Genomes and Genes
Affiliation: Stanford University
- Roles of Gr-1+ leukocytes in postincisional nociceptive sensitization and inflammationPeyman Sahbaie
Anesthesiology Service, Veterans Administration Palo Alto Health Care System, Palo Alto, California, and Department of Anesthesia, Stanford University, Palo Alto, California, USA
Anesthesiology 117:602-12. 2012..This research identifies the contribution of infiltrating neutrophils to incisional pain and inflammation...
- Preprotachykinin-A gene disruption attenuates nociceptive sensitivity after opioid administration and incision by peripheral and spinal mechanisms in micePeyman Sahbaie
Department of Anesthesia, Stanford University School of Medicine, Stanford, CA, USA
J Pain 13:997-1007. 2012..A similar pattern was seen for 5-HT3 receptor expression in tissue from dorsal root ganglia. Therefore, SP may work at both central and peripheral sites to enhance nociceptive sensitization after morphine treatment and incision...
- Gene expression changes associated with Barrett's esophagus and Barrett's-associated adenocarcinoma cell lines after acid or bile salt exposureYing Hao
Department of Medicine, Stanford University, Stanford, CA, USA
BMC Gastroenterol 7:24. 2007..In this study, we determined whether similar exposure to acid or bile salts results in gene expression changes that provide insights into malignant transformation...
- Role of substance P signaling in enhanced nociceptive sensitization and local cytokine production after incisionPeyman Sahbaie
Department of Anesthesia, Stanford University School of Medicine, Stanford, CA, USA
Pain 145:341-9. 2009..Therefore, SP supports nociceptive sensitization after hind paw incision and potentially participates directly in modulating the intensity of inflammatory response in peri-incisional tissue...
- Epigenetic regulation of spinal CXCR2 signaling in incisional hypersensitivity in miceYuan Sun
Postdoctoral Fellow, Research Associate, Senior Research Scientist, Professor, Department of Anesthesiology, Stanford University School of Medicine, Stanford, California, and Department of Anesthesiology, Veterans Affairs Palo Alto Health Care System, Palo Alto, California Senior Research Scientist, Research Assistant, Department of Anesthesiology, Stanford University School of Medicine Received from the Anesthesia and Perioperative Medicine Service, Veterans Affairs Palo Alto Health Care System, Palo Alto, California Submitted for publication February 19, 2013 Accepted for publication May 17, 2013 The work was supported by NIH award GM079126 Bethesda, Maryland and VA Merit Review award 5I01BX000881 Washington, D C The authors declare no competing interests Some findings included in this article were presented in abstract form at the annual meeting of the Society for Neuroscience, October 13 17, 2012, New Orleans, Louisiana
Anesthesiology 119:1198-208. 2013..The authors sought to investigate the role of histone acetylation on spinal CXCR2 signaling after incision...
- Caspase-1 modulates incisional sensitization and inflammationDe Yong Liang
Department of Anesthesiology, Veterans Affairs Palo Alto Health Care System, Palo Alto, California, USA
Anesthesiology 113:945-56. 2010..Caspase-1 is a key enzyme that cleaves prointerleukin-1β to its active form. We hypothesized that caspase-1 is a crucial regulator of incisional interleukin-1β levels, nociceptive sensitization, and inflammation...
- Expression genetics identifies spinal mechanisms supporting formalin late phase behaviorsXiangqi Li
Veterans Affairs Palo Alto Healthcare System, Palo Alto, CA, USA
Mol Pain 6:11. 2010..By using correlative analysis between spinal gene expression and mouse strain-dependent intensity of late phase behavior, we hypothesized genes participating in variability of the response could be identified...
- miR-203 regulates nociceptive sensitization after incision by controlling phospholipase A2 activating protein expressionYuan Sun
Department of Anesthesiology, Stanford University School of Medicine, Stanford, California, USA
Anesthesiology 117:626-38. 2012..microRNA 203 (miR-203) is known to be involved in keratinocyte growth, differentiation, and skin inflammation. We hypothesized that one or more of these mediators might be under the control of miR-203...
- Neuropeptides contribute to peripheral nociceptive sensitization by regulating interleukin-1β production in keratinocytesXiaoyou Shi
Veterans Affairs Palo Alto Health Care System, Palo Alto, California, USA
Anesth Analg 113:175-83. 2011..We therefore hypothesized that neuropeptides lead to nociceptive sensitization through activation of the skin's innate immune system by enhancing inflammasome expression and caspase-1 activity...
- Detection of colonic dysplasia in vivo using a targeted heptapeptide and confocal microendoscopyPei Lin Hsiung
Department of Pediatrics, Radiology and Microbiology and Immunology, Stanford University School of Medicine, 318 Campus Dr, Rm E 150, Stanford, California 94305, USA
Nat Med 14:454-8. 2008..This methodology represents a promising diagnostic imaging approach for the early detection of colorectal cancer and potentially of other epithelial malignancies...
- The complement component C5a receptor mediates pain and inflammation in a postsurgical pain modelDe Yong Liang
Department of Anesthesiology, Veterans Affairs Palo Alto Health Care System, Palo Alto, CA 94304, USA
Pain 153:366-72. 2012..C5aR may provide a novel target for the control of pain and inflammation after surgery...
- Gene expression profiling reveals stromal genes expressed in common between Barrett's esophagus and adenocarcinomaYing Hao
Department of Medicine, Stanford University, Stanford, California 94305 5187, USA
Gastroenterology 131:925-33. 2006....
- From mouse to man: the 5-HT3 receptor modulates physical dependence on opioid narcoticsLarry F Chu
Department of Anesthesiology, Stanford University, Palo Alto, California, USA
Pharmacogenet Genomics 19:193-205. 2009..The analysis of opioid dependence using contemporary in-silico techniques offers an approach to discover novel treatments for dependence and addiction...
- Gabrb3 gene deficient mice exhibit impaired social and exploratory behaviors, deficits in non-selective attention and hypoplasia of cerebellar vermal lobules: a potential model of autism spectrum disorderTimothy M DeLorey
Molecular Research Institute, 1000 Elwell Court, Suite 105, Palo Alto, CA 94303, USA
Behav Brain Res 187:207-20. 2008..The primary aim of this study was to assess whether gabrb3 gene deficient (gabrb3(-/-)) mice exhibit abnormal social behavior, a core deficit associated with autism spectrum disorder...
- Functional imaging of colonic mucosa with a fibered confocal microscope for real-time in vivo pathologyThomas D Wang
Division of Gastroenterology, Stanford University School of Medicine, Stanford, California, USA
Clin Gastroenterol Hepatol 5:1300-5. 2007..The aim of this study was to show the use of functional optical imaging of viable mucosa for quantitative evaluation of colonic neoplasia in real time...
- Effects of methyl donor diets on incisional pain in miceYuan Sun
Department of Anesthesiology, Stanford University School of Medicine, Stanford, California, United States of America Department of Anesthesiology, Veterans Affairs Palo Alto Health Care System, Palo Alto, California, United States of America
PLoS ONE 8:e77881. 2013..However, the dietary effects of methyl donors on pain have not been explored. In this study, we evaluated the effects of dietary methyl donor content on pain responses in mice...
- Selective influence on contextual memory: physiochemical properties associated with selectivity of benzodiazepine ligands at GABAA receptors containing the alpha5 subunitDanni Harris
Moltech Corporation, 1000 Elwell Court, Palo Alto, California 94303, USA
J Med Chem 51:3788-803. 2008..Surprisingly, both weak inverse agonist and antagonists that display binding selectivity toward the alpha5beta2gamma2 isoform were able to attenuate contextual memory impairment...
- Extracellular superoxide dismutase is important for hippocampal neurogenesis and preservation of cognitive functions after irradiationYani Zou
Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA 94304, USA
Proc Natl Acad Sci U S A 109:21522-7. 2012....
- Detection of endogenous biomolecules in Barrett's esophagus by Fourier transform infrared spectroscopyThomas D Wang
Division of Gastroenterology, Stanford University School of Medicine, Palo Alto Veterans Affairs Health Care System, Palo Alto, CA 94304, USA
Proc Natl Acad Sci U S A 104:15864-9. 2007....