David A Stevens

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. ncbi request reprint Experimental systemic infection with Cryptococcus neoformans var. grubii and Cryptococcus gattii in normal and immunodeficient mice
    Javier Capilla
    California Institute for Medical Research, San Jose, California, USA
    Med Mycol 44:601-10. 2006
  2. doi request reprint Immune responses induced by heat killed Saccharomyces cerevisiae: a vaccine against fungal infection
    Min Liu
    California Institute for Medical Research, San Jose, CA, USA
    Vaccine 29:1745-53. 2011
  3. pmc Escape of Candida from caspofungin inhibition at concentrations above the MIC (paradoxical effect) accomplished by increased cell wall chitin; evidence for beta-1,6-glucan synthesis inhibition by caspofungin
    David A Stevens
    Department of Medicine, Santa Clara Valley Medical Center, San Jose, CA 95128 2699, USA
    Antimicrob Agents Chemother 50:3160-1. 2006
  4. doi request reprint Expert opinion: what to do when there is Coccidioides exposure in a laboratory
    David A Stevens
    Department of Medicine, Santa Clara Valley Medical Center, San Jose, California 95128 2699, USA
    Clin Infect Dis 49:919-23. 2009
  5. ncbi request reprint Caspofungin
    Stanley C Deresinski
    Department of Medicine, Santa Clara Valley Medical Center, San Jose, CA, 95128, USA
    Clin Infect Dis 36:1445-57. 2003
  6. doi request reprint Halomonas johnsoniae: review of a medically underappreciated genus of growing human importance
    David A Stevens
    Department of Medicine, Division of Infectious Diseases, Santa Clara Valley Medical Center, San Jose, California 95128 2699, USA
    Am J Med Sci 345:335-8. 2013
  7. doi request reprint Advances in systemic antifungal therapy
    David A Stevens
    Department of Medicine, Division of Infectious Diseases, Santa Clara Valley Medical Center, 751 South Bascom Avenue, San Jose, CA 95128 2699, USA
    Clin Dermatol 30:657-61. 2012
  8. pmc Global population structure of Aspergillus terreus inferred by ISSR typing reveals geographical subclustering
    Carolyn O S Neal
    Mycotic Diseases Branch, Center for Disease Control and Prevention, 1600 Clifton Rd NE, Atlanta, GA 30329, USA
    BMC Microbiol 11:203. 2011
  9. ncbi request reprint Studies of the paradoxical effect of caspofungin at high drug concentrations
    David A Stevens
    Department of Medicine, Santa Clara Valley Medical Center, San Jose, CA 95128 2699, USA
    Diagn Microbiol Infect Dis 51:173-8. 2005
  10. doi request reprint Developing a vaccine against aspergillosis
    David A Stevens
    Department of Medicine, Division of Infectious Diseases, Santa Clara Valley Medical Center and California Institute for Medical Research, 751 South Bascom Avenue, San Jose, CA 95128 2699, USA
    Med Mycol 49:S170-6. 2011

Detail Information

Publications93

  1. ncbi request reprint Experimental systemic infection with Cryptococcus neoformans var. grubii and Cryptococcus gattii in normal and immunodeficient mice
    Javier Capilla
    California Institute for Medical Research, San Jose, California, USA
    Med Mycol 44:601-10. 2006
    ..This is the first report of C. gattii inducing experimental cutaneous and intestinal mucosal infection; Cn var. grubii did not affect these tissues, indicating differences in tissue tropism of these pathogens...
  2. doi request reprint Immune responses induced by heat killed Saccharomyces cerevisiae: a vaccine against fungal infection
    Min Liu
    California Institute for Medical Research, San Jose, CA, USA
    Vaccine 29:1745-53. 2011
    ..Taken together, the results suggested that HKY vaccination induces significant and specific Th1 type cellular immune responses and antibodies to glucan and mannan...
  3. pmc Escape of Candida from caspofungin inhibition at concentrations above the MIC (paradoxical effect) accomplished by increased cell wall chitin; evidence for beta-1,6-glucan synthesis inhibition by caspofungin
    David A Stevens
    Department of Medicine, Santa Clara Valley Medical Center, San Jose, CA 95128 2699, USA
    Antimicrob Agents Chemother 50:3160-1. 2006
    ..Beta-1,3-glucan declined 81% in the presence of caspofungin, as expected. Beta-1,6-glucan declined 73%. Chitin increased 898%, demonstrating a mechanism for paradoxical growth-a rapid shift in the key polymer...
  4. doi request reprint Expert opinion: what to do when there is Coccidioides exposure in a laboratory
    David A Stevens
    Department of Medicine, Santa Clara Valley Medical Center, San Jose, California 95128 2699, USA
    Clin Infect Dis 49:919-23. 2009
    ..On the basis of an artificially large exposure to arthroconidia that may occur as a result of a laboratory accident, a conservative approach of close observation and early treatment of exposed staff is discussed...
  5. ncbi request reprint Caspofungin
    Stanley C Deresinski
    Department of Medicine, Santa Clara Valley Medical Center, San Jose, CA, 95128, USA
    Clin Infect Dis 36:1445-57. 2003
    ..Caspofungin is an important addition to the antifungal pharmacopoeia...
  6. doi request reprint Halomonas johnsoniae: review of a medically underappreciated genus of growing human importance
    David A Stevens
    Department of Medicine, Division of Infectious Diseases, Santa Clara Valley Medical Center, San Jose, California 95128 2699, USA
    Am J Med Sci 345:335-8. 2013
    ..A patient developed Halomonas johnsoniae (previously reported only as dialysis unit environmental contaminants) bacteremia. The medical community is alerted to the pathogenic potential of the genus, particularly in a dialysis setting...
  7. doi request reprint Advances in systemic antifungal therapy
    David A Stevens
    Department of Medicine, Division of Infectious Diseases, Santa Clara Valley Medical Center, 751 South Bascom Avenue, San Jose, CA 95128 2699, USA
    Clin Dermatol 30:657-61. 2012
    ..The 3 newest drugs include posaconazole, micafungin, and anidulafungin, whose pharmacology, toxicology, and indications are presented...
  8. pmc Global population structure of Aspergillus terreus inferred by ISSR typing reveals geographical subclustering
    Carolyn O S Neal
    Mycotic Diseases Branch, Center for Disease Control and Prevention, 1600 Clifton Rd NE, Atlanta, GA 30329, USA
    BMC Microbiol 11:203. 2011
    ..We examined a large isolate collection (n = 117) for the presence of cryptic A. terreus species and employed a genome scanning method, Inter-Simple Sequence Repeat (ISSR) PCR to determine A. terreus population structure...
  9. ncbi request reprint Studies of the paradoxical effect of caspofungin at high drug concentrations
    David A Stevens
    Department of Medicine, Santa Clara Valley Medical Center, San Jose, CA 95128 2699, USA
    Diagn Microbiol Infect Dis 51:173-8. 2005
    ..We postulate high drug concentrations derepress or activate an as-yet undefined resistance mechanism(s)...
  10. doi request reprint Developing a vaccine against aspergillosis
    David A Stevens
    Department of Medicine, Division of Infectious Diseases, Santa Clara Valley Medical Center and California Institute for Medical Research, 751 South Bascom Avenue, San Jose, CA 95128 2699, USA
    Med Mycol 49:S170-6. 2011
    ..Our work so far suggests that some proteins may be sufficiently cross-immunogenic, such that combined with the appropriate glycan, it may be possible to develop a pan-fungal vaccine...
  11. doi request reprint Clinical aspergillosis for basic scientists
    David A Stevens
    Department of Medicine, Santa Clara Valley Medical Center, California Institute for Medical Research, San Jose, CA 95128 2699, USA
    Med Mycol 47:S1-4. 2009
    ..These various manifestations of the diseases, diagnosis and treatment are organized for basic scientists, so that they may better understand the dimensions and nature of the clinical challenges...
  12. doi request reprint Halomonas, a newly recognized human pathogen causing infections and contamination in a dialysis center: three new species
    David A Stevens
    Division of Infectious Diseases, Department of Medicine, Santa Clara Valley Medical Center, San Jose, California 95128Y2699, USA
    Medicine (Baltimore) 88:244-9. 2009
    ..Our experience, together with the review of the literature presented here, indicates the genus Halomonas has pathogenic potential...
  13. ncbi request reprint Vaccinate against aspergillosis! A call to arms of the immune system
    David A Stevens
    Division of Infectious Diseases, Department of Medicine, Santa Clara Valley Medical Center, San Jose, California 95128 2699, USA
    Clin Infect Dis 38:1131-6. 2004
    ..Successful immunizations have been demonstrated in turkeys and mice...
  14. ncbi request reprint Allergic bronchopulmonary aspergillosis in cystic fibrosis--state of the art: Cystic Fibrosis Foundation Consensus Conference
    David A Stevens
    Department of Medicine, Santa Clara Valley Medical Center, Stanford University Medical School, San Jose, California 95128 2699, USA
    Clin Infect Dis 37:S225-64. 2003
    ..Diagnostic criteria that could provide a framework for monitoring were adopted, and helpful imaging features were identified. New possibilities in therapy produced plans for managing diverse clinical presentations...
  15. doi request reprint Third Advances Against Aspergillosis Meeting 2008
    David A Stevens
    Division of Infectious Disease, Department of Medicine, Santa Clara Valley Medical Center, 751 South Bascom Avenue, San Jose, CA 95128 2699, USA
    Expert Rev Anti Infect Ther 6:851-3. 2008
    ....
  16. ncbi request reprint Posaconazole therapy for chronic refractory coccidioidomycosis
    David A Stevens
    Division of Infectious Diseases, Department of Medicine, Santa Clara Valley Medical Center, 751 South Bascom Ave, San Jose, CA 95128 2699, USA
    Chest 132:952-8. 2007
    ..Posaconazole, an oral extended-spectrum triazole agent, has been shown in vitro and in vivo to have potent activity against this fungus...
  17. ncbi request reprint Regulation by granulocyte-macrophage colony-stimulating factor and/or steroids given in vivo of proinflammatory cytokine and chemokine production by bronchoalveolar macrophages in response to Aspergillus conidia
    Elmer Brummer
    Department of Medicine, Division of Infectious Diseases, Santa Clara Valley Medical Center, and California Institute for Medical Research, San Jose, California 95128 2669, USA
    J Infect Dis 187:705-9. 2003
    ..The effect of GM-CSF on cortisone acetate suppression lasted at least 7 days. GM-CSF could promote resistance to conidia by maintaining proinflammatory responses...
  18. pmc Paradoxical effect of caspofungin: reduced activity against Candida albicans at high drug concentrations
    David A Stevens
    Department of Medicine, Santa Clara Valley Medical Center, 751 S Bascom Ave, San Jose, CA 95128 2699, USA
    Antimicrob Agents Chemother 48:3407-11. 2004
    ..We postulate that high drug concentrations derepress or activate resistance mechanisms. The abilities of subpopulations to survive at high drug concentrations could have in vivo consequences...
  19. ncbi request reprint Azole therapy of clinical and experimental coccidioidomycosis
    David A Stevens
    Department of Medicine, Santa Clara Valley Medical Center, 751 So Bascom Avenue, San Jose, CA 95128 2699, USA
    Ann N Y Acad Sci 1111:442-54. 2007
    ..More potent agents are still required, so that complete biological cure can be attained in meningeal and nonmeningeal coccidioidomycosis...
  20. doi request reprint Aspergillosis in the 'nonimmunocompromised' host
    David A Stevens
    Department of Medicine, Santa Clara Valley Medical Center, 751 So Bascom Ave, San Jose, CA 95128 2699, USA
    Immunol Invest 40:751-66. 2011
    ....
  21. pmc Evasion of innate immune responses: evidence for mannose binding lectin inhibition of tumor necrosis factor alpha production by macrophages in response to Blastomyces dermatitidis
    Adi Koneti
    California Institute for Medical Research and Division of Infectious Diseases, Department of Medicine, Santa Clara Valley Medical Center, San Jose, California 95128 2699, USA
    Infect Immun 76:994-1002. 2008
    ..dermatitidis is mediated by serum MBL binding to B. dermatitidis at 1,3-beta-glucan sites or sterically masking 1,3-beta-glucan sites, thus preventing 1,3-beta-glucan stimulation of PM for TNF-alpha production...
  22. ncbi request reprint Zeamatin, clotrimazole and nikkomycin Z in therapy of a Candida vaginitis model
    David A Stevens
    Department of Medicine, Santa Clara Valley Medical Center, San Jose 95128 2699, CA, USA
    J Antimicrob Chemother 50:361-4. 2002
    ..To study the interaction of antifungal drugs in topical therapy...
  23. ncbi request reprint Interferon- gamma as an antifungal
    David A Stevens
    Department of Medicine, Santa Clara Valley Medical Center and California Institute for Medical Research, San Jose, CA, 95128, USA
    J Infect Dis 194:S33-7. 2006
  24. ncbi request reprint Efficacy of Abelcet alone, or in combination therapy, against experimental central nervous system aspergillosis
    Karl V Clemons
    California Institute for Medical Research, San Jose, CA 95128, USA
    J Antimicrob Chemother 58:466-9. 2006
    ..CNS aspergillosis is the most frequent and devastating manifestation of dissemination and mortality is high...
  25. ncbi request reprint Efficacy of amphotericin B lipid complex in a rabbit model of coccidioidal meningitis
    Javier Capilla
    California Institute for Medical Research, San Jose, CA, USA
    J Antimicrob Chemother 60:673-6. 2007
    ..We compared the efficacy of treatments in a rabbit model of coccidioidal meningitis (CM)...
  26. pmc Comparative efficacies of conventional amphotericin b, liposomal amphotericin B (AmBisome), caspofungin, micafungin, and voriconazole alone and in combination against experimental murine central nervous system aspergillosis
    Karl V Clemons
    California Institute for Medical Research, Division of Infectious Diseases, Santa Clara Valley Medical Center, 751 South Bascom Ave, San Jose, California 95128 2699, USA
    Antimicrob Agents Chemother 49:4867-75. 2005
    ..These results indicate that AmBi in combination with VCZ may be superior for treatment of CNS aspergillosis; combinations of AmBi and MICA or CAS were not antagonistic and may have a slight benefit...
  27. pmc Comparative efficacies of lipid-complexed amphotericin B and liposomal amphotericin B against coccidioidal meningitis in rabbits
    Karl V Clemons
    California Institute for Medical Research, San Jose, California, USA
    Antimicrob Agents Chemother 53:1858-62. 2009
    ..There was no significant advantage of one drug over the other for this indication. Further studies are required to determine the lowest effective doses of these formulations...
  28. ncbi request reprint Efficacy of micafungin alone or in combination against experimental pulmonary aspergillosis
    Karl V Clemons
    California Institute for Medical Research, San Jose, CA 95128, USA
    Med Mycol 44:69-73. 2006
    ..Overall, these results indicate that MICA has moderate activity against pulmonary aspergillosis and might be useful in combination with conventional AMB...
  29. pmc Experimental central nervous system aspergillosis therapy: efficacy, drug levels and localization, immunohistopathology, and toxicity
    Karl V Clemons
    California Institute for Medical Research, San Jose, California, USA
    Antimicrob Agents Chemother 56:4439-49. 2012
    ..Hepatotoxicity may contribute to high-dose Abelcet and AmBisome failures. Our novel observation of endothelial amphotericin localization during infection may contribute to amphotericin mechanism of efficacy...
  30. pmc Development of an orogastrointestinal mucosal model of candidiasis with dissemination to visceral organs
    Karl V Clemons
    California Institute for Medical Research, San Jose, CA 95128, USA
    Antimicrob Agents Chemother 50:2650-7. 2006
    ..Drug efficacy in treating localized infection and in preventing or treating disseminated infection can be studied...
  31. ncbi request reprint Susceptibility to pulmonary blastomycosis in young compared to adult mice: immune deficiencies in young mice
    Neelima Kethineni
    Division of Infectious Diseases, Department of Medicine, Santa Clara Valley Medical Center, San Jose, CA 95128 2699, USA
    Med Mycol 44:51-60. 2006
    ..In a pilot reconstitution experiment in pulmonary blastomycosis, treatment of infected young mice with IFN-gamma (18.5 x 10(3) U, s.c.) on days 0, 1, and 2 significantly increased survival...
  32. ncbi request reprint IL-12 induction of resistance to pulmonary blastomycosis
    Elmer Brummer
    Department of Medicine, Santa Clara Valley Medical Center, San Jose, CA 95128 2699, USA
    Cytokine 35:221-8. 2006
    ....
  33. doi request reprint Correlation of restriction fragment length polymorphism genotyping with internal transcribed spacer sequence, randomly amplified polymorphic DNA and multilocus sequence groupings for Candida parapsilosis
    Eveline C van Asbeck
    Division of Infectious Diseases, Santa Clara Valley Medical Center, San Jose, CA 95128 2699, USA
    Mycoses 52:493-8. 2009
    ..RFLP subtype VII-1 and C. parapsilosis sensu stricto appear to be nearly identical; C. orthopsilosis, which can be subtyped by MLST, can also be subtyped by RFLP. C. metapsilosis appears rarely...
  34. doi request reprint Vaccination with mannan protects mice against systemic aspergillosis
    Min Liu
    California Institute for Medical Research, San Jose, California, USA
    Med Mycol 50:818-28. 2012
    ..05). Mannan-induced protection was improved about 40-fold by conjugation of BSA to mannan. Mannan-BSA (500 kDa) was more protective than 40 kDa mannan-BSA. Mannan is a candidate for a cross-protective conjugate fungal vaccine...
  35. doi request reprint Saccharomyces as a vaccine against systemic candidiasis
    Min Liu
    California Institute for Medical Research, San Jose, CA 95128, USA
    Immunol Invest 41:847-55. 2012
    ..To understand the protection induced by HKY against different fungal species, additional studies of epitope mapping are warranted...
  36. doi request reprint Saccharomyces as a vaccine against systemic aspergillosis: 'the friend of man' a friend again?
    Min Liu
    California Institute for Medical Research, San Jose, CA, USA
    J Med Microbiol 60:1423-32. 2011
    ....
  37. ncbi request reprint A murine model of coccidioidal meningitis
    Perparim Kamberi
    California Institute for Medical Research and Department of Medicine, Division of Infectious Diseases, Santa Clara Valley Medical Center, San Jose, California 95128, USA
    J Infect Dis 187:453-60. 2003
    ..With the development of these models, studies of pathogenesis, host response, and therapy are possible...
  38. pmc Comparison of itraconazole and fluconazole treatments in a murine model of coccidioidal meningitis
    Perparim Kamberi
    Division of Infectious Diseases, Department of Medicine, Santa Clara Valley Medical Center, 751 S Bascom Ave, San Jose, CA 95128 2699, USA
    Antimicrob Agents Chemother 51:998-1003. 2007
    ..05). Thus, both itraconazole and fluconazole were effective at controlling CM, but neither eliminated Coccidioides from tissues. Overall, itraconazole was more efficacious on an mg/kg basis; at high doses they were similarly effective...
  39. doi request reprint Effect of 3M-003, an imidazoquinoline, on phagocyte candidacidal activity directly and via induction of peripheral blood mononuclear cell cytokines
    Elmer Brummer
    Department of Medicine, Santa Clara Valley Medical Center and California Institute for Medical Research, San Jose, CA, USA
    FEMS Immunol Med Microbiol 59:81-9. 2010
    ..3M-003 could be a candidate for antifungal immunotherapy...
  40. doi request reprint Resistance of MBL gene-knockout mice to experimental systemic aspergillosis
    Karl V Clemons
    California Institute for Medical Research, 2260 Clove Dr, San Jose, CA 95128, United States
    Immunol Lett 128:105-7. 2010
    ..015). At the lowest inoculum used, deaths of KO mice were delayed, but survival was not significantly different than WT (P>0.05). These results suggest MBL may play a deleterious role in systemic aspergillosis...
  41. ncbi request reprint Efficacy of Abelcet and caspofungin, alone or in combination, against CNS aspergillosis in a murine model
    Jackie Imai
    California Institute for Medical Research, San Jose, 95128, USA
    J Antimicrob Chemother 56:166-71. 2005
    ..Currently, few options exist to treat central nervous system (CNS) aspergillosis, which is usually fatal. We tested the efficacy of Abelcet and caspofungin, alone and in combination for treatment of this disease...
  42. pmc Effect of lung surfactant collectins on bronchoalveolar macrophage interaction with Blastomyces dermatitidis: inhibition of tumor necrosis factor alpha production by surfactant protein D
    Madhavi Lekkala
    Division of Infectious Diseases, Department of Medicine, Santa Clara Valley Medical Center, 751 South Bascom Ave, San Jose, California 95128 2699, USA
    Infect Immun 74:4549-56. 2006
    ..dermatitidis may utilize BALF constituents, such as SP-D, to blunt the host defensive reaction; this effect could reduce inflammation and tissue destruction but could also promote disease...
  43. ncbi request reprint Combined action of micafungin, a new echinocandin, and human phagocytes for antifungal activity against Aspergillus fumigatus
    Jung Hyun Choi
    Department of Medicine, Division of Infectious Diseases, Santa Clara Valley Medical Center, San Jose, CA 95128 2699, USA
    Microbes Infect 6:383-9. 2004
    ..These findings support the thesis that the greater efficacy of micafungin in vivo compared with in vitro could be due to combined effect of phagocytic cells and micafungin...
  44. pmc Experimental evidence that granulocyte transfusions are efficacious in treatment of neutropenic hosts with pulmonary aspergillosis
    Marife Martinez
    California Institute for Medical Research, San Jose, California, USA
    Antimicrob Agents Chemother 57:1882-7. 2013
    ..Transfusions given every other day did not improve protection. Our present results provide an experimental basis for enthusiasm for PMN transfusions in the therapy of aspergillosis in humans...
  45. ncbi request reprint Experimental animal models of coccidioidomycosis
    Karl V Clemons
    Division of Infectious Diseases, Santa Clara Valley Medical Center, 751 South Bascom Ave, San Jose, CA 95128 2699, USA
    Ann N Y Acad Sci 1111:208-24. 2007
    ..However, cost and increased needs of animal care and husbandry are limitations that influence the use of the larger animal species...
  46. pmc Efficacy of posaconazole in a murine model of central nervous system aspergillosis
    Jackie K Imai
    Division of Infectious Diseases, Santa Clara Valley Medical Center, 751 South Bascom Ave, San Jose, CA 95128 2699, USA
    Antimicrob Agents Chemother 48:4063-6. 2004
    ..No antifungal regimen effected cure. No toxicity was noted. Overall, posaconazole shows potential for treating CNS aspergillosis...
  47. pmc Efficacy of caspofungin against central nervous system Aspergillus fumigatus infection in mice determined by TaqMan PCR and CFU methods
    Gaurav Singh
    California Institute for Medical Research, California, USA
    Antimicrob Agents Chemother 49:1369-76. 2005
    ..These results also suggest that, when there is drug efficacy in a therapeutic study, either method appears to be useful for determining Aspergillus fumigatus burdens...
  48. pmc Comparison of lipid amphotericin B preparations in treating murine zygomycosis
    Ashraf S Ibrahim
    Division of Infectious Diseases, Los Angeles Biomedical Research Institute at Harbor University of California Los Angeles Medical Center, Torrance, CA 90502, USA
    Antimicrob Agents Chemother 52:1573-6. 2008
    ..ABLC was as effective as LAmB in neutropenic but not DKA mice. Low-dose ABLC was less effective than LAmB at reducing brain fungal burdens in both models...
  49. doi request reprint Significant differences in drug susceptibility among species in the Candida parapsilosis group
    Eveline van Asbeck
    Division of Infectious Diseases, Department of Medicine, Santa Clara Valley Medical Center, San Jose, CA 95128, USA
    Diagn Microbiol Infect Dis 62:106-9. 2008
    ..metapsilosis was least susceptible to fluconazole. C. parapsilosis sensu stricto more frequently displayed (37%) paradoxical growth in CAS (P < or = 0.02). These species susceptibility differences could affect therapeutic choices...
  50. doi request reprint Molecular epidemiology of the global and temporal diversity of Candida parapsilosis
    Eveline C van Asbeck
    Division of Infectious Diseases, Santa Clara Valley Medical Center, and California Institute for Medical Research, San Jose, California 95128, USA
    Scand J Infect Dis 40:827-34. 2008
    ..There were no differences in distribution of types comparing babies versus adults, or bloodstream isolates versus colonizing or environmental isolates. RAPD typing showed 3 major profiles, but was less discriminatory...
  51. ncbi request reprint Inhibitor kappaB and nuclear factor kappaB in granulocyte-macrophage colony-stimulating factor antagonism of dexamethasone suppression of the macrophage response to Aspergillus fumigatus conidia
    Jung Hyun Choi
    California Institute for Medical Research, San Jose, USA
    J Infect Dis 193:1023-8. 2006
    ....
  52. ncbi request reprint Immunological basis for susceptibility and resistance to pulmonary blastomycosis in mouse strains
    Elmer Brummer
    Division of Infectious Diseases, Department of Medicine, Santa Clara Valley Medical Center, San Jose, CA 95128 2699, USA
    Cytokine 32:12-9. 2005
    ..Consistent with the in vitro enhancement of effector cell function by IFN-gamma, in vivo therapy with IFN-gamma significantly (P<0.0001) improved survival of BALB/c mice with pulmonary blastomycosis...
  53. doi request reprint Molecular epidemiology of Saccharomyces cerevisiae in an immunocompromised host unit
    Karl V Clemons
    California Institute for Medical Research, San Jose, CA 95128, USA
    Diagn Microbiol Infect Dis 68:220-7. 2010
    ..In almost all patients, S. cerevisiae was first recovered after admission. These data suggest an endemic source of colonizing organisms, possibly from the hospital food preparation area...
  54. doi request reprint Saccharomyces cerevisiae as a vaccine against coccidioidomycosis
    Javier Capilla
    California Inst for Med Res, San Jose, CA, United States
    Vaccine 27:3662-8. 2009
    ..HKY was superior to a successful recombinant vaccine, PRA plus adjuvant. This novel heterologous protection afforded by HKY vaccination offers a new approach to a vaccine against coccidioidomycosis...
  55. ncbi request reprint Production of IL-6, in contrast to other cytokines and chemokines, in macrophage innate immune responses: effect of serum and fungal (Blastomyces) challenge
    Elmer Brummer
    California Institute for Medical Research, Department of Medicine, Division of Infectious Diseases, Santa Clara Valley Medical Center, 751 San Jose, CA 95128 2699, USA
    Cytokine 39:163-70. 2007
    ..IL-6 production in vivo in response to fungal-serum complexes could affect pathogenesis by opposing the host defense modulation by proinflammatory cytokines or by modulating the destructive effects of inflammation on host tissues...
  56. pmc Assessment of the paradoxical effect of caspofungin in therapy of candidiasis
    Karl V Clemons
    California Institute for Medical Research, San Jose, CA 95128, USA
    Antimicrob Agents Chemother 50:1293-7. 2006
    ..Overall, these data indicate that CAS is highly efficacious against systemic murine candidiasis and a paradoxical effect was not reproducibly demonstrated in vivo...
  57. ncbi request reprint Regulation of bronchoalveolar macrophage proinflammatory cytokine production by dexamethasone and granulocyte-macrophage colony-stimulating factor after stimulation by Aspergillus conidia or lipopolysaccharide
    Marika Kamberi
    Division of Infectious Diseases, Department of Medicine, Santa Clara Valley Medical Center, San Jose, CA 95128 2699, USA
    Cytokine 19:14-20. 2002
    ..In summary, these data indicate that the risk factor for aspergillosis associated with DEX could be lessened in the pulmonary compartment with GM-CSF. On the other hand, desired effects of DEX could be maintained in other compartments...
  58. pmc Efficacy of amphotericin B or itraconazole in a murine model of central nervous system Aspergillus infection
    Tom M Chiller
    Division of Infectious Diseases, Department of Medicine, Santa Clara Valley Medical Center, San Jose, California 95128 2699, USA
    Antimicrob Agents Chemother 47:813-5. 2003
    ..05) compared with controls. Brains from surviving mice had CFU of Aspergillus fumigatus. This model can be used to compare newer antifungals and to study combination therapy or immunotherapy to find better therapeutic alternatives...
  59. pmc Genetic susceptibility of mice to Candida albicans vaginitis correlates with host estrogen sensitivity
    Karl V Clemons
    California Institute for Medical Research, and Department of Medicine, Division of Infectious Diseases, Santa Clara Valley Medical Center, San Jose, 95128, USA
    Infect Immun 72:4878-80. 2004
    ..Resistance to Candida vaginitis appears additive in CD10 x B6F1 animals and dominant in CD10 x CD3F1 animals...
  60. pmc Comparative efficacies of four amphotericin B formulations--Fungizone, amphotec (Amphocil), AmBisome, and Abelcet--against systemic murine aspergillosis
    Karl V Clemons
    California Institute for Medical Research and Department of Medicine, Santa Clara Valley Medical Center, San Jose, California 95128, USA
    Antimicrob Agents Chemother 48:1047-50. 2004
    ..Although higher doses could be given, no lipid-based formulation showed consistent superiority over Fungizone or over each other...
  61. pmc Influence of 17β-estradiol on gene expression of Paracoccidioides during mycelia-to-yeast transition
    Jata Shankar
    California Institute for Medical Research, Santa Clara Valley Medical Center, San Jose, California, United States of America
    PLoS ONE 6:e28402. 2011
    ..In this study we have profiled transcript expression to understand the molecular mechanism of how E(2) inhibits M-to-Y transition...
  62. pmc Efficacy of intravenous liposomal amphotericin B (AmBisome) against coccidioidal meningitis in rabbits
    Karl V Clemons
    Department of Medicine, Division of Infectious Diseases, Santa Clara Valley Medical Center, California Institute for Medical Research, 751 South Bascom Avenue, San Jose, CA 95128, USA
    Antimicrob Agents Chemother 46:2420-6. 2002
    ..These data indicate that AmBi may offer an improvement in the treatment of coccidioidal meningitis. Additional studies are warranted...
  63. doi request reprint Candida parapsilosis: a review of its epidemiology, pathogenesis, clinical aspects, typing and antimicrobial susceptibility
    Eveline C van Asbeck
    Division of Infectious Diseases, Santa Clara Valley Medical Center, and California Institute for Medical Research, San Jose, CA 95128, USA
    Crit Rev Microbiol 35:283-309. 2009
    ..Further investigations of the host-pathogen interactions are needed. This review summarizes basic science, clinical and experimental information about C. parapsilosis...
  64. doi request reprint A new method for the treatment of chronic fungal meningitis: continuous infusion into the cerebrospinal fluid for coccidioidal meningitis
    Carol D Berry
    Department of Medicine, Kaiser Permanente South Sacramento Medical Center, Sacramento, California, USA
    Am J Med Sci 338:79-82. 2009
    ..Drug delivery issues were addressed during this course that could guide future use of this modality, which is a promising novel avenue of therapy for chronic meningitis...
  65. ncbi request reprint Advances against aspergillosis (September 9-11, 2004, San Francisco, California)
    Karl V Clemons
    Department of Medicine, Santa Clara Valley Medical Center, 751 So Bascom Av, San Jose, California 95128 2699, USA
    Mycopathologia 159:315-7. 2005
  66. ncbi request reprint Coccidioidomycosis
    Tom M Chiller
    Division of Infectious Diseases, Department of Medicine, Santa Clara Valley Medical Center, 751 South Bascom Avenue, San Jose, CA 95128 2699, USA
    Infect Dis Clin North Am 17:41-57, viii. 2003
    ..Coccidioides, a fungus, is endemic to specific parts of the Western Hemisphere. This article examines the prevalence, pathogenesis and host defense, clinical manifestations, diagnosis, and treatment of coccidioidomycosis...
  67. pmc Defining responses to therapy and study outcomes in clinical trials of invasive fungal diseases: Mycoses Study Group and European Organization for Research and Treatment of Cancer consensus criteria
    Brahm H Segal
    Department of Medicine, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Clin Infect Dis 47:674-83. 2008
    ..We also discuss potential pitfalls in assessing outcome, such as conflicting clinical, radiological, and/or mycological data and gaps in knowledge...
  68. ncbi request reprint Animal models testing monotherapy versus combination antifungal therapy: lessons learned and future directions
    Karl V Clemons
    Department of Medicine, Division of Infectious Diseases, Santa Clara Valley Medical Center, San Jose, California 95128, USA
    Curr Opin Infect Dis 19:360-4. 2006
    ..Combination therapy using available drugs is an attractive choice, yet primarily only anecdotal clinical data are available. We review here data from animal models as an indicator of future potential...
  69. pmc Hormones and the resistance of women to paracoccidioidomycosis
    Jata Shankar
    California Institute for Medical Research, San Jose, California
    Clin Microbiol Rev 24:296-313. 2011
    ..These unique observations are consistent with an estrogen-fungus receptor-mediated effect on pathogenesis. The fungal genes responsive to estrogen action are under study...
  70. doi request reprint Efficacy of recombinant human mannose binding lectin alone and in combination with itraconazole against murine Candida albicans vaginitis
    Karl V Clemons
    California Institute for Medical Research, San Jose, California, USA
    Immunol Invest 40:553-68. 2011
    ..Overall, these data indicate that rhMBL may have utility in the treatment of candidal vaginitis when used as an adjunctive therapy...
  71. ncbi request reprint Development of a murine model of cerebral aspergillosis
    Tom M Chiller
    Division of Infectious Diseases and Geographic Medicine, Department of Medicine, Stanford University School of Medicine, California, USA
    J Infect Dis 186:574-7. 2002
    ..The model we established provides an opportunity to study immune responses to and therapeutic options for CNS disease in an immunologically defined, genetically manipulable, and inexpensive species...
  72. ncbi request reprint Protection of peritoneal macrophages by granulocyte/macrophage colony-stimulating factor (GM-CSF) against dexamethasone suppression of killing of Aspergillus, and the effect of human GM-CSF
    Elmer Brummer
    Department of Medicine, Division of Infectious Diseases, Santa Clara Valley Medical Center and California Institute for Medical Research, San Jose 95128 2699, USA
    Microbes Infect 4:133-8. 2002
    ..These studies suggest GM-CSF treatment prior to and concurrent with steroid immunosuppression may ameliorate the steroid effect on tissue macrophage antifungal activity, but does not affect steroid suppression of T-cell immunity...
  73. doi request reprint Collectins and fungal pathogens: roles of surfactant proteins and mannose binding lectin in host resistance
    Elmer Brummer
    Division of Infectious Diseases, Department of Medicine, Santa Clara Valley Medical Center and California Institute for Medical Research, San Jose, and Stanford University, Stanford, California 95128 2699, USA
    Med Mycol 48:16-28. 2010
    ..Increased understanding of these relationships in future will help understand fungal pathogenesis and host defenses against mycoses...
  74. ncbi request reprint Animal models: an important tool in mycology
    Javier Capilla
    California Institute for Medical Research, San Jose, USA
    Med Mycol 45:657-84. 2007
    ....
  75. ncbi request reprint Diagnosis of fungal infections: current status
    David A Stevens
    Division of Infectious Diseases, Department of Medicine, Santa Clara Valley Medical Center, Stanford University Medical School, San Jose, CA 95128 2699, USA
    J Antimicrob Chemother 49:11-9. 2002
    ..Gene probes have accelerated diagnosis by culture. In histoplasmosis, the antigenuria test's high sensitivity and specificity has dispelled the chronic confusion in interpreting antibody test results...
  76. ncbi request reprint Management of varicella-vaccinated patients and employees exposed to varicella in the healthcare setting
    Donna J Haiduven
    Infection Control Departmesnt, Santa Clara Valley Medical Center, San Jose, California 95128 2699, USA
    Infect Control Hosp Epidemiol 24:538-43. 2003
  77. ncbi request reprint Candida parapsilosis fungemia in neonates: genotyping results suggest healthcare workers hands as source, and review of published studies
    Eveline C van Asbeck
    Division of Infectious Diseases, Santa Clara Valley Medical Center, California Institute for Medical Research, 751 South Bascom Avenue, San Jose, CA 95128, USA
    Mycopathologia 164:287-93. 2007
    ..These findings reinforce prior studies that have implicated HCW hands as the source of nosocomial, including neonatal, fungemia...
  78. doi request reprint Treatment of aspergillosis: clinical practice guidelines of the Infectious Diseases Society of America
    Thomas J Walsh
    Pediatric Oncology Branch, National Cancer Institute, Bethesda, Maryland, USA
    Clin Infect Dis 46:327-60. 2008
  79. pmc Resistance mechanisms in clinical isolates of Candida albicans
    Theodore C White
    Department of Pathobiology, School of Public Health and Community Medicine, University of Washington, Seattle, Washington 98109 1651, USA
    Antimicrob Agents Chemother 46:1704-13. 2002
    ....
  80. ncbi request reprint Combination and sequential antifungal therapy for invasive aspergillosis: review of published in vitro and in vivo interactions and 6281 clinical cases from 1966 to 2001
    William J Steinbach
    Division of Pediatric Infectious Diseases, Department of Pediatrics, Duke University, Durham, North Carolina, USA
    Clin Infect Dis 37:S188-224. 2003
    ..Improvement was noted with amphotericin B or itraconazole followed by voriconazole but not with itraconazole followed by amphotericin B...
  81. ncbi request reprint Homozygosity at the Candida albicans MTL locus associated with azole resistance
    Tige R Rustad
    Department of Pathobiology, School of Public Health and Community Medicine, University of Washington, Seattle, WA 98195, USA
    Microbiology 148:1061-72. 2002
    ..Gene disruptions of the MTL loci were found to have no effect on azole susceptibility...
  82. ncbi request reprint Safety, tolerance, and efficacy of posaconazole therapy in patients with nonmeningeal disseminated or chronic pulmonary coccidioidomycosis
    Antonino Catanzaro
    University of California San Diego, San Diego, CA 92103, USA
    Clin Infect Dis 45:562-8. 2007
    ..Posaconazole is a new azole antifungal with potent activity against Coccidioides species, the causative agent of coccidioidomycosis...
  83. ncbi request reprint Coccidioidal meningitis
    David A Stevens
    Clin Infect Dis 43:385; author reply 385-6. 2006
  84. ncbi request reprint Treatment of invasive aspergillosis with posaconazole in patients who are refractory to or intolerant of conventional therapy: an externally controlled trial
    Thomas J Walsh
    Immunocompromised Host Section, National Cancer Institute, Bethesda, MD 20892, USA
    Clin Infect Dis 44:2-12. 2007
    ..Current treatments provide limited benefit. Posaconazole is an extended-spectrum triazole with in vitro and in vivo activity against Aspergillus species...
  85. ncbi request reprint Review of newer antifungal and immunomodulatory strategies for invasive aspergillosis
    William J Steinbach
    Division of Pediatric Infectious Diseases, Department of Pediatrics, Duke University, Durham, North Carolina, USA
    Clin Infect Dis 37:S157-87. 2003
    ..This review will detail the available in vitro, in vivo, and clinical experience with the newer antifungal and immunomodulatory therapies in development for treatment of invasive aspergillosis...
  86. ncbi request reprint Antifungal drug resistance
    Juergen Loeffler
    Eberhard Karls Universitat, Medizinische Klinik, Tuebingen, Germany
    Clin Infect Dis 36:S31-41. 2003
    ..The frequency, interpretation, and, in particular, mechanism of resistance to current classes of antifungal agents, particularly the azoles (where resistance has climbed most prominently) are discussed in this review...
  87. pmc Efficacy of micafungin alone or in combination against systemic murine aspergillosis
    Javier Capilla Luque
    University of Rovira i Virgili, Reus, Spain
    Antimicrob Agents Chemother 47:1452-5. 2003
    ..Although no survivors were free of infection, no antagonism was seen. Nikkomycin Z with FK showed significantly greater potency (P < 0.01) than either alone...
  88. ncbi request reprint Genotypic differences of Candida albicans and C. dubliniensis isolates related to ethnic/racial differences within the same geographic area
    Michael J McCullough
    Eastman Dental Institute, University College London, UK
    Mycopathologia 158:39-41. 2004
    ..002) from global populations. Therefore, C. albicans and C. dubliniensis genotype distribution differences in Israel are related to changes in all ethnic groups...
  89. ncbi request reprint Advances against aspergillosis
    William J Steinbach
    Division of Pediatric Infectious Diseases, Department of Pediatrics, Duke University, Durham, North Carolina, USA
    Clin Infect Dis 37:S155-6. 2003
  90. ncbi request reprint Coccidioidomycosis
    John N Galgiani
    Valley Fever Center for Excellence, Tucson, AZ 85723, USA
    Clin Infect Dis 41:1217-23. 2005
  91. pmc Molecular epidemiology of Candida
    David A Stevens
    J Clin Microbiol 40:2710. 2002
  92. ncbi request reprint DNA binding compounds targeting fungal pathogens: an emerging concept in the discovery of novel antifungal agents
    Lillian Lou
    Genelabs Technologies Inc, Redwood City, CA 94063, USA
    Curr Opin Investig Drugs 3:1437-45. 2002
    ..Selected compounds are fungicidal towards a variety of pathogenic yeasts and molds, and a selected lead compound is efficacious in a mouse model of systemic candidosis...
  93. doi request reprint A possible mechanism for synergy between antifungal therapy and immune defenses
    David A Stevens
    J Infect Dis 198:159-62. 2008