Research Topics
| T D SangerSummaryAffiliation: Stanford University Country: USA Publications
Research Grants
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Detail Information
Publications
Is cerebral palsy a wastebasket diagnosis?Terence D Sanger
J Child Neurol 23:726-8. 2008
Hypertonia in childhood secondary dystonia due to cerebral palsy is associated with reflex muscle activationJohan van Doornik
Department of Neurology and Neurological Sciences, Stanford University, Stanford, California 94305 5235, USA
Mov Disord 24:965-71. 2009....- Arm trajectories in dyskinetic cerebral palsy have increased random variabilityTerence D Sanger
Department of Neurology and Neurological Sciences, Stanford University, CA 94305 5235, USA
J Child Neurol 21:551-7. 2006..This result shows that there is increased movement variability, and it is consistent with the hypothesis that inadequate removal of noisy signals could be a cause of the movement disorder in dyskinetic cerebral palsy... - Botulinum toxin type B improves the speed of reaching in children with cerebral palsy and arm dystonia: an open-label, dose-escalation pilot studyTerence D Sanger
Division of Child Neurology and Movement Disorders, Stanford University Medical Center, 300 Pasteur, Room A345, Stanford, CA 94305 5235, USA
J Child Neurol 22:116-22. 2007..These results support the use of botulinum toxin type B as a safe and effective treatment for upper extremity dystonia in children with cerebral palsy. Larger controlled trials are needed to confirm these results... - Bayesian filtering of myoelectric signalsTerence D Sanger
Division of Child Neurology and Movement Disorders, Stanford University Medical Center, 300 Pasteur, Room A345, Stanford, CA 94305 5235
J Neurophysiol 97:1839-45. 2007..Use of the nonlinear filter significantly reduces noise compared with current algorithms, and it may therefore permit more effective use of the EMG signal for prosthetic control, biofeedback, and neurophysiology research... - Definition and classification of negative motor signs in childhoodTerence D Sanger
Division of Child Neurology and Movement Disorders, Stanford University Medical Center, 300 Pasteur, Room A345, Stanford, CA 94305 5235, USA
Pediatrics 118:2159-67. 2006.... - Prospective open-label clinical trial of trihexyphenidyl in children with secondary dystonia due to cerebral palsyTerence D Sanger
Stanford University, Stanford, California, USA
J Child Neurol 22:530-7. 2007..A larger, randomized prospective trial stratified by the presence or absence of hyperkinetic movements is needed to confirm these results... - Optimizing assisted communication devices for Children with motor impairments using a model of information rate and channel capacityTerence D Sanger
Stanford University Department of Neurology and Neurological Sciences, Division of Child Neurology, Stanford, CA 94305, USA
IEEE Trans Neural Syst Rehabil Eng 15:458-68. 2007..Optimization of the information rate may be useful for programming assisted communication devices... - Reaching movements in childhood dystonia contain signal-dependent noiseTerence D Sanger
Department of Neurology, Division of Child Neurology and Movement Disorders, Stanford University, Stanford, CA, USA
J Child Neurol 20:489-96. 2005..This finding is consistent with the hypothesis of increased signal-dependent noise in children with dystonia, and we present a simple computational model that provides a possible explanation for the origin of this noise... - Toward a definition of childhood dystoniaTerence D Sanger
Department of Neurology and Neurological Sciences, Stanford University Medical Center, Stanford, California 94305 5235, USA
Curr Opin Pediatr 16:623-7. 2004..The purpose of this review is to summarize recent progress toward providing a consistent, sensitive, specific, and useful definition of dystonia as it presents in childhood... - Failure of motor learning for large initial errorsTerence D Sanger
Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA 94305 5235, USA
Neural Comput 16:1873-86. 2004..We suggest that this may provide a model for the lack of improvement in human skills that can occur despite repeated practice of a complex task... - Severe resting clonus caused by thyrotoxicosis in a 16-year-old girl with hereditary spastic paraparesis: a case reportTerence D Sanger
Department of Neurology and Neurological Sciences, Stanford University Medical Center, Stanford, California 94305 5235, USA
Mov Disord 19:712-3. 2004..It also demonstrates the importance of investigating for common systemic diseases as a cause of movement disorders even in children with underlying known genetic disorders... 
Childhood onset generalised dystonia can be modelled by increased gain in the indirect basal ganglia pathwayT D Sanger
Department of Neurology and Neurosciences, Stanford University Medical Center, Stanford, California 95305 5235, USA
J Neurol Neurosurg Psychiatry 74:1509-15. 2003....- Pathophysiology of pediatric movement disordersTerence D Sanger
Department of Neurology and Neurological Sciences, Pediatric Movement Disorders Clinic, Stanford University Medical Center, Stanford, CA 94305 5235, USA
J Child Neurol 18:S9-24. 2003.... - Pediatric movement disordersTerence D Sanger
Department of Neurology and Neurological Sciences, Stanford University Medical Center, Stanford, CA 94305, USA
Curr Opin Neurol 16:529-35. 2003..The purpose of this review is to summarize recent advances in diagnosis and treatment for childhood movement disorders... - Neural population codesTerence D Sanger
Department of Neurology and Neurological Sciences, Pediatric Movement Disorders Clinic, Stanford University Medical Center, 300 Pasteur Drive, A345, Stanford, CA 94305 5235, USA
Curr Opin Neurobiol 13:238-49. 2003..We show that for population codes based on neurons that have a Poisson distribution of spike probabilities, the behavior and computational properties of the code can be understood in terms of the tuning properties of individual cells... - Classification and definition of disorders causing hypertonia in childhoodTerence D Sanger
Department of Neurology and Neurological Sciences, Stanford University Medical Center, Stanford, California 94305 5235, USA
Pediatrics 111:e89-97. 2003..The definitions presented here are designed to allow differentiation of clinical features even when more than 1 is present simultaneously... - Use of surface electromyography (EMG) in the diagnosis of childhood hypertonia: a pilot studyTerence D Sanger
Department of Neurology and Neurological Sciences, Stanford University, Stanford, California, USA
J Child Neurol 23:644-8. 2008..These results support the importance of further testing of surface EMG as an adjunct to the clinical examination of childhood hypertonia... - Abnormalities of tactile sensory function in children with dystonic and diplegic cerebral palsyTerence D Sanger
Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA 94305 5235, USA
J Child Neurol 22:289-93. 2007..These results are the first to test the spatial discrimination threshold using Johnson, Van Boven, Phillips domes in children with cerebral palsy... - Oral baclofen increases maximal voluntary neuromuscular activation of ankle plantar flexors in children with spasticity due to cerebral palsyJohan van Doornik
Department of Neurology and Neurological Sciences, Stanford University Medical Center, Stanford, CA 94305 5235, USA
J Child Neurol 23:635-9. 2008..Mean maximal plantar flexion torque did not change. We conjecture that antispasticity agents could facilitate strength training by increasing the ability to voluntarily activate muscle... - Force variability during isometric biceps contraction in children with secondary dystonia due to cerebral palsyWay Tong Virginia Chu
Department of Bioengineering, Stanford University, California, USA
Mov Disord 24:1299-305. 2009..These results contribute to a better understanding of movement variability in childhood dystonia and have potential use in therapeutic interventions designed to increase force production reliability... - Abnormal coupling of knee and hip moments during maximal exertions in persons with cerebral palsyDarryl D Thelen
Biomechanical Engineering Division, Mechanical Engineering Department, Stanford University, California, USA
Muscle Nerve 27:486-93. 2003..05). The patterns of joint moments generated by CP subjects are consistent with an extension synergy and may underlie the coupled motion patterns of the lower extremity in such persons... - Does dystonia always include co-contraction? A study of unconstrained reaching in children with primary and secondary dystoniaNicole Malfait
Department of Neurology and Neurological Sciences, Stanford University, 300 Pasteur Dr, A347, Stanford, CA 94305 5235, USA
Exp Brain Res 176:206-16. 2007.... - A probabilistic algorithm for estimating the intention of computer users with movement disordersAdam D Grossman
Department of Bioengineering, Stanford University, Stanford, CA 94305, USA
Conf Proc IEEE Eng Med Biol Soc 2007:3605-8. 2007..We also implement the algorithm as part of text-entry software and perform a preliminary case study on a patient with dystonia, using a joystick as a text input device... - Decoding neural spike trains: calculating the probability that a spike train and an external signal are relatedTerence D Sanger
Department of Child Neurology, Stanford University Medical Center, 300 Pasteur Drive, MS:5235, Stanford, CA 94305, USA
J Neurophysiol 87:1659-63. 2002..The performance of the new algorithm is compared with the performance of correlation methods on simulated data... - Nonlinear sensory cortex response to simultaneous tactile stimuli in writer's crampTerence D Sanger
Department of Child Neurology, Stanford University Medical Center, Stanford, California USA
Mov Disord 17:105-11. 2002..Results indicate a nonlinear interaction between the sensory cortical response to individual finger stimulation in writer's cramp. This altered interaction may contribute to the motor abnormalities... - Poor penmanship in children correlates with abnormal rhythmic tapping: a broad functional temporal impairmentHilla Ben-Pazi
Department of Child Neurology, Stanford Medical Center, Stanford, California, USA
J Child Neurol 22:543-9. 2007..Evaluation of dysfunctional motor performance should include temporal aspects, and further studies are needed to better delineate and address treatment of "dysrhythmia."..
Research Grants
- Arm Kinematics in Hyperkinetic Cerebral PalsyTerence Sanger; Fiscal Year: 2005..Hlatky will guide the design and implementation of clinical trials and outcome measure validation. The proposal includes coursework in cellular and molecular neurobiology and in the design of clinical research studies. ..
- Childhood Motor Impairment and Assisted CommunicationTerence Sanger; Fiscal Year: 2004....
- NIH Task Force on Childhood Motor DisordersTerence Sanger; Fiscal Year: 2006..The ultimate objective is to improve the functional abilities and societal participation of children with motor disorders. ..
- Neural control of abnormal movementTerence Sanger; Fiscal Year: 2006....
- Taskforce on Childhood Motor DisordersTerence Sanger; Fiscal Year: 2007..The result will be definitions and recommendations that will improve the effectiveness and success of clinical trials for children with disorders of movement. ..