R M Sapolsky

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. ncbi request reprint Cellular defenses against excitotoxic insults
    R M Sapolsky
    Department of Biological Sciences, Stanford University School of Medicine, Stanford, California 94305 5020, USA
    J Neurochem 76:1601-11. 2001
  2. ncbi request reprint Glucocorticoids and hippocampal atrophy in neuropsychiatric disorders
    R M Sapolsky
    Departments of Biological Sciences and Neurological Sciences, Stanford University School, Stanford, CA 94305 5020, USA
    Arch Gen Psychiatry 57:925-35. 2000
  3. ncbi request reprint Glucocorticoids, stress, and their adverse neurological effects: relevance to aging
    R M Sapolsky
    Department of Biological Sciences, Stanford University, CA 94305, USA
    Exp Gerontol 34:721-32. 1999
  4. ncbi request reprint Differential sensitivity of murine astrocytes and neurons from different brain regions to injury
    L Xu
    Department of Anesthesia, Stanford University School of Medicine, Stanford, CA 94305, USA
    Exp Neurol 169:416-24. 2001
  5. ncbi request reprint Limitations in the neuroprotective potential of gene therapy with Bcl-2
    R G Phillips
    Department of Biological Sciences, Stanford University, Stanford, CA, USA
    Brain Res 859:202-6. 2000
  6. ncbi request reprint Calbindin d28k overexpression protects striatal neurons from transient focal cerebral ischemia
    M A Yenari
    Department of Neurosurgery, Stanford University, California, USA
    Stroke 32:1028-35. 2001
  7. pmc SK2 potassium channel overexpression in basolateral amygdala reduces anxiety, stress-induced corticosterone secretion and dendritic arborization
    R Mitra
    Department of Biology, Stanford University, Stanford, CA 94305, USA
    Mol Psychiatry 14:847-55, 827. 2009
  8. ncbi request reprint Neuroprotective effects of an adenoviral vector expressing the glucose transporter: a detailed description of the mediating cellular events
    A Gupta
    Department of Biological Sciences, Stanford University, 95406, Stanford, CA, USA
    Brain Res 908:49-57. 2001
  9. ncbi request reprint Neuroprotection with herpes simplex vectors expressing virally derived anti-apoptotic agents
    M Roy
    Department of Biological Sciences, Stanford University, Stanford, CA 94305 5020, USA
    Brain Res 901:12-22. 2001
  10. ncbi request reprint Gene therapy for treatment of cerebral ischemia using defective herpes simplex viral vectors
    M A Yenari
    Department of Neurosurgery, Stanford Stroke Center, Stanford University Medical Center, Stanford, California, USA
    Ann N Y Acad Sci 939:340-57. 2001

Collaborators

Detail Information

Publications36

  1. ncbi request reprint Cellular defenses against excitotoxic insults
    R M Sapolsky
    Department of Biological Sciences, Stanford University School of Medicine, Stanford, California 94305 5020, USA
    J Neurochem 76:1601-11. 2001
    ..Such an advance would help pave the way for the rational design of therapeutic interventions against necrotic insults...
  2. ncbi request reprint Glucocorticoids and hippocampal atrophy in neuropsychiatric disorders
    R M Sapolsky
    Departments of Biological Sciences and Neurological Sciences, Stanford University School, Stanford, CA 94305 5020, USA
    Arch Gen Psychiatry 57:925-35. 2000
    ....
  3. ncbi request reprint Glucocorticoids, stress, and their adverse neurological effects: relevance to aging
    R M Sapolsky
    Department of Biological Sciences, Stanford University, CA 94305, USA
    Exp Gerontol 34:721-32. 1999
    ..This review considers the current cellular and molecular bases underlying these adverse glucocorticoid actions, and their relevance to brain aging...
  4. ncbi request reprint Differential sensitivity of murine astrocytes and neurons from different brain regions to injury
    L Xu
    Department of Anesthesia, Stanford University School of Medicine, Stanford, CA 94305, USA
    Exp Neurol 169:416-24. 2001
    ..Antioxidant state and levels of expression of bcl-x(L) can in part account for the differential injury observed. This suggests that different protective strategies may have different efficacies depending on brain region...
  5. ncbi request reprint Limitations in the neuroprotective potential of gene therapy with Bcl-2
    R G Phillips
    Department of Biological Sciences, Stanford University, Stanford, CA, USA
    Brain Res 859:202-6. 2000
    ..This finding supports the view that neurotoxicity induced by 3AP is likely to have only minimal apoptotic facets. On a broader level, it suggests some limitations in the neuroprotective potential of gene therapy with Bcl-2...
  6. ncbi request reprint Calbindin d28k overexpression protects striatal neurons from transient focal cerebral ischemia
    M A Yenari
    Department of Neurosurgery, Stanford University, California, USA
    Stroke 32:1028-35. 2001
    ..Calbindin D28K (CaBP) is one such intracellular calcium buffer. We investigated whether CaBP overexpression is neuroprotective against transient focal cerebral ischemia...
  7. pmc SK2 potassium channel overexpression in basolateral amygdala reduces anxiety, stress-induced corticosterone secretion and dendritic arborization
    R Mitra
    Department of Biology, Stanford University, Stanford, CA 94305, USA
    Mol Psychiatry 14:847-55, 827. 2009
    ..SK2 overexpression also reduced dendritic arborization of the amygdala neurons. Hence, SK2 is a potential gene therapy candidate molecule that can be used against stress-related neuropsychiatric disorders such as anxiety...
  8. ncbi request reprint Neuroprotective effects of an adenoviral vector expressing the glucose transporter: a detailed description of the mediating cellular events
    A Gupta
    Department of Biological Sciences, Stanford University, 95406, Stanford, CA, USA
    Brain Res 908:49-57. 2001
    ..Thus, the neuroprotective effects of this particular gene therapy occurs within the known framework of the mechanisms of necrotic neuronal injury...
  9. ncbi request reprint Neuroprotection with herpes simplex vectors expressing virally derived anti-apoptotic agents
    M Roy
    Department of Biological Sciences, Stanford University, Stanford, CA 94305 5020, USA
    Brain Res 901:12-22. 2001
    ..5 whereas all genes tested can protect against heat stress. Conversely, no genes tested can protect against metabolic poisoning by cyanide. Such a study helps us to further understand the nature of apoptotic signals in different insults...
  10. ncbi request reprint Gene therapy for treatment of cerebral ischemia using defective herpes simplex viral vectors
    M A Yenari
    Department of Neurosurgery, Stanford Stroke Center, Stanford University Medical Center, Stanford, California, USA
    Ann N Y Acad Sci 939:340-57. 2001
    ..Although gene therapy is limited to the few hundred cells the vector is capable of transfecting, we consider the possibility of such gene therapy becoming relevant to clinical neurology in the future...
  11. ncbi request reprint Gene therapy effectiveness differs for neuronal survival and behavioral performance
    R G Phillips
    Department of Biological Sciences, Stanford University, Stanford, CA 94305-5020 USA
    Gene Ther 8:579-85. 2001
    ..Despite equivalent magnitude and pattern of sparing of neurons with the immediate and 1 h delay approaches, the delay animals took a significantly longer time after insult to return to normal performance...
  12. ncbi request reprint Gene therapy for treatment of cerebral ischemia using defective herpes simplex viral vectors
    M A Yenari
    Department of Neurology, Stanford Stroke Center, Stanford, CA, USA
    Neurol Res 23:543-52. 2001
    ..Although gene therapy is limited to the few hundred cells the vector is capable of transfecting, we consider the possibility of such gene therapy becoming relevant to clinical neurology in the future...
  13. ncbi request reprint Glucocorticoids may alter antioxidant enzyme capacity in the brain: kainic acid studies
    L J McIntosh
    Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA
    Brain Res 791:215-22. 1998
    ..These experiments indicate that the impairment of antioxidant enzyme defenses, particularly the hippocampal peroxidases, could be a component of GC-mediated neuroendangerment...
  14. ncbi request reprint Quantification of neuron survival in monolayer cultures using an enzyme-linked immunosorbent assay approach, rather than by cell counting
    S M Brooke
    Department of Biological Sciences, Stanford University, CA 94305, USA
    Neurosci Lett 267:21-4. 1999
    ..The ABTS/ELISA method was found to be a fast, reliable and objective procedure for the quantification of neurotoxicity...
  15. ncbi request reprint Mechanisms of estrogenic protection against gp120-induced neurotoxicity
    S A Howard
    Department of Biological Sciences, Stanford University, Stanford, California 94305, USA
    Exp Neurol 168:385-91. 2001
    ..17beta-Estradiol does, however, decrease gp120-induced lipid peroxidation and accumulation of superoxide. Together the data suggest an antioxidant mechanism of estrogen protection that is independent of receptor binding...
  16. ncbi request reprint Overexpression of HSP72 after induction of experimental stroke protects neurons from ischemic damage
    B Hoehn
    Department of Neurosurgery, Stanford University, Stanford, California 94305-5487, USA
    J Cereb Blood Flow Metab 21:1303-9. 2001
    ..Future strategies aimed at enhancing HSP72 expression after clinical stroke may be worth pursuing. The authors suggest that in the future HSP72 may be an effective treatment for stroke...
  17. ncbi request reprint Gene therapy and the aging nervous system
    W O Ogle
    Department of Biological Sciences, Stanford University, Stanford, CA 94305 5020, USA
    Mech Ageing Dev 122:1555-63. 2001
    ....
  18. ncbi request reprint Overexpression of calbindin D(28k) in dentate gyrus granule cells alters mossy fiber presynaptic function and impairs hippocampal-dependent memory
    T C Dumas
    Department of Biological Sciences, Stanford University, Stanford, California, USA
    Hippocampus 14:701-9. 2004
    ..The results demonstrate the power of gene delivery in the study of the neural substrates of learning and memory and suggest that mossy fiber synaptic plasticity is critical for long-term spatial memory...
  19. pmc Viral caspase inhibitor p35, but not crmA, is neuroprotective in the ischemic penumbra following experimental stroke
    J H Sung
    Department of Neurosurgery, Stanford University, School of Medicine, 300 Pasteur Drive R200, Stanford, CA 94305 5327, USA
    Neuroscience 149:804-12. 2007
    ..Results of double immunofluorescence staining indicate that compared with neurons infected with crmA or control vectors, p35-infected neurons had less active caspase-3 expression, cytosolic cytochrome c and nuclear AIF translocation...
  20. ncbi request reprint Interactions among glucose, lactate and adenosine regulate energy substrate utilization in hippocampal cultures
    T M Bliss
    Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA
    Brain Res 899:134-41. 2001
    ..These results support the idea that after hypoxia-ischemia, neurons are biased in the direction of lactate rather than glucose utilization and this is accomplished through a number of regulatory steps...
  21. ncbi request reprint Glutathione peroxidase overexpression inhibits cytochrome C release and proapoptotic mediators to protect neurons from experimental stroke
    B Hoehn
    Department of Neurosurgery, Stanford University School of Medicine, 300 Pasteur Dr, Stanford, Calif 94305 5327, USA
    Stroke 34:2489-94. 2003
    ..Here we test whether overexpression with the use of gene therapy of the antioxidant glutathione peroxidase (Gpx), delivered before or after experimental stroke, is protective against ischemic injury...
  22. ncbi request reprint Glucocorticoids may alter antioxidant enzyme capacity in the brain: baseline studies
    L J McIntosh
    Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA
    Brain Res 791:209-14. 1998
    ....
  23. ncbi request reprint Restructuring the neuronal stress response with anti-glucocorticoid gene delivery
    D Kaufer
    Department of Biological Sciences, Stanford University, Stanford, California, USA
    Nat Neurosci 7:947-53. 2004
    ..Our findings elucidate three principal steps in the neuronal stress-response pathway, all of which are amenable to therapeutic intervention...
  24. ncbi request reprint Reproductive hormone profiles in captive male orangutans: implications for understanding developmental arrest
    A N Maggioncalda
    Department of Anthropological Sciences, Stanford University, California 94305 2145, USA
    Am J Phys Anthropol 109:19-32. 1999
    ..The authors discuss the relationship between these developmental pathways and male orangutan reproductive strategies, and hypothesize about their prepubertal socioendocrine determination...
  25. ncbi request reprint A cautionary note: the actions of adenosine agonists and antagonists may be reversed under certain conditions in primary cultures
    S M Brooke
    Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA
    Brain Res Bull 51:307-12. 2000
    ..We, therefore, present this paper as a cautionary note in experimenting with adenosine analogues...
  26. ncbi request reprint Gene therapy against neurological insults: sparing neurons versus sparing function
    T C Dumas
    Dept of Biological Sciences, Stanford University, Stanford, CA 94305, USA
    Trends Neurosci 24:695-700. 2001
    ..Additionally, functional sparing might depend on factors related to insult severity, neuron type involved or the step in the death cascade that is targeted...
  27. ncbi request reprint Sleep deprivation elevates plasma corticosterone levels in neonatal rats
    I S Hairston
    Neurosciences Program, Department of Biological Sciences, School of Medicine, Stanford University, Stanford, CA 94305-5020, USA. Ilana.Hairston.edu
    Neurosci Lett 315:29-32. 2001
    ..These observations suggest that younger animals are more sensitive to the effects of mild sleep deprivation than older ones...
  28. ncbi request reprint Glucocorticoid modulation of gp120-induced effects on calcium-dependent degenerative events in primary hippocampal and cortical cultures
    S A Howard
    Department of Biological Sciences, Stanford University, California 94305, USA
    Exp Neurol 158:164-70. 1999
    ....
  29. ncbi request reprint HSV-mediated delivery of virally derived anti-apoptotic genes protects the rat hippocampus from damage following excitotoxicity, but not metabolic disruption
    M Roy
    Department of Biological Sciences, Stanford University, Stanford, CA 94305 5020, USA
    Gene Ther 9:214-9. 2002
    ..Together, the results suggest that inhibitors of various apoptotic elements are capable of protecting under acute insult conditions both in vitro and in vivo, suggesting possible future therapeutic applications...
  30. ncbi request reprint Alzheimer's disease and some speculations about the evolution of its modifiers
    R M Sapolsky
    Department of Biological Sciences, Stanford University, Stanford, California 94305, USA
    Ann N Y Acad Sci 924:99-103. 2000
    ..We analyze this in the context of the altricial nature of new-born primates, their long period of dependency on competent maternal care, and the requirement of cognitive intactness for such competency...
  31. ncbi request reprint Growth hormone and thyroid stimulating hormone concentrations in captive male orangutans: implications for understanding developmental arrest
    A N Maggioncalda
    Department of Anthropological Sciences, Stanford University, California 94305 2145, USA
    Am J Primatol 50:67-76. 2000
    ....
  32. ncbi request reprint Inhibition of acidification rate in cultured fibroblasts by glucocorticoids. Application of silicon microphysiometry to endocrinology
    D M Redish
    Department of Biological Sciences, Stanford University, California
    Horm Metab Res 25:264-7. 1993
    ..We suggest that this inhibition of metabolism is secondary to the well-established inhibition of glucose transport and of protein synthesis in fibroblasts by glucocorticoids...
  33. pmc The effects of toxoplasma infection on rodent behavior are dependent on dose of the stimulus
    A Vyas
    Department of Biological Sciences, Stanford University, Stanford, CA 94305 5020, USA
    Neuroscience 148:342-8. 2007
    ..This report also demonstrates that toxoplasma affects emotional valence of the cat odor as indicated by altered learned fear induced by cat odor...
  34. ncbi request reprint Reproduction and resistance to stress: when and how
    J C Wingfield
    Department of Biology, University of Washington, Seattle, WA 98195, USA
    J Neuroendocrinol 15:711-24. 2003
    ..Future research will provide valuable information on the biology of stress and how organisms cope. Such mechanisms would be particularly insightful as the spectre of global change continues to unfold...
  35. ncbi request reprint Gene expression profiles associated with survival of individual rat dentate cells after endogenous corticosteroid deprivation
    S M Nair
    Netherlands Institute for Brain Research, Meibergdreef 33, 1105 AZ Amsterdam ZO, The Netherlands
    Eur J Neurosci 20:3233-43. 2004
    ..Therefore, removal of corticosteroids triggers a specific gene expression profile in surviving dentate granule cells; key components of this profile may be associated with their survival...
  36. ncbi request reprint Are subordinates always stressed? A comparative analysis of rank differences in cortisol levels among primates
    D H Abbott
    Department of Obstetrics Gynecology, University of Wisconsin, Madison, WI 53706, USA
    Horm Behav 43:67-82. 2003
    ....