Alan Schatzberg

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. ncbi request reprint Introduction: treating depression and anxiety to remission
    Alan F Schatzberg
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, Calif 94305 55717, USA
    J Clin Psychiatry 64:3-4. 2003
  2. doi request reprint Tachyphylaxis after repeated antidepressant drug exposure in patients with recurrent major depressive disorder
    Jay D Amsterdam
    Depression Research Unit, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 3309, USA
    Neuropsychobiology 59:227-33. 2009
  3. pmc International Study to Predict Optimized Treatment for Depression (iSPOT-D), a randomized clinical trial: rationale and protocol
    Leanne M Williams
    BRAINnet Foundation, 71 Stephenson Street, Suite 400, San Francisco, CA, 94105, USA
    Trials 12:4. 2011
  4. doi request reprint Glucocorticoid antagonists in neuropsychiatric [corrected] disorders
    Alan F Schatzberg
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, United States
    Eur J Pharmacol 583:358-64. 2008
  5. ncbi request reprint The relationship of chronic pain and depression
    Alan F Schatzberg
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto 94305 5717, USA
    J Clin Psychiatry 65:3-4. 2004
  6. ncbi request reprint Chronic depression: medication (nefazodone) or psychotherapy (CBASP) is effective when the other is not
    Alan F Schatzberg
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305 5717, USA
    Arch Gen Psychiatry 62:513-20. 2005
  7. ncbi request reprint Antidepressant discontinuation syndrome: consensus panel recommendations for clinical management and additional research
    Alan F Schatzberg
    Stanford University School of Medicine, Stanford, Calif 94305 5717, USA
    J Clin Psychiatry 67:27-30. 2006
  8. ncbi request reprint Pharmacologic treatments of major depression: are two mechanisms really better than one?
    Alan F Schatzberg
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, Calif 94305 5717, USA
    J Clin Psychiatry 65:3-4. 2004
  9. ncbi request reprint Efficacy and tolerability of duloxetine, a novel dual reuptake inhibitor, in the treatment of major depressive disorder
    Alan F Schatzberg
    Department of Psychiatry, Stanford University School of Medicine, Stanford, CA 94305 5717, USA
    J Clin Psychiatry 64:30-7. 2003
  10. ncbi request reprint Clinical use of nefazodone in major depression: a 6-year perspective
    Alan F Schatzberg
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Calif 94305 5717, USA
    J Clin Psychiatry 63:18-31. 2002

Research Grants

  1. MODEL OF HYPERCORTISOLISM FOR MAJOR DEPRESSIONS
    Alan Schatzberg; Fiscal Year: 2004
  2. MODEL OF HYPERCORTISOLISM FOR MAJOR DEPRESSION
    Alan Schatzberg; Fiscal Year: 2007
  3. HPA AXIS/DOPAMINE INTERACTIONS IN PSYCHOTIC DEPRESSION
    Alan Schatzberg; Fiscal Year: 2007
  4. REVAMP-Follow-Up Study
    Alan Schatzberg; Fiscal Year: 2007
  5. A BIOBEHAVIORAL RESEARCH TRAINING PROGRAM
    Alan Schatzberg; Fiscal Year: 2007
  6. HPA AXIS/DOPAMINE INTERACTIONS IN PSYCHOTIC DEPRESSION
    Alan Schatzberg; Fiscal Year: 2009
  7. HPA AXIS/DOPAMINE INTERACTIONS IN PSYCHOTIC DEPRESSION
    Alan Schatzberg; Fiscal Year: 2003
  8. MODEL OF HYPERCORTISOLISM FOR MAJOR DEPRESSIONS
    Alan Schatzberg; Fiscal Year: 1999
  9. MODEL OF HYPERCORTISOLISM FOR MAJOR DEPRESSION
    Alan F Schatzberg; Fiscal Year: 2010

Collaborators

Detail Information

Publications91

  1. ncbi request reprint Introduction: treating depression and anxiety to remission
    Alan F Schatzberg
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, Calif 94305 55717, USA
    J Clin Psychiatry 64:3-4. 2003
  2. doi request reprint Tachyphylaxis after repeated antidepressant drug exposure in patients with recurrent major depressive disorder
    Jay D Amsterdam
    Depression Research Unit, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 3309, USA
    Neuropsychobiology 59:227-33. 2009
    ..The aim of this post hoc analysis was to examine whether tachyphylaxis occurs after repeated courses of antidepressant drug therapy...
  3. pmc International Study to Predict Optimized Treatment for Depression (iSPOT-D), a randomized clinical trial: rationale and protocol
    Leanne M Williams
    BRAINnet Foundation, 71 Stephenson Street, Suite 400, San Francisco, CA, 94105, USA
    Trials 12:4. 2011
    ..The aim of iSPOT-D is to identify pretreatment measures that predict or moderate MDD treatment response or remission to escitalopram, sertraline or venlafaxine; and develop a model that incorporates multiple predictors and moderators...
  4. doi request reprint Glucocorticoid antagonists in neuropsychiatric [corrected] disorders
    Alan F Schatzberg
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, United States
    Eur J Pharmacol 583:358-64. 2008
    ..g., Alzheimer's disease and mild cognitive impairment), cognitive side effects of electroconvulsive therapy, and weight gain with atypical antipsychotic agents. Potential benefits and limitations are discussed...
  5. ncbi request reprint The relationship of chronic pain and depression
    Alan F Schatzberg
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto 94305 5717, USA
    J Clin Psychiatry 65:3-4. 2004
  6. ncbi request reprint Chronic depression: medication (nefazodone) or psychotherapy (CBASP) is effective when the other is not
    Alan F Schatzberg
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305 5717, USA
    Arch Gen Psychiatry 62:513-20. 2005
    ..Although various strategies are available to manage nonresponders to an initial treatment for depression, no controlled trials address the utility of switching from an antidepressant medication to psychotherapy or vice versa...
  7. ncbi request reprint Antidepressant discontinuation syndrome: consensus panel recommendations for clinical management and additional research
    Alan F Schatzberg
    Stanford University School of Medicine, Stanford, Calif 94305 5717, USA
    J Clin Psychiatry 67:27-30. 2006
    ..This article summarizes recommendations with respect to future research as well as clinical management recommendations for SRI discontinuation syndrome...
  8. ncbi request reprint Pharmacologic treatments of major depression: are two mechanisms really better than one?
    Alan F Schatzberg
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, Calif 94305 5717, USA
    J Clin Psychiatry 65:3-4. 2004
  9. ncbi request reprint Efficacy and tolerability of duloxetine, a novel dual reuptake inhibitor, in the treatment of major depressive disorder
    Alan F Schatzberg
    Department of Psychiatry, Stanford University School of Medicine, Stanford, CA 94305 5717, USA
    J Clin Psychiatry 64:30-7. 2003
    ..The continued presence of such symptoms may predict relapse. Accordingly, it is hoped that duloxetine therapy may reduce the likelihood of depressive relapse...
  10. ncbi request reprint Clinical use of nefazodone in major depression: a 6-year perspective
    Alan F Schatzberg
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Calif 94305 5717, USA
    J Clin Psychiatry 63:18-31. 2002
  11. ncbi request reprint New approaches to managing psychotic depression
    Alan F Schatzberg
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, CA 94305 5717, USA
    J Clin Psychiatry 64:19-23. 2003
    ..This article focuses on recognizing the features of psychotic depression, the success of current treatment options, and new treatments under investigation...
  12. ncbi request reprint The apolipoprotein E epsilon4 allele and antidepressant efficacy in cognitively intact elderly depressed patients
    Greer M Murphy
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California 94305, USA
    Biol Psychiatry 54:665-73. 2003
    ..We hypothesized that epsilon4 carriers would show impaired antidepressant response...
  13. ncbi request reprint Differential effects of nefazodone and cognitive behavioral analysis system of psychotherapy on insomnia associated with chronic forms of major depression
    Michael E Thase
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, PA 15213 2593, USA
    J Clin Psychiatry 63:493-500. 2002
    ..As nefazodone-mediated blockade of serotonin-2 receptors may directly relieve insomnia associated with depression, we examined the more specific effects of CBASP and nefazodone, singly and in combination, on sleep disturbances...
  14. ncbi request reprint HPA axis activation in major depression and response to fluoxetine: a pilot study
    Elizabeth A Young
    Department of Psychiatry, The Mental Health Research Institute, University of Michigan, 205 Zina Pitcher Place, Ann Arbor, MI 48109 0729, USA
    Psychoneuroendocrinology 29:1198-204. 2004
    ..This may reflect the greater severity of subjects with HPA axis dysregulation or the need to normalize the HPA axis with medications for optimal response...
  15. pmc Cognitive behavioral analysis system of psychotherapy and brief supportive psychotherapy for augmentation of antidepressant nonresponse in chronic depression: the REVAMP Trial
    James H Kocsis
    Department of Psychiatry, Weill Cornell Medical College, 1300 York Ave, New York, NY 10065, USA
    Arch Gen Psychiatry 66:1178-88. 2009
    ..Previous studies have found that few chronically depressed patients remit with antidepressant medications alone...
  16. ncbi request reprint Double-blind, randomized comparison of mirtazapine and paroxetine in elderly depressed patients
    Alan F Schatzberg
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 401 Quarry Road, Rm 300, Stanford, CA 94305 5548, USA
    Am J Geriatr Psychiatry 10:541-50. 2002
    ..Authors studied the efficacy and tolerability of mirtazapine and paroxetine in elderly patients with major depression during an acute phase (8 weeks) and an extension phase (16 weeks)...
  17. ncbi request reprint Effects of the serotonin transporter gene promoter polymorphism on mirtazapine and paroxetine efficacy and adverse events in geriatric major depression
    Greer M Murphy
    Neuroscience Research Laboratories, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, Calif, USA
    Arch Gen Psychiatry 61:1163-9. 2004
    ..Some but not all studies have found that the short form of 5HTTLPR (S allele) results in decreased efficacy of selective serotonin reuptake inhibitors...
  18. ncbi request reprint A double-blind, randomized study of olanzapine and olanzapine/fluoxetine combination for major depression with psychotic features
    Anthony J Rothschild
    Department of Psychiatry, University of Massachusetts Medical School, Worcester, MA 01605, USA
    J Clin Psychopharmacol 24:365-73. 2004
    ....
  19. doi request reprint Genetic polymorphisms in the treatment of depression: speculations from an augmentation study using atomoxetine
    Frederick Reimherr
    Department of Psychiatry, University of Utah Health Sciences Center, Salt Lake City, UT 84132, USA
    Psychiatry Res 175:67-73. 2010
    ..Although this study is speculative, it represents a pharmacologically and genotypically well-defined patient population...
  20. ncbi request reprint A double-blind, placebo-controlled study of venlafaxine and fluoxetine in geriatric outpatients with major depression
    Alan Schatzberg
    Stanford University School of Medicine, Stanford, CA 94605 5548, USA
    Am J Geriatr Psychiatry 14:361-70. 2006
    ..This masked, placebo-controlled trial assessed the efficacy and safety of venlafaxine and fluoxetine in depressed patients older than 65 years...
  21. ncbi request reprint Employing pharmacologic treatment of bipolar disorder to greatest effect
    Alan F Schatzberg
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305 6811, USA
    J Clin Psychiatry 65:15-20. 2004
    ..Lamotrigine stabilizes mood by reducing depression. The atypical anti-psychotics have been shown to be effective either as monotherapy or in combination with mood stabilizers...
  22. ncbi request reprint Does psychosocial functioning improve independent of depressive symptoms? A comparison of nefazodone, psychotherapy, and their combination
    Robert M A Hirschfeld
    Department of Psychiatry and Behavioral Sciences, University of Texas Medical Branch, Galveston, Texas 77555 0188, USA
    Biol Psychiatry 51:123-33. 2002
    ..This study compared efficacy of nefazodone, psychotherapy, and their combination in improving psychosocial functioning in chronically depressed outpatients...
  23. ncbi request reprint Monoamine oxidase and catechol-o-methyltransferase enzyme activity and gene expression in response to sustained glucocorticoids
    Steven E Lindley
    Department of Psychiatry, Veterans Affairs Palo Alto Health Care System, CA 94304, USA
    Psychoneuroendocrinology 30:785-90. 2005
    ..The results do not support inhibition of DA metabolism as a mechanism by which glucocorticoids influence DA-mediated behaviors...
  24. ncbi request reprint Prevention of recurrent episodes of depression with venlafaxine ER in a 1-year maintenance phase from the PREVENT Study
    James H Kocsis
    Department of Psychiatry, Weill Cornell Medical College, New York, NY 10012, USA
    J Clin Psychiatry 68:1014-23. 2007
    ..To test the long-term efficacy and safety of venlafaxine extended-release (ER) in preventing recurrence in patients with major depression...
  25. doi request reprint A pilot study of the phase angle between cortisol and melatonin in major depression - a potential biomarker?
    Theresa M Buckley
    Dept of Psychiatry and Behavioral Sciences, Stanford University Medical School, 401 Quarry Road, Stanford, CA 94305 5730, United States
    J Psychiatr Res 44:69-74. 2010
    ..In this pilot study, we link cortisol and melatonin rhythms and propose that the phase angle between cortisol acrophase (CA) and dim-light melatonin onset (20 pg/ml) (DLMO-20) may yield a useful state specific biomarker for MDD...
  26. ncbi request reprint New paradigm for treating recurrent depression: from symptom control to managing enduring vulnerabilities
    Alan F Schatzberg
    Stanford University School of Medicine, CA 94605 5548, USA
    CNS Spectr 11:22-7. 2006
    ..A new treatment paradigm, which focuses on identifying patients with risk factors and managing the disease process rather than suppression of symptoms, is needed for recurrent depression...
  27. doi request reprint Rosiglitazone add-on in treatment of depressed patients with insulin resistance: a pilot study
    Natalie L Rasgon
    Stanford Center for Neuroscience in Women s Health, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, USA
    ScientificWorldJournal 10:321-8. 2010
    ..These results suggest the potential novel use for an insulin-sensitizing agent in the treatment of depressive disorders. Larger placebo-controlled studies are warranted...
  28. ncbi request reprint Extended treatment with bupropion SR for cigarette smoking cessation
    Joel D Killen
    Stanford University School of Medicine, Stanford, CA 94305 5705, USA
    J Consult Clin Psychol 74:286-94. 2006
    ..001; week 25: 48% vs. 31%, p = .001; week 52: 39% vs. 27%, p = .01). Because most smokers suffer relapse with any current cessation treatment, the comparatively high abstinence percentages achieved in this trial are of interest...
  29. ncbi request reprint Using treatment process data to predict maintained smoking abstinence
    Steffani R Bailey
    Stanford University School of Medicine, Stanford Prevention Research Center, 1070 Arastradero Road, Palo Alto, CA 94304 1334, USA
    Am J Health Behav 34:801-10. 2010
    ..To identify distinct subgroups of treatment responders and nonresponders to aid in the development of tailored smoking-cessation interventions for long-term maintenance using signal detection analysis (SDA)...
  30. doi request reprint Aberrant brain activation during a working memory task in psychotic major depression
    Amy Garrett
    Center for Interdisciplinary Brain Sciences Research, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, USA
    Am J Psychiatry 168:173-82. 2011
    ..The authors sought to better understand the neural circuitry associated with working memory deficits in psychotic major depression by examining brain function during an N-back task...
  31. doi request reprint Effects of major depression diagnosis and cortisol levels on indices of neurocognitive function
    Rowena G Gomez
    Pacific Graduate School of Psychology, 405 Broadway, Redwood City, CA 94063, USA
    Psychoneuroendocrinology 34:1012-8. 2009
    ..Our study suggests that cortisol has an independent effect on verbal memory. Also, our study produced evidence of an interaction between diagnosis and cortisol on response inhibition...
  32. ncbi request reprint The neuropsychological profile of psychotic major depression and its relation to cortisol
    Rowena G Gomez
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305 5723, USA
    Biol Psychiatry 60:472-8. 2006
    ..We predicted that higher cortisol levels would be associated with greater cognitive deficits...
  33. pmc Maternal mediation, stress inoculation, and the development of neuroendocrine stress resistance in primates
    Karen J Parker
    Department of Psychiatry and Behavioral Sciences, Stanford University, 1201 Welch Road, MSLS P104, Stanford, CA 94305 5485, USA
    Proc Natl Acad Sci U S A 103:3000-5. 2006
    ..Results from both experiments demonstrate that stress inoculation, rather than high levels of maternal care, promotes the development of primate stress resistance...
  34. pmc Animal models of early life stress: Implications for understanding resilience
    David M Lyons
    Department of Psychiatry and Behavioral Sciences, Stanford University, 1201 Welch Rd, MSLS P104, Stanford, CA 94305, USA
    Dev Psychobiol 52:402-10. 2010
    ..Implications for programs designed to enhance resilience in human development are discussed...
  35. doi request reprint Chronic pain and major depressive disorder in the general population
    Maurice M Ohayon
    Department of Psychiatry and Behavioral Sciences, School of Medicine, Stanford University, Stanford, CA 94303, USA
    J Psychiatr Res 44:454-61. 2010
    ..It deteriorates physical, occupational and socio-professional activities. Pain and sleep disturbances are a prime motive of consultation rather than depressed mood, underlining the risk of missing a depression diagnosis...
  36. pmc Current issues in the classification of psychotic major depression
    Jennifer Keller
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305 5723, USA
    Schizophr Bull 33:877-85. 2007
    ..We then propose some improvements to the current unipolar major depression categorization system. Finally, we identify important issues in need of further research to help elucidate the subtype of unipolar PMD...
  37. pmc Hippocampal and amygdalar volumes in psychotic and nonpsychotic unipolar depression
    Jennifer Keller
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 401 Quarry Rd, Stanford, CA 94305 5723, USA
    Am J Psychiatry 165:872-80. 2008
    ..The purpose of the present study was to examine differences in hippocampal and amygdalar volumes in patients with depression subtypes relative to healthy comparison subjects...
  38. doi request reprint In search of moderators and mediators of hyperglycemia with atypical antipsychotic treatment
    Gerald M Reaven
    Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Psychiatr Res 43:997-1002. 2009
    ..These findings provide a quantitative approach to identify those at greatest treatment-associated risk to develop glucose intolerance, and emphasize the need to address co-morbid medical disorders in these patients...
  39. pmc Withdrawal symptoms over time among adolescents in a smoking cessation intervention: do symptoms vary by level of nicotine dependence?
    Steffani R Bailey
    Stanford University School of Medicine, Stanford Prevention Research Center, Suite 300, Palo Alto, CA 94304 1334, USA
    Addict Behav 34:1017-22. 2009
    ..Craving was rated as the most problematic symptom at the baseline assessment. The results of this study may help guide the development of future research on diagnostic and cessation treatment strategies for teens...
  40. doi request reprint Extended cognitive behavior therapy for cigarette smoking cessation
    Joel D Killen
    Stanford University School of Medicine, Stanford, CA 94305 5705, USA
    Addiction 103:1381-90. 2008
    ..PRIMARY AIM: Examine the effectiveness of extended cognitive behavior therapy (CBT) in promoting longer-term smoking abstinence...
  41. pmc FKBP5 polymorphisms and antidepressant response in geriatric depression
    Jane E Sarginson
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305 5485, USA
    Am J Med Genet B Neuropsychiatr Genet 153:554-60. 2010
    ..These results suggest that FKBP5 is unlikely to play a major role in determining antidepressant treatment outcomes in geriatric patients...
  42. doi request reprint Disrupted amygdalar subregion functional connectivity and evidence of a compensatory network in generalized anxiety disorder
    Amit Etkin
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA
    Arch Gen Psychiatry 66:1361-72. 2009
    ..A functional connectivity approach at the subregional level may therefore yield novel insights into GAD...
  43. ncbi request reprint The acute effects of a mineralocorticoid receptor (MR) agonist on nocturnal hypothalamic-adrenal-pituitary (HPA) axis activity in healthy controls
    Theresa M Buckley
    Department of Psychiatry and Behavioral Sciences, Stanford University Medical School, CA 94301, USA
    Psychoneuroendocrinology 32:859-64. 2007
    ..Herein, we propose that an MR agonist may inhibit the HPA axis without first "unloading" receptors of endogenous cortisol...
  44. pmc Preliminary evidence that hippocampal volumes in monkeys predict stress levels of adrenocorticotropic hormone
    David M Lyons
    Department of Psychiatry and Behavioral Sciences, Stanford University Medical Center, Stanford, California 94305 5485, USA
    Biol Psychiatry 62:1171-4. 2007
    ..Hippocampal volumes previously determined in monkeys by magnetic resonance imaging are used to test the hypothesis that small hippocampi predict increased stress levels of adrenocorticotropic hormone (ACTH)...
  45. ncbi request reprint Cortisol circadian rhythm alterations in psychotic major depression
    Jennifer Keller
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California 94305 5723, USA
    Biol Psychiatry 60:275-81. 2006
    ..There are limited data on cortisol levels during specific times of the day...
  46. ncbi request reprint From clinical research to clinical practice: a 4-year review of ziprasidone
    Charles B Nemeroff
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 101 Woodruff Circle, Atlanta, GA 30322, USA
    CNS Spectr 10:1-20. 2005
    ..This monograph summarizes the efficacy, tolerability, and safety of oral ziprasidone in the treatment of schizophrenia, schizoaffective disorder, and bipolar mania...
  47. ncbi request reprint Relating semantic and episodic memory systems
    Vinod Menon
    Department of Psychiatry and Behavioral Sciences, 401 Quarry Road, Stanford University School of Medicine, Stanford, CA 94305 5719, USA
    Brain Res Cogn Brain Res 13:261-5. 2002
    ..Here we provide direct evidence for a functional relationship between these two memory systems by showing that left lateral temporal lobe regions involved in semantic memory play an important role in accurate episodic memory retrieval...
  48. ncbi request reprint Neuroendocrine aspects of hypercortisolism in major depression
    Karen J Parker
    Department of Psychiatry and Behavioral Sciences, Stanford University Medical School, 1201 Welch Road, MSLS Room P104, Mail Code 5485, Stanford, CA 94305 5485, USA
    Horm Behav 43:60-6. 2003
    ..In considering the evidence for hypercortisolism in humans, studies of nonhuman primates are presented and their utility and limitations as comparative models of human depression are discussed...
  49. ncbi request reprint Cognitive correlates of white matter growth and stress hormones in female squirrel monkey adults
    David M Lyons
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California 94305 5485, USA
    J Neurosci 24:3655-62. 2004
    ....
  50. ncbi request reprint Neuropsychological correlates of psychotic features in major depressive disorders: a review and meta-analysis
    Shelley K Fleming
    Department of Psychiatry and Behavioral Science, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Psychiatr Res 38:27-35. 2004
    ..This review also provides a summary model of the pathophysiology of PMD to provide the necessary context to understanding the biological mechanisms of these impairments...
  51. ncbi request reprint Pharmacogenetics of antidepressant medication intolerance
    Greer M Murphy
    Neruroscience Research Laboratories Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford CA 94305 5548, USA
    Am J Psychiatry 160:1830-5. 2003
    ..However, variation in genes encoding serotonin receptors could also explain antidepressant side effects (pharmacodynamic effect)...
  52. ncbi request reprint Early maternal availability and prefrontal correlates of reward-related memory
    David M Lyons
    Department of Psychiatry and Behavioral Science, Stanford University Medical School, Stanford, CA 94305 5485, USA
    Neurobiol Learn Mem 80:97-104. 2003
    ..Differences in performance were also discerned after each spatial reversal. These findings indicate that maternal availability alters developing ventral medial prefrontal brain regions involved in reward-related memory...
  53. ncbi request reprint Regional analysis of hippocampal activation during memory encoding and retrieval: fMRI study
    Michael D Greicius
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California 94305 5719, USA
    Hippocampus 13:164-74. 2003
    ..Finally, this study is the first to quantify the effects of susceptibility-induced signal loss on hippocampal activation and suggests that this artifact has significantly biased the interpretation of earlier fMRI studies...
  54. doi request reprint Social phobia and depression: prevalence and comorbidity
    Maurice M Ohayon
    Stanford Sleep Epidemiology Research Center, School of Medicine, Stanford University, Stanford, CA 94303, USA
    J Psychosom Res 68:235-43. 2010
    ..Social phobia may seriously impair the functioning of affected individuals. It is frequently associated with other mental disorders...
  55. ncbi request reprint Mesotelencephalic dopamine neurochemical responses to glucocorticoid administration and adrenalectomy in Fischer 344 and Lewis rats
    Steven E Lindley
    National Center for PTSD, Department of Veterans Affairs, Palo Alto Health Care Systema, PTSD 352 117, 795 Willow Road, Menlo Park, CA 94025, USA
    Brain Res 958:414-22. 2002
    ..The findings indicate a pattern of changes in neurochemical measurements consistent with a small magnitude inhibition of basal dopamine metabolism, but not with a change neuronal activity, release or reuptake...
  56. ncbi request reprint Prevalence of depressive episodes with psychotic features in the general population
    Maurice M Ohayon
    Department of Psychiatry and Behavioral Sciences, School of Medicine, Stanford University, Stanford Sleep Epidemiology Research Center, 401 Quarry Rd, Suite 3301, Stanford, CA 94305, USA
    Am J Psychiatry 159:1855-61. 2002
    ..The study evaluated the prevalence of major depressive episodes with psychotic features in the general population and sought to determine which depressive symptoms are most frequently associated with psychotic features...
  57. ncbi request reprint Pharmacological principles of antidepressant efficacy
    Alan F Schatzberg
    Department of Psychiatry, Behavioral Sciences, Stanford University School of Medicine, Stanford, California 94305 5717, USA
    Hum Psychopharmacol 17:S17-22. 2002
    ..This may help to explain clinical evidence suggesting that mirtazapine has a faster onset of action than the more selective antidepressants...
  58. ncbi request reprint Experience-dependent asymmetric variation in primate prefrontal morphology
    David M Lyons
    Department of Psychiatry and Behavioral Science, Psychiatry Neuroscience, Stanford University Medical School, 1201 Welch Road, MSLS Room P104, Mail Code 5485, CA 94305 5485, USA
    Behav Brain Res 136:51-9. 2002
    ..Follow-up studies now need to determine whether maternal availability directly affects or interacts with subsequent experiences to alter prefrontal substrates of emotional processing and sensitivity to stress...
  59. ncbi request reprint Prospective investigation of stress inoculation in young monkeys
    Karen J Parker
    Department of Psychiatry and Behavioral Sciences, Stanford University Medical School, Stanford, Calif 94305 5485, USA
    Arch Gen Psychiatry 61:933-41. 2004
    ..Retrospective studies in humans have identified characteristics that promote stress resistance, including childhood exposure to moderately stressful events (ie, stress inoculation)...
  60. ncbi request reprint Mild early life stress enhances prefrontal-dependent response inhibition in monkeys
    Karen J Parker
    Department of Psychiatry and Behavioral Sciences, Stanford University Medical School, Stanford, California 94305 5485, USA
    Biol Psychiatry 57:848-55. 2005
    ..e., stress inoculation) strengthens emotional and neuroendocrine resistance to subsequent stressors. Herein we extend this research to examine the effects of mild early life stress on cognition...
  61. ncbi request reprint On the interactions of the hypothalamic-pituitary-adrenal (HPA) axis and sleep: normal HPA axis activity and circadian rhythm, exemplary sleep disorders
    Theresa M Buckley
    Stanford Sleep Disorders Clinic and Research Center and Department of Psychiatry, Stanford University, 401 Quarry Road, Suite 3301, Stanford, California 94305, USA
    J Clin Endocrinol Metab 90:3106-14. 2005
    ..Mechanisms by which cortisol can affect slow wave sleep are discussed, as is the role the HPA axis plays in secondary effects of primary sleep disorders...
  62. ncbi request reprint Clinical and biological effects of mifepristone treatment for psychotic depression
    Benjamin H Flores
    Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA 94305 5723, USA
    Neuropsychopharmacology 31:628-36. 2006
    ..These results suggest that short-term use of mifepristone may be effective in the treatment of PMD and may re-regulate the HPA axis. Additional blinded studies are warranted...
  63. ncbi request reprint Detecting psychotic major depression using psychiatric rating scales
    Jennifer Keller
    Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 401 Quarry Road, Stanford, CA 94305 5723, USA
    J Psychiatr Res 40:22-9. 2006
    ..The aim of this study was to assess whether individual or clusters of psychiatric symptoms can differentiate patients with psychotic major depression (PMD) from those with nonpsychotic depression (NPMD)...
  64. ncbi request reprint Mutations in squirrel monkey glucocorticoid receptor impair nuclear translocation
    Song Her
    Department of Psychiatry, Stanford University Medical Center, Stanford, CA 94305 5485, USA
    J Steroid Biochem Mol Biol 94:319-26. 2005
    ..Three back-mutations of gsmGR to hGR (Thr551Ser, Ala616Ser, and Ser618Ala) in the LBD confirmed that these amino acids play a role in diminished translocation...
  65. ncbi request reprint Major depression among adolescent smokers undergoing treatment for nicotine dependence
    Joel D Killen
    Stanford Prevention Research Center, Stanford University School of Medicine, Hoover Pavilion, Room N072, 211 Quarry Road, CA 94305 5705, USA
    Addict Behav 29:1517-26. 2004
    ....
  66. ncbi request reprint Aging and the role of the HPA axis and rhythm in sleep and memory-consolidation
    Theresa M Buckley
    Stanford Sleep Disorders Clinic and Research Center TMB, Stanford, CA, USA
    Am J Geriatr Psychiatry 13:344-52. 2005
    ..In this regard, the authors propose that drugs that act directly on the HPA axis (e.g., mineralocorticoid agonists) may be potentially quite useful for improving both sleep and declarative memory consolidation during sleep...
  67. ncbi request reprint Randomized clinical trial of the efficacy of bupropion combined with nicotine patch in the treatment of adolescent smokers
    Joel D Killen
    Department of Medicine, Stanford University, Stanford, CA 94305, USA
    J Consult Clin Psychol 72:729-35. 2004
    ..These findings are encouraging and suggest new avenues for research. For example, treatments of the kind examined in this report, augmented by extended maintenance therapies, may yield higher long-term success rates...
  68. doi request reprint Failure of anterior cingulate activation and connectivity with the amygdala during implicit regulation of emotional processing in generalized anxiety disorder
    Amit Etkin
    Department of Psychiatry and Behavioral Sciences, the Center for Interdisciplinary Brain Science Research, and the Program in Neuroscience, Stanford University, USA
    Am J Psychiatry 167:545-54. 2010
    ..Here the authors examined whether this form of noninstructed emotion regulation is perturbed in generalized anxiety disorder...
  69. ncbi request reprint Using chronic pain to predict depressive morbidity in the general population
    Maurice M Ohayon
    Stanford Sleep Epidemiology Research Center, School of Medicine, Stanford University, 3430 W Bayshore Rd, Suite 102, Palo Alto, CA 94303, USA
    Arch Gen Psychiatry 60:39-47. 2003
    ....
  70. ncbi request reprint Intranasal oxytocin administration attenuates the ACTH stress response in monkeys
    Karen J Parker
    Department of Psychiatry and Behavioral Sciences, Stanford University Medical School, CA 94305 5485, USA
    Psychoneuroendocrinology 30:924-9. 2005
    ..This primate model offers critical opportunities to improve our understanding of the anti-stress effects of OT and may lead to novel pharmacological treatments for stress-related psychiatric disorders...
  71. pmc Preliminary evidence that plasma oxytocin levels are elevated in major depression
    Karen J Parker
    Department of Psychiatry and Behavioral Sciences, School of Medicine, Stanford University, Stanford, CA 94305, USA
    Psychiatry Res 178:359-62. 2010
    ..Additional research is required to elucidate the role of OT in the pathophysiology of this psychiatric disorder...
  72. pmc Failure to improve cigarette smoking abstinence with transdermal selegiline + cognitive behavior therapy
    Joel D Killen
    Departments of Medicine and Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, CA 94303 1334, USA
    Addiction 105:1660-8. 2010
    ..To examine the effectiveness of transdermal selegiline for producing cigarette smoking abstinence...
  73. doi request reprint Animal models of early life stress: implications for understanding resilience
    David M Lyons
    Department of Psychiatry and Behavioral Sciences, Stanford University, CA 94305, USA
    Dev Psychobiol 52:616-24. 2010
    ..Implications for programs designed to enhance resilience in human development are discussed...
  74. pmc Early life stress and novelty seeking behavior in adolescent monkeys
    Karen J Parker
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 1201 Welch Road, MSLS Room P104, Mail Code 5485, Stanford, CA 94305 5485, USA
    Psychoneuroendocrinology 32:785-92. 2007
    ..These trait-like differences in novelty seeking appear to reflect mild early stress-induced adaptations that enhance curiosity and resilience...
  75. ncbi request reprint A prospective trial of bupropion SR augmentation of partial and non-responders to serotonergic antidepressants
    Charles DeBattista
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine Stanford, CA 94305 5723, USA
    J Clin Psychopharmacol 23:27-30. 2003
    ..This prospective, open-label trial supports the use of bupropion SR in the augmentation of SSRIs and venlafaxine. Placebo controlled trials should be completed to further evaluate the efficacy of this strategy...
  76. pmc Stress coping stimulates hippocampal neurogenesis in adult monkeys
    David M Lyons
    Departments of Psychiatry and Behavioral Sciences, Stanford University Medical Center, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 107:14823-7. 2010
    ..These findings support recent indications that stress coping stimulates hippocampal neurogenesis in adult rodents. Psychotherapies designed to promote stress coping potentially have similar effects in humans with major depression...
  77. ncbi request reprint Social stress-related behavior affects hippocampal cell proliferation in mice
    Rupshi Mitra
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305 5020, USA
    Physiol Behav 89:123-7. 2006
    ....
  78. pmc Resting-state functional connectivity in major depression: abnormally increased contributions from subgenual cingulate cortex and thalamus
    Michael D Greicius
    Department of Neurology and Neurological Sciences, Stanford University Medical Center, Stanford, California 94305 5235, USA
    Biol Psychiatry 62:429-37. 2007
    ..The goal of this study was to examine resting-state, default-mode network functional connectivity in subjects with major depression and in healthy controls...
  79. pmc The acute and post-discontinuation effects of a glucocorticoid receptor (GR) antagonist probe on sleep and the HPA axis in chronic insomnia: a pilot study
    Theresa Buckley
    Department of Psychiatry, Stanford University Medical School, Stanford, CA, USA
    J Clin Sleep Med 4:235-41. 2008
    ..Aglucocorticoid receptor (GR) antagonist may re-regulate HPA axis activity even after discontinuation and may have clinical benefit...
  80. doi request reprint Monitoring mental health treatment acceptance and initial treatment adherence in veterans: veterans of Operations Enduring Freedom and Iraqi Freedom versus other veterans of other eras
    Steven Lindley
    Department of Psychiatry, Stanford University School of Medicine, Stanford, California, USA
    Ann N Y Acad Sci 1208:104-13. 2010
    ..No variables predicted OEF/OIF acceptance/attendance. In conclusion, our findings illustrate the importance of close, continual monitoring of clinical process data to help reveal targets for improving mental health care for veterans...
  81. ncbi request reprint Onset of major depression during treatment for nicotine dependence
    Joel D Killen
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 1000 Welch Road, Palo Alto, CA 94304, USA
    Addict Behav 28:461-70. 2003
    ..The evidence indicates that those who treat nicotine dependence must be prepared to monitor and respond to the emergence of depression associated with treatment...
  82. doi request reprint Efficacy and safety of agomelatine in the treatment of major depressive disorder: a multicenter, randomized, double-blind, placebo-controlled trial
    John Zajecka
    Treatment Research Center, Department of Psychiatry, Rush University Medical Center, Chicago, IL 60612, USA
    J Clin Psychopharmacol 30:135-44. 2010
    ..The results showed significant antidepressant efficacy of agomelatine 50 mg/d, including a positive effect on sleep compared with placebo in outpatients with moderate to severe major depressive disorder...
  83. pmc Differential responses to psychotherapy versus pharmacotherapy in patients with chronic forms of major depression and childhood trauma
    Charles B Nemeroff
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322
    Proc Natl Acad Sci U S A 100:14293-6. 2003
    ..Our results suggest that psychotherapy may be an essential element in the treatment of patients with chronic forms of major depression and a history of childhood trauma...
  84. ncbi request reprint Depression-free days as a summary measure of the temporal pattern of response and remission in the treatment of major depression: a comparison of venlafaxine, selective serotonin reuptake inhibitors, and placebo
    Rajiv Mallick
    Global Health Outcomes Assessment, Wyeth Research, Collegeville, PA, USA
    J Clin Psychiatry 64:321-30. 2003
    ....
  85. pmc Dissociable intrinsic connectivity networks for salience processing and executive control
    William W Seeley
    Department of Neurology, School of Medicine, University of California, San Francisco, San Francisco, California 94143, USA
    J Neurosci 27:2349-56. 2007
    ..Our findings suggest that task-free analysis of intrinsic connectivity networks may help elucidate the neural architectures that support fundamental aspects of human behavior...
  86. ncbi request reprint Addition of atomoxetine for depression incompletely responsive to sertraline: a randomized, double-blind, placebo-controlled study
    David Michelson
    Lilly Research Laboratories, Eli Lilly and Co, Indianapolis, Ind, USA
    J Clin Psychiatry 68:582-7. 2007
    ..Addition of a noradrenergic intervention in patients poorly or partially responsive to SSRIs may improve outcomes, but few well-controlled studies testing this hypothesis have been reported...
  87. ncbi request reprint Duloxetine 60 mg once-daily in the treatment of painful physical symptoms in patients with major depressive disorder
    Stephen K Brannan
    Cyberonics, Houston, TX 77058, USA
    J Psychiatr Res 39:43-53. 2005
    ..The efficacy of duloxetine, a balanced and potent dual reuptake inhibitor of 5-HT and NE, was evaluated within a cohort of depressed patients with associated painful physical symptoms...
  88. ncbi request reprint Depression in the elderly
    William M McDonald
    Fuqua Center for Late Life Depression, Emory University, Atlanta, USA
    Psychopharmacol Bull 36:112-22. 2002
    ..Treatment should also take into account the likelihood of achieving and maintaining remission of symptoms in order to restore the patient to a baseline level of functioning appropriate for their age...
  89. ncbi request reprint The Prevention of Recurrent Episodes of Depression with Venlafaxine for Two Years (PREVENT) study: outcomes from the acute and continuation phases
    Martin B Keller
    Brown University, Providence, Rhode Island 02906, USA
    Biol Psychiatry 62:1371-9. 2007
    ..We evaluated the comparative efficacy and safety of venlafaxine extended release (ER) and fluoxetine in the acute and continuation phases of treatment...
  90. ncbi request reprint Slowing the progression of cognitive decline in Alzheimer's disease using mifepristone
    Joseph K Belanoff
    Corcept Therapeutics, Inc, Menlo Park, CA 94025, USA
    J Mol Neurosci 19:201-6. 2002
    ..Additionally, this study test the hypothesis that AD subjects with elevated cortisol at baseline will perform more poorly on neuropsychological exams that do subjects with low cortisol...
  91. ncbi request reprint The Prevention of Recurrent Episodes of Depression with Venlafaxine for Two Years (PREVENT) Study: Outcomes from the 2-year and combined maintenance phases
    Martin B Keller
    Department of Psychiatry and Human Behavior, Brown University, Providence, RI 02906, USA
    J Clin Psychiatry 68:1246-56. 2007
    ..To report second-year results from the 2-year maintenance phase of a long-term study to evaluate the efficacy and safety of venlafaxine extended release (ER) in preventing recurrence of depression...

Research Grants34

  1. MODEL OF HYPERCORTISOLISM FOR MAJOR DEPRESSIONS
    Alan Schatzberg; Fiscal Year: 2004
    ..However, despite some apparent similarities between rodent and primate brain circuits, there is a paucity of data regarding CNS modulation of stress response in primates. ..
  2. MODEL OF HYPERCORTISOLISM FOR MAJOR DEPRESSION
    Alan Schatzberg; Fiscal Year: 2007
    ....
  3. HPA AXIS/DOPAMINE INTERACTIONS IN PSYCHOTIC DEPRESSION
    Alan Schatzberg; Fiscal Year: 2007
    ..Of particular importance is that the treatment may be effective even when given intermittently. ..
  4. REVAMP-Follow-Up Study
    Alan Schatzberg; Fiscal Year: 2007
    ....
  5. A BIOBEHAVIORAL RESEARCH TRAINING PROGRAM
    Alan Schatzberg; Fiscal Year: 2007
    ....
  6. HPA AXIS/DOPAMINE INTERACTIONS IN PSYCHOTIC DEPRESSION
    Alan Schatzberg; Fiscal Year: 2009
    ..Of particular importance is that the treatment may be effective even when given intermittently. ..
  7. HPA AXIS/DOPAMINE INTERACTIONS IN PSYCHOTIC DEPRESSION
    Alan Schatzberg; Fiscal Year: 2003
    ..abstract_text> ..
  8. MODEL OF HYPERCORTISOLISM FOR MAJOR DEPRESSIONS
    Alan Schatzberg; Fiscal Year: 1999
    ....
  9. MODEL OF HYPERCORTISOLISM FOR MAJOR DEPRESSION
    Alan F Schatzberg; Fiscal Year: 2010
    ....