A F Schatzberg

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. pmc Exon expression in lymphoblastoid cell lines from subjects with schizophrenia before and after glucose deprivation
    Maureen V Martin
    Department of Psychiatry and Human Behavior, Univ of California, Irvine, CA, USA
    BMC Med Genomics 2:62. 2009
  2. ncbi request reprint Pharmacological principles of antidepressant efficacy
    Alan F Schatzberg
    Department of Psychiatry, Behavioral Sciences, Stanford University School of Medicine, Stanford, California 94305 5717, USA
    Hum Psychopharmacol 17:S17-22. 2002
  3. ncbi request reprint New paradigm for treating recurrent depression: from symptom control to managing enduring vulnerabilities
    Alan F Schatzberg
    Stanford University School of Medicine, CA 94605 5548, USA
    CNS Spectr 11:22-7. 2006
  4. ncbi request reprint Pharmacogenetics of antidepressant medication intolerance
    Greer M Murphy
    Neruroscience Research Laboratories Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford CA 94305 5548, USA
    Am J Psychiatry 160:1830-5. 2003
  5. ncbi request reprint A double-blind, placebo-controlled study of venlafaxine and fluoxetine in geriatric outpatients with major depression
    Alan Schatzberg
    Stanford University School of Medicine, Stanford, CA 94605 5548, USA
    Am J Geriatr Psychiatry 14:361-70. 2006
  6. ncbi request reprint Neuropsychological deficits in psychotic versus nonpsychotic major depression and no mental illness
    A F Schatzberg
    Department of Psychiatry, Stanford University, CA 94305 5717, USA
    Am J Psychiatry 157:1095-100. 2000
  7. ncbi request reprint 24-Hour monitoring of cortisol and corticotropin secretion in psychotic and nonpsychotic major depression
    J A Posener
    Department of Psychiatry, Washington University School of Medicine, 660 S Euclid Ave, Box 8134, St Louis, MO 63110, USA
    Arch Gen Psychiatry 57:755-60. 2000
  8. ncbi request reprint Early environmental regulation of glucocorticoid feedback sensitivity in young adult monkeys
    D M Lyons
    Department of Psychiatry and Behavioral Science, Stanford University School of Medicine, Stanford, CA 94305 5485, USA
    J Neuroendocrinol 12:723-8. 2000
  9. ncbi request reprint Acute antidepressant effects of intravenous hydrocortisone and CRH in depressed patients: a double-blind, placebo-controlled study
    C DeBattista
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, CA 94305 5723, USA
    Am J Psychiatry 157:1334-7. 2000
  10. ncbi request reprint Stress-level cortisol treatment impairs inhibitory control of behavior in monkeys
    D M Lyons
    Department of Psychiatry and Behavioral Science, Stanford University School of Medicine, Stanford, California 94305 5485, USA
    J Neurosci 20:7816-21. 2000

Collaborators

Detail Information

Publications85

  1. pmc Exon expression in lymphoblastoid cell lines from subjects with schizophrenia before and after glucose deprivation
    Maureen V Martin
    Department of Psychiatry and Human Behavior, Univ of California, Irvine, CA, USA
    BMC Med Genomics 2:62. 2009
    ..The purpose of this study was to examine the effects of glucose reduction stress on lymphoblastic cell line (LCL) gene expression in subjects with schizophrenia compared to non-psychotic relatives...
  2. ncbi request reprint Pharmacological principles of antidepressant efficacy
    Alan F Schatzberg
    Department of Psychiatry, Behavioral Sciences, Stanford University School of Medicine, Stanford, California 94305 5717, USA
    Hum Psychopharmacol 17:S17-22. 2002
    ..This may help to explain clinical evidence suggesting that mirtazapine has a faster onset of action than the more selective antidepressants...
  3. ncbi request reprint New paradigm for treating recurrent depression: from symptom control to managing enduring vulnerabilities
    Alan F Schatzberg
    Stanford University School of Medicine, CA 94605 5548, USA
    CNS Spectr 11:22-7. 2006
    ..A new treatment paradigm, which focuses on identifying patients with risk factors and managing the disease process rather than suppression of symptoms, is needed for recurrent depression...
  4. ncbi request reprint Pharmacogenetics of antidepressant medication intolerance
    Greer M Murphy
    Neruroscience Research Laboratories Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford CA 94305 5548, USA
    Am J Psychiatry 160:1830-5. 2003
    ..However, variation in genes encoding serotonin receptors could also explain antidepressant side effects (pharmacodynamic effect)...
  5. ncbi request reprint A double-blind, placebo-controlled study of venlafaxine and fluoxetine in geriatric outpatients with major depression
    Alan Schatzberg
    Stanford University School of Medicine, Stanford, CA 94605 5548, USA
    Am J Geriatr Psychiatry 14:361-70. 2006
    ..This masked, placebo-controlled trial assessed the efficacy and safety of venlafaxine and fluoxetine in depressed patients older than 65 years...
  6. ncbi request reprint Neuropsychological deficits in psychotic versus nonpsychotic major depression and no mental illness
    A F Schatzberg
    Department of Psychiatry, Stanford University, CA 94305 5717, USA
    Am J Psychiatry 157:1095-100. 2000
    ..The current study explored specific impairments in cognitive function in subjects with psychotic major depression, subjects with nonpsychotic major depression, and healthy comparison subjects studied under drug-free conditions...
  7. ncbi request reprint 24-Hour monitoring of cortisol and corticotropin secretion in psychotic and nonpsychotic major depression
    J A Posener
    Department of Psychiatry, Washington University School of Medicine, 660 S Euclid Ave, Box 8134, St Louis, MO 63110, USA
    Arch Gen Psychiatry 57:755-60. 2000
    ..Comparison of depressed patients with and without psychotic features is also important because HPA axis abnormalities may be especially pronounced in psychotic depressed patients...
  8. ncbi request reprint Early environmental regulation of glucocorticoid feedback sensitivity in young adult monkeys
    D M Lyons
    Department of Psychiatry and Behavioral Science, Stanford University School of Medicine, Stanford, CA 94305 5485, USA
    J Neuroendocrinol 12:723-8. 2000
    ....
  9. ncbi request reprint Acute antidepressant effects of intravenous hydrocortisone and CRH in depressed patients: a double-blind, placebo-controlled study
    C DeBattista
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, CA 94305 5723, USA
    Am J Psychiatry 157:1334-7. 2000
    ..The primary objective of this investigation was to examine the acute antidepressant effects of intravenous hydrocortisone and ovine corticotropin releasing hormone (CRH) infusions in patients with major depression...
  10. ncbi request reprint Stress-level cortisol treatment impairs inhibitory control of behavior in monkeys
    D M Lyons
    Department of Psychiatry and Behavioral Science, Stanford University School of Medicine, Stanford, California 94305 5485, USA
    J Neurosci 20:7816-21. 2000
    ....
  11. ncbi request reprint Cortisol feedback during the HPA quiescent period in patients with major depression
    J A Posener
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Am J Psychiatry 158:2083-5. 2001
    ..The authors tested the hypothesis that patients with major depression have a defect in the mechanism by which cortisol exerts negative feedback on the hypothalamic-pituitary-adrenal (HPA) axis during the HPA axis quiescent period...
  12. ncbi request reprint Cortisol activity and cognitive changes in psychotic major depression
    J K Belanoff
    Department of Psychiatry, Stanford University School of Medicine, Stanford, CA 94305, USA
    Am J Psychiatry 158:1612-6. 2001
    ..This study examined differences in performance on a verbal memory test and in cortisol levels between patients with psychotic and nonpsychotic major depression and healthy volunteers...
  13. ncbi request reprint Postnatal experiences and genetic effects on squirrel monkey social affinities and emotional distress
    D M Lyons
    Department of Psychiatry and Behavioral Science, Stanford University School of Medicine, Stanford, California 94305 5485, USA
    Horm Behav 36:266-75. 1999
    ..These findings concur with human twin studies that suggest genetic and experiential factors contribute to individual differences in vulnerability to emotional distress...
  14. ncbi request reprint Gender differences in treatment response to sertraline versus imipramine in chronic depression
    S G Kornstein
    Department of Psychiatry, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA 23298 0710, USA
    Am J Psychiatry 157:1445-52. 2000
    ..The authors examined gender differences in treatment response to sertraline, a selective serotonin reuptake inhibitor (SSRI), and to imipramine, a tricyclic antidepressant, in chronic depression...
  15. ncbi request reprint Corticosteroids and cognition
    J K Belanoff
    Stanford University School of Medicine, Department of Psychiatry, Stanford, CA 94305, USA
    J Psychiatr Res 35:127-45. 2001
    ..The possibility that cognitive dysfunction caused by glucocorticoids can be pharmacologically managed is introduced...
  16. ncbi request reprint Separation induced changes in squirrel monkey hypothalamic-pituitary-adrenal physiology resemble aspects of hypercortisolism in humans
    D M Lyons
    Department of Psychiatry and Behavioral Science, Stanford University School of Medicine, CA 94305 5485, USA
    Psychoneuroendocrinology 24:131-42. 1999
    ..Similar findings in humans have been reported in clinical studies of hypercortisolism and major depression...
  17. ncbi request reprint Cognitive-behavioral group therapy for social phobia in female adolescents: results of a pilot study
    C Hayward
    Department of Psychiatry and Behavioral Sciences, Stanford University, CA 94305 5722, USA
    J Am Acad Child Adolesc Psychiatry 39:721-6. 2000
    ..To examine the efficacy of cognitive-behavioral group therapy for adolescents (CBGT-A) in females with social phobia and the effect of this treatment on the risk for major depression...
  18. ncbi request reprint Early life stress and inherited variation in monkey hippocampal volumes
    D M Lyons
    Department of Psychiatry and Behavioral Science, 1201 Welch Rd, Medical School Laboratory Surge Bldg, Room P104 Mail Code 5485, Stanford University School of Medicine, Stanford, CA 94305 5485, USA
    Arch Gen Psychiatry 58:1145-51. 2001
    ..Therefore, this longitudinal study investigated early life stress and inherited variation in monkey hippocampal volumes...
  19. ncbi request reprint Nocturnal sleep apnea/hypopnea is associated with lower memory performance in APOE epsilon4 carriers
    R O'HARA
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305 5550, USA
    Neurology 65:642-4. 2005
    ..This is the first study to provide preliminary evidence for a negative interaction of APOE epsilon4 and OSAH on memory in older adults, which may have important implications for treating cognitive decline and delaying dementia onset...
  20. ncbi request reprint Strain differences in mesotelencephalic dopaminergic neuronal regulation between Fischer 344 and Lewis rats
    S E Lindley
    National Center for PTSD, Department of Veterans Affairs, Palo Alto Health Care System Division PTSD 352 117, 795 Willow Road, Menlo Park, CA 94025, USA
    Brain Res 832:152-8. 1999
    ..Together these findings suggest that the inbred, behaviorally divergent F344 and Lewis rats have selective differences in mesocortical, nigrostriatal and mesolimbic DA neuronal regulation...
  21. ncbi request reprint Sertraline versus imipramine to prevent relapse in chronic depression
    L M Koran
    Stanford University Medical Center, CA, USA
    J Affect Disord 65:27-36. 2001
    ..Chronic depressions are common, disabling and under-treated, and long-term treatment is little studied. We report the continuation phase results from a long-term treatment study...
  22. ncbi request reprint Dilative cardiomyopathy leading to congestive heart failure in a male squirrel monkey (Saimiri sciureus)
    R J Tolwani
    Department of Comparative Medicine, Stanford University School of Medicine, CA 94305, USA
    J Med Primatol 29:42-5. 2000
    ..Spontaneous dilative cardiomyopathy may be infrequently observed in the squirrel monkeys because they are not routinely housed in the research environment during their advancing years...
  23. ncbi request reprint Nicotine patch and paroxetine for smoking cessation
    J D Killen
    Stanford University School of Medicine, Palo Alto, California 94304 1885, USA
    J Consult Clin Psychol 68:883-9. 2000
    ..The differences between paroxetine groups and placebo at Week 4 were statistically significant. Although paroxetine may add value to the current standard of care in excess of potential risk, more conclusive evidence is needed...
  24. ncbi request reprint Rapid reversal of psychotic depression using mifepristone
    J K Belanoff
    Department of Psychiatry, Stanford University Medical Center, California 94305, USA
    J Clin Psychopharmacol 21:516-21. 2001
    ..These preliminary results suggest that short-term use of GR antagonists may be effective in the treatment of psychotic major depression and that additional study, perhaps using higher doses or more treatment days, seems warranted...
  25. pmc Serotonin transporter polymorphism, memory and hippocampal volume in the elderly: association and interaction with cortisol
    R O'HARA
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford University, Stanford, CA 94305 5550, USA
    Mol Psychiatry 12:544-55. 2007
    ....
  26. ncbi request reprint Functional brain imaging of olfactory processing in monkeys
    J M Boyett-Anderson
    Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA 94305, USA
    Neuroimage 20:257-64. 2003
    ..More broadly, this study suggests that olfactory processing in sedated monkeys and nonsedated humans shares similar neural substrates both within and beyond the primary olfactory system...
  27. ncbi request reprint Stress-induced changes in primate prefrontal profiles of gene expression
    A M Karssen
    Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA 94305 5485, USA
    Mol Psychiatry 12:1089-102. 2007
    ....
  28. ncbi request reprint Extended treatment with bupropion SR for cigarette smoking cessation
    Joel D Killen
    Stanford University School of Medicine, Stanford, CA 94305 5705, USA
    J Consult Clin Psychol 74:286-94. 2006
    ..001; week 25: 48% vs. 31%, p = .001; week 52: 39% vs. 27%, p = .01). Because most smokers suffer relapse with any current cessation treatment, the comparatively high abstinence percentages achieved in this trial are of interest...
  29. pmc Maternal mediation, stress inoculation, and the development of neuroendocrine stress resistance in primates
    Karen J Parker
    Department of Psychiatry and Behavioral Sciences, Stanford University, 1201 Welch Road, MSLS P104, Stanford, CA 94305 5485, USA
    Proc Natl Acad Sci U S A 103:3000-5. 2006
    ..Results from both experiments demonstrate that stress inoculation, rather than high levels of maternal care, promotes the development of primate stress resistance...
  30. ncbi request reprint Cortisol circadian rhythm alterations in psychotic major depression
    Jennifer Keller
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California 94305 5723, USA
    Biol Psychiatry 60:275-81. 2006
    ..There are limited data on cortisol levels during specific times of the day...
  31. ncbi request reprint Detecting psychotic major depression using psychiatric rating scales
    Jennifer Keller
    Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 401 Quarry Road, Stanford, CA 94305 5723, USA
    J Psychiatr Res 40:22-9. 2006
    ..The aim of this study was to assess whether individual or clusters of psychiatric symptoms can differentiate patients with psychotic major depression (PMD) from those with nonpsychotic depression (NPMD)...
  32. ncbi request reprint Clinical and biological effects of mifepristone treatment for psychotic depression
    Benjamin H Flores
    Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA 94305 5723, USA
    Neuropsychopharmacology 31:628-36. 2006
    ..These results suggest that short-term use of mifepristone may be effective in the treatment of PMD and may re-regulate the HPA axis. Additional blinded studies are warranted...
  33. ncbi request reprint Prevention of recurrent episodes of depression with venlafaxine ER in a 1-year maintenance phase from the PREVENT Study
    James H Kocsis
    Department of Psychiatry, Weill Cornell Medical College, New York, NY 10012, USA
    J Clin Psychiatry 68:1014-23. 2007
    ..To test the long-term efficacy and safety of venlafaxine extended-release (ER) in preventing recurrence in patients with major depression...
  34. ncbi request reprint Intranasal oxytocin administration attenuates the ACTH stress response in monkeys
    Karen J Parker
    Department of Psychiatry and Behavioral Sciences, Stanford University Medical School, CA 94305 5485, USA
    Psychoneuroendocrinology 30:924-9. 2005
    ..This primate model offers critical opportunities to improve our understanding of the anti-stress effects of OT and may lead to novel pharmacological treatments for stress-related psychiatric disorders...
  35. ncbi request reprint Monoamine oxidase and catechol-o-methyltransferase enzyme activity and gene expression in response to sustained glucocorticoids
    Steven E Lindley
    Department of Psychiatry, Veterans Affairs Palo Alto Health Care System, CA 94304, USA
    Psychoneuroendocrinology 30:785-90. 2005
    ..The results do not support inhibition of DA metabolism as a mechanism by which glucocorticoids influence DA-mediated behaviors...
  36. ncbi request reprint Aging and the role of the HPA axis and rhythm in sleep and memory-consolidation
    Theresa M Buckley
    Stanford Sleep Disorders Clinic and Research Center TMB, Stanford, CA, USA
    Am J Geriatr Psychiatry 13:344-52. 2005
    ..In this regard, the authors propose that drugs that act directly on the HPA axis (e.g., mineralocorticoid agonists) may be potentially quite useful for improving both sleep and declarative memory consolidation during sleep...
  37. ncbi request reprint Mutations in squirrel monkey glucocorticoid receptor impair nuclear translocation
    Song Her
    Department of Psychiatry, Stanford University Medical Center, Stanford, CA 94305 5485, USA
    J Steroid Biochem Mol Biol 94:319-26. 2005
    ..Three back-mutations of gsmGR to hGR (Thr551Ser, Ala616Ser, and Ser618Ala) in the LBD confirmed that these amino acids play a role in diminished translocation...
  38. ncbi request reprint Mild early life stress enhances prefrontal-dependent response inhibition in monkeys
    Karen J Parker
    Department of Psychiatry and Behavioral Sciences, Stanford University Medical School, Stanford, California 94305 5485, USA
    Biol Psychiatry 57:848-55. 2005
    ..e., stress inoculation) strengthens emotional and neuroendocrine resistance to subsequent stressors. Herein we extend this research to examine the effects of mild early life stress on cognition...
  39. pmc The acute and post-discontinuation effects of a glucocorticoid receptor (GR) antagonist probe on sleep and the HPA axis in chronic insomnia: a pilot study
    Theresa Buckley
    Department of Psychiatry, Stanford University Medical School, Stanford, CA, USA
    J Clin Sleep Med 4:235-41. 2008
    ..Aglucocorticoid receptor (GR) antagonist may re-regulate HPA axis activity even after discontinuation and may have clinical benefit...
  40. ncbi request reprint Antidepressant discontinuation syndrome: consensus panel recommendations for clinical management and additional research
    Alan F Schatzberg
    Stanford University School of Medicine, Stanford, Calif 94305 5717, USA
    J Clin Psychiatry 67:27-30. 2006
    ..This article summarizes recommendations with respect to future research as well as clinical management recommendations for SRI discontinuation syndrome...
  41. doi request reprint Glucocorticoid antagonists in neuropsychiatric [corrected] disorders
    Alan F Schatzberg
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, United States
    Eur J Pharmacol 583:358-64. 2008
    ..g., Alzheimer's disease and mild cognitive impairment), cognitive side effects of electroconvulsive therapy, and weight gain with atypical antipsychotic agents. Potential benefits and limitations are discussed...
  42. ncbi request reprint The Prevention of Recurrent Episodes of Depression with Venlafaxine for Two Years (PREVENT) Study: Outcomes from the 2-year and combined maintenance phases
    Martin B Keller
    Department of Psychiatry and Human Behavior, Brown University, Providence, RI 02906, USA
    J Clin Psychiatry 68:1246-56. 2007
    ..To report second-year results from the 2-year maintenance phase of a long-term study to evaluate the efficacy and safety of venlafaxine extended release (ER) in preventing recurrence of depression...
  43. ncbi request reprint The Prevention of Recurrent Episodes of Depression with Venlafaxine for Two Years (PREVENT) study: outcomes from the acute and continuation phases
    Martin B Keller
    Brown University, Providence, Rhode Island 02906, USA
    Biol Psychiatry 62:1371-9. 2007
    ..We evaluated the comparative efficacy and safety of venlafaxine extended release (ER) and fluoxetine in the acute and continuation phases of treatment...
  44. ncbi request reprint The neuropsychological profile of psychotic major depression and its relation to cortisol
    Rowena G Gomez
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305 5723, USA
    Biol Psychiatry 60:472-8. 2006
    ..We predicted that higher cortisol levels would be associated with greater cognitive deficits...
  45. ncbi request reprint The acute effects of a mineralocorticoid receptor (MR) agonist on nocturnal hypothalamic-adrenal-pituitary (HPA) axis activity in healthy controls
    Theresa M Buckley
    Department of Psychiatry and Behavioral Sciences, Stanford University Medical School, CA 94301, USA
    Psychoneuroendocrinology 32:859-64. 2007
    ..Herein, we propose that an MR agonist may inhibit the HPA axis without first "unloading" receptors of endogenous cortisol...
  46. pmc Early life stress and novelty seeking behavior in adolescent monkeys
    Karen J Parker
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 1201 Welch Road, MSLS Room P104, Mail Code 5485, Stanford, CA 94305 5485, USA
    Psychoneuroendocrinology 32:785-92. 2007
    ..These trait-like differences in novelty seeking appear to reflect mild early stress-induced adaptations that enhance curiosity and resilience...
  47. pmc Preliminary evidence that hippocampal volumes in monkeys predict stress levels of adrenocorticotropic hormone
    David M Lyons
    Department of Psychiatry and Behavioral Sciences, Stanford University Medical Center, Stanford, California 94305 5485, USA
    Biol Psychiatry 62:1171-4. 2007
    ..Hippocampal volumes previously determined in monkeys by magnetic resonance imaging are used to test the hypothesis that small hippocampi predict increased stress levels of adrenocorticotropic hormone (ACTH)...
  48. pmc Current issues in the classification of psychotic major depression
    Jennifer Keller
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305 5723, USA
    Schizophr Bull 33:877-85. 2007
    ..We then propose some improvements to the current unipolar major depression categorization system. Finally, we identify important issues in need of further research to help elucidate the subtype of unipolar PMD...
  49. ncbi request reprint Addition of atomoxetine for depression incompletely responsive to sertraline: a randomized, double-blind, placebo-controlled study
    David Michelson
    Lilly Research Laboratories, Eli Lilly and Co, Indianapolis, Ind, USA
    J Clin Psychiatry 68:582-7. 2007
    ..Addition of a noradrenergic intervention in patients poorly or partially responsive to SSRIs may improve outcomes, but few well-controlled studies testing this hypothesis have been reported...
  50. pmc Hippocampal and amygdalar volumes in psychotic and nonpsychotic unipolar depression
    Jennifer Keller
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 401 Quarry Rd, Stanford, CA 94305 5723, USA
    Am J Psychiatry 165:872-80. 2008
    ..The purpose of the present study was to examine differences in hippocampal and amygdalar volumes in patients with depression subtypes relative to healthy comparison subjects...
  51. pmc Dissociable intrinsic connectivity networks for salience processing and executive control
    William W Seeley
    Department of Neurology, School of Medicine, University of California, San Francisco, San Francisco, California 94143, USA
    J Neurosci 27:2349-56. 2007
    ..Our findings suggest that task-free analysis of intrinsic connectivity networks may help elucidate the neural architectures that support fundamental aspects of human behavior...
  52. ncbi request reprint Social stress-related behavior affects hippocampal cell proliferation in mice
    Rupshi Mitra
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305 5020, USA
    Physiol Behav 89:123-7. 2006
    ....
  53. ncbi request reprint On the interactions of the hypothalamic-pituitary-adrenal (HPA) axis and sleep: normal HPA axis activity and circadian rhythm, exemplary sleep disorders
    Theresa M Buckley
    Stanford Sleep Disorders Clinic and Research Center and Department of Psychiatry, Stanford University, 401 Quarry Road, Suite 3301, Stanford, California 94305, USA
    J Clin Endocrinol Metab 90:3106-14. 2005
    ..Mechanisms by which cortisol can affect slow wave sleep are discussed, as is the role the HPA axis plays in secondary effects of primary sleep disorders...
  54. ncbi request reprint Employing pharmacologic treatment of bipolar disorder to greatest effect
    Alan F Schatzberg
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305 6811, USA
    J Clin Psychiatry 65:15-20. 2004
    ..Lamotrigine stabilizes mood by reducing depression. The atypical anti-psychotics have been shown to be effective either as monotherapy or in combination with mood stabilizers...
  55. ncbi request reprint New approaches to managing psychotic depression
    Alan F Schatzberg
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, CA 94305 5717, USA
    J Clin Psychiatry 64:19-23. 2003
    ..This article focuses on recognizing the features of psychotic depression, the success of current treatment options, and new treatments under investigation...
  56. ncbi request reprint Regional analysis of hippocampal activation during memory encoding and retrieval: fMRI study
    Michael D Greicius
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California 94305 5719, USA
    Hippocampus 13:164-74. 2003
    ..Finally, this study is the first to quantify the effects of susceptibility-induced signal loss on hippocampal activation and suggests that this artifact has significantly biased the interpretation of earlier fMRI studies...
  57. ncbi request reprint Neuroendocrine aspects of hypercortisolism in major depression
    Karen J Parker
    Department of Psychiatry and Behavioral Sciences, Stanford University Medical School, 1201 Welch Road, MSLS Room P104, Mail Code 5485, Stanford, CA 94305 5485, USA
    Horm Behav 43:60-6. 2003
    ..In considering the evidence for hypercortisolism in humans, studies of nonhuman primates are presented and their utility and limitations as comparative models of human depression are discussed...
  58. ncbi request reprint A prospective trial of bupropion SR augmentation of partial and non-responders to serotonergic antidepressants
    Charles DeBattista
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine Stanford, CA 94305 5723, USA
    J Clin Psychopharmacol 23:27-30. 2003
    ..This prospective, open-label trial supports the use of bupropion SR in the augmentation of SSRIs and venlafaxine. Placebo controlled trials should be completed to further evaluate the efficacy of this strategy...
  59. ncbi request reprint Using chronic pain to predict depressive morbidity in the general population
    Maurice M Ohayon
    Stanford Sleep Epidemiology Research Center, School of Medicine, Stanford University, 3430 W Bayshore Rd, Suite 102, Palo Alto, CA 94303, USA
    Arch Gen Psychiatry 60:39-47. 2003
    ....
  60. ncbi request reprint Depression in the elderly
    William M McDonald
    Fuqua Center for Late Life Depression, Emory University, Atlanta, USA
    Psychopharmacol Bull 36:112-22. 2002
    ..Treatment should also take into account the likelihood of achieving and maintaining remission of symptoms in order to restore the patient to a baseline level of functioning appropriate for their age...
  61. ncbi request reprint Mesotelencephalic dopamine neurochemical responses to glucocorticoid administration and adrenalectomy in Fischer 344 and Lewis rats
    Steven E Lindley
    National Center for PTSD, Department of Veterans Affairs, Palo Alto Health Care Systema, PTSD 352 117, 795 Willow Road, Menlo Park, CA 94025, USA
    Brain Res 958:414-22. 2002
    ..The findings indicate a pattern of changes in neurochemical measurements consistent with a small magnitude inhibition of basal dopamine metabolism, but not with a change neuronal activity, release or reuptake...
  62. ncbi request reprint Prevalence of depressive episodes with psychotic features in the general population
    Maurice M Ohayon
    Department of Psychiatry and Behavioral Sciences, School of Medicine, Stanford University, Stanford Sleep Epidemiology Research Center, 401 Quarry Rd, Suite 3301, Stanford, CA 94305, USA
    Am J Psychiatry 159:1855-61. 2002
    ..The study evaluated the prevalence of major depressive episodes with psychotic features in the general population and sought to determine which depressive symptoms are most frequently associated with psychotic features...
  63. ncbi request reprint Experience-dependent asymmetric variation in primate prefrontal morphology
    David M Lyons
    Department of Psychiatry and Behavioral Science, Psychiatry Neuroscience, Stanford University Medical School, 1201 Welch Road, MSLS Room P104, Mail Code 5485, CA 94305 5485, USA
    Behav Brain Res 136:51-9. 2002
    ..Follow-up studies now need to determine whether maternal availability directly affects or interacts with subsequent experiences to alter prefrontal substrates of emotional processing and sensitivity to stress...
  64. ncbi request reprint Double-blind, randomized comparison of mirtazapine and paroxetine in elderly depressed patients
    Alan F Schatzberg
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 401 Quarry Road, Rm 300, Stanford, CA 94305 5548, USA
    Am J Geriatr Psychiatry 10:541-50. 2002
    ..Authors studied the efficacy and tolerability of mirtazapine and paroxetine in elderly patients with major depression during an acute phase (8 weeks) and an extension phase (16 weeks)...
  65. ncbi request reprint Slowing the progression of cognitive decline in Alzheimer's disease using mifepristone
    Joseph K Belanoff
    Corcept Therapeutics, Inc, Menlo Park, CA 94025, USA
    J Mol Neurosci 19:201-6. 2002
    ..Additionally, this study test the hypothesis that AD subjects with elevated cortisol at baseline will perform more poorly on neuropsychological exams that do subjects with low cortisol...
  66. ncbi request reprint Differential effects of nefazodone and cognitive behavioral analysis system of psychotherapy on insomnia associated with chronic forms of major depression
    Michael E Thase
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, PA 15213 2593, USA
    J Clin Psychiatry 63:493-500. 2002
    ..As nefazodone-mediated blockade of serotonin-2 receptors may directly relieve insomnia associated with depression, we examined the more specific effects of CBASP and nefazodone, singly and in combination, on sleep disturbances...
  67. ncbi request reprint Relating semantic and episodic memory systems
    Vinod Menon
    Department of Psychiatry and Behavioral Sciences, 401 Quarry Road, Stanford University School of Medicine, Stanford, CA 94305 5719, USA
    Brain Res Cogn Brain Res 13:261-5. 2002
    ..Here we provide direct evidence for a functional relationship between these two memory systems by showing that left lateral temporal lobe regions involved in semantic memory play an important role in accurate episodic memory retrieval...
  68. ncbi request reprint Clinical use of nefazodone in major depression: a 6-year perspective
    Alan F Schatzberg
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Calif 94305 5717, USA
    J Clin Psychiatry 63:18-31. 2002
  69. ncbi request reprint Depression-free days as a summary measure of the temporal pattern of response and remission in the treatment of major depression: a comparison of venlafaxine, selective serotonin reuptake inhibitors, and placebo
    Rajiv Mallick
    Global Health Outcomes Assessment, Wyeth Research, Collegeville, PA, USA
    J Clin Psychiatry 64:321-30. 2003
    ....
  70. ncbi request reprint Early maternal availability and prefrontal correlates of reward-related memory
    David M Lyons
    Department of Psychiatry and Behavioral Science, Stanford University Medical School, Stanford, CA 94305 5485, USA
    Neurobiol Learn Mem 80:97-104. 2003
    ..Differences in performance were also discerned after each spatial reversal. These findings indicate that maternal availability alters developing ventral medial prefrontal brain regions involved in reward-related memory...
  71. ncbi request reprint Effects of the serotonin transporter gene promoter polymorphism on mirtazapine and paroxetine efficacy and adverse events in geriatric major depression
    Greer M Murphy
    Neuroscience Research Laboratories, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, Calif, USA
    Arch Gen Psychiatry 61:1163-9. 2004
    ..Some but not all studies have found that the short form of 5HTTLPR (S allele) results in decreased efficacy of selective serotonin reuptake inhibitors...
  72. ncbi request reprint Duloxetine 60 mg once-daily in the treatment of painful physical symptoms in patients with major depressive disorder
    Stephen K Brannan
    Cyberonics, Houston, TX 77058, USA
    J Psychiatr Res 39:43-53. 2005
    ..The efficacy of duloxetine, a balanced and potent dual reuptake inhibitor of 5-HT and NE, was evaluated within a cohort of depressed patients with associated painful physical symptoms...
  73. ncbi request reprint Major depression among adolescent smokers undergoing treatment for nicotine dependence
    Joel D Killen
    Stanford Prevention Research Center, Stanford University School of Medicine, Hoover Pavilion, Room N072, 211 Quarry Road, CA 94305 5705, USA
    Addict Behav 29:1517-26. 2004
    ....
  74. ncbi request reprint Prospective investigation of stress inoculation in young monkeys
    Karen J Parker
    Department of Psychiatry and Behavioral Sciences, Stanford University Medical School, Stanford, Calif 94305 5485, USA
    Arch Gen Psychiatry 61:933-41. 2004
    ..Retrospective studies in humans have identified characteristics that promote stress resistance, including childhood exposure to moderately stressful events (ie, stress inoculation)...
  75. ncbi request reprint The relationship of chronic pain and depression
    Alan F Schatzberg
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto 94305 5717, USA
    J Clin Psychiatry 65:3-4. 2004
  76. ncbi request reprint Randomized clinical trial of the efficacy of bupropion combined with nicotine patch in the treatment of adolescent smokers
    Joel D Killen
    Department of Medicine, Stanford University, Stanford, CA 94305, USA
    J Consult Clin Psychol 72:729-35. 2004
    ..These findings are encouraging and suggest new avenues for research. For example, treatments of the kind examined in this report, augmented by extended maintenance therapies, may yield higher long-term success rates...
  77. ncbi request reprint HPA axis activation in major depression and response to fluoxetine: a pilot study
    Elizabeth A Young
    Department of Psychiatry, The Mental Health Research Institute, University of Michigan, 205 Zina Pitcher Place, Ann Arbor, MI 48109 0729, USA
    Psychoneuroendocrinology 29:1198-204. 2004
    ..This may reflect the greater severity of subjects with HPA axis dysregulation or the need to normalize the HPA axis with medications for optimal response...
  78. ncbi request reprint Cognitive correlates of white matter growth and stress hormones in female squirrel monkey adults
    David M Lyons
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California 94305 5485, USA
    J Neurosci 24:3655-62. 2004
    ....
  79. ncbi request reprint Pharmacologic treatments of major depression: are two mechanisms really better than one?
    Alan F Schatzberg
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, Calif 94305 5717, USA
    J Clin Psychiatry 65:3-4. 2004
  80. ncbi request reprint Neuropsychological correlates of psychotic features in major depressive disorders: a review and meta-analysis
    Shelley K Fleming
    Department of Psychiatry and Behavioral Science, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Psychiatr Res 38:27-35. 2004
    ..This review also provides a summary model of the pathophysiology of PMD to provide the necessary context to understanding the biological mechanisms of these impairments...
  81. ncbi request reprint Introduction: treating depression and anxiety to remission
    Alan F Schatzberg
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, Calif 94305 55717, USA
    J Clin Psychiatry 64:3-4. 2003
  82. pmc Differential responses to psychotherapy versus pharmacotherapy in patients with chronic forms of major depression and childhood trauma
    Charles B Nemeroff
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322
    Proc Natl Acad Sci U S A 100:14293-6. 2003
    ..Our results suggest that psychotherapy may be an essential element in the treatment of patients with chronic forms of major depression and a history of childhood trauma...
  83. ncbi request reprint Efficacy and tolerability of duloxetine, a novel dual reuptake inhibitor, in the treatment of major depressive disorder
    Alan F Schatzberg
    Department of Psychiatry, Stanford University School of Medicine, Stanford, CA 94305 5717, USA
    J Clin Psychiatry 64:30-7. 2003
    ..The continued presence of such symptoms may predict relapse. Accordingly, it is hoped that duloxetine therapy may reduce the likelihood of depressive relapse...
  84. ncbi request reprint The apolipoprotein E epsilon4 allele and antidepressant efficacy in cognitively intact elderly depressed patients
    Greer M Murphy
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California 94305, USA
    Biol Psychiatry 54:665-73. 2003
    ..We hypothesized that epsilon4 carriers would show impaired antidepressant response...
  85. ncbi request reprint Does psychosocial functioning improve independent of depressive symptoms? A comparison of nefazodone, psychotherapy, and their combination
    Robert M A Hirschfeld
    Department of Psychiatry and Behavioral Sciences, University of Texas Medical Branch, Galveston, Texas 77555 0188, USA
    Biol Psychiatry 51:123-33. 2002
    ..This study compared efficacy of nefazodone, psychotherapy, and their combination in improving psychosocial functioning in chronically depressed outpatients...