Shawn F Sorrells

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. ncbi An inflammatory review of glucocorticoid actions in the CNS
    Shawn F Sorrells
    Department of Biological Sciences, Stanford University, Gilbert Lab MC 5020, Stanford, CA 94305 5020, USA
    Brain Behav Immun 21:259-72. 2007
  2. ncbi The stressed CNS: when glucocorticoids aggravate inflammation
    Shawn F Sorrells
    Department of Biological Sciences, Stanford University, Gilbert Lab MC 5020, Stanford, CA 94305 5020, USA
    Neuron 64:33-9. 2009
  3. ncbi Glucocorticoid signaling in myeloid cells worsens acute CNS injury and inflammation
    Shawn F Sorrells
    Departments of Biology, Neurosurgery, Neurology and Neurological Sciences, Stanford University, Stanford, California 94305 5020, and Department of Pharmacology, Institute of Biomedical Science, University of Sao Paulo, Sao Paulo, Brazil, 05508 900
    J Neurosci 33:7877-89. 2013
  4. ncbi Glucocorticoids exacerbate lipopolysaccharide-induced signaling in the frontal cortex and hippocampus in a dose-dependent manner
    Carolina Demarchi Munhoz
    Department of Biological Sciences, Stanford University, Stanford, California 94305 5020, USA
    J Neurosci 30:13690-8. 2010
  5. ncbi Derivation of injury-responsive dendritic cells for acute brain targeting and therapeutic protein delivery in the stroke-injured rat
    Nathan C Manley
    Department of Biology, Stanford University, Stanford, California, United States of America Department of Neurosurgery, Stanford University School of Medicine, Stanford, California, United States of America Stanford Stroke Center and Stanford Institute for Neuro Innovation and Translational Neurosciences, Stanford University School of Medicine, Stanford, California, United States of America
    PLoS ONE 8:e61789. 2013

Detail Information

Publications5

  1. ncbi An inflammatory review of glucocorticoid actions in the CNS
    Shawn F Sorrells
    Department of Biological Sciences, Stanford University, Gilbert Lab MC 5020, Stanford, CA 94305 5020, USA
    Brain Behav Immun 21:259-72. 2007
    ..We consider how these unexpected effects of glucocorticoids can co-exist with their well-established anti-inflammatory properties, as well as the considerable clinical implications of these findings...
  2. ncbi The stressed CNS: when glucocorticoids aggravate inflammation
    Shawn F Sorrells
    Department of Biological Sciences, Stanford University, Gilbert Lab MC 5020, Stanford, CA 94305 5020, USA
    Neuron 64:33-9. 2009
    ..In this minireview we discuss the contexts wherein GCs increase CNS inflammation and point out directions for future investigation...
  3. ncbi Glucocorticoid signaling in myeloid cells worsens acute CNS injury and inflammation
    Shawn F Sorrells
    Departments of Biology, Neurosurgery, Neurology and Neurological Sciences, Stanford University, Stanford, California 94305 5020, and Department of Pharmacology, Institute of Biomedical Science, University of Sao Paulo, Sao Paulo, Brazil, 05508 900
    J Neurosci 33:7877-89. 2013
    ..Finally, GCs compromised neuron survival, an effect mediated by GR in myeloid and endothelial cells to a greater extent than by neuronal GR...
  4. ncbi Glucocorticoids exacerbate lipopolysaccharide-induced signaling in the frontal cortex and hippocampus in a dose-dependent manner
    Carolina Demarchi Munhoz
    Department of Biological Sciences, Stanford University, Stanford, California 94305 5020, USA
    J Neurosci 30:13690-8. 2010
    ..These findings suggest that GCs do not uniformly suppress neuroinflammation and can even enhance it at multiple levels in the pathway linking LPS exposure to inflammation...
  5. ncbi Derivation of injury-responsive dendritic cells for acute brain targeting and therapeutic protein delivery in the stroke-injured rat
    Nathan C Manley
    Department of Biology, Stanford University, Stanford, California, United States of America Department of Neurosurgery, Stanford University School of Medicine, Stanford, California, United States of America Stanford Stroke Center and Stanford Institute for Neuro Innovation and Translational Neurosciences, Stanford University School of Medicine, Stanford, California, United States of America
    PLoS ONE 8:e61789. 2013
    ..These results demonstrate a non-invasive method to target ischemic brain injury and may ultimately provide a way to selectively deliver therapeutic compounds to the injured brain...