Stoll
    Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA
    N Engl J Med 347:240-7. 2002
    ....
  63. pmc Neonatal outcomes of extremely preterm infants from the NICHD Neonatal Research Network
    Barbara J Stoll
    Department of Pediatrics, Emory University School of Medicine and Children s Healthcare of Atlanta, 2015 Uppergate Dr, Atlanta, GA 30322, USA
    Pediatrics 126:443-56. 2010
    ....
  64. pmc Perinatal systemic inflammatory response syndrome and retinopathy of prematurity
    Beena G Sood
    Department of Pediatrics, Wayne State University, Detroit, Michigan 48201, USA
    Pediatr Res 67:394-400. 2010
    ..We conclude that perinatal inflammation may be involved in the pathogenesis of ROP...
  65. ncbi request reprint NICHD Conference on Kernicterus: Research on Prevention of Bilirubin-Induced Brain Injury and Kernicterus: Bench-to-Bedside--Diagnostic Methods and Prevention and Treatment Strategies
    David K Stevenson
    Division of Neonatal and Developmental Medicine, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94304 5731, USA
    J Perinatol 24:521-5. 2004
    ....
  66. doi request reprint Management of jaundice and prevention of severe neonatal hyperbilirubinemia in infants >or=35 weeks gestation
    Vinod K Bhutani
    School of Medicine at Stanford University, Stanford, CA, USA
    Neonatology 94:63-7. 2008
    ..Translational research is needed to better understand the mechanisms of bilirubin neurotoxicity and potential therapeutic interventions...
  67. ncbi request reprint Laparotomy versus peritoneal drainage for necrotizing enterocolitis or isolated intestinal perforation in extremely low birth weight infants: outcomes through 18 months adjusted age
    Martin L Blakely
    University of Tennessee Health Science Center, Memphis, Tennessee, USA
    Pediatrics 117:e680-7. 2006
    ....
  68. ncbi request reprint Neonatal hyperbilirubinemia in African American males: the importance of glucose-6-phosphate dehydrogenase deficiency
    Michael Kaplan
    Shaare Zedek Medical Center, Faculty of Medicine of the Hebrew University, Jerusalem, Israel
    J Pediatr 149:83-8. 2006
    ..To perform risk factor analysis for the prediction of hyperbilirubinemia in an African American male neonatal cohort...
  69. ncbi request reprint Risk factors for early death among extremely low-birth-weight infants
    Seetha Shankaran
    Wayne State University, Detroit, Michigan, USA
    Am J Obstet Gynecol 186:796-802. 2002
    ....
  70. ncbi request reprint Hemolysis and bilirubin conjugation in association with UDP-glucuronosyltransferase 1A1 promoter polymorphism
    Michael Kaplan
    Department of Neonatology, Clinical Genetics Service, Shaare Zedek Medical Center, Faculty of Medicine of the Hebrew University, Jerusalem, Israel
    Hepatology 35:905-11. 2002
    ..The increased hemolysis may contribute to the pathogenesis of increased STB values seen in Gilbert's syndrome, and exacerbate neonatal hyperbilirubinemia associated with the promoter polymorphism...
  71. ncbi request reprint Imbalance between production and conjugation of bilirubin: a fundamental concept in the mechanism of neonatal jaundice
    Michael Kaplan
    Department of Neonatology, Shaare Zedek Medical Center, Jerusalem, Israel Faculty of Medicine of the Hebrew University, Jerusalem, Israel
    Pediatrics 110:e47. 2002
    ..The objective of this study was to evaluate the roles of production and conjugation of bilirubin, individually and in combination, in the mechanism of neonatal jaundice...
  72. ncbi request reprint Reduction in hospital readmission rates for hyperbilirubinemia is associated with use of transcutaneous bilirubin measurements
    David K Stevenson
    Clin Chem 51:481-2. 2005
  73. ncbi request reprint Preemie abandonment? Multidisciplinary experts consider how to best meet preemies needs at "preterm infants: a collaborative approach to specialized care" roundtable
    Heidelise Als
    Harvard Medical School Children s Hospital, Boston, USA
    Mod Healthc 37:17-24. 2007
    ....
  74. pmc Effects of sample dilution, peroxidase concentration, and chloride ion on the measurement of unbound bilirubin in premature newborns
    Charles E Ahlfors
    PO Box 2904, Vashon, WA 98070, USA
    Clin Biochem 40:261-7. 2007
    ....
  75. ncbi request reprint (TA)n UGT 1A1 promoter polymorphism: a crucial factor in the pathophysiology of jaundice in G-6-PD deficient neonates
    Michael Kaplan
    Department of Neonatology, Shaare Zedek Medical Center, Jerusalem 91031, Israel
    Pediatr Res 61:727-31. 2007
    ..8 +/- 3.4 mg/dL, p = 0.02). In the steady state, similar rates of hemolysis, but increased PTB in the G-6-PD- deficient, (TA)7/(TA)7 homozygotes, imply that (TA)7/(TA)7, homozygosity is central to increased PTB...
  76. ncbi request reprint Whole-body hypothermia for neonatal encephalopathy: animal observations as a basis for a randomized, controlled pilot study in term infants
    Seetha Shankaran
    Wayne State University, Detroit, Michigan, USA
    Pediatrics 110:377-85. 2002
    ....
  77. ncbi request reprint Trends in neonatal morbidity and mortality for very low birthweight infants
    Avroy A Fanaroff
    Department of Pediatrics, Case Western Reserve University, Cleveland, OH
    Am J Obstet Gynecol 196:147.e1-8. 2007
    ..To document the mortality and morbidity of infants weighing 501-1500 g at birth according to gestational age, birthweight, and sex...
  78. ncbi request reprint A prospective randomized controlled study of phototherapy using blue and blue-green light-emitting devices, and conventional halogen-quartz phototherapy
    Daniel S Seidman
    Department of Obstetrics and Gynecology, Chain Medical Center, Tel Hashomer and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    J Perinatol 23:123-7. 2003
    ..The devices made of high-intensity gallium nitride light-emitting diodes (LEDs) were also compared to conventional halogen-quartz bulbs phototherapy...
  79. ncbi request reprint Heme oxygenase-2 protects against lipid peroxidation-mediated cell loss and impaired motor recovery after traumatic brain injury
    Edward F Chang
    Department of Neurosurgery, University of California, San Francisco, San Francisco, California 94143 0520, USA
    J Neurosci 23:3689-96. 2003
    ..These findings demonstrate that HO-2 expression protects neurons against TBI by reducing lipid peroxidation via the catabolism of free heme...
  80. ncbi request reprint Introduction. Newborn jaundice
    Vinod K Bhutani
    Semin Perinatol 28:317-8. 2004
  81. ncbi request reprint Is carbon monoxide-mediated cyclic guanosine monophosphate production responsible for low blood pressure in neonatal respiratory distress syndrome?
    Frank van Bel
    Department of Neonatology, Rm KE 04 123 1, Wilhelmina Children s Hospital, University Medical Center, PO Box 85090, 3508 AB Utrecht, The Netherlands
    J Appl Physiol 98:1044-9. 2005
    ..001). We conclude that a CO-mediated increase in cGMP causes systemic vasodilation with a consequent lower blood pressure and increased need for blood pressure support in preterm infants with RDS...
  82. pmc Aggressive vs. conservative phototherapy for infants with extremely low birth weight
    Brenda H Morris
    University of Texas Medical School, Houston, TX 77030, USA
    N Engl J Med 359:1885-96. 2008
    ..It is unclear whether aggressive phototherapy to prevent neurotoxic effects of bilirubin benefits or harms infants with extremely low birth weight (1000 g or less)...
  83. pmc Neurodevelopmental outcome of extremely low birth weight infants with posthemorrhagic hydrocephalus requiring shunt insertion
    Ira Adams-Chapman
    Department of Pediatrics Division of Neonatology, Emory University School of Medicine, 46 Jesse Hill Jr Drive SE, Atlanta, GA 30303, USA
    Pediatrics 121:e1167-77. 2008
    ..We aimed to evaluate neurodevelopmental and growth outcomes among extremely low birth weight infants who had severe intraventricular hemorrhage that required shunt insertion compared with infants without shunt insertion...
  84. ncbi request reprint Role of carbon monoxide and nitric oxide in newborn infants with postasphyxial hypoxic-ischemic encephalopathy
    Hendrik J Vreman
    Pediatrics 109:715-6; author reply 715-6. 2002
  85. ncbi request reprint Hyperbilirubinemia among African American, glucose-6-phosphate dehydrogenase-deficient neonates
    Michael Kaplan
    Department of Neonatology, Shaare Zedek Medical Center, PO Box 3525, Jerusalem 91031, Israel
    Pediatrics 114:e213-9. 2004
    ..Although glucose-6-phosphate dehydrogenase (G-6-PD) deficiency is prevalent in African Americans, their risk of associated neonatal hyperbilirubinemia has not been prospectively studied...
  86. ncbi request reprint Phototherapy and photo-oxidation in premature neonates
    Michael Kaplan
    Department of Neonatology, Shaare Zedek Medical Center, Jerusalem, Israel
    Biol Neonate 87:44-50. 2005
    ..The potential for photo-oxidation during phototherapy in premature neonates was assessed by measuring parameters reflective of photo-oxidation...
  87. ncbi request reprint On the caffeination of prematurity
    David K Stevenson
    N Engl J Med 357:1967-8. 2007
  88. ncbi request reprint Determination of in vivo carbon monoxide production in laboratory animals via exhaled air
    Ryan A Dercho
    Department of Pharmacology and Toxicology, Queen s University, Kingston, ON, Canada K7L 3N6
    J Pharmacol Toxicol Methods 54:288-95. 2006
    ..Here, we describe a modified flow-through method for the collection and quantitation of CO from small laboratory animals...
  89. ncbi request reprint Neurodevelopmental outcome of premature infants after antenatal phenobarbital exposure
    Seetha Shankaran
    Wayne State University, Detroit, MI, USA
    Am J Obstet Gynecol 187:171-7. 2002
    ....
  90. ncbi request reprint Reducing Candida infections during neonatal intensive care: management choices, infection control, and fluconazole prophylaxis
    Sarah S Long
    J Pediatr 147:135-41. 2005

Research Grants23

  1. Effects of Statins on Heme Oxygenase-1 Regulation
    David Stevenson; Fiscal Year: 2007
    ..concerted effort to delineate the role of HO-1 as a novel therapeutic target for statins and mediator of protective effects under conditions of insufficient HO-1 expression such as pre-eclampsia and other pregnancy-related disorders ..
  2. DEVELOPMENTAL AND NEONATAL BIOLOGY TRAINING PROGRAM
    David Stevenson; Fiscal Year: 2007
    ....
  3. Therapeutic Use of Heme Analogs: Absorption in Intestine
    David Stevenson; Fiscal Year: 2009
    ....
  4. Therapeutic Use of Heme Analogs: Absorption in Intestine
    David Stevenson; Fiscal Year: 2009
    ....
  5. REGULATION OF HEME OXYGENASE IN NEONATAL ANIMALS
    David Stevenson; Fiscal Year: 2005
    ..abstract_text> ..
  6. REGULATION OF HEME OXYGENASE IN NEONATAL ANIMALS
    David Stevenson; Fiscal Year: 2001
    ..We can then combine this data without knowledge of pharmacologic properties of HO inhibitors to select compounds that control hyperbilirubinemia and prevent or treat neonatal jaundice. ..
  7. Therapeutic Use of Heme Analogs: Absorption in Intestine
    David Stevenson; Fiscal Year: 2004
    ..Furthermore, these studies will provide answers regarding the chemotherapeutic potential of Mps for the treatment and prevention of neonatal hyperbilirubinemia. ..
  8. Chromium Mesoporphyrin in the Prevention of Neonatal Jaundice
    David K Stevenson; Fiscal Year: 2010
    ....