Gerald D Silverberg
Affiliation: Stanford University
- Temporal course of cerebrospinal fluid dynamics and amyloid accumulation in the aging rat brain from three to thirty monthsCatherine Chiu
Department of Neurosurgery, Warren Alpert Medical School, Brown University and Aldrich Neurosurgery Research Laboratories, Rhode Island Hospital, Providence, RI, 02903, USA
Fluids Barriers CNS 9:3. 2012..abstract:..
- Amyloid efflux transporter expression at the blood-brain barrier declines in normal agingGerald D Silverberg
Department of Neurosurgery, Warren Alpert Medical School, Brown University, Providence, Rhode Island, USA
J Neuropathol Exp Neurol 69:1034-43. 2010..0004). These data indicate that alterations in LRP-1 and P-gp expression seem to contribute progressively to Aβ accumulation in aging...
- Amyloid and Tau accumulate in the brains of aged hydrocephalic ratsGerald D Silverberg
Department of Clinical Neuroscience, Rhode Island Hospital and the Warren Alpert Medical School, Brown University, Providence, RI, USA
Brain Res 1317:286-96. 2010..As distinct from brain injury models, no increase in AbetaPP expression was demonstrated. Rather, altered CSF dynamics appears to impair Abeta clearance in this NPH model...
- The cerebrospinal fluid production rate is reduced in dementia of the Alzheimer's typeG D Silverberg
Department of Neurosurgery, Stanford University School of Medicine, CA 94305 5327, USA
Neurology 57:1763-6. 2001..To evaluate the production rate of CSF in patients with differing disease states...
- Amyloid deposition and influx transporter expression at the blood-brain barrier increase in normal agingGerald D Silverberg
Department of Clinical Neuroscience, Warren Alpert Medical School, Brown University and Aldrich Neurosurgery Research Laboratories, Rhode Island Hospital, Providence, Rhode Island, USA
J Neuropathol Exp Neurol 69:98-108. 2010..These data indicate an association between amyloid and microvessel RAGE during aging. An increase in capillary RAGE expression seems to play a role in the later Abeta accumulation but not in the initial increase...
- Amyloid-beta transporter expression at the blood-CSF barrier is age-dependentCrissey L Pascale
Warren Alpert Medical School Brown University, RI Hospital Department of Neurosurgery 593 Eddy St, Providence, RI 02903 USA
Fluids Barriers CNS 8:21. 2011..abstract:..
- Continuous CSF drainage in AD: results of a double-blind, randomized, placebo-controlled studyG D Silverberg
Warren Alpert School of Medicine, Brown University, Providence, RI, USA
Neurology 71:202-9. 2008..We hypothesized that improving clearance of macromolecules from the CNS might slow the progression of dementia...
- Hippocampal RAGE immunoreactivity in early and advanced Alzheimer's diseaseMiles C Miller
Division of Neuropathology, Department of Pathology, Rhode Island Hospital and The Warren Alpert Medical School of Brown University, 593 Eddy Street APC 12 219, Providence, RI 02903, USA
Brain Res 1230:273-80. 2008..038). Our data suggest that microvascular RAGE levels increase in conjunction with the onset of AD, and continue to increase linearly as a function of AD pathologic severity (p < 0.0001)...
- Brain ventricular volume and cerebrospinal fluid biomarkers of Alzheimer's diseaseBrian R Ott
Department of Neurology, Warren Alpert Medical School of Brown University, Providence, RI 02903, USA
J Alzheimers Dis 20:647-57. 2010..The basis for the apparent effect of APOE epsilon4 genotype on the relationship of ventricular volume to Abeta and tau levels is unknown, but could involve altered CSF-blood-brain barrier function during the course of disease...
- RAGE, LRP-1, and amyloid-beta protein in Alzheimer's diseaseJohn E Donahue
Department of Clinical Neurosciences, Rhode Island Hospital and Brown Medical School, Providence, RI 02903, USA
Acta Neuropathol 112:405-15. 2006..They also suggest that the proportion of amyloid within the brains of AD patients that is derived from the systemic circulation may be significant...
- Novel ventriculo-peritoneal shunt in Alzheimer's disease cerebrospinal fluid biomarkersGerald D Silverberg
Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA 94305, USA
Expert Rev Neurother 4:97-107. 2004....
- Multiplicity of cerebrospinal fluid functions: New challenges in health and diseaseConrad E Johanson
Department of Clinical Neurosciences, Warren Alpert Medical School at Brown University, Providence, RI 02903, USA
Cerebrospinal Fluid Res 5:10. 2008..2 Arachnoid villi vs. olfactory drainage routes9.3 Fluid reabsorption along spinal nerves9.4 Reabsorption across capillary aquaporin channels10 Developing translationally effective models for restoring CSF balance11 Conclusion...
- Kaolin-induced chronic hydrocephalus accelerates amyloid deposition and vascular disease in transgenic rats expressing high levels of human APPGerald D Silverberg
Department of Neurosurgery, The Warren Alpert Medical School of Brown University and the Aldrich Laboratories at Rhode Island Hospital, 593 Eddy Street, Providence, RI 02903 USA Stanford University, 710 Frenchmans Rd, Stanford, CA 94305 USA
Fluids Barriers CNS 12:2. 2015..al. Brain Res. 2010, 1317:286-296). We postulated that hydrocephalus would similarly affect an AD rat model...
- Biologic effects of and clinical disorders caused by nonprotein amino acidsE Rubenstein
Department of Medicine, Stanford University School of Medicine, California, USA
Medicine (Baltimore) 79:80-9. 2000..To what extent this mechanism is responsible for highly prevalent diseases of autoimmunity remains to be determined...
- P-glycoprotein expression and amyloid accumulation in human aging and Alzheimer's disease: preliminary observationsCatherine Chiu
Department of Neurosurgery, Warren Alpert Medical School, Brown University and Aldrich Neurosurgery Research Laboratories, Rhode Island Hospital, Providence, RI, USA
Neurobiol Aging 36:2475-82. 2015..Decreased P-gp expression may be related to Aβ plaques in aging and AD. Downregulating P-gp to allow pharmaceuticals into the central nervous system may increase Aβ accumulation. ..
- Low levels of amyloid-beta and its transporters in neonatal rats with and without hydrocephalusKelley E Deren
Department of Neurosurgery, Division of Pediatric Neurosurgery, Primary Children s Medical Center and the University of Utah, Salt Lake City, Utah 84132, USA
Cerebrospinal Fluid Res 6:4. 2009..Because hydrocephalus occurs frequently in children, we evaluated the expression of Abeta and its transporters and reactive astrocytosis in animals with neonatal hydrocephalus...
- Alzheimer's disease, normal-pressure hydrocephalus, and senescent changes in CSF circulatory physiology: a hypothesisGerald D Silverberg
Stanford University School of Medicine, Stanford, CA 94305, USA
Lancet Neurol 2:506-11. 2003..We postulate a new nosological entity of CSF circulatory failure, with features of AD and NPH. NPH-AD may cover an important subset of patients who carry the diagnosis of either AD or NPH...
- Relationship of senescence of cerebrospinal fluid circulatory system to dementias of the agedE Rubenstein
Stanford University School of Medicine, California, USA
Lancet 351:283-5. 1998..The hypothesis is that senescence of the cerebrospinal fluid circulatory system plays a part in some dementias of the aged...