George L Sen

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. pmc Control of differentiation in a self-renewing mammalian tissue by the histone demethylase JMJD3
    George L Sen
    VA Palo Alto Health Care System, Palo Alto, California 94305, USA
    Genes Dev 22:1865-70. 2008
  2. ncbi request reprint A brief history of RNAi: the silence of the genes
    George L Sen
    Department of Molecular Pharmacology, Baxter Laboratory in Genetic Pharmacology, 269 Campus Dr, CCSR 4225A, Stanford University School of Medicine, Stanford, California 94305, USA
    FASEB J 20:1293-9. 2006
  3. pmc DNMT1 maintains progenitor function in self-renewing somatic tissue
    George L Sen
    Programs in Epithelial Biology and Cancer Biology and the Stanford Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, California 94305, USA
    Nature 463:563-7. 2010
  4. pmc Genomic profiling of a human organotypic model of AEC syndrome reveals ZNF750 as an essential downstream target of mutant TP63
    Brian J Zarnegar
    Program in Epithelial Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Am J Hum Genet 91:435-43. 2012
  5. ncbi request reprint Argonaute 2/RISC resides in sites of mammalian mRNA decay known as cytoplasmic bodies
    George L Sen
    Department of Molecular Pharmacology, 269 Campus Drive, CCSR 4225A, Stanford University School of Medicine, Stanford, CA 94305, USA
    Nat Cell Biol 7:633-6. 2005
  6. ncbi request reprint mRNA translation is not a prerequisite for small interfering RNA-mediated mRNA cleavage
    George L Sen
    Department of Molecular Pharmacology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Differentiation 73:287-93. 2005

Collaborators

  • David R Berk
  • Brian J Zarnegar
  • Paul A Khavari
  • Dan E Webster
  • Karen J Yan
  • Kun Qu
  • Brook Vander Stoep Hunt
  • Vanessa Lopez-Pajares

Detail Information

Publications6

  1. pmc Control of differentiation in a self-renewing mammalian tissue by the histone demethylase JMJD3
    George L Sen
    VA Palo Alto Health Care System, Palo Alto, California 94305, USA
    Genes Dev 22:1865-70. 2008
    ..Within epidermal tissue, JMJD3 depletion blocked differentiation, while active JMJD3 dominantly induced it. These results indicate that epigenetic derepression by JMJD3 controls mammalian epidermal differentiation...
  2. ncbi request reprint A brief history of RNAi: the silence of the genes
    George L Sen
    Department of Molecular Pharmacology, Baxter Laboratory in Genetic Pharmacology, 269 Campus Dr, CCSR 4225A, Stanford University School of Medicine, Stanford, California 94305, USA
    FASEB J 20:1293-9. 2006
    ..Behind this remarkable pathway is an intricate network of proteins that ensures the degradation of the target mRNA. In this review, we explore the history of RNAi as well as highlighting recent discoveries...
  3. pmc DNMT1 maintains progenitor function in self-renewing somatic tissue
    George L Sen
    Programs in Epithelial Biology and Cancer Biology and the Stanford Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, California 94305, USA
    Nature 463:563-7. 2010
    ..These data demonstrate that proteins involved in the dynamic regulation of DNA methylation patterns are required for progenitor maintenance and self-renewal in mammalian somatic tissue...
  4. pmc Genomic profiling of a human organotypic model of AEC syndrome reveals ZNF750 as an essential downstream target of mutant TP63
    Brian J Zarnegar
    Program in Epithelial Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Am J Hum Genet 91:435-43. 2012
    ..Incorporating disease-causing mutants into regenerated human tissue can thus dissect pathomechanisms and identify targets that reverse disease features...
  5. ncbi request reprint Argonaute 2/RISC resides in sites of mammalian mRNA decay known as cytoplasmic bodies
    George L Sen
    Department of Molecular Pharmacology, 269 Campus Drive, CCSR 4225A, Stanford University School of Medicine, Stanford, CA 94305, USA
    Nat Cell Biol 7:633-6. 2005
    ..In addition, Argonaute 1, another Argonaute family member, is concentrated in cytoplasmic bodies. These results provide new insight into the mechanism of RNAi function...
  6. ncbi request reprint mRNA translation is not a prerequisite for small interfering RNA-mediated mRNA cleavage
    George L Sen
    Department of Molecular Pharmacology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Differentiation 73:287-93. 2005
    ..Our results show that mRNA degradation by siRNAs is not dependent on mRNA translation...