Rajat Rohatgi

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. pmc Lateral transport of Smoothened from the plasma membrane to the membrane of the cilium
    Ljiljana Milenkovic
    Howard Hughes Medical Institute, Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Cell Biol 187:365-74. 2009
  2. pmc Oxysterols are allosteric activators of the oncoprotein Smoothened
    Sigrid Nachtergaele
    Department of Biochemistry, Stanford University School of Medicine, Stanford, California, USA
    Nat Chem Biol 8:211-20. 2012
  3. pmc The ciliary membrane
    Rajat Rohatgi
    Department of Medicine, Stanford University School of Medicine, 279 Campus Drive, Stanford, CA 94305, USA
    Curr Opin Cell Biol 22:541-6. 2010
  4. ncbi request reprint Patched1 regulates hedgehog signaling at the primary cilium
    Rajat Rohatgi
    Departments of Developmental Biology, Genetics, and Bioengineering and Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305, USA
    Science 317:372-6. 2007
  5. pmc The output of Hedgehog signaling is controlled by the dynamic association between Suppressor of Fused and the Gli proteins
    Eric W Humke
    Division of Oncology, Department of Medicine, Stanford University School of Medicine, Stanford, California 94305, USA
    Genes Dev 24:670-82. 2010
  6. pmc Hedgehog signal transduction by Smoothened: pharmacologic evidence for a 2-step activation process
    Rajat Rohatgi
    Department of Developmental Biology, Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 106:3196-201. 2009
  7. pmc EFCAB7 and IQCE regulate hedgehog signaling by tethering the EVC-EVC2 complex to the base of primary cilia
    Ganesh V Pusapati
    Departments of Biochemistry and Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
    Dev Cell 28:483-96. 2014
  8. pmc A Smoothened-Evc2 complex transduces the Hedgehog signal at primary cilia
    Karolin V Dorn
    Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
    Dev Cell 23:823-35. 2012
  9. doi request reprint Cell biology. Arrestin' movement in cilia
    Rajat Rohatgi
    Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305 5439, USA
    Science 320:1726-7. 2008
  10. ncbi request reprint Patching the gaps in Hedgehog signalling
    Rajat Rohatgi
    Department of Developmental Biology, Howard Hughes Medical Institute, Clark Center West W252, 318 Campus Drive, Stanford University School of Medicine, Stanford, CA 94305 5439, USA
    Nat Cell Biol 9:1005-9. 2007

Research Grants

  1. Biochemical Mechanisms of Hedgehog Signaling
    Rajat Rohatgi; Fiscal Year: 2007

Collaborators

  • Matthew P Scott
  • Joel W Neal
  • Yan Ma
  • Bradley K Weiner
  • Gilbert Chu
  • S Tim Yoon
  • Eugene J Carragee
  • L Aravind
  • Karolin V Dorn
  • Eric W Humke
  • Casey E Hughes
  • Ljiljana Milenkovic
  • Christopher M Earhart
  • Ganesh V Pusapati
  • Pawel Niewiadomski
  • Sigrid Nachtergaele
  • Dapeng Zhang
  • Robert Ahrends
  • Heather A Wakelee
  • Richard S Gaster
  • Stephen B Willingham
  • Mary N Teruel
  • Erich J Schwartz
  • Robert J Wilson
  • Lingyun Xu
  • Shan X Wang
  • Sohini Khan
  • Lisa Y Zhou
  • Jennifer H Kong
  • Bennett G Novitch
  • Priscilla Sugianto
  • Irving L Weissman
  • Stefanie S Jeffrey
  • Chin Chun Ooi
  • Dawson J Wong
  • Laurel K Mydock
  • Paul H Schlesinger
  • Kathiresan Krishnan
  • Jayan Rammohan
  • Douglas F Covey

Detail Information

Publications13

  1. pmc Lateral transport of Smoothened from the plasma membrane to the membrane of the cilium
    Ljiljana Milenkovic
    Howard Hughes Medical Institute, Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Cell Biol 187:365-74. 2009
    ..We anticipate that this alternative route will be used by other signaling proteins that function at cilia. The path taken by Smo may allow novel strategies for modulation of Hh signaling in cancer and regeneration...
  2. pmc Oxysterols are allosteric activators of the oncoprotein Smoothened
    Sigrid Nachtergaele
    Department of Biochemistry, Stanford University School of Medicine, Stanford, California, USA
    Nat Chem Biol 8:211-20. 2012
    ..Our work suggests that these enigmatic sterols, which have multiple effects on cell physiology, may act as ligands for signaling receptors and provides a generally applicable framework for probing sterol signaling mechanisms...
  3. pmc The ciliary membrane
    Rajat Rohatgi
    Department of Medicine, Stanford University School of Medicine, 279 Campus Drive, Stanford, CA 94305, USA
    Curr Opin Cell Biol 22:541-6. 2010
    ..The regulated movement of membrane proteins and lipids across this barrier is central to the sensory function of these organelles...
  4. ncbi request reprint Patched1 regulates hedgehog signaling at the primary cilium
    Rajat Rohatgi
    Departments of Developmental Biology, Genetics, and Bioengineering and Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305, USA
    Science 317:372-6. 2007
    ..When Shh bound to Ptc1, Ptc1 left the cilia, leading to accumulation of Smo and activation of signaling. Thus, primary cilia sense Shh and transduce signals that play critical roles in development, carcinogenesis, and stem cell function...
  5. pmc The output of Hedgehog signaling is controlled by the dynamic association between Suppressor of Fused and the Gli proteins
    Eric W Humke
    Division of Oncology, Department of Medicine, Stanford University School of Medicine, Stanford, California 94305, USA
    Genes Dev 24:670-82. 2010
    ..We propose that the Sufu-Gli3 interaction is a major control point in the Hedgehog pathway, a pathway that plays important roles in both development and cancer...
  6. pmc Hedgehog signal transduction by Smoothened: pharmacologic evidence for a 2-step activation process
    Rajat Rohatgi
    Department of Developmental Biology, Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 106:3196-201. 2009
    ..This 2-step mechanism--localization followed by activation--has direct implications for the design and use of anticancer therapeutics targeted against Smo...
  7. pmc EFCAB7 and IQCE regulate hedgehog signaling by tethering the EVC-EVC2 complex to the base of primary cilia
    Ganesh V Pusapati
    Departments of Biochemistry and Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
    Dev Cell 28:483-96. 2014
    ..Evolutionary analysis suggests that emergence of these complexes might have been important for adaptation of an ancient organelle, the cilium, for an animal-specific signaling network...
  8. pmc A Smoothened-Evc2 complex transduces the Hedgehog signal at primary cilia
    Karolin V Dorn
    Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
    Dev Cell 23:823-35. 2012
    ..Our data suggest that the Smo-Evc2 signaling complex at the EvC zone is required for Hh signal transmission and elucidate the molecular basis of two human ciliopathies...
  9. doi request reprint Cell biology. Arrestin' movement in cilia
    Rajat Rohatgi
    Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305 5439, USA
    Science 320:1726-7. 2008
  10. ncbi request reprint Patching the gaps in Hedgehog signalling
    Rajat Rohatgi
    Department of Developmental Biology, Howard Hughes Medical Institute, Clark Center West W252, 318 Campus Drive, Stanford University School of Medicine, Stanford, CA 94305 5439, USA
    Nat Cell Biol 9:1005-9. 2007
    ....
  11. ncbi request reprint Cancer risk after use of recombinant bone morphogenetic protein-2 for spinal arthrodesis
    Eugene J Carragee
    Department of Orthopaedic Surgery, Stanford University School of Medicine, 450 Broadway Street, Pavilion C, 4th Floor, Redwood City, CA 94063, USA
    J Bone Joint Surg Am 95:1537-45. 2013
    ..The effect of rhBMP-2 on the risk of cancer has been a concern. We sought to evaluate the risk of new cancers in patients receiving high-dose rhBMP-2...
  12. ncbi request reprint Isolation and mutational analysis of circulating tumor cells from lung cancer patients with magnetic sifters and biochips
    Christopher M Earhart
    Department of Materials Science and Engineering, Stanford University, Stanford, CA 94305, USA
    Lab Chip 14:78-88. 2014
    ..The use of these magnetic technologies, which are separate devices, may lead the way to routine preparation and characterization of "liquid biopsies" from cancer patients. ..
  13. pmc Gli protein activity is controlled by multisite phosphorylation in vertebrate hedgehog signaling
    Pawel Niewiadomski
    Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA Department of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305, USA Department of Cell Biology, Nencki Institute of Experimental Biology, 02 093 Warsaw, Poland Electronic address
    Cell Rep 6:168-81. 2014
    ....

Research Grants2

  1. Biochemical Mechanisms of Hedgehog Signaling
    Rajat Rohatgi; Fiscal Year: 2007
    ..Most importantly, it will put me in an ideal position for a tenure-track position in an oncology department, where I plan to spend ~80-90% of my time in research and teaching and 10-20% of my time in the care of cancer patients. ..