Matthew P Scott
Affiliation: Stanford University
- Gene expression during the life cycle of Drosophila melanogasterMichelle N Arbeitman
Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA
Science 297:2270-5. 2002....
- Obituary: Edward B. Lewis (1918-2004)Matthew P Scott
Matthew P Scott is in the Departments of Developmental Biology, Genetics and Bioengineering, Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, California 94305 5439, USA E mail
Nature 431:143. 2004
- Developmental genomics of the most dangerous animalMatthew P Scott
Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305 5439, USA
Proc Natl Acad Sci U S A 104:11865-6. 2007
- Patching the gaps in Hedgehog signallingRajat Rohatgi
Department of Developmental Biology, Howard Hughes Medical Institute, Clark Center West W252, 318 Campus Drive, Stanford University School of Medicine, Stanford, CA 94305 5439, USA
Nat Cell Biol 9:1005-9. 2007....
- Assessing the conservation of mammalian gene expression using high-density exon arraysYi Xing
Mol Biol Evol 24:1283-5. 2007..Our analysis provides strong evidence for widespread stabilizing selection pressure on transcript abundance during mammalian evolution...
- Automated MEMS-based Drosophila embryo injection system for high-throughput RNAi screensStefan Zappe
E L Ginzton Lab, Stanford University, Stanford, CA 94305 4085, USA
Lab Chip 6:1012-9. 2006..01 microM. Almost 80% of the injected embryos expressed an expected strong loss-of-function phenotype. Our system can replace current manual injection technologies and will support systematic identification of Drosophila gene functions...
- A Drosophila model of the Niemann-Pick type C lysosome storage disease: dnpc1a is required for molting and sterol homeostasisXun Huang
Departments of Developmental Biology, Genetics, and Bioengineering, Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305 5439, USA
Development 132:5115-24. 2005..We propose that dnpc1a mutants have sterols trapped in aberrant organelles, leading to a shortage of sterol in the endoplasmic reticulum and/or mitochondria of ring gland cells, and, consequently, inadequate ecdysone synthesis...
- Communicating with HedgehogsJoan E Hooper
Department of Cell and Developmental Biology, University of Colorado School of Medicine, 12801 East 17th Avenue, Box 8018, Aurora, Colorado 80045, USA
Nat Rev Mol Cell Biol 6:306-17. 2005..The cellular machinery that is responsible for the unique molecular mechanisms of Hh signal transduction has been largely conserved during metazoan evolution...
- A genome-wide study of gene activity reveals developmental signaling pathways in the preimplantation mouse embryoQ Tian Wang
Department of Biochemistry and Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305, USA
Dev Cell 6:133-44. 2004..Overall, these data provide a detailed temporal profile of gene expression that reveals the richness of signaling processes in early mammalian development...
- Notch and Ras signaling pathway effector genes expressed in fusion competent and founder cells during Drosophila myogenesisRuben Artero
Developmental Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
Development 130:6257-72. 2003..Whereas genes such as phyllopod play a crucial role during specification of particular muscles, others such as tartan are necessary for normal muscle morphogenesis...
- Transcriptional profiling of the Sonic hedgehog response: a critical role for N-myc in proliferation of neuronal precursorsTrudy G Oliver
Department of Pharmacology and Cancer Biology and Bioinformatics Shared Resource, Duke University Medical Center, Durham, NC 27710, USA
Proc Natl Acad Sci U S A 100:7331-6. 2003..Finally, cyclin D1 and N-myc are overexpressed in murine medulloblastoma. These findings suggest that cyclin D1 and N-myc are important mediators of Shh-induced proliferation and tumorigenesis...
- Drosophila Niemann-Pick type C-2 genes control sterol homeostasis and steroid biosynthesis: a model of human neurodegenerative diseaseXun Huang
Department of Developmental Biology, Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305 5439, USA
Development 134:3733-42. 2007..Moreover, npc2a; npc2b double mutants undergo apoptotic neurodegeneration, thus constituting a new fly model of human neurodegenerative disease...