Robert Robbins

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. ncbi request reprint In vivo visualization of cardiac allograft rejection and trafficking passenger leukocytes using bioluminescence imaging
    Masashi Tanaka
    Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA 94305 5407, USA
    Circulation 112:I105-10. 2005
  2. ncbi request reprint Ten- and 20-year survivors of pediatric orthotopic heart transplantation
    Michael Ross
    Department of Pediatrics, Stanford University, Stanford, California, USA
    J Heart Lung Transplant 25:261-70. 2006
  3. doi request reprint Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS)-defined morbidity and mortality associated with pediatric ventricular assist device support at a single US center: the Stanford experience
    Mary Lynette Stein
    Stanford University, Stanford, CA 94305, USA
    Circ Heart Fail 3:682-8. 2010
  4. ncbi request reprint Induction therapy for pediatric and adult heart transplantation: comparison between OKT3 and daclizumab
    Clifford Chin
    Division of Pediatric Cardiology, Stanford University, Palo Alto, CA 94304, USA
    Transplantation 80:477-81. 2005
  5. ncbi request reprint The value of transesophageal echocardiography for endovascular graft stenting of the ascending aorta
    Pieter van der Starre
    Department of Anesthesia, Stanford University Medical Center, 300 Pasteur Drive, Stanford, CA 94305, USA
    J Cardiothorac Vasc Anesth 18:466-8. 2004
  6. pmc The endogenous peptide apelin potently improves cardiac contractility and reduces cardiac loading in vivo
    Euan A Ashley
    Donald W Reynolds Cardiovascular Research Center, Division of Cardiovascular Medicine, Stanford University, Stanford, CA 94305, USA
    Cardiovasc Res 65:73-82. 2005
  7. ncbi request reprint Novel role for the potent endogenous inotrope apelin in human cardiac dysfunction
    Mary M Chen
    Donald W Reynolds Cardiovascular Research Center, Division of Cardiovascular Medicine, Falk CVRC, Stanford University, 300 Pasteur Dr, Stanford, Calif 94305, USA
    Circulation 108:1432-9. 2003
  8. ncbi request reprint Successful treatment of a Stanford type A dissection by percutaneous placement of a covered stent graft in the ascending aorta
    Kai Ihnken
    Department of Cardiothoracic Surgery, Stanford University School of Medicine, CA, USA
    J Thorac Cardiovasc Surg 127:1808-10. 2004
  9. ncbi request reprint Long-term follow-up after total lymphoid irradiation in pediatric heart transplant recipients
    Clifford Chin
    Department of Pediatrics, Stanford University, Stanford, California, USA
    J Heart Lung Transplant 21:667-73. 2002
  10. ncbi request reprint Hyperacute rejection of hDAF-transgenic pig organ xenografts in cynomolgus monkeys: influence of pre-existing anti-pig antibodies and prevention by the alpha GAL glycoconjugate GAS914
    Tuan T Lam
    Transplantation Immunology, Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA 94305 5407, USA
    Xenotransplantation 11:517-24. 2004

Research Grants

Detail Information

Publications71

  1. ncbi request reprint In vivo visualization of cardiac allograft rejection and trafficking passenger leukocytes using bioluminescence imaging
    Masashi Tanaka
    Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA 94305 5407, USA
    Circulation 112:I105-10. 2005
    ..We investigated the feasibility of bioluminescence imaging (BLI) for the in vivo assessment of cardiac allograft viability and visualization of passenger leukocytes during the course of acute rejection...
  2. ncbi request reprint Ten- and 20-year survivors of pediatric orthotopic heart transplantation
    Michael Ross
    Department of Pediatrics, Stanford University, Stanford, California, USA
    J Heart Lung Transplant 25:261-70. 2006
    ..Pediatric heart transplantation is entering its third decade, allowing for the first time an analysis of a large group of true long-term survivors, specifically children who have survived > or =10 years post-transplantation...
  3. doi request reprint Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS)-defined morbidity and mortality associated with pediatric ventricular assist device support at a single US center: the Stanford experience
    Mary Lynette Stein
    Stanford University, Stanford, CA 94305, USA
    Circ Heart Fail 3:682-8. 2010
    ....
  4. ncbi request reprint Induction therapy for pediatric and adult heart transplantation: comparison between OKT3 and daclizumab
    Clifford Chin
    Division of Pediatric Cardiology, Stanford University, Palo Alto, CA 94304, USA
    Transplantation 80:477-81. 2005
    ..Daclizumab, a highly humanized, specific interleukin-2 receptor blocker, may be efficacious to the monoclonal agent, OKT3. Due to its specific action and properties, the safety profile of this agent may be superior to OKT3...
  5. ncbi request reprint The value of transesophageal echocardiography for endovascular graft stenting of the ascending aorta
    Pieter van der Starre
    Department of Anesthesia, Stanford University Medical Center, 300 Pasteur Drive, Stanford, CA 94305, USA
    J Cardiothorac Vasc Anesth 18:466-8. 2004
  6. pmc The endogenous peptide apelin potently improves cardiac contractility and reduces cardiac loading in vivo
    Euan A Ashley
    Donald W Reynolds Cardiovascular Research Center, Division of Cardiovascular Medicine, Stanford University, Stanford, CA 94305, USA
    Cardiovasc Res 65:73-82. 2005
    ..The endogenous peptide apelin is differentially regulated in cardiovascular disease but the nature of its role in cardiac function remains unclear...
  7. ncbi request reprint Novel role for the potent endogenous inotrope apelin in human cardiac dysfunction
    Mary M Chen
    Donald W Reynolds Cardiovascular Research Center, Division of Cardiovascular Medicine, Falk CVRC, Stanford University, 300 Pasteur Dr, Stanford, Calif 94305, USA
    Circulation 108:1432-9. 2003
    ..Apelin is among the most potent stimulators of cardiac contractility known. However, no physiological or pathological role for apelin-angiotensin receptor-like 1 (APJ) signaling has ever been described...
  8. ncbi request reprint Successful treatment of a Stanford type A dissection by percutaneous placement of a covered stent graft in the ascending aorta
    Kai Ihnken
    Department of Cardiothoracic Surgery, Stanford University School of Medicine, CA, USA
    J Thorac Cardiovasc Surg 127:1808-10. 2004
  9. ncbi request reprint Long-term follow-up after total lymphoid irradiation in pediatric heart transplant recipients
    Clifford Chin
    Department of Pediatrics, Stanford University, Stanford, California, USA
    J Heart Lung Transplant 21:667-73. 2002
    ..Short-term success and complication rates have been reported in pediatric and adult cardiac transplant populations. We report the long-term efficacy and safety of TLI in treating intractable rejection in pediatric patients...
  10. ncbi request reprint Hyperacute rejection of hDAF-transgenic pig organ xenografts in cynomolgus monkeys: influence of pre-existing anti-pig antibodies and prevention by the alpha GAL glycoconjugate GAS914
    Tuan T Lam
    Transplantation Immunology, Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA 94305 5407, USA
    Xenotransplantation 11:517-24. 2004
    ..We evaluated the efficacy of GAS914, a Gal alpha 1-3Gal trisaccharide linked to a poly-l-lysine backbone, in inhibition of HAR...
  11. ncbi request reprint New directions in cardiac transplantation
    Abdulaziz Al-Khaldi
    Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, California, USA
    Annu Rev Med 57:455-71. 2006
    ....
  12. ncbi request reprint Transcriptional profiling of reporter genes used for molecular imaging of embryonic stem cell transplantation
    Joseph C Wu
    Division of Cardiology, Department of Medicine, Stanford University School of Medicine, Stanford, USA
    Physiol Genomics 25:29-38. 2006
    ..Taken together, this is the first study to analyze in detail the effects of reporter genes on molecular imaging of ES cells...
  13. ncbi request reprint Are heart-lung transplant recipients protected from developing bronchiolitis obliterans syndrome?
    Susan D Moffatt-Bruce
    Department of Cardiothoracic Surgery, Stanford University, Stanford, California, USA
    Ann Thorac Surg 81:286-91; discussion 291. 2006
    ..In addition, the risk factors for developing BOS after lung transplantation were analyzed...
  14. ncbi request reprint Dimethylarginine dimethylaminohydrolase overexpression suppresses graft coronary artery disease
    Masashi Tanaka
    Department of Cardiothoracic Surgery, Stanford University Medical Center, Stanford, CA, USA
    Circulation 112:1549-56. 2005
    ..We hypothesized that lowering ADMA concentrations by dimethylarginine dimethylaminohydrolase (DDAH) overexpression in the recipient might suppress GCAD and long-term immune responses in murine cardiac allografts...
  15. ncbi request reprint Haematopoietic stem cells and repair of the ischaemic heart
    Leora B Balsam
    Department of Cardiothoracic Surgery, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA
    Clin Sci (Lond) 109:483-92. 2005
    ..It also describes the current state of the art in clinical trials of bone marrow transplantation for heart failure...
  16. ncbi request reprint Allopurinol/uricase and ibuprofen enhance engraftment of cardiomyocyte-enriched human embryonic stem cells and improve cardiac function following myocardial injury
    Theo Kofidis
    Cardiothoracic Surgery Falk Research Center, Stanford University Medical School, Stanford, CA, USA
    Eur J Cardiothorac Surg 29:50-5. 2006
    ....
  17. ncbi request reprint Thoratec ventricular assist devices in pediatric patients: update on clinical results
    Olaf Reinhartz
    Stanford University, Department of Cardiothoracic Surgery, 300 Pasteur Drive, Stanford, CA 94605, USA
    ASAIO J 51:501-3. 2005
    ..3 m2. This subgroup had a higher incidence of congenital heart disease and a slightly lower survival (52%). Aspects of the particular risks and device management in these small patients are discussed...
  18. ncbi request reprint Embryonic stem cell immunogenicity increases upon differentiation after transplantation into ischemic myocardium
    Rutger Jan Swijnenburg
    Department of Surgery, Leiden University School of Medicine, The Netherlands
    Circulation 112:I166-72. 2005
    ..We investigated whether differentiation of embryonic stem cells (ESCs) in ischemic myocardium enhances their immunogenicity, thereby increasing their chance for rejection...
  19. ncbi request reprint Novel injectable bioartificial tissue facilitates targeted, less invasive, large-scale tissue restoration on the beating heart after myocardial injury
    Theo Kofidis
    Cardiovascular Surgery, Stanford University Medical School, Stanford, California, USA
    Circulation 112:I173-7. 2005
    ..With the liquid bioartificial tissue compound used in this study, we achieved targeted large-scale support of the infarcted left ventricular wall and improvement of heart function...
  20. ncbi request reprint Prolonged cold ischemia in rat cardiac allografts promotes ischemia-reperfusion injury and the development of graft coronary artery disease in a linear fashion
    Masashi Tanaka
    Department of Cardiothoracic Surgery, Stanford University Medical Center, Stanford, California 94305, USA
    J Heart Lung Transplant 24:1906-14. 2005
    ..We investigated the effect of varying lengths of cold ischemia on inflammation and apoptosis during ischemia-reperfusion injury and correlated this with the degree of GCAD in rat cardiac allografts...
  21. ncbi request reprint Dual in vivo magnetic resonance evaluation of magnetically labeled mouse embryonic stem cells and cardiac function at 1.5 t
    Takayasu Arai
    Division of Cardiovascular Medicine, Stanford University, California 94305 5233, USA
    Magn Reson Med 55:203-9. 2006
    ..Thus, in vivo MRI enables simultaneous detection of transplanted mESC and their therapeutic effect on the injured myocardium...
  22. ncbi request reprint Hyposecretion, not hyperabsorption, is the basic defect of cystic fibrosis airway glands
    Nam Soo Joo
    Cystic Fibrosis Research Laboratory, RM 516, Bldg 420, Main Quad, Stanford University, Stanford, CA 94305 2130, USA
    J Biol Chem 281:7392-8. 2006
    ..Our results suggest that CF glands do not display excessive, ENaC-mediated fluid absorption, leaving defective, anion-mediated fluid secretion as the most likely mechanism for defective mucus secretion from CF glands...
  23. pmc Short hairpin RNA interference therapy for ischemic heart disease
    Mei Huang
    Stanford University School of Medicine, Edwards Building R354, Stanford, CA 94305 5344, USA
    Circulation 118:S226-33. 2008
    ..Here we hypothesize that short hairpin RNA (shRNA) interference therapy targeting PHD2 can be used for treatment of myocardial ischemia and this process can be followed noninvasively by molecular imaging...
  24. pmc Comparison of different adult stem cell types for treatment of myocardial ischemia
    Koen E A van der Bogt
    Laboratory of Cardiothoracic Transplantation, Stanford University School of Medicine, Stanford, CA 94305 5324, USA
    Circulation 118:S121-9. 2008
    ..This study is designed to evaluate the therapeutic efficacy of 4 cell types in a murine model of myocardial infarction...
  25. pmc Immunosuppressive therapy mitigates immunological rejection of human embryonic stem cell xenografts
    Rutger Jan Swijnenburg
    Department of Cardiothoracic Surgery, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 105:12991-6. 2008
    ..This process can be mitigated by a combined immunosuppressive regimen as assessed by molecular imaging approaches...
  26. doi request reprint Novel immunosuppression: R348, a JAK3- and Syk-inhibitor attenuates acute cardiac allograft rejection
    Tobias Deuse
    Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA
    Transplantation 85:885-92. 2008
    ..Janus kinase (JAK)3 is crucial for signal transduction downstream of various cytokine receptors in immune cells. This is the first report on the novel JAK3 inhibitor R348...
  27. doi request reprint Pneumatic paracorporeal ventricular assist device in infants and children: initial Stanford experience
    S Chris Malaisrie
    Department of Cardiothoracic Surgery, Stanford University Medical Center, Stanford, California 94305 5407, USA
    J Heart Lung Transplant 27:173-7. 2008
    ..Eighty-seven devices have been placed in North America through February 2007. We describe our single-center experience in 8 children...
  28. pmc Genetic modification of embryonic stem cells with VEGF enhances cell survival and improves cardiac function
    Xiaoyan Xie
    The Department of Radiology and Molecular Imaging Program at Stanford, Stanford University, Stanford, California, USA
    Cloning Stem Cells 9:549-63. 2007
    ..With further validation, this platform may have broad applications for current basic research and further clinical studies...
  29. pmc In vivo genetic profiling and cellular localization of apelin reveals a hypoxia-sensitive, endothelial-centered pathway activated in ischemic heart failure
    Ahmad Y Sheikh
    Division of Cardiovascular Medicine, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA
    Am J Physiol Heart Circ Physiol 294:H88-98. 2008
    ..The apelin-APJ pathway may thus provide a mechanism for systemic endothelial monitoring of tissue perfusion and adaptive regulation of cardiovascular function...
  30. ncbi request reprint Antisense oligonucleotides: design, construction, and applications to cardiac allograft transfer
    Leora B Balsam
    Falk Cardiovascular Research Center, Department of Cardiothoracic Surgery, Stanford University School of Medicine, CA, USA
    Methods Mol Biol 219:129-33. 2003
  31. ncbi request reprint Pharmacological inhibition of epsilon PKC suppresses chronic inflammation in murine cardiac transplantation model
    Tomoyoshi Koyanagi
    Department of Chemical and Systems Biology, Stanford University School of Medicine CCSR, Rm 3145A, 269 Campus Drive Stanford, CA 94305 5174, USA
    J Mol Cell Cardiol 43:517-22. 2007
    ....
  32. pmc Molecular imaging of bone marrow mononuclear cell homing and engraftment in ischemic myocardium
    Ahmad Y Sheikh
    Department of Cardiothoracic Surgery, Stanford University School of Medicine, Edwards Building R354, Stanford, California 94305 5344, USA
    Stem Cells 25:2677-84. 2007
    ..Specifically, we have demonstrated that systemically delivered BMMCs preferentially home to and are retained by injured myocardium. Disclosure of potential conflicts of interest is found at the end of this article...
  33. ncbi request reprint In vivo optical bioluminescence imaging of collagen-supported cardiac cell grafts
    Ingo Kutschka
    Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, California, USA
    J Heart Lung Transplant 26:273-80. 2007
    ..In this study we introduce two new experimental models for longitudinal in vivo survival studies of cardiac cell grafts using optical bioluminescence imaging...
  34. ncbi request reprint Magnetic resonance imaging of progressive cardiomyopathic changes in the db/db mouse
    Patrick Yue
    Division of Cardiovascular Medicine, Department of Medicine, Stanford University Medical Center, 300 Pasteur Drive, Stanford, CA 94305 5406, USA
    Am J Physiol Heart Circ Physiol 292:H2106-18. 2007
    ..In summary, as assessed by CMR, db/db mice develop characteristic structural and functional changes consistent with cardiomyopathy...
  35. ncbi request reprint Adenoviral human BCL-2 transgene expression attenuates early donor cell death after cardiomyoblast transplantation into ischemic rat hearts
    Ingo Kutschka
    Department of Cardiothoracic Surgery, Stanford University, School of Medicine, Stanford, California, USA
    Circulation 114:I174-80. 2006
    ..Therefore, we studied the potential benefit of hBcl-2 transgene expression on the survival of cardiomyoblast grafts in ischemic rat hearts...
  36. ncbi request reprint Collagen matrices enhance survival of transplanted cardiomyoblasts and contribute to functional improvement of ischemic rat hearts
    Ingo Kutschka
    Department of Cardiothoracic Surgery, Stanford University, School of Medicine, Stanford, California, USA
    Circulation 114:I167-73. 2006
    ..Cardiac cell transplantation is limited by poor graft viability. We aimed to enhance the survival of transplanted cardiomyoblasts using growth factor-supplemented collagen matrices...
  37. ncbi request reprint Outcome analysis of donor gender in heart transplantation
    Abdulaziz Al-Khaldi
    Department of Cardiothoracic Surgery, Stanford University Medical Center, Stanford, California 94305 5407, USA
    J Heart Lung Transplant 25:461-8. 2006
    ..We evaluated our own experience in heart transplantation in the cyclosporine era, since 1980, to determine the effect of donor gender on survival...
  38. pmc Synergistic airway gland mucus secretion in response to vasoactive intestinal peptide and carbachol is lost in cystic fibrosis
    Jae Young Choi
    Cystic Fibrosis Research Laboratory, Stanford University, Stanford, California, USA
    J Clin Invest 117:3118-27. 2007
    ..Loss of "housekeeping" gland mucus secretion in CF, in combination with demonstrated defects in surface epithelia, may play a role in the vulnerability of CF airways to bacterial infections...
  39. ncbi request reprint Molecular imaging using labeled donor tissues reveals patterns of engraftment, rejection, and survival in transplantation
    Yu An Cao
    Department of Pediatrics, Stanford School of Medicine, Stanford, California, USA
    Transplantation 80:134-9. 2005
    ..This imaging approach is sensitive and reproducible, permits study of the dynamic range of the entire process of transplantation, and will greatly enhance studies across various disciplines involving transplantation...
  40. ncbi request reprint Early inhibition of caspase-3 activity lessens the development of graft coronary artery disease
    Leora B Balsam
    Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, California 94305, USA
    J Heart Lung Transplant 24:827-32. 2005
    ..We hypothesized that early inhibition of apoptosis with a caspase-3 inhibitor would also lessen the development of GCAD...
  41. ncbi request reprint The impact of brain death on survival after heart transplantation: time is of the essence
    Bernard Cantin
    Quebec Heart Institute, Quebec City, Quebec, Canada
    Transplantation 76:1275-9. 2003
    ..It has been suggested that the modality of brain death and time from brain death until harvest impact survival and rejection after heart transplantation...
  42. ncbi request reprint L-Arginine polymers enhance coronary flow and reduce oxidative stress following cardiac transplantation in rats
    Murray H Kown
    Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA 94305 5247, USA
    J Thorac Cardiovasc Surg 126:1065-70. 2003
    ..The current study examined whether these polymers improved coronary flow and reduced myocardial oxidative stress after rat heart transplantation...
  43. ncbi request reprint Longer-term risks associated with 10-year survival after heart transplantation in the cyclosporine era
    Nobuyuki Shiba
    Division of Cardiovascular Medicine, Falk Cardiovascular Research Building, Stanford University Medical Center, 300 Pasteur Drive, Palo Alto, CA 94305, USA
    J Heart Lung Transplant 22:1098-106. 2003
    ..The purpose of this study is to identify factors associated with 10-year survival after heart transplantation...
  44. ncbi request reprint Bcl-2-mediated inhibition of apoptosis in rat cardiac allografts worsens development of graft coronary artery disease
    Murray H Kown
    Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, California, USA
    J Heart Lung Transplant 22:986-92. 2003
    ..We hypothesized that adenovirally mediated Bcl-2 transfection of donor hearts would reduce the apoptosis that occurs during acute rejection while worsening the development of chronic graft coronary artery disease (GCAD)...
  45. ncbi request reprint Effects of adenoviral up-regulation of bcl-2 on oxidative stress and graft coronary artery disease in rat heart transplants
    Douglas N Miniati
    Department of Cardiothoracic Surgery, Stanford University School of Medicine, CA 94305, USA
    Transplantation 76:382-6. 2003
    ..We hypothesized that adenoviral up-regulation of bcl-2 would decrease early oxidative stress and inhibit GCAD after heart transplantation...
  46. ncbi request reprint Long-term results of heart transplantation in patients older than 60 years
    Philippe Demers
    Department of Cardiothoracic Surgery, Stanford University School of Medicine, CA 94305 5247, USA
    J Thorac Cardiovasc Surg 126:224-31. 2003
    ..Older patients are now considered as potential candidates for heart transplantation. The objective of this study was to evaluate the long-term results of heart transplantation in patients older than 60 years...
  47. ncbi request reprint Elevated cyclic adenosine monophosphate ameliorates ischemia-reperfusion injury in rat cardiac allografts
    Seiichiro Murata
    Department of Cardiothoracic Surgery, Stanford University Medical Center, Stanford, California 94305, USA
    J Heart Lung Transplant 22:802-9. 2003
    ..We hypothesized that augmenting allograft cAMP levels with the water-soluble adenylate cyclase activator, NKH477, could decrease ischemia-reperfusion injury and inhibit the progression of GCAD...
  48. ncbi request reprint Novel index for invasively assessing the coronary microcirculation
    William F Fearon
    Division of Cardiovascular Medicine, Stanford University Medical Center, Stanford, CA 94305, USA
    Circulation 107:3129-32. 2003
    ..A relatively simple, invasive method for quantitatively assessing the status of the coronary microcirculation independent of the epicardial artery is lacking...
  49. ncbi request reprint Coronary atherosclerosis in cardiac transplant patients treated with total lymphoid irradiation
    Marc P Pelletier
    Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, California 94305 5407, USA
    J Heart Lung Transplant 22:124-9. 2003
    ..Total lymphoid irradiation (TLI) has been shown to be a successful treatment for persistent allograft rejection, but its effect on coronary arterial disease has yet to be evaluated...
  50. ncbi request reprint Absent secretion to vasoactive intestinal peptide in cystic fibrosis airway glands
    Nam Soo Joo
    Cystic Fibrosis Research Laboratory, Stanford University, Stanford, California 94305 2130, USA
    J Biol Chem 277:50710-5. 2002
    ..The complete absence of secretion to agents that elevate [cAMP](i) suggests that altered secretion of gland mucus could contribute to CF lung disease...
  51. ncbi request reprint Consensus conference report: maximizing use of organs recovered from the cadaver donor: cardiac recommendations, March 28-29, 2001, Crystal City, Va
    Jonathan G Zaroff
    UCSF Medical Center, San Francisco, Calif 94143 0124, USA
    Circulation 106:836-41. 2002
    ....
  52. ncbi request reprint Lung and heart-lung transplantation in patients with end-stage cystic fibrosis: the Stanford experience
    Luca A Vricella
    Department of Cardiothoracic Surgery, Stanford University School of Medicine, California 94305 5407, USA
    Ann Thorac Surg 74:13-7; discussion 17-8. 2002
    ..We reviewed our 13-year experience with thoracic transplantation for cystic fibrosis with an operative approach that favors use of cardiopulmonary bypass for BLTx...
  53. ncbi request reprint Zinc chloride-mediated reduction of apoptosis as an adjunct immunosuppressive modality in cardiac transplantation
    Murray H Kown
    Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, California 94305 5247, USA
    J Heart Lung Transplant 21:360-5. 2002
    ..Simultaneous treatment of rat recipients of heterotopic heart transplants with zinc chloride (ZnCl(2)) thus may allow lower doses of CsA for immunosuppression...
  54. ncbi request reprint Up-regulation of Bcl-2 through hyperbaric pressure transfection of TGF-beta1 ameliorates ischemia-reperfusion injury in rat cardiac allografts
    Jurg Grunenfelder
    Department of Cardiothoracic Surgery, Falk Cardiovascular Research Building, Stanford University School of Medicine, Stanford, California, USA
    J Heart Lung Transplant 21:244-50. 2002
    ..Transforming growth factor (TGF)-beta1 is known to attenuate ischemia-reperfusion injury and inhibits apoptosis of myofibroblasts. We hypothesize that TGF-beta1, prevents bcl-2 cleavage and increased TNF-alpha production...
  55. ncbi request reprint Analysis of survivors more than 10 years after heart transplantation in the cyclosporine era: Stanford experience
    Nobuyuki Shiba
    Division of Cardiovascular Medicine, Stanford University Medical Center, Stanford, California 94305, USA
    J Heart Lung Transplant 23:155-64. 2004
    ..Truly long term survival post heart transplantation has become increasingly frequent over the past two decades...
  56. ncbi request reprint Haematopoietic stem cells adopt mature haematopoietic fates in ischaemic myocardium
    Leora B Balsam
    Departments of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, California 94305, USA
    Nature 428:668-73. 2004
    ..1(lo) Lin- Sca-1+ long-term reconstituting haematopoietic stem cells adopt only traditional haematopoietic fates...
  57. ncbi request reprint Myocardial restoration with embryonic stem cell bioartificial tissue transplantation
    Theo Kofidis
    Department of Cardiothoracic Surgery, Falk Research Center, Stanford University Medical School, Stanford, California, USA
    J Heart Lung Transplant 24:737-44. 2005
    ..The present study utilizes embryonic stem cells as the substrate of bioartificial myocardial tissue and evaluates engraftment in, and functional recovery of, the recipient heart...
  58. ncbi request reprint Progression of alloresponse and tissue-specific immunity during graft coronary artery disease
    Masashi Tanaka
    Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA 94305 5407, USA
    Am J Transplant 5:1286-96. 2005
    ..Our data suggest that both allo- and tissue-specific immunity might contribute to the induction of GCAD. They indicate that continual autoimmune response against graft tissue antigens may provide for GCAD sustenance...
  59. ncbi request reprint Stimulation of paracrine pathways with growth factors enhances embryonic stem cell engraftment and host-specific differentiation in the heart after ischemic myocardial injury
    Theo Kofidis
    Department of Cardiothoracic Surgery, Falk Research Center, Stanford University Medical School, Stanford, Calif 94305, USA
    Circulation 111:2486-93. 2005
    ..We examine the potential of growth factors to enhance cell engraftment and differentiation and to promote functional improvement after transfer of undifferentiated embryonic stem cells into the injured heart...
  60. ncbi request reprint Inhibition of heart transplant injury and graft coronary artery disease after prolonged organ ischemia by selective protein kinase C regulators
    Masashi Tanaka
    Department of Cardiothoracic Surgery, Stanford University Medical Center, Falk Cardiovascular Research Center, Stanford, CA 94305, USA
    J Thorac Cardiovasc Surg 129:1160-7. 2005
    ....
  61. ncbi request reprint Caspase-3 inhibition preserves myocardial geometry and long-term function after infarction
    Leora B Balsam
    Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Surg Res 124:194-200. 2005
    ..We hypothesized that inhibition of caspase-3 activity might limit dysfunction and remodeling after permanent coronary artery ligation...
  62. ncbi request reprint Cyclosporine mitigates graft coronary artery disease in murine cardiac allografts: description and validation of a novel fully allogeneic model
    Masashi Tanaka
    Department of Cardiothoracic Surgery, Stanford University Medical Center, Stanford, California 94305, USA
    J Heart Lung Transplant 24:446-53. 2005
    ..We developed a novel allogeneic mouse model of heart transplantation and investigated the effect of CsA on acute rejection and GCAD...
  63. ncbi request reprint Cyclosporine treatment of high dose and long duration reduces the severity of graft coronary artery disease in rodent cardiac allografts
    Maarten A Lijkwan
    Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands
    J Heart Lung Transplant 24:439-45. 2005
    ..The objective of this study was to correlate GCAD with the level of immunosuppression in an established allogeneic rodent cardiac chronic rejection model to better understand the mechanisms of GCAD in this system...
  64. ncbi request reprint Lung transplantation: a decade of experience
    Susan D Moffatt
    Department of Cardiothoracic Surgery, Stanford University, Stanford, CA 94305, USA
    J Heart Lung Transplant 24:145-51. 2005
    ..The purpose of this study was to review a single institution's long-term experience with single and double lung transplantation and to assess the effect of different immunosuppressive therapies on outcomes...
  65. ncbi request reprint Pre-transplant blood transfusion and cyclosporin A induce long-term hamster cardiac xenograft survival in immunocompetent rats
    Patrick W Vriens
    Department of Cardiothoracic Surgery, Stanford University Medical Center, Stanford, CA, USA
    Xenotransplantation 12:63-71. 2005
    ..In this study we test the combination of pre-transplant HBT with cyclosporin A (CSA) in immunocompetent Lewis rats...
  66. ncbi request reprint Insulin-like growth factor promotes engraftment, differentiation, and functional improvement after transfer of embryonic stem cells for myocardial restoration
    Theo Kofidis
    Cardiothoracic Surgery, Falk Research Center, Stanford University Medical School, Stanford, CA 94305, USA
    Stem Cells 22:1239-45. 2004
    ..01). IGF did not affect the cellular response to the donor cells or tumorigenicity. IGF-1 promotes expression of cardiomyocyte phenotype in ESCs in vivo. It should be considered as an adjuvant to cell transfer for myocardial restoration...
  67. ncbi request reprint Overexpression of human copper/zinc superoxide dismutase (SOD1) suppresses ischemia-reperfusion injury and subsequent development of graft coronary artery disease in murine cardiac grafts
    Masashi Tanaka
    Department of Cardiothoracic Surgery, Stanford University Medical Center, Stanford, Calif, USA
    Circulation 110:II200-6. 2004
    ..Ischemia-reperfusion injury is an important risk factor for graft coronary artery disease (GCAD). We hypothesized that overexpression of SOD1 in donor hearts would suppress ischemia-reperfusion injury and thereby reduce GCAD...
  68. ncbi request reprint Suppression of graft coronary artery disease by a brief treatment with a selective epsilonPKC activator and a deltaPKC inhibitor in murine cardiac allografts
    Masashi Tanaka
    Department of Cardiothoracic Surgery, Stanford University School of Medicine, Falk Cardiovascular Research Center, Stanford, CA 94305 5407, USA
    Circulation 110:II194-9. 2004
    ..Here, we examined whether limiting ischemia-reperfusion injury inhibits graft coronary artery disease (GCAD) and improves murine cardiac allografting...
  69. ncbi request reprint Cardiomyocyte-specific Bcl-2 overexpression attenuates ischemia-reperfusion injury, immune response during acute rejection, and graft coronary artery disease
    Masashi Tanaka
    Department of Cardiothoracic Surgery, Falk Cardiovascular Research Center, 300 Pasteur Dr CVRB, Stanford University School of Medicine, Stanford, CA 94305 5407, USA
    Blood 104:3789-96. 2004
    ..In conclusion, our findings suggest that the modulation of Bcl-2 expression by pharmacologic up-regulation or gene transfer may be of clinical benefit in the short- and long-term function of cardiac allografts...
  70. ncbi request reprint Microvascular resistance is not influenced by epicardial coronary artery stenosis severity: experimental validation
    William F Fearon
    Division of Cardiovascular Medicine, Stanford University Medical Center, Stanford, Calif, USA
    Circulation 109:2269-72. 2004
    ..The effect of epicardial artery stenosis on myocardial microvascular resistance remains controversial. Recruitable collateral flow, which may affect resistance, was not incorporated into previous measurements...
  71. ncbi request reprint Heart transplantation: a thirty-year perspective
    Douglas N Miniati
    Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, California, 94025, USA
    Annu Rev Med 53:189-205. 2002
    ..This review addresses the history, current surgical technique, recipient and donor selection, postoperative care, immunosuppression, short- and long-term complications, and clinical outcomes associated with this procedure...

Research Grants5

  1. Oxidative Stress Signaling in Graft Coronary Disease
    Robert Robbins; Fiscal Year: 2004
    ..abstract_text> ..