Affiliation: Stanford University
- The ciliary membraneRajat Rohatgi
Department of Medicine, Stanford University School of Medicine, 279 Campus Drive, Stanford, CA 94305, USA
Curr Opin Cell Biol 22:541-6. 2010..The regulated movement of membrane proteins and lipids across this barrier is central to the sensory function of these organelles...
- Lateral transport of Smoothened from the plasma membrane to the membrane of the ciliumLjiljana Milenkovic
Howard Hughes Medical Institute, Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
J Cell Biol 187:365-74. 2009..We anticipate that this alternative route will be used by other signaling proteins that function at cilia. The path taken by Smo may allow novel strategies for modulation of Hh signaling in cancer and regeneration...
- The output of Hedgehog signaling is controlled by the dynamic association between Suppressor of Fused and the Gli proteinsEric W Humke
Division of Oncology, Department of Medicine, Stanford University School of Medicine, Stanford, California 94305, USA
Genes Dev 24:670-82. 2010..We propose that the Sufu-Gli3 interaction is a major control point in the Hedgehog pathway, a pathway that plays important roles in both development and cancer...
- A Smoothened-Evc2 complex transduces the Hedgehog signal at primary ciliaKarolin V Dorn
Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
Dev Cell 23:823-35. 2012..Our data suggest that the Smo-Evc2 signaling complex at the EvC zone is required for Hh signal transmission and elucidate the molecular basis of two human ciliopathies...
- Hedgehog signal transduction by Smoothened: pharmacologic evidence for a 2-step activation processRajat Rohatgi
Department of Developmental Biology, Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305, USA
Proc Natl Acad Sci U S A 106:3196-201. 2009..This 2-step mechanism--localization followed by activation--has direct implications for the design and use of anticancer therapeutics targeted against Smo...
- Cell biology. Arrestin' movement in ciliaRajat Rohatgi
Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305 5439, USA
Science 320:1726-7. 2008
- Patched1 regulates hedgehog signaling at the primary ciliumRajat Rohatgi
Departments of Developmental Biology, Genetics, and Bioengineering and Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305, USA
Science 317:372-6. 2007..When Shh bound to Ptc1, Ptc1 left the cilia, leading to accumulation of Smo and activation of signaling. Thus, primary cilia sense Shh and transduce signals that play critical roles in development, carcinogenesis, and stem cell function...
- Biochemical Mechanisms of Hedgehog SignalingRajat Rohatgi; Fiscal Year: 2007..Most importantly, it will put me in an ideal position for a tenure-track position in an oncology department, where I plan to spend ~80-90% of my time in research and teaching and 10-20% of my time in the care of cancer patients. ..