Wen Jun Shen

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. ncbi Effects of rosiglitazone and high fat diet on lipase/esterase expression in adipose tissue
    Wen Jun Shen
    Division of Endocrinology, Stanford University and VA Palo Alto Health Care System, Palo Alto, CA 94304, USA
    Biochim Biophys Acta 1771:177-84. 2007
  2. ncbi Regulation of hormone-sensitive lipase in islets
    Wen Jun Shen
    Department of Medicine, Stanford University, Stanford, CA 94305, USA
    Diabetes Res Clin Pract 75:14-26. 2007
  3. ncbi Hormone-sensitive lipase modulates adipose metabolism through PPARγ
    Wen Jun Shen
    Division of Endocrinology, Stanford University, CA 94305 5103, USA
    Biochim Biophys Acta 1811:9-16. 2011
  4. ncbi Interaction of hormone-sensitive lipase with steroidogenic acute regulatory protein: facilitation of cholesterol transfer in adrenal
    Wen Jun Shen
    Veterans Affairs Palo Alto Health Care System, Palo Alto, California 94304 1290, USA
    J Biol Chem 278:43870-6. 2003
  5. ncbi Resistance to high-fat diet-induced obesity and altered expression of adipose-specific genes in HSL-deficient mice
    Kenji Harada
    Veterans Affairs Palo Alto Health Care System, Palo Alto, California 94304, USA
    Am J Physiol Endocrinol Metab 285:E1182-95. 2003
  6. ncbi Adrenal neutral cholesteryl ester hydrolase: identification, subcellular distribution, and sex differences
    Fredric B Kraemer
    Veterans Affairs Palo Alto Health Care System, Palo Alto, California 94304, USA
    Endocrinology 143:801-6. 2002
  7. ncbi Ablation of vimentin results in defective steroidogenesis
    Wen Jun Shen
    Division of Endocrinology, Gerontology, and Metabolism, Stanford University, Palo Alto, California 94304, USA
    Endocrinology 153:3249-57. 2012
  8. ncbi Hormone-sensitive lipase-knockout mice maintain high bone density during aging
    Wen Jun Shen
    Division of Endocrinology, Stanford University, Stanford, CA 94305 5103, USA
    FASEB J 25:2722-30. 2011
  9. ncbi The LDL receptor is not necessary for acute adrenal steroidogenesis in mouse adrenocortical cells
    Fredric B Kraemer
    Veterans Affairs Palo Alto Health Care System, Palo Alto, CA, USA
    Am J Physiol Endocrinol Metab 292:E408-12. 2007
  10. ncbi Differential roles of cysteine residues in the cellular trafficking, dimerization, and function of the high-density lipoprotein receptor, SR-BI
    Jie Hu
    Geriatric Research, Education and Clinical Center, VA Palo Alto Health Care System, Palo Alto, California 94304, United States
    Biochemistry 50:10860-75. 2011

Collaborators

Detail Information

Publications31

  1. ncbi Effects of rosiglitazone and high fat diet on lipase/esterase expression in adipose tissue
    Wen Jun Shen
    Division of Endocrinology, Stanford University and VA Palo Alto Health Care System, Palo Alto, CA 94304, USA
    Biochim Biophys Acta 1771:177-84. 2007
    ..In conclusion, these data highlight the complexity of the regulation of the expression of intracellular neutral lipase/esterases involved in lipolysis...
  2. ncbi Regulation of hormone-sensitive lipase in islets
    Wen Jun Shen
    Department of Medicine, Stanford University, Stanford, CA 94305, USA
    Diabetes Res Clin Pract 75:14-26. 2007
    ..Therefore, these results suggest that the beta-cell isoform of HSL is involved in maintaining lipid homeostasis in islets and contributes to the proper control of GSIS...
  3. ncbi Hormone-sensitive lipase modulates adipose metabolism through PPARγ
    Wen Jun Shen
    Division of Endocrinology, Stanford University, CA 94305 5103, USA
    Biochim Biophys Acta 1811:9-16. 2011
    ..These results suggest that one of the mechanisms by which HSL modulates adipose metabolism is by providing intrinsic ligands or pro-ligands for PPARγ...
  4. ncbi Interaction of hormone-sensitive lipase with steroidogenic acute regulatory protein: facilitation of cholesterol transfer in adrenal
    Wen Jun Shen
    Veterans Affairs Palo Alto Health Care System, Palo Alto, California 94304 1290, USA
    J Biol Chem 278:43870-6. 2003
    ..It is proposed that the interaction of HSL with StAR in cytosol increases the hydrolytic activity of HSL and that together HSL and StAR facilitate cholesterol movement from lipid droplets to mitochondria for steroidogenesis...
  5. ncbi Resistance to high-fat diet-induced obesity and altered expression of adipose-specific genes in HSL-deficient mice
    Kenji Harada
    Veterans Affairs Palo Alto Health Care System, Palo Alto, California 94304, USA
    Am J Physiol Endocrinol Metab 285:E1182-95. 2003
    ..Our results suggest that impaired lipolysis in HSL deficiency affects lipid metabolism through alterations of adipose differentiation and adipose-derived hormone levels...
  6. ncbi Adrenal neutral cholesteryl ester hydrolase: identification, subcellular distribution, and sex differences
    Fredric B Kraemer
    Veterans Affairs Palo Alto Health Care System, Palo Alto, California 94304, USA
    Endocrinology 143:801-6. 2002
    ..Thus, HSL appears to be responsible for most, if not all, of adrenal neutral CEH activity, is prominently expressed in microsomes, and its activity is influenced by sex...
  7. ncbi Ablation of vimentin results in defective steroidogenesis
    Wen Jun Shen
    Division of Endocrinology, Gerontology, and Metabolism, Stanford University, Palo Alto, California 94304, USA
    Endocrinology 153:3249-57. 2012
    ....
  8. ncbi Hormone-sensitive lipase-knockout mice maintain high bone density during aging
    Wen Jun Shen
    Division of Endocrinology, Stanford University, Stanford, CA 94305 5103, USA
    FASEB J 25:2722-30. 2011
    ..5-fold, P<0.05) and osteocalcin (4-fold, P<0.05). The absence of HSL directs cells within the bone marrow toward osteoblast differentiation and favors the maintenance of bone density with aging...
  9. ncbi The LDL receptor is not necessary for acute adrenal steroidogenesis in mouse adrenocortical cells
    Fredric B Kraemer
    Veterans Affairs Palo Alto Health Care System, Palo Alto, CA, USA
    Am J Physiol Endocrinol Metab 292:E408-12. 2007
    ..In contrast, HSL occupies a vital role in adrenal steroidogenesis because of its link to utilization of selectively delivered cholesteryl esters from lipoproteins...
  10. ncbi Differential roles of cysteine residues in the cellular trafficking, dimerization, and function of the high-density lipoprotein receptor, SR-BI
    Jie Hu
    Geriatric Research, Education and Clinical Center, VA Palo Alto Health Care System, Palo Alto, California 94304, United States
    Biochemistry 50:10860-75. 2011
    ....
  11. ncbi Hormone-sensitive lipase: control of intracellular tri-(di-)acylglycerol and cholesteryl ester hydrolysis
    Fredric B Kraemer
    Division of Endocrinology, Department of Medicine, Stanford University, Stanford, CA, USA
    J Lipid Res 43:1585-94. 2002
    ..The published reports examining the regulation, and function of HSL in normal physiology and disease are reviewed in this paper...
  12. ncbi MicroRNAs 125a and 455 repress lipoprotein-supported steroidogenesis by targeting scavenger receptor class B type I in steroidogenic cells
    ZhiGang Hu
    Geriatric Research, Education and Clinical Center, VA Palo Alto Health Care System, Palo Alto, California, USA
    Mol Cell Biol 32:5035-45. 2012
    ....
  13. ncbi Functional interaction of hormone-sensitive lipase and perilipin in lipolysis
    Wen Jun Shen
    Division of Endocrinology, Stanford University, Stanford, California 94305, USA
    J Lipid Res 50:2306-13. 2009
    ..The results suggest the translocation of HSL to the lipid droplet occurs by virtue of Plin localization to the surface of lipid droplets and a physical interaction of HSL occurring with sequences within the N-terminal region of Plin...
  14. ncbi Nordihydroguaiaretic acid improves metabolic dysregulation and aberrant hepatic lipid metabolism in mice by both PPARα-dependent and -independent pathways
    Haiyan Zhang
    Geriatric Research, Education and Clinical Center, VA Palo Alto Health Care System, Palo Alto, CA 94304, USA
    Am J Physiol Gastrointest Liver Physiol 304:G72-86. 2013
    ..However, PPARα-independent pathways also contribute to NDGA's action to ameliorate hepatic steatosis...
  15. ncbi Characterization of age-related gene expression profiling in bone marrow and epididymal adipocytes
    Li Fen Liu
    Division of Endocrinology, Stanford University, CA 94305 5103, USA
    BMC Genomics 12:212. 2011
    ..The aim of this study was to characterize and compare the age-related gene expression profiles in bone marrow adipocytes and epididymal adipocytes...
  16. ncbi Mutational analysis of the "regulatory module" of hormone-sensitive lipase
    Jining Wang
    VA Palo Alto Health Care System, Palo Alto, California, USA
    Biochemistry 44:1953-9. 2005
    ....
  17. ncbi Vimentin is a functional partner of hormone sensitive lipase and facilitates lipolysis
    Wen Jun Shen
    Division of Endocrinology, Stanford University and VA Palo Alto Health Care System, Palo Alto, California 94304, USA
    J Proteome Res 9:1786-94. 2010
    ..The current studies provide evidence that vimentin participates in lipolysis through direct, hormonally regulated interactions with HSL...
  18. ncbi LDL and cAMP cooperate to regulate the functional expression of the LRP in rat ovarian granulosa cells
    Salman Azhar
    Geriatric Research, Education, and Clinical Center, Department of Veterans Affairs Palo Alto Health Care System, Palo Alto, CA, USA
    J Lipid Res 47:2538-50. 2006
    ..In summary, our studies demonstrate a role for LRP in lipoprotein-supported ovarian granulosa cell steroidogenesis...
  19. ncbi IL-17 regulates adipogenesis, glucose homeostasis, and obesity
    Luis A Zuniga
    Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305 5324, USA
    J Immunol 185:6947-59. 2010
    ..Our findings implicate IL-17 as a negative regulator of adipogenesis and glucose metabolism in mice, and show that it delays the development of obesity...
  20. ncbi Adipocytes decrease Runx2 expression in osteoblastic cells: roles of PPARγ and adiponectin
    Li Fen Liu
    Division of Endocrinology, Stanford University, Stanford, California, USA
    J Cell Physiol 225:837-45. 2010
    ..Thus, we conclude that adipocytes modulate key metabolic functions of osteoblasts through the release of secretory products. PPARγ plays a key role in mediating the effects of adipocytes on osteoblasts...
  21. ncbi Hormone-sensitive lipase is required for high-density lipoprotein cholesteryl ester-supported adrenal steroidogenesis
    Fredric B Kraemer
    Veterans Affairs Palo Alto Health Care System, California 94304, USA
    Mol Endocrinol 18:549-57. 2004
    ..These findings suggest that HSL is functionally linked to the selective pathway and is critically involved in the intracellular processing and availability of cholesterol for adrenal steroidogenesis...
  22. ncbi Generation of novel adipocyte monolayer cultures from embryonic stem cells
    Theresa L Chen
    Veterans Affairs, Palo Alto Health Care System, Palo Alto, CA 94304, USA
    Stem Cells Dev 16:371-80. 2007
    ..The adipocytes are functionally active, as evidenced by their response to lipolytic agents, such as forskolin, Bt2-cAMP, and isoproterenol, with more than 20-fold increases in glycerol release...
  23. ncbi Cellular cholesterol delivery, intracellular processing and utilization for biosynthesis of steroid hormones
    Jie Hu
    Geriatric Research, Education and Clinical Center, VA Palo Alto Health Care System, Palo Alto, California 94304, USA
    Nutr Metab (Lond) 7:47. 2010
    ....
  24. ncbi Oxidative stress-induced inhibition of adrenal steroidogenesis requires participation of p38 mitogen-activated protein kinase signaling pathway
    Parveen Abidi
    Department of Veterans Affairs Palo Alto Health Care System, Geriatric Research, Education and Clinical Center, 3801 Miranda Avenue, Palo Alto, California 94304, USA
    J Endocrinol 198:193-207. 2008
    ..These results indicate that activated p38 MAPK mediates oxidant (excessive oxidative stress)-induced inhibition of adrenal steroidogenesis...
  25. ncbi Cardiac overexpression of hormone-sensitive lipase inhibits myocardial steatosis and fibrosis in streptozotocin diabetic mice
    Masami Ueno
    Third Department of Internal Medicine, Faculty of Medical Science, University of Fukui, Fukui, Japan
    Am J Physiol Endocrinol Metab 294:E1109-18. 2008
    ..In conclusion, since HSL overexpression inhibits cardiac steatosis and fibrosis by apparently hydrolyzing toxic lipid metabolites, cardiac HSL could be a therapeutic target for regulating diabetic cardiomyopathy...
  26. ncbi Control of adipose triglyceride lipase action by serine 517 of perilipin A globally regulates protein kinase A-stimulated lipolysis in adipocytes
    Hideaki Miyoshi
    Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts 02111, USA
    J Biol Chem 282:996-1002. 2007
    ..Thus, serine 517 is a novel "master regulator" of PKA-stimulated adipocyte lipolysis...
  27. ncbi Fatty acid-binding protein-hormone-sensitive lipase interaction. Fatty acid dependence on binding
    Anne E Jenkins-Kruchten
    Department of Biochemistry, The University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Biol Chem 278:47636-43. 2003
    ..These results suggest that binding and activation of HSL by FABPs are separate and distinct functions and that HSL contains a site for fatty acid binding that allows for FABP association...
  28. ncbi Absence of hormone-sensitive lipase inhibits obesity and adipogenesis in Lep ob/ob mice
    Motohiro Sekiya
    Departments of Metabolic Diseases and Cardiovascular Medicine, Faculty of Medicine, University of Tokyo, Tokyo 113 8655, Japan
    J Biol Chem 279:15084-90. 2004
    ..Thus, deficiency of both leptin and HSL has unmasked novel roles of HSL in adipogenesis as well as in feeding behavior...
  29. ncbi Overexpression of leptin in transgenic mice leads to decreased basal lipolysis, PKA activity, and perilipin levels
    Yaohuang Ke
    Department of Laboratory Medicine, 505 Parnassus Avenue, University of California, San Francisco, CA 94143 0134, USA
    Biochem Biophys Res Commun 312:1165-70. 2003
    ....
  30. ncbi Cardiac gene expression profile and lipid accumulation in response to starvation
    Jinya Suzuki
    Third Department of Internal Medicine, Fukui Medical University, Fukui 910 1193, Japan
    Am J Physiol Endocrinol Metab 283:E94-E102. 2002
    ..These data provide a broad perspective of the molecular events occurring physiologically in the heart in response to starvation...
  31. ncbi Function of hormone-sensitive lipase in diacylglycerol-protein kinase C pathway
    Hideo Kanehara
    Third Department of Internal Medicine, Faculty of Medical Science, University of Fukui, Fukui 910-1193, Japan
    Diabetes Res Clin Pract 65:209-15. 2004
    ....