Rajat Rohatgi

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. pmc The ciliary membrane
    Rajat Rohatgi
    Department of Medicine, Stanford University School of Medicine, 279 Campus Drive, Stanford, CA 94305, USA
    Curr Opin Cell Biol 22:541-6. 2010
  2. pmc Lateral transport of Smoothened from the plasma membrane to the membrane of the cilium
    Ljiljana Milenkovic
    Howard Hughes Medical Institute, Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Cell Biol 187:365-74. 2009
  3. pmc The output of Hedgehog signaling is controlled by the dynamic association between Suppressor of Fused and the Gli proteins
    Eric W Humke
    Division of Oncology, Department of Medicine, Stanford University School of Medicine, Stanford, California 94305, USA
    Genes Dev 24:670-82. 2010
  4. pmc A Smoothened-Evc2 complex transduces the Hedgehog signal at primary cilia
    Karolin V Dorn
    Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
    Dev Cell 23:823-35. 2012
  5. pmc Hedgehog signal transduction by Smoothened: pharmacologic evidence for a 2-step activation process
    Rajat Rohatgi
    Department of Developmental Biology, Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 106:3196-201. 2009
  6. doi request reprint Cell biology. Arrestin' movement in cilia
    Rajat Rohatgi
    Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305 5439, USA
    Science 320:1726-7. 2008
  7. ncbi request reprint Patched1 regulates hedgehog signaling at the primary cilium
    Rajat Rohatgi
    Departments of Developmental Biology, Genetics, and Bioengineering and Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305, USA
    Science 317:372-6. 2007

Research Grants

  1. Biochemical Mechanisms of Hedgehog Signaling
    Rajat Rohatgi; Fiscal Year: 2007

Collaborators

  • Karolin V Dorn
  • Ljiljana Milenkovic
  • Eric W Humke
  • Matthew P Scott
  • Casey E Hughes

Detail Information

Publications7

  1. pmc The ciliary membrane
    Rajat Rohatgi
    Department of Medicine, Stanford University School of Medicine, 279 Campus Drive, Stanford, CA 94305, USA
    Curr Opin Cell Biol 22:541-6. 2010
    ..The regulated movement of membrane proteins and lipids across this barrier is central to the sensory function of these organelles...
  2. pmc Lateral transport of Smoothened from the plasma membrane to the membrane of the cilium
    Ljiljana Milenkovic
    Howard Hughes Medical Institute, Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Cell Biol 187:365-74. 2009
    ..We anticipate that this alternative route will be used by other signaling proteins that function at cilia. The path taken by Smo may allow novel strategies for modulation of Hh signaling in cancer and regeneration...
  3. pmc The output of Hedgehog signaling is controlled by the dynamic association between Suppressor of Fused and the Gli proteins
    Eric W Humke
    Division of Oncology, Department of Medicine, Stanford University School of Medicine, Stanford, California 94305, USA
    Genes Dev 24:670-82. 2010
    ..We propose that the Sufu-Gli3 interaction is a major control point in the Hedgehog pathway, a pathway that plays important roles in both development and cancer...
  4. pmc A Smoothened-Evc2 complex transduces the Hedgehog signal at primary cilia
    Karolin V Dorn
    Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
    Dev Cell 23:823-35. 2012
    ..Our data suggest that the Smo-Evc2 signaling complex at the EvC zone is required for Hh signal transmission and elucidate the molecular basis of two human ciliopathies...
  5. pmc Hedgehog signal transduction by Smoothened: pharmacologic evidence for a 2-step activation process
    Rajat Rohatgi
    Department of Developmental Biology, Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 106:3196-201. 2009
    ..This 2-step mechanism--localization followed by activation--has direct implications for the design and use of anticancer therapeutics targeted against Smo...
  6. doi request reprint Cell biology. Arrestin' movement in cilia
    Rajat Rohatgi
    Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305 5439, USA
    Science 320:1726-7. 2008
  7. ncbi request reprint Patched1 regulates hedgehog signaling at the primary cilium
    Rajat Rohatgi
    Departments of Developmental Biology, Genetics, and Bioengineering and Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305, USA
    Science 317:372-6. 2007
    ..When Shh bound to Ptc1, Ptc1 left the cilia, leading to accumulation of Smo and activation of signaling. Thus, primary cilia sense Shh and transduce signals that play critical roles in development, carcinogenesis, and stem cell function...

Research Grants2

  1. Biochemical Mechanisms of Hedgehog Signaling
    Rajat Rohatgi; Fiscal Year: 2007
    ..Most importantly, it will put me in an ideal position for a tenure-track position in an oncology department, where I plan to spend ~80-90% of my time in research and teaching and 10-20% of my time in the care of cancer patients. ..