NORMAN RUBY

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. ncbi request reprint The suprachiasmatic nucleus is essential for circadian body temperature rhythms in hibernating ground squirrels
    Norman F Ruby
    Department of Biological Sciences, Stanford University, Stanford, California 94305 5020, USA
    J Neurosci 22:357-64. 2002
  2. pmc Hippocampal-dependent learning requires a functional circadian system
    Norman F Ruby
    Department of Biology, Stanford University, Stanford, CA 94305 5020, USA
    Proc Natl Acad Sci U S A 105:15593-8. 2008
  3. doi request reprint Circadian locomotor rhythms are normal in Ts65Dn "Down syndrome" mice and unaffected by pentylenetetrazole
    Norman F Ruby
    Biology Department, Stanford University, Stanford, CA 94305 5020, USA
    J Biol Rhythms 25:63-6. 2010
  4. pmc Spatial memory and long-term object recognition are impaired by circadian arrhythmia and restored by the GABAAAntagonist pentylenetetrazole
    Norman F Ruby
    Biology Department, Stanford University, Stanford, California, USA
    PLoS ONE 8:e72433. 2013
  5. ncbi request reprint Phenotypic differences in reentrainment behavior and sensitivity to nighttime light pulses in siberian hamsters
    Norman F Ruby
    Department of Biological Sciences, Stanford University, Stanford, CA 94305 5020, USA
    J Biol Rhythms 19:530-41. 2004
  6. ncbi request reprint Hibernation: when good clocks go cold
    Norman F Ruby
    Department of Biological Sciences, Stanford University, Stanford, CA 94305 5020, USA
    J Biol Rhythms 18:275-86. 2003
  7. ncbi request reprint Constant darkness restores entrainment to phase-delayed Siberian hamsters
    Norman F Ruby
    Department of Biological Sciences, Stanford University, Stanford, California 94305, USA
    Am J Physiol Regul Integr Comp Physiol 283:R1314-20. 2002
  8. ncbi request reprint Role of melanopsin in circadian responses to light
    Norman F Ruby
    Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA
    Science 298:2211-3. 2002
  9. ncbi request reprint Homeostatic regulation of sleep in arrhythmic Siberian hamsters
    Jennie E Larkin
    Dept Biological Sciences, Stanford Univ, 371 Serra Mall, Stanford, CA 94305 5020, USA
    Am J Physiol Regul Integr Comp Physiol 287:R104-11. 2004
  10. pmc Melanopsin as a sleep modulator: circadian gating of the direct effects of light on sleep and altered sleep homeostasis in Opn4(-/-) mice
    Jessica W Tsai
    Department of Biology, Stanford University, Stanford, CA, USA
    PLoS Biol 7:e1000125. 2009

Research Grants

  1. CIRCADIAN RHYTHM ENTRAINMENT
    NORMAN RUBY; Fiscal Year: 2004

Detail Information

Publications19

  1. ncbi request reprint The suprachiasmatic nucleus is essential for circadian body temperature rhythms in hibernating ground squirrels
    Norman F Ruby
    Department of Biological Sciences, Stanford University, Stanford, California 94305 5020, USA
    J Neurosci 22:357-64. 2002
    ....
  2. pmc Hippocampal-dependent learning requires a functional circadian system
    Norman F Ruby
    Department of Biology, Stanford University, Stanford, CA 94305 5020, USA
    Proc Natl Acad Sci U S A 105:15593-8. 2008
    ..Arrhythmic hamsters may have failed to perform this task because of chronic inhibitory signaling from the SCN that interfered with the plastic mechanisms that encode learning in the hippocampus...
  3. doi request reprint Circadian locomotor rhythms are normal in Ts65Dn "Down syndrome" mice and unaffected by pentylenetetrazole
    Norman F Ruby
    Biology Department, Stanford University, Stanford, CA 94305 5020, USA
    J Biol Rhythms 25:63-6. 2010
    ..Thus, locomotor activity is under strict circadian control in Ts65Dn mice, suggesting that their cognitive deficits and sleep disturbances are not due to dysfunctional circadian timing as proposed previously...
  4. pmc Spatial memory and long-term object recognition are impaired by circadian arrhythmia and restored by the GABAAAntagonist pentylenetetrazole
    Norman F Ruby
    Biology Department, Stanford University, Stanford, California, USA
    PLoS ONE 8:e72433. 2013
    ..Our findings support the hypothesis that circadian arrhythmia impairs declarative memory by increasing the relative influence of GABAergic inhibition in the hippocampus. ..
  5. ncbi request reprint Phenotypic differences in reentrainment behavior and sensitivity to nighttime light pulses in siberian hamsters
    Norman F Ruby
    Department of Biological Sciences, Stanford University, Stanford, CA 94305 5020, USA
    J Biol Rhythms 19:530-41. 2004
    ..Phenotypic variation in both traits is due to underlying differences in circadian organization and suggests a common genetic basis for reentrainment responses and photoperiodic responsiveness...
  6. ncbi request reprint Hibernation: when good clocks go cold
    Norman F Ruby
    Department of Biological Sciences, Stanford University, Stanford, CA 94305 5020, USA
    J Biol Rhythms 18:275-86. 2003
    ..In addition to its role as a circadian pacemaker, the SCN may serve a noncircadian function in hibernators related to maintenance of energy balance...
  7. ncbi request reprint Constant darkness restores entrainment to phase-delayed Siberian hamsters
    Norman F Ruby
    Department of Biological Sciences, Stanford University, Stanford, California 94305, USA
    Am J Physiol Regul Integr Comp Physiol 283:R1314-20. 2002
    ..The dichotomy of circadian responses to DD suggests "entrainment" phenotypes that are similar to those of photoperiodic responders and nonresponders...
  8. ncbi request reprint Role of melanopsin in circadian responses to light
    Norman F Ruby
    Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA
    Science 298:2211-3. 2002
    ..Although melanopsin is not essential for the circadian clock to receive photic input, it contributes significantly to the magnitude of photic responses...
  9. ncbi request reprint Homeostatic regulation of sleep in arrhythmic Siberian hamsters
    Jennie E Larkin
    Dept Biological Sciences, Stanford Univ, 371 Serra Mall, Stanford, CA 94305 5020, USA
    Am J Physiol Regul Integr Comp Physiol 287:R104-11. 2004
    ..Thus loss of circadian control did not alter the homeostatic response to SD. This supports the view that circadian and homeostatic influences on sleep regulation are independent processes...
  10. pmc Melanopsin as a sleep modulator: circadian gating of the direct effects of light on sleep and altered sleep homeostasis in Opn4(-/-) mice
    Jessica W Tsai
    Department of Biology, Stanford University, Stanford, CA, USA
    PLoS Biol 7:e1000125. 2009
    ..Our study, furthermore, demonstrates that lack of melanopsin alters sleep homeostasis. These findings call for a reevaluation of the role of light on mammalian physiology and behavior...
  11. ncbi request reprint Glycogen content in the cerebral cortex increases with sleep loss in C57BL/6J mice
    Paul Franken
    Department of Biological Sciences, Stanford University, Stanford, CA, USA
    Neurosci Lett 402:176-9. 2006
    ..Maintaining this energy store seems thus not to be functionally related to sleep in this strain...
  12. ncbi request reprint Sleep deprivation effects on growth factor expression in neonatal rats: a potential role for BDNF in the mediation of delta power
    Ilana S Hairston
    Department of Biological Sciences, Stanford University, Stanford, California 94305 5020, USA
    J Neurophysiol 91:1586-95. 2004
    ..We conclude that cortical BDNF expression reflects the onset of adult sleep-homeostatic response, whereas the profile of expression of both growth factors suggests a trophic effect of mild sleep deprivation...
  13. ncbi request reprint Sleep deprivation decreases glycogen in the cerebellum but not in the cortex of young rats
    Phung Gip
    Department of Biological Sciences, Stanford University, 371 Serra Mall, Stanford, CA 94305 5020, USA
    Am J Physiol Regul Integr Comp Physiol 283:R54-9. 2002
    ..These results show that brain glycogen reserves are sensitive to SD...
  14. pmc BK calcium-activated potassium channels regulate circadian behavioral rhythms and pacemaker output
    Andrea L Meredith
    Department of Molecular and Cellular Physiology and Howard Hughes Medical Institute, Stanford University, Stanford, California 94305, USA
    Nat Neurosci 9:1041-9. 2006
    ..Our findings implicate BK channels as important regulators of the SFR and suggest that the SCN pacemaker governs the expression of circadian behavioral rhythms through SFR modulation...
  15. ncbi request reprint Light induces c-fos and per1 expression in the suprachiasmatic nucleus of arrhythmic hamsters
    Monique T Barakat
    Department of Biological Sciences, 371 Serra Mall, Stanford University, Stanford, California 94305 5020, USA
    Am J Physiol Regul Integr Comp Physiol 289:R1381-6. 2005
    ..Whereas LL induces arrhythmicity by desynchronizing SCN neurons, phase delay-induced arrhythmicity may be due to a loss of circadian rhythms at the level of individual SCN neurons...
  16. ncbi request reprint Light pulses do not induce c-fos or per1 in the SCN of hamsters that fail to reentrain to the photocycle
    Monique T Barakat
    Department of Biological Sciences, 371 Serra Mall, Stanford University, Stanford, CA 94305 5020, USA
    J Biol Rhythms 19:287-97. 2004
    ..This finding is the first report of acute shift in a photocycle eliminating photosensitivity in the SCN and suggests that a specific pattern of light exposure may desensitize the SCN to subsequent photic input...
  17. ncbi request reprint Changes in brain glycogen after sleep deprivation vary with genotype
    Paul Franken
    Department of Biological Sciences, Stanford University, Stanford, CA 94305 5020, USA
    Am J Physiol Regul Integr Comp Physiol 285:R413-9. 2003
    ..e., AK and D2, did not differ in their glycogen response. Thus glycogen content per se is an unlikely end point of sleep's functional role in brain energy homeostasis...
  18. ncbi request reprint Glucocorticoids influence brain glycogen levels during sleep deprivation
    Phung Gip
    Stanford Genome Technology Center, Stanford University, CA 94304 8307, USA
    Am J Physiol Regul Integr Comp Physiol 286:R1057-62. 2004
    ..Our findings suggest that the elevated glucocorticoid secretion during SD causes brain glycogenolysis in response to energy demands...
  19. ncbi request reprint Sleep and circadian rhythms in mammalian torpor
    H Craig Heller
    Department of Biological Sciences, Stanford University, Stanford, California 94305 5020, USA
    Annu Rev Physiol 66:275-89. 2004
    ..There is good evidence from some species, however, that the circadian system plays important roles in the timing of bouts of torpor...

Research Grants5

  1. CIRCADIAN RHYTHM ENTRAINMENT
    NORMAN RUBY; Fiscal Year: 2004
    ..We chose to focus on melatonin because its effects on the circadian system of Siberian hamsters suggest a role for this hormone in entrainment. ..