Daniel Spielman

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. pmc In vivo measurement of ethanol metabolism in the rat liver using magnetic resonance spectroscopy of hyperpolarized [1-13C]pyruvate
    Daniel M Spielman
    Stanford University Department of Radiology, Lucas Center for Medical Imaging, Stanford, CA 94305, USA
    Magn Reson Med 62:307-13. 2009
  2. pmc Neurometabolite effects of response to quetiapine and placebo in adolescents with bipolar depression
    Kiki Chang
    Pediatric Bipolar Disorders Program, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California 94305 5540, USA
    J Child Adolesc Psychopharmacol 22:261-8. 2012
  3. pmc Quantification of in vivo metabolic kinetics of hyperpolarized pyruvate in rat kidneys using dynamic 13C MRSI
    Tao Xu
    Department of Electrical Engineering, Stanford University, Stanford, CA, USA
    NMR Biomed 24:997-1005. 2011
  4. pmc Neurochemical deficits in the cerebellar vermis in child offspring of parents with bipolar disorder
    Manpreet K Singh
    Pediatric Bipolar Disorders Research Program, Division of Child and Adolescent Psychiatry, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 401 Quarry Road, Stanford, CA 94305, USA
    Bipolar Disord 13:189-97. 2011
  5. pmc In vivo measurement of aldehyde dehydrogenase-2 activity in rat liver ethanol model using dynamic MRSI of hyperpolarized [1-(13) C]pyruvate
    Sonal Josan
    SRI International, Neuroscience Program, Menlo Park, CA, USA
    NMR Biomed 26:607-12. 2013
  6. pmc In vivo investigation of cardiac metabolism in the rat using MRS of hyperpolarized [1-13C] and [2-13C]pyruvate
    Sonal Josan
    SRI International, Neuroscience Program, Menlo Park, CA, USA Stanford University, Department of Radiology, Lucas MRI Center, Stanford, CA, USA
    NMR Biomed 26:1680-7. 2013
  7. ncbi request reprint N-acetylaspartate levels in bipolar offspring with and at high-risk for bipolar disorder
    Kim A Gallelli
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA
    Bipolar Disord 7:589-97. 2005
  8. pmc Designing adiabatic radio frequency pulses using the Shinnar-Le Roux algorithm
    Priti Balchandani
    Department of Radiology, Stanford University, Stanford, California, USA
    Magn Reson Med 64:843-51. 2010
  9. pmc Interleaved narrow-band PRESS sequence with adiabatic spatial-spectral refocusing pulses for 1H MRSI at 7T
    Priti Balchandani
    Department of Electrical Engineering, Stanford University, Stanford, CA 94305, USA
    Magn Reson Med 59:973-9. 2008
  10. pmc Slice-selective tunable-flip adiabatic low peak-power excitation pulse
    Priti Balchandani
    Department of Electrical Engineering, Stanford University, 1201 Welch Road, Stanford, CA 94305, USA
    Magn Reson Med 59:1072-8. 2008

Research Grants

  1. Metabolic Imaging of the Cardioprotective Effects of Alcohol and ALDH2 Activators
    Daniel M Spielman; Fiscal Year: 2010
  2. 1H MRSI of the Human Brain at 7T
    Daniel M Spielman; Fiscal Year: 2010
  3. 1H MRSI of the Human Brain at 7T
    Daniel Spielman; Fiscal Year: 2009
  4. MAGNETIC RESONANCE SPECTROSCOPIC NEOPLASM IMAGING
    Daniel Spielman; Fiscal Year: 2003
  5. MR SPECTROSCOPIC IMAGING IN ALZHEIMER'S DISEASE
    Daniel Spielman; Fiscal Year: 2003

Collaborators

Detail Information

Publications46

  1. pmc In vivo measurement of ethanol metabolism in the rat liver using magnetic resonance spectroscopy of hyperpolarized [1-13C]pyruvate
    Daniel M Spielman
    Stanford University Department of Radiology, Lucas Center for Medical Imaging, Stanford, CA 94305, USA
    Magn Reson Med 62:307-13. 2009
    ....
  2. pmc Neurometabolite effects of response to quetiapine and placebo in adolescents with bipolar depression
    Kiki Chang
    Pediatric Bipolar Disorders Program, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California 94305 5540, USA
    J Child Adolesc Psychopharmacol 22:261-8. 2012
    ..We examined the effects of quetiapine (QUET), an atypical antipsychotic, on these neurochemicals, and potential predictors of response to QUET in adolescents with bipolar depression...
  3. pmc Quantification of in vivo metabolic kinetics of hyperpolarized pyruvate in rat kidneys using dynamic 13C MRSI
    Tao Xu
    Department of Electrical Engineering, Stanford University, Stanford, CA, USA
    NMR Biomed 24:997-1005. 2011
    ....
  4. pmc Neurochemical deficits in the cerebellar vermis in child offspring of parents with bipolar disorder
    Manpreet K Singh
    Pediatric Bipolar Disorders Research Program, Division of Child and Adolescent Psychiatry, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 401 Quarry Road, Stanford, CA 94305, USA
    Bipolar Disord 13:189-97. 2011
    ....
  5. pmc In vivo measurement of aldehyde dehydrogenase-2 activity in rat liver ethanol model using dynamic MRSI of hyperpolarized [1-(13) C]pyruvate
    Sonal Josan
    SRI International, Neuroscience Program, Menlo Park, CA, USA
    NMR Biomed 26:607-12. 2013
    ..Results from a rat liver ethanol model (n = 9) show that changes in (13) C-lactate labeling following the bolus injection of hyperpolarized pyruvate are highly correlated with changes in ALDH2 activity (R(2) = 0.76)...
  6. pmc In vivo investigation of cardiac metabolism in the rat using MRS of hyperpolarized [1-13C] and [2-13C]pyruvate
    Sonal Josan
    SRI International, Neuroscience Program, Menlo Park, CA, USA Stanford University, Department of Radiology, Lucas MRI Center, Stanford, CA, USA
    NMR Biomed 26:1680-7. 2013
    ..Using a high dose of pyruvate may provide an improved ability to observe changes in glutamate...
  7. ncbi request reprint N-acetylaspartate levels in bipolar offspring with and at high-risk for bipolar disorder
    Kim A Gallelli
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA
    Bipolar Disord 7:589-97. 2005
    ..To address this question, we used proton magnetic resonance spectroscopy ((1)H-MRS) to compare DLPFC levels of NAA among bipolar offspring with early-onset BD, bipolar offspring with subsyndromal symptoms of BD and healthy children...
  8. pmc Designing adiabatic radio frequency pulses using the Shinnar-Le Roux algorithm
    Priti Balchandani
    Department of Radiology, Stanford University, Stanford, California, USA
    Magn Reson Med 64:843-51. 2010
    ..Simulations and phantom experiments demonstrate that RF pulses designed using this new method behave adiabatically...
  9. pmc Interleaved narrow-band PRESS sequence with adiabatic spatial-spectral refocusing pulses for 1H MRSI at 7T
    Priti Balchandani
    Department of Electrical Engineering, Stanford University, Stanford, CA 94305, USA
    Magn Reson Med 59:973-9. 2008
    ..In comparison with conventional PRESS, this new approach generated high-quality spectra from an appreciably larger region of interest and achieved higher overall SNR...
  10. pmc Slice-selective tunable-flip adiabatic low peak-power excitation pulse
    Priti Balchandani
    Department of Electrical Engineering, Stanford University, 1201 Welch Road, Stanford, CA 94305, USA
    Magn Reson Med 59:1072-8. 2008
    ..Phantom and in vivo results demonstrate the adiabaticity and slice selectivity of the STABLE pulse...
  11. pmc Fat suppression for 1H MRSI at 7T using spectrally selective adiabatic inversion recovery
    Priti Balchandani
    Department of Electrical Engineering, Stanford University, Stanford, CA 94305, USA
    Magn Reson Med 59:980-8. 2008
    ..7T phantom and in vivo data show that both pulses significantly suppress fat, while leaving most of the metabolite signal intact...
  12. pmc Self-refocused spatial-spectral pulse for positive contrast imaging of cells labeled with SPIO nanoparticles
    Priti Balchandani
    Department of Radiology, Stanford University, Stanford, California 94305 5488, USA
    Magn Reson Med 62:183-92. 2009
    ..Phantom and in vivo data demonstrate that positive contrast and slice-selectivity are achieved using this novel RF pulse...
  13. pmc Application of double spin echo spiral chemical shift imaging to rapid metabolic mapping of hyperpolarized [1-¹³C]-pyruvate
    Sonal Josan
    SRI International, Neuroscience Program, Menlo Park, CA 94025, USA
    J Magn Reson 209:332-6. 2011
    ..Care must be taken for dynamic imaging to ensure that the spins remain within the B₁-homogeneous sensitive volume of the RF coil...
  14. ncbi request reprint Quality assurance of magnetic resonance spectroscopic imaging-derived metabolic data
    Sandeep Hunjan
    Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305 5304, USA
    Int J Radiat Oncol Biol Phys 57:1159-73. 2003
    ..We present a quality assurance procedure for MRSI-derived metabolic data acquired ultimately for guiding conformal radiotherapy...
  15. pmc In vivo 1H magnetic resonance spectroscopy of lactate in patients with stage IV head and neck squamous cell carcinoma
    Quynh Thu Le
    Department of Radiation Oncology, Stanford University Medical Center, Stanford, CA 94305 5847, USA
    Int J Radiat Oncol Biol Phys 71:1151-7. 2008
    ..To investigate in vivo(1)H magnetic resonance spectroscopy imaging of lactate for assessing tumor hypoxia in head and neck cancers and to determine its utility in predicting the response and outcomes...
  16. ncbi request reprint Inverse planning for functional image-guided intensity-modulated radiation therapy
    Lei Xing
    Department of Radiation Oncology, Stanford University School of Medicine, CA 94305 5304, USA
    Phys Med Biol 47:3567-78. 2002
    ..This should enhance our capability to safely and intelligently escalate dose and lays the technical foundation for future clinical studies of the efficacy of functional imaging-guided IMRT...
  17. ncbi request reprint Fast metabolic imaging of systems with sparse spectra: application for hyperpolarized 13C imaging
    Dirk Mayer
    Richard M Lucas Center for Magnetic Resonance Spectroscopy and Imaging, Department of Radiology, Stanford University, Stanford, California 94305 5488, USA
    Magn Reson Med 56:932-7. 2006
    ..The metabolic maps of Ala and Lac for single-shot spCSI contain minor artifacts due to signal overlap of aliased resonances...
  18. pmc Parallel spectroscopic imaging reconstruction with arbitrary trajectories using k-space sparse matrices
    Meng Gu
    Lucas Center for MR Spectroscopy and Imaging, Department of Radiology, Stanford University, Stanford, California 94305 5488, USA
    Magn Reson Med 61:267-72. 2009
    ..The results are demonstrated in both phantom and in vivo studies. Spectroscopic images very similar to that reconstructed with fully sampled spiral k-space data are obtained at different reduction factors...
  19. pmc Reproducibility study of whole-brain 1H spectroscopic imaging with automated quantification
    Meng Gu
    Department of Electrical Engineering, Stanford University, Stanford, California 94305 5488, USA
    Magn Reson Med 60:542-7. 2008
    ..The results demonstrate that reproducible whole-brain (1)H-MRSI data can be robustly obtained with the proposed methods...
  20. pmc Application of subsecond spiral chemical shift imaging to real-time multislice metabolic imaging of the rat in vivo after injection of hyperpolarized 13C1-pyruvate
    Dirk Mayer
    Department of Radiology, Stanford University, Richard M Lucas Center for Imaging, Stanford, California 94305 5488, USA
    Magn Reson Med 62:557-64. 2009
    ..These results demonstrate the feasibility of real-time, hyperpolarized metabolic imaging and highlight its potential in assessing organ-specific kinetic parameters...
  21. ncbi request reprint Regularized higher-order in vivo shimming
    Dong Hyun Kim
    Radiological Sciences Laboratory, Department of Radiology, Stanford University, California, USA
    Magn Reson Med 48:715-22. 2002
    ..The fully automated shimming package is implemented on a 3 T GE Signa system and its robust performance is demonstrated in phantom and in vivo studies...
  22. pmc In vivo application of sub-second spiral chemical shift imaging (CSI) to hyperpolarized 13C metabolic imaging: comparison with phase-encoded CSI
    Dirk Mayer
    Stanford University, Department of Radiology, Richard M Lucas Center for Imaging, 1201 Welch Rd, Stanford, CA 94305, USA
    J Magn Reson 204:340-5. 2010
    ..The presented results demonstrate that dramatic reductions in scan time are feasible in hyperpolarized (13)C metabolic imaging without a penalty in SNR or spatial resolution...
  23. pmc Breathheld autocalibrated phase-contrast imaging
    Calvin Lew
    Department of Radiology, Stanford University, Stanford, California 94305, USA
    J Magn Reson Imaging 31:1004-14. 2010
    ..To compare generalized autocalibrating partially parallel acquisitions (GRAPPA), modified sensitivity encoding (mSENSE), and SENSE in phase-contrast magnetic resonance imaging (PC-MRI) applications...
  24. pmc B1 and T1 insensitive water and lipid suppression using optimized multiple frequency-selective preparation pulses for whole-brain 1H spectroscopic imaging at 3T
    Meng Gu
    Department of Electrical Engineering, Stanford University, Stanford, California 94305 5488, USA
    Magn Reson Med 61:462-6. 2009
    ....
  25. ncbi request reprint Simple analytic variable density spiral design
    Dong Hyun Kim
    Radiological Sciences Laboratory, Department of Radiology, Stanford University, Stanford, California 94305 5488, USA
    Magn Reson Med 50:214-9. 2003
    ..The method enables real-time waveform prescription on scanners with limited computational power. Both slew rate-limited and amplitude-limited regimes are incorporated in the design process...
  26. pmc Dynamic and high-resolution metabolic imaging of hyperpolarized [1-13C]-pyruvate in the rat brain using a high-performance gradient insert
    Dirk Mayer
    SRI International, Neuroscience Program, Menlo Park, California 94025, USA
    Magn Reson Med 65:1228-33. 2011
    ....
  27. ncbi request reprint Spiral readout gradients for the reduction of motion artifacts in chemical shift imaging
    Dong Hyun Kim
    Radiological Sciences Laboratory, Department of Radiology, Stanford University, Stanford, California, USA
    Magn Reson Med 51:458-63. 2004
    ..Both phantom and in vivo spectra reconstructed using the new motion artifact reduction algorithm showed significant signal-to-noise ratio (SNR) improvements as compared to uncorrected data...
  28. doi request reprint Fast parallel spiral chemical shift imaging at 3T using iterative SENSE reconstruction
    Dirk Mayer
    Stanford University, Richard M Lucas Center for Magnetic Resonance Spectroscopy and Imaging, Department of Radiology, Stanford, California 94305 5488, USA
    Magn Reson Med 59:891-7. 2008
    ....
  29. ncbi request reprint Estimation of renal extraction fraction based on postcontrast venous and arterial differential T1 values: an error analysis
    Yakir S Levin
    Department of Electrical Engineering, Stanford University, Stanford, California, USA
    Magn Reson Med 54:309-16. 2005
    ..Because of limitations on measurement accuracy and precision, this method appears to be impractical at this time...
  30. ncbi request reprint Detection of glutamate in the human brain at 3 T using optimized constant time point resolved spectroscopy
    Dirk Mayer
    Stanford University, Lucas MRS Imaging Center, Department of Radiology, Stanford, California 94305 5488, USA
    Magn Reson Med 54:439-42. 2005
    ..However, glutamine resonances could not be resolved due to severe signal overlap from glutamate and N-acetyl aspartate...
  31. ncbi request reprint Fast CT-PRESS-based spiral chemical shift imaging at 3 Tesla
    Dirk Mayer
    Richard M Lucas Center for Magnetic Resonance Spectroscopy and Imaging, Department of Radiology, Stanford University, Stanford, California 94305 5488, USA
    Magn Reson Med 55:974-8. 2006
    ..Signals from N-acetyl-aspartate, total creatine, choline-containing compounds (Cho), Glu, and mI were detected in a healthy volunteer with no or only minor baseline distortions within 14 min on a 3 T MR scanner...
  32. pmc Peak velocity and flow quantification validation for sensitivity-encoded phase-contrast MR imaging
    Calvin D Lew
    Lucas MRS I Center, Stanford University, 1201 Welch Road, Stanford, CA 94305
    Acad Radiol 14:258-69. 2007
    ..Parallel imaging using sensitivity encoding (SENSE) may substantially reduce scan time. We demonstrate the utility of PC-MRI measurements accelerated by SENSE under clinical conditions...
  33. ncbi request reprint RF refocused echoes of J-coupled spin systems: effects on RARE-based spectroscopic imaging
    Dirk Mayer
    Lucas MRS Imaging Center, Department of Radiology, Stanford University, Stanford, California 94305 5488, USA
    Magn Reson Med 57:967-71. 2007
    ..When the pulse interval falls short of the fast pulse rate regime, spectroscopic U-FLARE provides an improved spatial impulse response in the phase-encoding (PE) direction compared to spectroscopic RARE...
  34. pmc Improved slice-selective adiabatic excitation
    Priti Balchandani
    Department of Radiology, Stanford University, Stanford, California, USA
    Magn Reson Med 71:75-82. 2014
    ..An additional aim is to design a variant of this pulse to achieve B1 -insensitive, fat-suppressed excitation...
  35. pmc Prospective neurochemical characterization of child offspring of parents with bipolar disorder
    Manpreet K Singh
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 401 Quarry Road, Stanford, CA 94305, USA Electronic address
    Psychiatry Res 214:153-60. 2013
    ..It may be the case that with intervention youth at risk for BD are normalizing otherwise potentially aberrant neurochemical trajectories in the DLPFC. A longer period of follow-up may be required before observing any group differences. ..
  36. ncbi request reprint In vivo prostate magnetic resonance spectroscopic imaging using two-dimensional J-resolved PRESS at 3 T
    Dong Hyun Kim
    Department of Radiology, Stanford University, CA 94305, USA
    Magn Reson Med 53:1177-82. 2005
    ..Phantom and in vivo data are presented to illustrate the multivoxel 2D J-resolved spiral chemical shift imaging sequence...
  37. pmc Brain glutamatergic characteristics of pediatric offspring of parents with bipolar disorder
    Manpreet Singh
    Department of Psychiatry and Behavioral Sciences, Division of Child and Adolescent Psychiatry, Stanford University School of Medicine, 401 Quarry Road, Stanford, CA 94305, USA
    Psychiatry Res 182:165-71. 2010
    ..Longitudinal studies are necessary to confirm whether prefrontal glutamate decreases only after the onset of full mania...
  38. ncbi request reprint Noninvasive measurement of extraction fraction and single-kidney glomerular filtration rate with MR imaging in swine with surgically created renal arterial stenoses
    Curtis H Coulam
    Department of Radiology, Stanford University School of Medicine, 300 Pasteur Dr, H 1307, Stanford, CA 94305, USA
    Radiology 223:76-82. 2002
    ....
  39. pmc MRI and (1)H MRS of the breast: presence of a choline peak as malignancy marker is related to K21 value of the tumor in patients with invasive ductal carcinoma
    Patricia R Geraghty
    Department of Radiology, Stanford University School of Medicine, Stanford, CA 94305 5488, USA
    Breast J 14:574-80. 2008
    ..This study showed that false-negative (1)H MRS examinations do occur in breast cancer patients, and that the presence of a choline peak on (1)H MRS as malignancy marker is related to the k21 value of the invasive tumor being imaged...
  40. pmc Self-refocused adiabatic pulse for spin echo imaging at 7 T
    Priti Balchandani
    Department of Radiology, Stanford University, Stanford, CA, USA
    Magn Reson Med 67:1077-85. 2012
    ..The self-refocused adiabatic pulse produced transmit profiles that were substantially more uniform than those achieved using a conventional spin echo sequence...
  41. pmc Methods for metabolic evaluation of prostate cancer cells using proton and (13)C HR-MAS spectroscopy and [3-(13)C] pyruvate as a metabolic substrate
    Yakir S Levin
    Department of Radiology, Stanford University, Stanford, California 94158, USA
    Magn Reson Med 62:1091-8. 2009
    ..These methods will allow further characterization of metabolic properties of prostate cancer cells in the future. Magn Reson Med, 2009. (c) 2009 Wiley-Liss, Inc...
  42. pmc Evaluation of dynamic contrast-enhanced MRI in detecting renal scarring in a rat injury model
    Bingyin Wang
    Department of Urology, Stanford University School of Medicine, Stanford, California, USA
    J Magn Reson Imaging 31:1132-6. 2010
    ..To create a reliable rat model with small renal cortical scars and evaluate the accuracy and sensitivity of dynamic contrast-enhanced MRI in detecting the kinds of lesions that are associated with reflux nephropathy...
  43. pmc Fast multivoxel two-dimensional spectroscopic imaging at 3 T
    Dong Hyun Kim
    Department of Radiology, University of California San Francisco, San Francisco, CA, USA
    Magn Reson Imaging 25:1155-61. 2007
    ..All protocols were designed to acquire data within a 17-min scan time at a field strength of 3 T...
  44. ncbi request reprint Reducing gradient imperfections for spiral magnetic resonance spectroscopic imaging
    Dong Hyun Kim
    Department of Radiology, University of California San Francisco, San Francisco, California 94143, USA
    Magn Reson Med 56:198-203. 2006
    ..The use of the measured trajectories in the reconstruction process yielded an up to 20% increase in signal amplitude recovery...
  45. ncbi request reprint Stroke volume and cardiac output in juvenile elephant seals during forced dives
    Sheila J Thornton
    Department of Zoology, University of British Columbia, Vancouver, Canada
    J Exp Biol 208:3637-43. 2005
    ..In this study, the degree of bradycardia during diving was less than in previous pinniped studies, suggesting that the reduction in vagal input may contribute to the observed increase in Vs...
  46. ncbi request reprint Low N-acetyl-aspartate and high choline in the anterior cingulum of recently abstinent methamphetamine-dependent subjects: a preliminary proton MRS study. Magnetic resonance spectroscopy
    Thomas E Nordahl
    Department of Psychiatry and Behavioral Sciences, University of California, Davis, CA, USA
    Psychiatry Res 116:43-52. 2002
    ..The neuronal compromise that these changes reflect may contribute to the attentional deficits and dampened reward system in MD...

Research Grants14

  1. Metabolic Imaging of the Cardioprotective Effects of Alcohol and ALDH2 Activators
    Daniel M Spielman; Fiscal Year: 2010
    ..The ultimate clinical goal is to develop metabolic imaging of hyperpolarized pyruvate as a diagnostic tool both to optimize choice of treatment and to monitor response to therapy. ..
  2. 1H MRSI of the Human Brain at 7T
    Daniel M Spielman; Fiscal Year: 2010
    ....
  3. 1H MRSI of the Human Brain at 7T
    Daniel Spielman; Fiscal Year: 2009
    ....
  4. MAGNETIC RESONANCE SPECTROSCOPIC NEOPLASM IMAGING
    Daniel Spielman; Fiscal Year: 2003
    ..abstract_text> ..
  5. MR SPECTROSCOPIC IMAGING IN ALZHEIMER'S DISEASE
    Daniel Spielman; Fiscal Year: 2003
    ..The cognitive correlates of the regional MRSI data will be examined by testing specific brain-behavior relationships through double dissociation models. ..