George L Sen
Affiliation: Stanford University
- Control of differentiation in a self-renewing mammalian tissue by the histone demethylase JMJD3George L Sen
VA Palo Alto Health Care System, Palo Alto, California 94305, USA
Genes Dev 22:1865-70. 2008..Within epidermal tissue, JMJD3 depletion blocked differentiation, while active JMJD3 dominantly induced it. These results indicate that epigenetic derepression by JMJD3 controls mammalian epidermal differentiation...
- A brief history of RNAi: the silence of the genesGeorge L Sen
Department of Molecular Pharmacology, Baxter Laboratory in Genetic Pharmacology, 269 Campus Dr, CCSR 4225A, Stanford University School of Medicine, Stanford, California 94305, USA
FASEB J 20:1293-9. 2006..Behind this remarkable pathway is an intricate network of proteins that ensures the degradation of the target mRNA. In this review, we explore the history of RNAi as well as highlighting recent discoveries...
- DNMT1 maintains progenitor function in self-renewing somatic tissueGeorge L Sen
Programs in Epithelial Biology and Cancer Biology and the Stanford Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, California 94305, USA
Nature 463:563-7. 2010..These data demonstrate that proteins involved in the dynamic regulation of DNA methylation patterns are required for progenitor maintenance and self-renewal in mammalian somatic tissue...
- Genomic profiling of a human organotypic model of AEC syndrome reveals ZNF750 as an essential downstream target of mutant TP63Brian J Zarnegar
Program in Epithelial Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
Am J Hum Genet 91:435-43. 2012..Incorporating disease-causing mutants into regenerated human tissue can thus dissect pathomechanisms and identify targets that reverse disease features...
- Argonaute 2/RISC resides in sites of mammalian mRNA decay known as cytoplasmic bodiesGeorge L Sen
Department of Molecular Pharmacology, 269 Campus Drive, CCSR 4225A, Stanford University School of Medicine, Stanford, CA 94305, USA
Nat Cell Biol 7:633-6. 2005..In addition, Argonaute 1, another Argonaute family member, is concentrated in cytoplasmic bodies. These results provide new insight into the mechanism of RNAi function...
- mRNA translation is not a prerequisite for small interfering RNA-mediated mRNA cleavageGeorge L Sen
Department of Molecular Pharmacology, Stanford University School of Medicine, Stanford, CA 94305, USA
Differentiation 73:287-93. 2005..Our results show that mRNA degradation by siRNAs is not dependent on mRNA translation...