Gary Shaw

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. ncbi request reprint Genetic variation of infant reduced folate carrier (A80G) and risk of orofacial and conotruncal heart defects
    Gary M Shaw
    March of Dimes Birth Defects Foundation, California Birth Defects Monitoring Program, Oakland, CA, USA
    Am J Epidemiol 158:747-52. 2003
  2. doi request reprint Thymidylate synthase polymorphisms and risks of human orofacial clefts
    Gary M Shaw
    Department of Pediatrics, Division of Neonatal and Developmental Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
    Birth Defects Res A Clin Mol Teratol 97:95-100. 2013
  3. doi request reprint Periconceptional intake of folic acid and food folate and risks of preterm delivery
    Gary M Shaw
    Stanford University School of Medicine, Stanford, California, USA
    Am J Perinatol 28:747-52. 2011
  4. pmc Estimated dietary phytoestrogen intake and major food sources among women during the year before pregnancy
    Suzan L Carmichael
    Department of Pediatrics, Stanford University, Stanford, CA, USA
    Nutr J 10:105. 2011
  5. pmc Genes encoding critical transcriptional activators for murine neural tube development and human spina bifida: a case-control study
    Wei Lu
    Dell Pediatric Research Institute, UT Austin, Austin, TX, USA
    BMC Med Genet 11:141. 2010
  6. pmc 118 SNPs of folate-related genes and risks of spina bifida and conotruncal heart defects
    Gary M Shaw
    Department of Pediatrics, Division of Neonatal and Developmental Medicine, Stanford University School of Medicine, Stanford, CA, USA
    BMC Med Genet 10:49. 2009
  7. doi request reprint Choline and risk of neural tube defects in a folate-fortified population
    Gary M Shaw
    Stanford University School of Medicine, Stanford, California, USA
    Epidemiology 20:714-9. 2009
  8. pmc Nested case-control study of one-carbon metabolites in mid-pregnancy and risks of cleft lip with and without cleft palate
    Gary M Shaw
    Department of Pediatrics, Stanford University School of Medicine, Palo Alto, CA, 94305, USA
    Pediatr Res 66:501-6. 2009
  9. pmc Periconceptional nutrient intakes and risks of conotruncal heart defects
    Gary M Shaw
    Stanford University School of Medicine, Stanford, California 94305, USA
    Birth Defects Res A Clin Mol Teratol 88:144-51. 2010
  10. doi request reprint Reduced risks of neural tube defects and orofacial clefts with higher diet quality
    Suzan L Carmichael
    Department of Pediatrics, Stanford University, CA 94305 5415, USA
    Arch Pediatr Adolesc Med 166:121-6. 2012

Detail Information

Publications32

  1. ncbi request reprint Genetic variation of infant reduced folate carrier (A80G) and risk of orofacial and conotruncal heart defects
    Gary M Shaw
    March of Dimes Birth Defects Foundation, California Birth Defects Monitoring Program, Oakland, CA, USA
    Am J Epidemiol 158:747-52. 2003
    ..Thus, this study found modest evidence for a gene-nutrient interaction between infant RFC1 genotype and periconceptional intake of vitamins on the risk of conotruncal defects...
  2. doi request reprint Thymidylate synthase polymorphisms and risks of human orofacial clefts
    Gary M Shaw
    Department of Pediatrics, Division of Neonatal and Developmental Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
    Birth Defects Res A Clin Mol Teratol 97:95-100. 2013
    ..We investigated effect measure modification between these variants and maternal folate intake for cleft risk...
  3. doi request reprint Periconceptional intake of folic acid and food folate and risks of preterm delivery
    Gary M Shaw
    Stanford University School of Medicine, Stanford, California, USA
    Am J Perinatol 28:747-52. 2011
    ..Findings suggest some evidence that folates influenced risks; however, an interpretation of results was also consistent with no association between intake of folates and preterm delivery...
  4. pmc Estimated dietary phytoestrogen intake and major food sources among women during the year before pregnancy
    Suzan L Carmichael
    Department of Pediatrics, Stanford University, Stanford, CA, USA
    Nutr J 10:105. 2011
    ..Recently published data on phytoestrogen content of a wide range of foods provide an opportunity to improve estimation of dietary phytoestrogen intake...
  5. pmc Genes encoding critical transcriptional activators for murine neural tube development and human spina bifida: a case-control study
    Wei Lu
    Dell Pediatric Research Institute, UT Austin, Austin, TX, USA
    BMC Med Genet 11:141. 2010
    ..Mutations in transcriptional co-activator genes-Cited2, p300, Cbp, Tfap2α, Carm1 and Cart1 result in NTDs in murine models, thus prompt us to investigate whether homologues of these genes are associated with NTDs in humans...
  6. pmc 118 SNPs of folate-related genes and risks of spina bifida and conotruncal heart defects
    Gary M Shaw
    Department of Pediatrics, Division of Neonatal and Developmental Medicine, Stanford University School of Medicine, Stanford, CA, USA
    BMC Med Genet 10:49. 2009
    ..Investigations into genetic variation that influences transport and metabolism of folate will help fill this data gap. We focused on 118 SNPs involved in folate transport and metabolism...
  7. doi request reprint Choline and risk of neural tube defects in a folate-fortified population
    Gary M Shaw
    Stanford University School of Medicine, Stanford, California, USA
    Epidemiology 20:714-9. 2009
    ..Even so, NTDs continue to occur despite individual supplementation or population fortification with folic acid. We investigated other nutrients related to one-carbon metabolism that may affect NTD risk...
  8. pmc Nested case-control study of one-carbon metabolites in mid-pregnancy and risks of cleft lip with and without cleft palate
    Gary M Shaw
    Department of Pediatrics, Stanford University School of Medicine, Palo Alto, CA, 94305, USA
    Pediatr Res 66:501-6. 2009
    ..These data did not show meaningful differences between cases and controls for any other analytes...
  9. pmc Periconceptional nutrient intakes and risks of conotruncal heart defects
    Gary M Shaw
    Stanford University School of Medicine, Stanford, California 94305, USA
    Birth Defects Res A Clin Mol Teratol 88:144-51. 2010
    ..We investigated the observed association between conotruncal heart defects and periconceptional vitamin use, as well as potential associations with other dietary nutrients...
  10. doi request reprint Reduced risks of neural tube defects and orofacial clefts with higher diet quality
    Suzan L Carmichael
    Department of Pediatrics, Stanford University, CA 94305 5415, USA
    Arch Pediatr Adolesc Med 166:121-6. 2012
    ..To examine whether better maternal diet quality was associated with reduced risk for selected birth defects...
  11. pmc Craniosynostosis and nutrient intake during pregnancy
    Suzan L Carmichael
    California Research Division, March of Dimes Foundation, Oakland, California, USA
    Birth Defects Res A Clin Mol Teratol 88:1032-9. 2010
    ..To examine the association of craniosynostosis with maternal intake of folic acid-containing supplements and dietary nutrients...
  12. ncbi request reprint Screening for novel PAX3 polymorphisms and risks of spina bifida
    Wei Lu
    Center for Environmental and Genetic Medicine, Institute of Biosciences and Technology, Texas A and M University System Health Science Center, Houston, Texas 77030, and Children s Hospital Oakland Research Institute, CA, USA
    Birth Defects Res A Clin Mol Teratol 79:45-9. 2007
    ..Mutations in the murine homologue, pax3, are responsible for the phenotype of splotch mice, in which nullizygotes are 100% penetrant for NTDs...
  13. doi request reprint Hypospadias and intake of nutrients related to one-carbon metabolism
    Suzan L Carmichael
    California Research Division, March of Dimes Foundation, Oakland, California, USA
    J Urol 181:315-21; discussion 321. 2009
    ....
  14. pmc Neural tube defects and maternal folate intake among pregnancies conceived after folic acid fortification in the United States
    Bridget S Mosley
    Department of Pediatrics, University of Arkansas for Medical Sciences and Arkansas Children s Hospital Research Institute, Little Rock, Arkansas 72202, USA
    Am J Epidemiol 169:9-17. 2009
    ..Further investigation is warranted to possibly identify women who remain at increased risk of preventable neural tube defects...
  15. pmc Prepregnant obesity and risks of selected birth defects in offspring
    Gary M Shaw
    March of Dimes, California Research Division, Children s Hospital Oakland Research Institute, Oakland, CA, USA
    Epidemiology 19:616-20. 2008
    ..We investigated the previously observed association between obesity and spina bifida and also possible associations between obesity and other birth defects...
  16. ncbi request reprint Maternal occupational chemical exposures and biotransformation genotypes as risk factors for selected congenital anomalies
    Gary M Shaw
    March of Dimes Birth Defects Foundation, California Birth Defects Monitoring Program, Oakland, CA, USA
    Am J Epidemiol 157:475-84. 2003
    ..Although potential associations were observed, most results suggested that maternal occupational chemical exposures did not contribute substantially to the occurrence of these anomalies in this California population...
  17. ncbi request reprint Maternal periconceptional alcohol consumption and risk for conotruncal heart defects
    Suzan L Carmichael
    March of Dimes Birth Defects Foundation California Department of Health Services, California Birth Defects Monitoring Program, Oakland, California, USA
    Birth Defects Res A Clin Mol Teratol 67:875-8. 2003
    ..e., 1 month before conception to 3 months after conception)...
  18. pmc VAX1 mutation associated with microphthalmia, corpus callosum agenesis, and orofacial clefting: the first description of a VAX1 phenotype in humans
    Anne M Slavotinek
    Department of Pediatrics, Division of Genetics, University of California, San Francisco, California 94143 0748, USA
    Hum Mutat 33:364-8. 2012
    ..We did not identify any mutations in VAX2. This is the first description of a phenotype associated with a VAX1 mutation in humans and establishes VAX1 as a new causative gene for A/M...
  19. ncbi request reprint Maternal corticosteroid use and orofacial clefts
    Suzan L Carmichael
    March of Dimes Foundation California Department of Health Services, California Birth Defects Monitoring Program, Berkeley, CA, USA
    Am J Obstet Gynecol 197:585.e1-7; discussion 683-4, e1-7. 2007
    ..The purpose of this study was to examine whether maternal corticosteroid use during pregnancy is associated with delivering an infant with an orofacial cleft...
  20. ncbi request reprint Dieting behaviors and risk of neural tube defects
    Suzan L Carmichael
    March of Dimes Birth Defects Foundation California Department of Health Services, California Birth Defects Monitoring Program, Oakland, CA, USA
    Am J Epidemiol 158:1127-31. 2003
    ..7, 95% confidence interval: 0.7, 10.2). This study suggests that maternal dieting behaviors involving restricted food intake during the first trimester may be associated with increased NTD risk...
  21. pmc Occurrence of low birthweight and preterm delivery among California infants before and after compulsory food fortification with folic acid
    Gary M Shaw
    March of Dimes Birth Defects Foundation, California Birth Defects Monitoring Program, Berkeley, CA, USA
    Public Health Rep 119:170-3. 2004
    ..S. The objective of this study was to investigate the frequencies of low birthweight and preterm delivery after mandatory folic acid fortification among approximately six million California births...
  22. ncbi request reprint Maternal smoking, genetic variation of glutathione s-transferases, and risk for orofacial clefts
    Edward J Lammer
    Children s Hospital Oakland Research Institute, Oakland, CA, USA
    Epidemiology 16:698-701. 2005
    ..We investigated whether risk is greater among offspring who lack the genetic capacity to produce glutathione S-transferase enzymes relevant to detoxification of chemicals in cigarette smoke...
  23. ncbi request reprint Selected gene polymorphisms and their interaction with maternal smoking, as risk factors for gastroschisis
    Claudine P Torfs
    Public Health Institute, Oakland, California, USA
    Birth Defects Res A Clin Mol Teratol 76:723-30. 2006
    ..Its etiology is unknown, but the prevailing hypothesis is that it results from a vascular accident at the time of involution of the right umbilical vein or of the development of the superior mesenteric artery...
  24. pmc Maternal stressful life events and risks of birth defects
    Suzan L Carmichael
    March of Dimes Birth Defect Foundation, California Department of Health Services, California Birth Defects Monitoring Program, Berkeley, CA, USA
    Epidemiology 18:356-61. 2007
    ..Several previous studies suggest that maternal stress may be associated with increased risk of certain birth defects. This study examined the association of maternal stressful life events with risks of several birth defects...
  25. ncbi request reprint Nutrient intakes in women and risks of anophthalmia and microphthalmia in their offspring
    Gary M Shaw
    March of Dimes Birth Defects Foundation, California Research Division, Oakland, California, USA
    Birth Defects Res A Clin Mol Teratol 79:708-13. 2007
    ..In this population-based case-control study we investigated whether periconceptional intakes of supplemental folic acid, dietary folate, vitamin A, and several other nutrients were associated with these eye defects...
  26. ncbi request reprint Congenital malformations co-occurring with hypospadias in California, 1983-1997
    Wei Yang
    March of Dimes, California Research Division, Children s Hospital Oakland Research Institute, Oakland, California, USA
    Am J Med Genet A 143:2627-34. 2007
    ..Computations were extended to 4-digit level BPA codes. Almost all observed relative risks for malformations co-occurring with hypospadias overall and three subgroups were less than 1...
  27. ncbi request reprint Hypospadias in California: trends and descriptive epidemiology
    Suzan L Carmichael
    March of Dimes Birth Defect Foundation, California Birth Defects Monitoring Program, Oakland, California, USA
    Epidemiology 14:701-6. 2003
    ..We used actively ascertained, population-based data for which detailed clinical descriptions permitted careful phenotypic classifications...
  28. ncbi request reprint Gene-environment interactions in rare diseases that include common birth defects
    John M Graham
    Medical Genetics Institute, Steven Spielberg Pediatric Research Center, Cedars Sinai Medical Center, Department of Pediatrics, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    Birth Defects Res A Clin Mol Teratol 73:865-7. 2005
    ..The specific types of birth defects examined included cardiovascular defects, holoprosencephaly, clefts of the lip and/or palate, neural tube defects, and diaphragmatic hernias...
  29. ncbi request reprint Epidemiologic characteristics of anotia and microtia in California, 1989-1997
    Gary M Shaw
    March of Dimes Birth Defects Foundation, California Birth Defects Monitoring Program, Berkeley, California, USA
    Birth Defects Res A Clin Mol Teratol 70:472-5. 2004
    ..There is a paucity of epidemiologic information about the external ear malformations anotia and microtia...
  30. ncbi request reprint Array comparative genomic hybridization in patients with congenital diaphragmatic hernia: mapping of four CDH-critical regions and sequencing of candidate genes at 15q26.1-15q26.2
    Anne M Slavotinek
    Department of Pediatrics, Division of Genetics, University of California, San Francisco, Room U585P, 533 Parnassus St, San Francisco, CA 94143 0748, USA
    Eur J Hum Genet 14:999-1008. 2006
    ..In addition, there is evidence for substantial genetic heterogeneity in CDH and diaphragmatic hernias can be non-penetrant in patients who have deletions involving CDH-critical regions...
  31. pmc Examination of FGFRL1 as a candidate gene for diaphragmatic defects at chromosome 4p16.3 shows that Fgfrl1 null mice have reduced expression of Tpm3, sarcomere genes and Lrtm1 in the diaphragm
    Nelson LopezJimenez
    Division of Genetics, Department of Pediatrics, University of California, 533 Parnassus St, Room U585P, San Francisco, CA 94143 0748, USA
    Hum Genet 127:325-36. 2010
    ..Further studies to determine if Lrtm1 has a similar function to Slit3 and if reduced Fgfrl1 expression can cause diaphragm hypoplasia through a mechanism involving decreased myoblast motility and/or myoblast fusion, seem indicated...
  32. ncbi request reprint Craniosynostosis and maternal smoking
    Suzan L Carmichael
    March of Dimes Foundation, California Research Division, Oakland, California, USA
    Birth Defects Res A Clin Mol Teratol 82:78-85. 2008
    ..Several previous studies suggested increased risk of craniosynostosis among infants born to women who smoked...

Research Grants12

  1. Gene-nutrient Etiologies of Neural Tube Defects
    Gary Shaw; Fiscal Year: 2007
    ..Because NTDs result in substantial morbidity as well as high emotional and economic costs, further scientific understanding leading to possible prevention would greatly benefit society. ..
  2. Gene-nutrient Etiologies of Neural Tube Defects
    Gary M Shaw; Fiscal Year: 2010
    ..Because NTDs result in substantial morbidity as well as high emotional and economic costs, further scientific understanding leading to possible prevention would greatly benefit society. ..
  3. FOLATE PATHWAY GENES AND RISK FOR OROFACIAL CLEFTS
    Gary Shaw; Fiscal Year: 2000
    ..abstract_text> ..
  4. Gene and Nutrient Etiologies of Human Heart Defects
    Gary M Shaw; Fiscal Year: 2010
    ..Because these defects result in substantial morbidity as well as high emotional and economic costs, further scientific understanding leading to possible prevention would greatly benefit society. ..
  5. Gene and Nutrient Etiologies of Human Heart Defects
    Gary Shaw; Fiscal Year: 2009
    ..Because these defects result in substantial morbidity as well as high emotional and economic costs, further scientific understanding leading to possible prevention would greatly benefit society. ..
  6. Gene and Nutrient Etiologies of Human Heart Defects
    Gary Shaw; Fiscal Year: 2006
    ..Because these defects result in substantial morbidity as well as high emotional and economic costs, further scientific understanding leading to possible prevention would greatly benefit society. ..
  7. Gene-nutrient Etiologies of Neural Tube Defects
    Gary Shaw; Fiscal Year: 2006
    ..Because NTDs result in substantial morbidity as well as high emotional and economic costs, further scientific understanding leading to possible prevention would greatly benefit society. ..
  8. Gene-nutrient Etiologies of Neural Tube Defects
    Gary Shaw; Fiscal Year: 2005
    ..Because NTDs result in substantial morbidity as well as high emotional and economic costs, further scientific understanding leading to possible prevention would greatly benefit society. ..
  9. FOLATE PATHWAY GENES AND RISK FOR OROFACIAL CLEFTS
    Gary Shaw; Fiscal Year: 2002
    ..abstract_text> ..
  10. FOLATE PATHWAY GENES AND RISK FOR OROFACIAL CLEFTS
    Gary Shaw; Fiscal Year: 2001
    ..abstract_text> ..