Research Topics
| G N SomeroSummaryAffiliation: Stanford University Country: USA Publications
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Detail Information
Publications
Peter Hochachka: adventures in biochemical adaptationGeorge N Somero
Department of Biological Sciences, Hopkins Marine Station, Stanford University, Pacific Grove, California 93950 3094, USA
Annu Rev Physiol 67:25-37. 2005....
Transcriptomic responses to heat stress in invasive and native blue mussels (genus Mytilus): molecular correlates of invasive successBrent L Lockwood
Hopkins Marine Station, Stanford University, Oceanview Blvd, Pacific Grove, CA 93950, USA
J Exp Biol 213:3548-58. 2010..galloprovincialis and showed only a small change in M. trossulus. These different responses to acute heat stress may help to explain--and predict--the invasive success of M. galloprovincialis in a warming world...- The physiology of global change: linking patterns to mechanismsGeorge N Somero
Department of Biology, Hopkins Marine Station, Stanford University, Pacific Grove, California 93950, USA
Ann Rev Mar Sci 4:39-61. 2012..stress? Can physiological measurements, including new molecular ("-omic") approaches, provide indices of the degree of sublethal stress an organism experiences? And can physiological evolution keep pace with global change?.. - Comparative physiology: a "crystal ball" for predicting consequences of global changeGeorge N Somero
Hopkins Marine Station, Dept of Biology, Stanford University, Pacific Grove, CA 93950 3094, USA
Am J Physiol Regul Integr Comp Physiol 301:R1-14. 2011..7) Losses of protein-coding genes and temperature-responsive gene regulatory abilities in stenothermal ectotherms of the Southern Ocean may lead to broad extinctions... - The physiology of climate change: how potentials for acclimatization and genetic adaptation will determine 'winners' and 'losers'G N Somero
Hopkins Marine Station, Department of Biology, Stanford University, Pacific Grove, CA 93950, USA
J Exp Biol 213:912-20. 2010..These extreme stenotherms, along with warm-adapted eurytherms living near their thermal limits, may be the major 'losers' from climate change... - Following the heart: temperature and salinity effects on heart rate in native and invasive species of blue mussels (genus Mytilus)Caren E Braby
Hopkins Marine Station, Department of Biological Sciences, Stanford University, Oceanview Boulevard, Pacific Grove, CA 93950, USA
J Exp Biol 209:2554-66. 2006..galloprovincialis, the potential for further range expansion along the Pacific coast of North America... - Adaptation of enzymes to temperature: searching for basic "strategies"George N Somero
Department of Biological Sciences, Hopkins Marine Station, Stanford University, Oceanview Blvd, Pacific Grove, CA 93950, USA
Comp Biochem Physiol B Biochem Mol Biol 139:321-33. 2004.... - Protein adaptations to temperature and pressure: complementary roles of adaptive changes in amino acid sequence and internal milieuGeorge N Somero
Department of Biological Sciences, Hopkins Marine Station, Stanford University, Oceanview Blvd, Pacific Grove, CA 93950, USA
Comp Biochem Physiol B Biochem Mol Biol 136:577-91. 2003..Protein-stabilizing solutes like trimethylamine-N-oxide (TMAO) conserve protein function and structure at elevated hydrostatic pressures... 
Hot spots in cold adaptation: localized increases in conformational flexibility in lactate dehydrogenase A4 orthologs of Antarctic notothenioid fishesP A Fields
Hopkins Marine Station, Stanford University, Pacific Grove, CA 93950 3094, USA
Proc Natl Acad Sci U S A 95:11476-81. 1998..However, at a common temperature of measurement, the higher configurational entropy of a cold-adapted enzyme may foster conformations that bind ligands poorly, leading to high Km values relative to warm-adapted orthologs...- Temperature adaptation in Gillichthys (Teleost: Gobiidae) A(4)-lactate dehydrogenases: identical primary structures produce subtly different conformationsPeter A Fields
Hopkins Marine Station, Biological Sciences Department, Stanford University, Pacific Grove, CA 93950, USA
J Exp Biol 205:1293-303. 2002..Subtle differences in conformation around this residue probably play a role both in altered flexibility and in the potentially adaptive differences in kinetics between the two A(4)-LDH forms... - Intrinsic versus extrinsic stabilization of enzymes: the interaction of solutes and temperature on A4-lactate dehydrogenase orthologs from warm-adapted and cold-adapted marine fishesP A Fields
Hopkins Marine Station, Department of Biological Sciences, Stanford University, Pacific Grove, California 93950 3094, USA
Eur J Biochem 268:4497-505. 2001.... - The cellular response to heat stress in the goby Gillichthys mirabilis: a cDNA microarray and protein-level analysisBradley A Buckley
Hopkins Marine Station, Stanford University, Pacific Grove, CA 93950, USA
J Exp Biol 209:2660-77. 2006.... - Transcriptional responses to thermal acclimation in the eurythermal fish Gillichthys mirabilis (Cooper 1864)Cheryl A Logan
Department of Biology, Stanford University, Pacific Grove, California, USA
Am J Physiol Regul Integr Comp Physiol 299:R843-52. 2010..This pattern of transcriptional alteration in steady-state acclimated fish may be a signature of eurythermy... - Transcriptomic responses to salinity stress in invasive and native blue mussels (genus Mytilus)Brent L Lockwood
Hopkins Marine Station, Stanford University, Oceanview Blvd, Pacific Grove, CA 93950, USA
Mol Ecol 20:517-29. 2011..galloprovincialis and M. trossulus in response to salinity stress are subtle and involve only a minor fraction of the overall suite of gene regulatory responses... - Changes in gene expression associated with acclimation to constant temperatures and fluctuating daily temperatures in an annual killifish Austrofundulus limnaeusJason E Podrabsky
Hopkins Marine Station of Stanford University, 120 Oceanview Boulevard, Pacific Grove, CA 93950 3094, USA
J Exp Biol 207:2237-54. 2004..This study illustrates the utility of cDNA microarray approaches in both hypothesis-driven and 'discovery-based' investigations of environmental effects on organisms... - Interspecific- and acclimation-induced variation in levels of heat-shock proteins 70 (hsp70) and 90 (hsp90) and heat-shock transcription factor-1 (HSF1) in congeneric marine snails (genus Tegula): implications for regulation of hsp gene expressionLars Tomanek
Hopkins Marine Station, Stanford University, Pacific Grove, CA 93950 3094, USA
J Exp Biol 205:677-85. 2002..The ratio of hsp72 to hsp74 may provide a more accurate estimate of environmental heat stress than the total concentrations of both hsp70 isoforms... - Evolutionary convergence in adaptation of proteins to temperature: A4-lactate dehydrogenases of Pacific damselfishes (Chromis spp.)Glenn C Johns
Hopkins Marine Station, Stanford University, Pacific Grove, California1, USA
Mol Biol Evol 21:314-20. 2004.... - A microarray-based transcriptomic time-course of hyper- and hypo-osmotic stress signaling events in the euryhaline fish Gillichthys mirabilis: osmosensors to effectorsTyler G Evans
Hopkins Marine Station, Stanford University, Pacific Grove, CA 93950, USA
J Exp Biol 211:3636-49. 2008..Our data indicate multiple major signaling pathways work in concert to modify diverse effectors, and that these molecules operate within a framework of regulatory proteins... - Time course and magnitude of synthesis of heat-shock proteins in congeneric marine snails (Genus tegula) from different tidal heightsL Tomanek
Hopkins Marine Station, Stanford University, Pacific Grove, California 93950 3094, USA
Physiol Biochem Zool 73:249-56. 2000..brunnea but not in T. funebralis. The different time courses and magnitudes of hsp synthesis in these congeners suggest that the vertical limits of their distributions may be set in part by thermal stress... - A comparative analysis of the evolutionary patterning and mechanistic bases of lactate dehydrogenase thermal stability in porcelain crabs, genus PetrolisthesJ H Stillman
Hopkins Marine Station, Stanford University, Pacific Grove, CA 93950, USA
J Exp Biol 204:767-76. 2001..We conclude that the overall structural stability and functional properties of proteins can evolve independently and that in vivo protein-protein interactions can provide another means to regulate protein stability selectively... - Evolutionary and acclimation-induced variation in the thermal limits of heart function in congeneric marine snails (genus Tegula): implications for vertical zonationEmily Stenseng
Hopkins Marine Station, Department of Biological Sciences, Stanford University, Pacific Grove, California 93950-3094, USA
Biol Bull 208:138-44. 2005.... - Phylogenetic relationships and biochemical properties of the duplicated cytosolic and mitochondrial isoforms of malate dehydrogenase from a teleost fish, Sphyraena idiastesJen-Jen Lin
Hopkins Marine Station, Department of Biological Sciences, Stanford University, Pacific Grove, CA 93950-3094 USA
J Mol Evol 54:107-17. 2002.... - Temperature adaptation of cytosolic malate dehydrogenases of limpets (genus Lottia): differences in stability and function due to minor changes in sequence correlate with biogeographic and vertical distributionsYunwei Dong
Hopkins Marine Station, Department of Biology, Stanford University, Pacific Grove, CA 93950, USA
J Exp Biol 212:169-77. 2009.... - Heat-shock protein expression is absent in the antarctic fish Trematomus bernacchii (family Nototheniidae)G E Hofmann
Department of Biology, Arizona State University, Tempe, AZ 85287 1501, USA
J Exp Biol 203:2331-9. 2000.... - Base compositions of genes encoding alpha-actin and lactate dehydrogenase-A from differently adapted vertebrates show no temperature-adaptive variation in G + C contentRachael A Ream
Hopkins Marine Station of Stanford University, Pacific Grove, California, USA
Mol Biol Evol 20:105-10. 2003.... - An inducible 70 kDa-class heat shock protein is constitutively expressed during early development and diapause in the annual killifish Austrofundulus limnaeusJason E Podrabsky
Department of Biology, Portland State University, PO Box 751, Portland, OR 97207 0751, USA
Cell Stress Chaperones 12:199-204. 2007..Constitutive expression of Hsp70 during development may afford these embryos protection from environmental stresses during development more quickly than relying on the induction of a classic heat shock response... - Obituary: Peter W. Hochachka (1937-2002)George N Somero
Stanford University, Pacific Grove, CA
Comp Biochem Physiol C Toxicol Pharmacol 133:471-3. 2002 - Local selection and latitudinal variation in a marine predator-prey interactionEric Sanford
Stanford University, Hopkins Marine Station, Pacific Grove, CA 93950, USA
Science 300:1135-7. 2003..Marine communities separated by hundreds of kilometers may have intrinsically different dynamics, with interactions shaped by restricted gene flow and spatially varying selection... - Temperature sensitivities of cytosolic malate dehydrogenases from native and invasive species of marine mussels (genus Mytilus): sequence-function linkages and correlations with biogeographic distributionPeter A Fields
Biology Department, Franklin and Marshall College, Lancaster, PA 17604 3003, USA
J Exp Biol 209:656-67. 2006..The relative warm adaptation of M. galloprovincialis cMDH may be one of a suite of physiological characters that enhance the competitive ability of this invasive species in warm habitats... - Biochemical adaptations of notothenioid fishes: comparisons between cold temperate South American and New Zealand species and Antarctic speciesZulema L Coppes Petricorena
Faculty of Chemistry, Montevideo, Uruguay
Comp Biochem Physiol A Mol Integr Physiol 147:799-807. 2007.... - Preface to Peter Hochachka memorial volumeGeorge N Somero
Comp Biochem Physiol B Biochem Mol Biol 139:311-5. 2004 - Influences of thermal acclimation and acute temperature change on the motility of epithelial wound-healing cells (keratocytes) of tropical, temperate and Antarctic fishRachael A Ream
Biochemistry Department, Beckman Center, Room 473A, Stanford University School of Medicine, Stanford, CA 94305-5307, USA
J Exp Biol 206:4539-51. 2003..Keratocytes represent a useful study system for evaluating the effects of temperature at the cellular level and for studying adaptive variation in actin-based cellular movement and capacity for wound healing...