Research Topics
Species | M M SarwalSummaryAffiliation: Stanford University Country: USA Publications
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Detail Information
Publications
Immunosuppression minimization in pediatric transplantationM Sarwal
Department of Pediatrics, Stanford University, Palo Alto, CA, USA
Am J Transplant 7:2227-35. 2007..This article reviews published experience to date with steroid and calcineurin minimization in pediatric renal transplantation and discusses the risks and benefits of these approaches...
Non-HLA antibodies to immunogenic epitopes predict the evolution of chronic renal allograft injuryTara K Sigdel
Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305 5208, USA
J Am Soc Nephrol 23:750-63. 2012..Validation in a larger, prospective transplant cohort may lead to a noninvasive method to predict and monitor for CAI...
In praise of arraysLihua Ying
Department of Pediatrics, Stanford University, 300 Pasteur Drive, Stanford, CA 94305, USA
Pediatr Nephrol 24:1643-59; quiz 1655, 1659. 2009....- The yin and yang of B cells in graft rejection and toleranceValeriya Zarkhin
Department of Pediatrics, Stanford University, Stanford, CA, USA
Transplant Rev (Orlando) 24:67-78. 2010..In addition, novel therapies targeting specific B-cell lineages in graft rejection are also discussed, with a view to developing more targeted therapies for graft rejection... - Biomarkers in solid organ transplantation: establishing personalized transplantation medicineSilke Roedder
Department of Pediatrics and Immunology, Stanford University, G306 300 Pasteur Drive, Palo Alto, CA 94304, USA
Genome Med 3:37. 2011..Several multi-gene expression-based biomarker panels have been identified that accurately predicted graft accommodation in liver transplant recipients and may be developed into a predictive biomarker assay... - Deconvoluting the 'omics' for organ transplantationMinnie M Sarwal
Department of Pediatrics, Stanford University, Stanford, California, USA
Curr Opin Organ Transplant 14:544-51. 2009..This article reviews some recent applications of the many evolving 'omic technologies to organ transplantation... - Chipping into the human genome: novel insights for transplantationMinnie M Sarwal
Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94304, USA
Immunol Rev 210:138-55. 2006..Bioinformatics support is integral to the unraveling of the mysteries of the human genome, proteome, and metabolome in disease and in health... - Designer genes: Filling the gap in transplantationMinnie M Sarwal
Department of Pediatrics, Stanford University School of Medicine, Palo Alto, CA 94305, USA
Transplantation 82:1261-72. 2006..This article will review the current applications of microarray technology in the field of organ transplantation and discuss the potential impact of this technology on transplantation medicine... - Molecular heterogeneity in acute renal allograft rejection identified by DNA microarray profilingMinnie Sarwal
Department of Pediatrics, Stanford University, Stanford, Calif, USA
N Engl J Med 349:125-38. 2003..We hypothesized that previously unrecognized molecular heterogeneity might underlie some of the variability in the clinical course of acute renal allograft rejection and in its response to treatment... - Out with the old, in with the new: immunosuppression minimization in childrenMinnie M Sarwal
Department of Pediatrics, Stanford University School of Medicine, Stanford, California 94304, USA
Curr Opin Organ Transplant 13:513-21. 2008..To cover the current literature on immunosuppression minimization strategies in pediatric transplantation, with an emphasis on an application of these strategies in renal transplantation... - Granulysin expression is a marker for acute rejection and steroid resistance in human renal transplantationM M Sarwal
Department of Pediatrics, Stanford University, Stanford, CA 94305, USA
Hum Immunol 62:21-31. 2001..Memory CTL abound in steroid resistant grafts and may have a markedly different response to CSA immunotherapy, suggesting a possible mechanism for steroid resistance... - Profiling of autoantibodies in IgA nephropathy, an integrative antibiomics approachTara K Sigdel
Departments of Pediatrics Nephrology, Stanford University School of Medicine, Stanford, CA 94304, USA
Clin J Am Soc Nephrol 6:2775-84. 2011..Autoantibody (autoAb) biomarkers to detect and track progression of IgAN are an unmet clinical need. The objective of the study was to identify IgA-specific autoAbs specific to IgAN... - A randomized, prospective trial of rituximab for acute rejection in pediatric renal transplantationV Zarkhin
Department of Pediatrics, Stanford University Medical Center, Stanford, CA, USA
Am J Transplant 8:2607-17. 2008..There was no change in DSA in either group, independent of rejection resolution. This study reports safety and suggests further investigation of Rituximab as an adjunctive treatment for B-cell-mediated graft rejection... - Promising early outcomes with a novel, complete steroid avoidance immunosuppression protocol in pediatric renal transplantationM M Sarwal
Department of Surgery, Stanford University Medical Center, 703 Welch Road, Suite H-5, Palo Alto, CA 94304, USA
Transplantation 72:13-21. 2001..This protocol avoids the morbid side effects of steroids without increasing infection, and may play a future critical role in avoiding noncompliance, although optimizing renal function and growth... - Steroid-free immunosuppression since 1999: 129 pediatric renal transplants with sustained graft and patient benefitsL Li
Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA
Am J Transplant 9:1362-72. 2009.... - The proteogenomic path towards biomarker discoveryTara K Sigdel
Department of Pediatrics Nephrology, Stanford University Medical School, Stanford University, Stanford, CA 94305, USA
Pediatr Transplant 12:737-47. 2008..In this review, we look into the current status and latest developments in the field of biomarker discovery using genomics and proteomics related to organ transplantation, with an emphasis on the evolution of proteomic technologies... - A 100% 2-year graft survival can be attained in high-risk 15-kg or smaller infant recipients of kidney allograftsM T Millan
Stanford University Medical Center, 750 Welch Rd, Suite 319, Palo Alto, CA 94304, USA
Arch Surg 135:1063-8; discussion 1068-9. 2000..The principal causes of graft loss have been graft thrombosis, primary nonfunction, technical error, and irreversible acute rejection... - A common peripheral blood gene set for diagnosis of operational tolerance in pediatric and adult liver transplantationL Li
Division of Nephrology, Department of Pediatrics, Stanford University, Palo Alto, CA, USA
Am J Transplant 12:1218-28. 2012.... - Potential influence of tacrolimus and steroid avoidance on early graft function in pediatric renal transplantationL Li
Division of Pediatric Nephrology, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305 5208, USA
Pediatr Transplant 12:701-7. 2008..In patients with slow recovery of early graft function, short-term perioperative steroids may be considered... - Expression of complement components differs between kidney allografts from living and deceased donorsMaarten Naesens
Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305, USA
J Am Soc Nephrol 20:1839-51. 2009..In addition, complement gene expression at the time of implantation was associated with both early and late graft function. These data suggest that complement-modulating therapy may improve graft outcomes in renal transplantation... - Continued superior outcomes with modification and lengthened follow-up of a steroid-avoidance pilot with extended daclizumab induction in pediatric renal transplantationMinnie M Sarwal
Department of Pediatrics, Stanford University, Palo Alto, CA 94305, USA
Transplantation 76:1331-9. 2003..This pilot study provides preliminary data to test this protocol in a prospective, multicenter randomized study... - Sodium ferric gluconate therapy in renal transplant and renal failure patientsP D Yorgin
Department of Pediatrics, Section of Pediatric Nephrology, Stanford University, Lucille Salter Packard Children s Hospital, 703 Welch Road, Suite H5, Stanford, CA 94305, USA
Pediatr Nephrol 15:171-5. 2000..0 units/kg/week (P = 0.02). Although sodium ferric gluconate appears to be effective and safe at the doses used, multicenter, prospective pharmacokinetic and clinical trials of sodium ferric gluconate should be conducted in children... - Visual loss caused by pseudotumor cerebri in an infant on peritoneal dialysisA Belson
Department of Pediatrics, Stanford University School of Medicine, Palo Alto, CA 94305, USA
Pediatr Nephrol 16:216-8. 2001..Physicians responsible for the care of children with renal failure should be aware of the potential for PTC, as the diagnosis should be made as early as possible to prevent permanent visual loss... - Abnormal mitochondrial autophagy in nephropathic cystinosisPoonam Sansanwal
Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA
Autophagy 6:971-3. 2010..This study provides ultrastructural and functional evidence of abnormal mitochondrial autophagy in nephropathic cystinosis, which may contribute to renal Fanconi syndrome and progressive renal injury... - Using gene arrays in diagnosis of rejectionPurvesh Khatri
Division of Nephrology, Department of Pediatrics, Stanford University, Stanford, California, USA
Curr Opin Organ Transplant 14:34-9. 2009..This article reviews recent studies in organ transplantation using microarrays and highlights the issues that should be addressed in order to use microarrays in diagnosis of rejection... - Gastrointestinal leukocytoclastic vasculitis: an adverse effect of sirolimusSuja Nagarajan
Department of Pediatric Nephrology, Stanford University, Stanford, CA 94305, USA
Pediatr Transplant 9:97-100. 2005..In light of this report, drug-induced leukocytoclastic vasculitis caused by SRL should be considered in the differential diagnosis of chronic abdominal pain in a patient with organ transplantation... - Combined liver-kidney transplantation in children: indications and outcomeScott M Sutherland
Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA
Pediatr Transplant 12:835-46. 2008..While it focuses on the specific primary diseases which impact liver and kidney function simultaneously, it addresses the indications based on concomitant hepatic and renal failure, such as seen in the hepatorenal syndrome, as well... - One hundred percent patient and kidney allograft survival with simultaneous liver and kidney transplantation in infants with primary hyperoxaluria: a single-center experienceMaria T Millan
Stanford University School of Medicine, Palo Alto, CA 94304, USA
Transplantation 76:1458-63. 2003..Although others have reported on overall results of transplantation for PH1 covering a wide age spectrum, none has specifically addressed the high-risk infantile form of the disease... - A novel, semiquantitative, clinically correlated calcineurin inhibitor toxicity score for renal allograft biopsiesNeeraja Kambham
Department of Pathology, Stanford, CA 94305 5324, USA
Clin J Am Soc Nephrol 2:135-42. 2007..021) and 24 mo (P = 0.03) calculated creatinine clearance. Arteriolar medial hyalinosis seems to be the most important factor contributing to the clinical impact of the CNIT score... - Integrative urinary peptidomics in renal transplantation identifies biomarkers for acute rejectionXuefeng B Ling
Divisions of Biotechnology Core, Department of Pediatrics, Stanford University School of Medicine, Stanford University, Stanford, California, USA
J Am Soc Nephrol 21:646-53. 2010..98). These data suggest that changes in collagen remodeling characterize AR and that detection of the corresponding proteolytic degradation products in urine provides a noninvasive diagnostic approach... - Insights into novel cellular injury mechanisms by gene expression profiling in nephropathic cystinosisPoonam Sansanwal
Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA
J Inherit Metab Dis 33:775-86. 2010..Further analysis of these genes and pathways may offer critical insights into the clinical spectrum of cystinosis patients and ultimately lead to novel links for targeted therapy... - Protein microarrays identify antibodies to protein kinase Czeta that are associated with a greater risk of allograft loss in pediatric renal transplant recipientsScott M Sutherland
Division of Nephrology, Department of Pediatrics, Stanford University Medical Center, Stanford, CA 94305, USA
Kidney Int 76:1277-83. 2009..Prospective assessment of serum anti-PKCzeta levels at allograft rejection will be needed to confirm these results... - Extended daclizumab monotherapy for rejection-free survival in non-adherent adolescent recipients of renal allograftsAbanti Chaudhuri
Department of Pediatrics and Surgery, Stanford University School of Medicine, CA, USA
Pediatr Transplant 13:927-32. 2009.... - Microangiopathy of brain, retina, and inner ear (Susac's syndrome) in an adolescent female presenting as acute disseminated encephalomyelitisJin S Hahn
Department of Neurology, Stanford University School of Medicine, Stanford, California, USA
Pediatrics 114:276-81. 2004..The full triad did not develop until 2.5 years after the initial neurologic presentation... - Microarrays: a monitoring tool for transplant patients?Lauren A Weintraub
Department of Pediatrics, Stanford University, Stanford, CA 94305, USA
Transpl Int 19:775-88. 2006..This article will review the current applications of microarray technology in the field of transplantation, and discuss the potential impact of this technology on monitoring of solid organ transplant recipients... - Arraying the orchestration of allograft pathologyElaine S Mansfield
Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA
Am J Transplant 4:853-62. 2004..This report reviews the current literature of microarray use in transplantation research, compares currently available array platforms, and discusses future application of this technology to clinical organ transplantation... - Steroid-free immunosuppression in pediatric renal transplantation: rationale for and [corrected] outcomes following conversion to steroid based therapyScott Sutherland
Division of Nephrology, Department of Pediatrics, Stanford University Medical Center, Stanford, CA 94305, USA
Transplantation 87:1744-8. 2009..Short-term outcomes using steroid-free immunosuppression after renal transplantation have been promising. No studies have examined the incidence of and reasons for steroid-avoidance protocol failures... - Complete steroid avoidance is effective and safe in children with renal transplants: a multicenter randomized trial with three-year follow-upM M Sarwal
California Pacific Medical Center, Sutter Health Care, San Francisco, CA, USA
Am J Transplant 12:2719-29. 2012..017) and lower cholesterol levels (p = 0.034). In conclusion, complete steroid avoidance is safe and effective in unsensitized children receiving primary kidney transplants... - A peripheral blood diagnostic test for acute rejection in renal transplantationL Li
California Pacific Medical Center, Research Institute, San Francisco, CA, USA
Am J Transplant 12:2710-8. 2012..The 5-gene set can diagnose AR potentially avoiding the need for invasive renal biopsy. These data support the conduct of a prospective study to validate the clinical predictive utility of this diagnostic tool... - Expression of soluble HLA-G identifies favorable outcomes in liver transplant recipientsValeriya Zarkhin
Division of Nephrology, Department of Pediatrics, Stanford University, Palo Alto, CA 94304, USA
Transplantation 90:1000-5. 2010..However, the clinical relevance of soluble serum HLA-G molecules in tolerant pediatric and young adult liver transplant patients remains to be studied... - Compartmental localization and clinical relevance of MICA antibodies after renal transplantationLi Li
Department of Pediatrics, Stanford University, Stanford, CA, USA 2 Department of Pathology, Stanford University, Stanford, CA 94304, USA
Transplantation 89:312-9. 2010..Antibodies (Ab) responses to major and minor human leukocyte antigen loci may impact graft survival after organ transplantation... - Identifying compartment-specific non-HLA targets after renal transplantation by integrating transcriptome and "antibodyome" measuresLi Li
Department of Pediatrics, Blood and Marrow Transplantation Division, Stanford University, 300 Pasteur Drive, Stanford, CA 94304, USA
Proc Natl Acad Sci U S A 106:4148-53. 2009..Correlation of the most significant non-HLA antibody responses with transplant health and dysfunction are currently underway... - Molecular profiling of anemia in acute renal allograft rejection using DNA microarraysMei-Sze Chua
Department of Pediatrics, Stanford University School of Medicine, CCSR, Stanford CA, USA
Am J Transplant 3:17-22. 2003..The possible relationship between alterations in the expression of this cluster, reduced renal function, the alloimmune process itself, and other influences on the renal transplant awaits further analysis... - Increased expression of cytotoxic effector molecules: different interpretations for steroid-based and steroid-free immunosuppressionThomas Satterwhite
Department of Pediatrics, Stanford University School of Medicine, 269 Campus Drive, CCSR, Stanford, California 94305, USA
Pediatr Transplant 7:53-8. 2003.... - Corticosteroid avoidance in pediatric renal transplantation: can it be achieved?Jayakumar R Vidhun
Department of Pediatrics, Stanford University, Palo Alto, California 94305, USA
Paediatr Drugs 6:273-87. 2004..This protocol may also be applicable to other areas of solid organ transplantation in all age groups... - Corticosteroid avoidance in pediatric renal transplantationJayakumar R Vidhun
Department of Pediatrics, Stanford University, 300 Pasteur Drive, Palo Alto, CA 94305, USA
Pediatr Nephrol 20:418-26. 2005.... - Proteinuria in pediatric renal transplant recipients during the first 60 post-transplant daysAnnabelle N Chua
Department of Pediatrics, Section of Pediatric Nephrology, Stanford University, Stanford, CA, USA
Pediatr Transplant 10:957-61. 2006..0001) and days post-transplant (-0.531, p < 0.0001). Independent of primary diagnosis, proteinuria persists throughout the first 60 days in most pediatric renal transplant patients, decreasing relative to time post-transplant... - Cell type-specific gene expression differences in complex tissuesShai S Shen-Orr
Department of Pediatrics, Stanford University School of Medicine, Stanford, California, USA
Nat Methods 7:287-9. 2010.... - Microarrays: monitoring for transplant tolerance and mechanistic insightsValeriya Zarkhin
Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94304, USA
Clin Lab Med 28:385-410, vi. 2008..High throughput microarray technology offers a means to study disease-specific transcriptional changes in tissue biopsy, peripheral blood, and biofluids... - Characterization of intra-graft B cells during renal allograft rejectionValeriya Zarkhin
Department of Pediatrics, Stanford University Medical Center, Stanford, California, USA
Kidney Int 74:664-73. 2008..These studies suggest that detailed analysis of interstitial cellular infiltrates may allow better use of B-cell lineage specific treatments to improve graft outcomes... - Standardizing resistive indices in healthy pediatric transplant recipients of adult-sized kidneysSepideh Gholami
Department of Surgery, Stanford University, Stanford, CA 94304, USA
Pediatr Transplant 14:126-31. 2010.... - Management of methylmalonic acidaemia by combined liver-kidney transplantationS Nagarajan
Pediatric Nephrology, Stanford University, California 94305-5208, USA
J Inherit Metab Dis 28:517-24. 2005.... - The evolution of nonimmune histological injury and its clinical relevance in adult-sized kidney grafts in pediatric recipientsM Naesens
Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA
Am J Transplant 7:2504-14. 2007.... - Transplant reno-vascular stenoses associated with early erythropoietin useSuja Nagarajan
Department of Pediatrics Nephrology Stanford University, Palo Alto, CA 94305 5208, USA
Clin Transplant 21:597-608. 2007..The HTN was secondary to atypical, reno-vascular abnormalities (RVA) of the transplanted vasculature, temporally associated with erythropoietin (EPO) use... - Microarrays: new tools for transplantation researchMei-Sze Chua
Department of Pediatrics, Stanford University School of Medicine, G320, 300 Pasteur Drive, CA 94305, Stanford, USA
Pediatr Nephrol 18:319-27. 2003.... - Interpreting the proteome and peptidome in transplantationTara K Sigdel
Department of Pediatrics Nephrology, Stanford University Medical School, Stanford University, Stanford, California 94305, USA
Adv Clin Chem 47:139-69. 2009..In this review, we describe the basic techniques used in proteomic and peptidomic approaches, point out special considerations in using these methods, and discuss their applications in recently published studies in organ transplantation... - Noncirrhotic portal hypertension in association with juvenile nephropathic cystinosis: case presentation and review of the literatureP DiDomenico
Department of Pediatric Nephrology, Lucile Packard Children's Hospital, Stanford University Medical Center, Palo Alto, California, USA
J Inherit Metab Dis 27:693-9. 2004..An understanding of the pathophysiology of hepatic dysfunction will be required to manage this potential late complication of the disease... - Subclinical cytomegalovirus and Epstein-Barr virus viremia are associated with adverse outcomes in pediatric renal transplantationLi Li
Department of Pediatrics, Stanford University, Palo Alto, CA, USA
Pediatr Transplant 11:187-95. 2007.... - Option of pre-emptive nephrectomy and renal transplantation for Bartter's syndromeAbanti Chaudhuri
Department of Pediatrics and Surgery, Stanford University, CA, USA
Pediatr Transplant 10:266-70. 2006.... - Mitochondrial autophagy promotes cellular injury in nephropathic cystinosisPoonam Sansanwal
Department of Pediatrics, G306, 300 Pasteur Drive, Stanford, CA 94304, USA
J Am Soc Nephrol 21:272-83. 2010..This study provides ultrastructural and functional evidence of abnormal mitophagy in nephropathic cystinosis, which may contribute to the renal Fanconi syndrome and progressive renal injury... - Expression profiling of murine double-negative regulatory T cells suggest mechanisms for prolonged cardiac allograft survivalBoris P-L Lee
Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada
J Immunol 174:4535-44. 2005..These findings shed light on the mechanisms by which DN Treg cells down-regulate immune responses and prolong cardiac allograft survival... - Transcriptional analysis of the molecular basis of human kidney aging using cDNA microarray profilingAnette Melk
Division of Nephrology and Transplantation Immunology, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
Kidney Int 68:2667-79. 2005..The molecular basis of renal aging is not completely understood... - Mycophenolate mofetil in pediatric renal transplantationRobert Ettenger
Mattel Children s Hospital, UCLA Medical Center, Los Angeles, CA 90095 1752, USA
Transplantation 80:S201-10. 2005..Finally, recent studies showing that newer agents used in combination with MMF can further increase efficacy and reduce the risk of adverse events such as posttransplant lymphoproliferative disease are discussed...
Research Grants
- Defining Biomarkers in Pediatric Renal TransplantationMinnie Sarwal; Fiscal Year: 2007..The genomic and tissue microarray databases will be made publicly available for the academic community to facilitate future large-scale collaborative studies. ..
- Gene and Cytokine Expression in Tolerance and GVHDSamuel Strober; Fiscal Year: 2009..In addition to providing information about guidance of drug withdrawal, the studies are designed to provide further insight into the cellular and molecular immune mechanisms of tolerance and GVHD protection. ..
- Gene and Cytokine Expression in Tolerance and GVHDSamuel Strober; Fiscal Year: 2010..In addition to providing information about guidance of drug withdrawal, the studies are designed to provide further insight into the cellular and molecular immune mechanisms of tolerance and GVHD protection. ..
- Urinary Proteome Monitoring for Transplant InjuryMINNIE M contact SARWAL; Fiscal Year: 2010..We are going to use two most powerful proteomic methods to identify these biomarkers which will be first of its kind in the field of transplantation. ..