Research Topics
| Gerald M ReavenSummaryAffiliation: Stanford University Country: USA Publications
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Publications
Multiple CHD risk factors in type 2 diabetes: beyond hyperglycaemiaGerald M Reaven
Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, California, USA
Diabetes Obes Metab 4:S13-8. 2002..The opportunities for new therapeutic approaches to reduce cardiovascular risk will undoubtedly evolve along with our understanding of the complex factors responsible for insulin resistance, compensatory hyperinsulinaemia, and CHD...
Apelin is necessary for the maintenance of insulin sensitivityPatrick Yue
Div of Cardiovascular Medicine, Stanford University School of Medicine, 300 Pasteur Dr, Falk CVRC, Stanford, CA 94305 5406, USA
Am J Physiol Endocrinol Metab 298:E59-67. 2010..We conclude that apelin is necessary for the maintenance of insulin sensitivity in vivo. Apelin's effects on glucose uptake and Akt phosphorylation are in part mediated by a G(i) and AMPK-dependent pathway...
Pioglitazone administration decreases cardiovascular disease risk factors in insulin-resistant smokersFahim Abbasi
Stanford University School of Medicine, CA 94305, USA
Metabolism 57:1108-14. 2008....- The relationship between plasma adiponectin concentration and insulin resistance is altered in smokersFahim Abbasi
Department of Medicien, Stanford University School of Medicine, CA 94305, USA
J Clin Endocrinol Metab 91:5002-7. 2006..These findings suggest that low levels of adiponectin in smokers may be independent of both insulin resistance and a generalized inflammatory response... - Plasma adiponectin concentrations do not increase in association with moderate weight loss in insulin-resistant, obese womenFahim Abbasi
Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
Metabolism 53:280-3. 2004..Adiponectin concentrations did not change with weight loss in either group. Thus, neither weight loss, per se, nor enhanced insulin sensitivity resulted in a change in plasma adiponectin concentrations... - Rosiglitazone reduces glucose-stimulated insulin secretion rate and increases insulin clearance in nondiabetic, insulin-resistant individualsSun H Kim
Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305-5406, USA
Diabetes 54:2447-52. 2005..In conclusion, enhanced insulin sensitivity in rosiglitazone-treated nondiabetic insulin-resistant individuals was associated with a shift to the right in the GS-ISR dose-response curve and an increase in I-MCR... - Effect of rosiglitazone treatment on circulating vascular and inflammatory markers in insulin-resistant subjectsJames W Chu
Department of Medicine, Stanford University School of Medicine, Stanford, California, 94305, USA
Diab Vasc Dis Res 2:37-41. 2005.... - Comparison of three treatment approaches to decreasing cardiovascular disease risk in nondiabetic insulin-resistant dyslipidemic subjectsFahim Abbasi
Stanford University School of Medicine, Stanford, CA, USA
Am J Cardiol 102:64-9. 2008..In conclusion, there did not appear to be 1 therapeutic intervention that effectively treated all metabolic abnormalities present in these patients at greatly increased risk of cardiovascular disease... - Body mass index and waist circumference associate to a comparable degree with insulin resistance and related metabolic abnormalities in South Asian women and menFahim Abbasi
Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
Diab Vasc Dis Res 9:296-300. 2012..The aim of this study was to test the hypothesis that body mass index (BMI) and waist circumference (WC) associate to a comparable degree with insulin resistance and cardiometabolic risk factors in South Asians... - Effect of metformin treatment on multiple cardiovascular disease risk factors in patients with type 2 diabetes mellitusFahim Abbasi
Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA
Metabolism 53:159-64. 2004..Administration of metformin, either as monotherapy or in combination with a sulfonylurea drug, improved glycemic control and led to a decrease in several CVD risk factors in patients with type 2 diabetes... - Glucose-stimulated insulin secretion in gastric bypass patients with hypoglycemic syndrome: no evidence for inappropriate pancreatic beta-cell functionSun H Kim
Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA
Obes Surg 20:1110-6. 2010..The syndrome is believed to occur due to insulin hypersecretion from either pancreatic beta-cell hyperplasia or hyperfunction... - Plasma asymmetric dimethylarginine concentrations are elevated in obese insulin-resistant women and fall with weight lossTracey McLaughlin
Division of Endocrinology, Stanford University School of Medicine, Stanford, California 94305-5103, USA
J Clin Endocrinol Metab 91:1896-900. 2006..CONCLUSION: Plasma ADMA levels are higher in obese, IR women than in equally obese, IS women and decrease in response to weight loss when associated with enhancement of insulin sensitivity... - The metabolic syndrome: one step forward, two steps backSun H Kim
Stanford Medical Center, 300 Pasteur Drive, Stanford, CA 94305-5406, USA
Diab Vasc Dis Res 1:68-75. 2004..This review critically evaluates the similarities and differences between the two groups' concepts of the metabolic syndrome and questions the clinical utility of making the diagnosis with either set of definitions... - Relationship between changes in insulin sensitivity and associated cardiovascular disease risk factors in thiazolidinedione-treated, insulin-resistant, nondiabetic individuals: pioglitazone versus rosiglitazoneFahim Abbasi
Division of Cardiovascular Medicine, Falk Cardiovascular Research Center, Stanford University School of Medicine, Stanford, CA 94305, USA
Metabolism 58:373-8. 2009..However, despite these similarities, their effects on lipoprotein metabolism seem to be quite different, with beneficial effects confined to PIO-treated individuals... - Isolated impaired fasting glucose and peripheral insulin sensitivity: not a simple relationshipSun H Kim
Department of Medicine, Stanford University School of Medicine, Stanford, California, USA
Diabetes Care 31:347-52. 2008..quot; To subject this conclusion to further validation, we evaluated the relationship between glucose tolerance categories and peripheral insulin sensitivity in a large nondiabetic population... - Plasma glucose and insulin regulation is abnormal following gastric bypass surgery with or without neuroglycopeniaSun H Kim
Department of Medicine, Stanford University Medical Center, 300 Pasteur Drive, Room S025, Stanford, CA 94305 5103, USA
Obes Surg 19:1550-6. 2009.... - In search of moderators and mediators of hyperglycemia with atypical antipsychotic treatmentGerald M Reaven
Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
J Psychiatr Res 43:997-1002. 2009..These findings provide a quantitative approach to identify those at greatest treatment-associated risk to develop glucose intolerance, and emphasize the need to address co-morbid medical disorders in these patients... - Lipoprotein abnormalities are associated with insulin resistance in South Asian Indian womenLatha P Palaniappan
Stanford Prevention Research Center and Division of Cardiovascular Medicine Department of Medicine, Stanford University Medical Center, Stanford, CA 94305, USA
Metabolism 56:899-904. 2007..These results indicate that a highly atherogenic lipoprotein profile seen in South Asian Indian women is significantly associated with insulin resistance independent of differences in WC... - Differential intra-abdominal adipose tissue profiling in obese, insulin-resistant womenAlice Liu
Division of Endocrinology, Department of Medicine, Stanford University Medical Center, 300 Pasteur Drive Rm S 025, Stanford, CA 94305, USA
Obes Surg 19:1564-73. 2009..We compared cell size distribution and genetic markers in SAT and VAT of IR individuals undergoing bariatric surgery... - Comparison of two methods using plasma triglyceride concentration as a surrogate estimate of insulin action in nondiabetic subjects: triglycerides × glucose versus triglyceride/high-density lipoprotein cholesterolFahim Abbasi
Falk Cardiovascular Research Center, Stanford, CA 94305 5406, USA
Metabolism 60:1673-6. 2011..Calculations of TG/HDL-C ratio and TyG index correlated with SSPG concentration to a similar degree, and the relationships were comparable to estimates using fasting insulin. The strongest relationship was between SSPG and insulin-AUC... - Insulin resistance: the link between obesity and cardiovascular diseaseGerald M Reaven
Division of Cardiovascular Medicine, Stanford University School of Medicine, Falk CVRC, Stanford Medical Center, 300 Pasteur Drive, Stanford, CA 94305, USA
Med Clin North Am 95:875-92. 2011..If this is done, then intense efforts at weight control can be brought to bear on those who not only need it the most but also have the most to gain by losing weight... - Body mass index and waist circumference both contribute to differences in insulin-mediated glucose disposal in nondiabetic adultsHelke M F Farin
Stanford University School of Medicine, Stanford, CA 94305, USA
Am J Clin Nutr 83:47-51. 2006..Furthermore, there was no difference in the relation between the degree of insulin resistance and either index of adiposity... - Discrimination between obesity and insulin resistance in the relationship with adiponectinFahim Abbasi
Divisions of Cardiovascular Medicine and Endocrinology and Metabolism, Department of Medicine, Stanford University School of Medicine, Stanford, California, USA
Diabetes 53:585-90. 2004..These results suggest that adiponectin concentrations are more closely related to differences in insulin-mediated glucose disposal than obesity... - Insulin resistance: the link between obesity and cardiovascular diseaseGerald M Reaven
Division of Cardiovascular Medicine, Stanford University School of Medicine, Falk CVRC, Stanford Medical Center, 300 Pasteur Drive, Stanford, CA 94305, USA
Endocrinol Metab Clin North Am 37:581-601, vii-viii. 2008..Finally, it appears that the adverse impact of overall obesity, as estimated by body mass index, is comparable to that of abdominal obesity, as quantified by waist circumference... - Comparison of the 1997 and 2003 American Diabetes Association classification of impaired fasting glucose: impact on prevalence of impaired fasting glucose, coronary heart disease risk factors, and coronary heart disease in a community-based medical practiSun H Kim
Department of Medicine, Stanford University School of Medicine, Stanford, California, USA
J Am Coll Cardiol 48:293-7. 2006.... - Impact of degree of obesity on surrogate estimates of insulin resistanceSun H Kim
Department of Medicine, Stanford University School of Medicine, Stanford, California, USA
Diabetes Care 27:1998-2002. 2004..Surrogate estimates of IMGU based on fasting insulin and glucose account for no more than 13% of the variability in insulin action in the normal-weight group, 30% in the overweight group, and 37% in the obese group... - Effect of moderate alcoholic beverage consumption on insulin sensitivity in insulin-resistant, nondiabetic individualsSun H Kim
Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305 5103, USA
Metabolism 58:387-92. 2009.... - Relationship between body mass index and insulin resistance in patients treated with second generation antipsychotic agentsSun H Kim
Department of Medicine, 300 Pasteur Drive, S025, Stanford, CA 94305 5103, USA
J Psychiatr Res 44:493-8. 2010..Olanzapine also appears to have an independent effect on insulin resistance that is above and beyond obesity... - Relationship between insulin resistance and an endogenous nitric oxide synthase inhibitorMarkus C Stühlinger
Division of Cardiovascular Medicine, Stanford University School of Medicine, Falk Cardiovascular Research Center, 300 Pasteur Dr, Stanford, CA 94305, USA
JAMA 287:1420-6. 2002..Several cardiovascular risk factors are associated with reduced sensitivity to insulin, but elevated ADMA concentrations have not been fully linked to the metabolic syndrome... - Ethnic differences in the relationship between adiponectin and insulin sensitivity in South Asian and Caucasian womenMarlene Martin
Stanford University School of Medicine, Stanford, California, USA
Diabetes Care 31:798-801. 2008..To assess whether lower adiponectin concentrations in South Asian Indians may be responsible for their greater degree of insulin resistance... - Insulin resistance and hyperinsulinemia: you can't have one without the otherSun H Kim
Department of Medicine, Stanford University School of Medicine, Stanford, California, USA
Diabetes Care 31:1433-8. 2008..To evaluate this suggestion, we assessed the degree of discordance between insulin sensitivity and insulin response in a healthy, nondiabetic population... - Methods for quantifying insulin resistance in human immunodeficiency virus-positive patientsJames W Chu
Department of Medicine, Stanford University School of Medicine, CA, USA
Metabolism 52:858-61. 2003..43 to 0.61), thereby possessing limited ability to predict SSPG variability (r2=0.18 to 0.37). In conclusion, indirect measures of IMGU need to be applied with caution when evaluating insulin action in HIV-infected patients... - A1 adenosine receptor partial agonist lowers plasma FFA and improves insulin resistance induced by high-fat diet in rodentsArvinder K Dhalla
Department of Pharmacological Sciences, CV Therapeutics, Palo Alto, California, USA
Am J Physiol Endocrinol Metab 292:E1358-63. 2007..01) increased glucose infusion rate to values similar to that for chow-fed mice. In conclusion, CVT-3619 treatment lowers FFA and TG concentrations and improves insulin sensitivity in rodent models of insulin resistance... - The metabolic syndrome: is this diagnosis necessary?Gerald M Reaven
Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
Am J Clin Nutr 83:1237-47. 2006.... - Metabolic impact of switching antipsychotic therapy to aripiprazole after weight gain: a pilot studySun H Kim
Division of Endocrinology, Stanford University, Stanford, CA, USA
J Clin Psychopharmacol 27:365-8. 2007..In conclusion, switching to aripiprazole alone does not ameliorate the highly prevalent metabolic abnormalities in the schizophrenia population who have gained weight on other second generation antipsychotic medications... - Metabolic and ovarian effects of rosiglitazone treatment for 12 weeks in insulin-resistant women with polycystic ovary syndromeNicholas A Cataldo
Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
Hum Reprod 21:109-20. 2006..Insulin sensitizers have favourable metabolic and ovarian effects in polycystic ovary syndrome (PCOS). This study examined rosiglitazone, a thiazolidinedione, in PCOS... - The insulin resistance syndrome: definition and dietary approaches to treatmentGerald M Reaven
Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, California 94305, USA
Annu Rev Nutr 25:391-406. 2005..This chapter will focus on defining the abnormalities and clinical syndromes that compose the IRS and evaluating the dietary changes that can ameliorate its adverse consequences... - Metabolic syndrome: do clinical criteria identify similar individuals among overweight premenopausal women?Sofiya Alhassan
Stanford Prevention Research Center, Stanford University School of Medicine, Stanford, CA 94305, USA
Metabolism 57:49-56. 2008..Regardless of MetSyn clinical criteria, >/=7% reduction in body weight has a beneficial impact on variables used to define MetSyn... - Body mass index and waist circumference correlate to the same degree with insulin-mediated glucose uptakeHelke M F Farin
Cardiovascular Medicine Division/Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
Metabolism 54:1323-8. 2005..To summarize, (1) BMI and WC correlate closely within an individual and equally well with IMGU, and (2) BMI is as effective as WC in identifying insulin-resistant individuals... - Compensatory hyperinsulinemia and the development of an atherogenic lipoprotein profile: the price paid to maintain glucose homeostasis in insulin-resistant individualsGerald M Reaven
Division of Cardiovascular Medicine, Falk Cardiovascular Research Center, Stanford Medical Center, Stanford, CA 94305, USA
Endocrinol Metab Clin North Am 34:49-62. 2005.... - What is the effect of rosiglitazone treatment on insulin secretory function in insulin-resistant individuals? It depends on how you measure itFahim Abbasi
Stanford University School of Medicine, Stanford, CA 94305 5406, USA
Metabolism 60:57-62. 2011.... - Apelin decreases lipolysis via G(q), G(i), and AMPK-Dependent MechanismsPatrick Yue
Department of Medicine Cardiovascular Medicine, Stanford University School of Medicine, Stanford, California 94350, USA
Endocrinology 152:59-68. 2011..In conclusion, apelin negatively regulates lipolysis. Its actions may be mediated by pathways involving G(q), G(i), and AMP-activated protein kinase... - Comparison of body mass index versus waist circumference with the metabolic changes that increase the risk of cardiovascular disease in insulin-resistant individualsHelke M F Farin
Stanford University School of Medicine, Stanford, California, USA
Am J Cardiol 98:1053-6. 2006..In conclusion, because BMI performed at least as well as WC in identifying differences in insulin sensitivity and multiple CVD risk factors, either estimate can be used to identify patients at increased CVD risk... - The individual components of the metabolic syndrome: is there a raison d'etre?Gerald M Reaven
Division of Cardiovascular Medicine, Stanford University School of Medicine, Falk Cardiovascular Research Center, 300 Pasteur Drive, Stanford, CA 94305, USA
J Am Coll Nutr 26:191-5. 2007 - Comparison in patients with type 2 diabetes of fibric acid versus hepatic hydroxymethyl glutaryl-coenzyme a reductase inhibitor treatment of combined dyslipidemiaTracey McLaughlin
Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA
Metabolism 51:1355-9. 2002..As such, the clinical utility of statin monotherapy in the treatment of combined dyslipidemia may have been underestimated... - Effect of orlistat added to diet (30% of calories from fat) on plasma lipids, glucose, and insulin in obese patients with hypercholesterolemiaCharles P Lucas
Medical Center, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA
Am J Cardiol 91:961-4. 2003..The beneficial metabolic effects of weight loss were accentuated in response to orlistat administration, and the improvement was greatest in patients with combined dyslipidemia (type IIB)... - Insulin resistance in idiopathic dilated cardiomyopathy: a possible etiologic linkRonald M Witteles
Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, California 94305-5406, USA
J Am Coll Cardiol 44:78-81. 2004..05) more common in patients with IDCM (49% vs. 23%). CONCLUSIONS: Insulin resistance and abnormal glucose tolerance are more prevalent in patients with IDCM and represent potentially reversible metabolic derangements in these individuals... - Relations between obesity, insulin resistance, and 25-hydroxyvitamin DCynthia A Lamendola
Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA
Am J Clin Nutr 95:1055-9. 2012..Although low circulating 25-hydroxyvitamin D [25(OH)D] concentrations have been associated with insulin resistance and obesity, the relations between these 3 variables have not been completely resolved... - Importance of identifying the overweight patient who will benefit the most by losing weightGerald M Reaven
Stanford University, Stanford, California, USA
Ann Intern Med 138:420-3. 2003..Thoughtful use of this information will help identify the subset of persons who will benefit the most from intense therapeutic efforts to lose weight... - HIF-1 regulates hypoxia- and insulin-induced expression of apelin in adipocytesAlexander J Glassford
Department of Medicine, Stanford University Medical Center, Stanford, CA, USA
Am J Physiol Endocrinol Metab 293:E1590-6. 2007..In summary, in cultured 3T3-L1 adipocytes and differentiated MEFs, HIF-1 appears to be involved in hypoxia- and insulin-induced apelin expression... - Insulin secretory function in type 2 diabetes: Does it matter how you measure it?Gerald M Reaven
Stanford University School of Medicine, California, USA
J Diabetes 1:142-50. 2009..It is concluded that it may be time to challenge current conventional wisdom as to the role of the β-cell in the natural history of 2DM... - Hyperinsulinemia predicts hepatic fat content in healthy individuals with normal transaminase concentrationsDiego Ardigo
Department of Internal Medicine and Biomedical Sciences, University of Parma, Parma 43100, Italy Falk Cardiovascular Research Center, School of Medicine, Stanford University, Stanford, CA 94305, USA
Metabolism 54:1566-70. 2005..Fasting plasma insulin (a surrogate estimate of IR/CH) predicts hepatic fat content and ALT in healthy volunteers with normal transaminase concentrations, independently of the other anthropometric and metabolic variables measured... - Measurement of insulin-mediated glucose uptake: direct comparison of the modified insulin suppression test and the euglycemic, hyperinsulinemic clampJoshua W Knowles
Stanford University, Division of Cardiovascular Medicine, Falk CVRC, 300 Pasteur Dr, Stanford, CA 94305 5406, USA
Metabolism 62:548-53. 2013..To determine the agreement between SSPG and M and to develop transformation equations to convert SSPG to M and vice versa, we directly compared these two measurements in the same individuals... - Estimates of insulin secretory function in apparently healthy volunteers vary as a function of how the relevant variables are quantifiedBarry R Johns
Department of Medicine, Division of Endocrinology, Gerontology, and Metabolism, Stanford University School of Medicine, Stanford, CA, USA
Clin Chem 57:627-32. 2011..0 mmol/L (126 mg/dL)... - Multiple lipoprotein abnormalities associated with insulin resistance in healthy volunteers are identified by the vertical auto profile-II methodologyJames W Chu
Stanford University School of Medicine, Department of Medicine, Stanford, CA 94305, USA
Clin Chem 49:1014-7. 2003 - Relationships among insulin resistance, type 2 diabetes, essential hypertension, and cardiovascular disease: similarities and differencesGerald M Reaven
Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
J Clin Hypertens (Greenwich) 13:238-43. 2011.... - The insulin resistance syndromeGerald M Reaven
Falk CVRC, Stanford Medical Center, 300 Pasteur Drive, Stanford, CA 94305, USA
Curr Atheroscler Rep 5:364-71. 2003 - Insulin resistance/compensatory hyperinsulinemia, essential hypertension, and cardiovascular diseaseGerald M Reaven
Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, California 94305, USA
J Clin Endocrinol Metab 88:2399-403. 2003 - Increased aortic stiffness in the insulin-resistant Zucker fa/fa ratAkhilesh K Sista
Division of Cardiovascular Sciences, Dept. of Cardiovascular Medicine, Stanford School of Medicine, 300 Pasteur Dr, Stanford, CA 94305, USA
Am J Physiol Heart Circ Physiol 289:H845-51. 2005..Thus there is mechanical, structural, and molecular evidence of arteriosclerosis in the Zucker fa/fa rat at the glucose-intolerant, hyperinsulinemic stage... - Risk for obstructive sleep apnea in obese, nondiabetic adults varies with insulin resistance statusAlice Liu
Department of Medicine, Stanford University Medical Center, Stanford, CA, USA
Sleep Breath 17:333-8. 2013..The study's aim was to utilize questionnaires that assess OSA risk and symptoms to test the hypothesis that the most insulin-resistant subset of obese individuals is at highest risk for OSA... - The metabolic syndrome: requiescat in paceGerald M Reaven
Division of Cardiovascular Medicine, Falk CVRC, Stanford Medical Center, 300 Pasteur Dr, Stanford, CA 94305, USA
Clin Chem 51:931-8. 2005.... - Relationship between obesity, insulin resistance, and coronary heart disease riskFahim Abbasi
Department of Medicine, Stanford, California, USA
J Am Coll Cardiol 40:937-43. 2002..CONCLUSIONS: Obesity and insulin resistance are both powerful predictors of CHD risk, and insulin resistance at any given degree of obesity accentuates the risk of CHD and type 2 diabetes... - Why Syndrome X? From Harold Himsworth to the insulin resistance syndromeGerald M Reaven
Division of Cardiovascular Medicine, Falk CVRC, Stanford Medical Center, California 94305, USA
Cell Metab 1:9-14. 2005..In addition, the developments in the last 16 years that have led from the notion of Syndrome X to the broader concept of an Insulin Resistance Syndrome (IRS) will be briefly summarized... - Preferential involvement of larger vessels in a rat model of diabetes-induced graft vasculopathyBernard Cantin
Division of Cardiovascular Medicine, Stanford University School of Medicine, California, USA
J Heart Lung Transplant 21:1040-3. 2002..Severe TxCAD, defined as a luminal occlusion > or =75%, was more prevalent in the larger vessels. We observed a differential involvement based on vessel size in diabetes-induced TxCAD... - Reversal of diabetes-induced rat graft transplant coronary artery disease by metforminBernard Cantin
Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, California 94305-5406, USA
J Heart Lung Transplant 21:637-43. 2002..CONCLUSIONS: Metformin reduced luminal occlusion and severe TxCAD in the larger vessels but did not alter the course of TxCAD in the smaller vessels. These results may have therapeutic implications for patients... - Impaired nitric oxide synthase pathway in diabetes mellitus: role of asymmetric dimethylarginine and dimethylarginine dimethylaminohydrolaseKen Y Lin
Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, Calif 94305, USA
Circulation 106:987-92. 2002..CONCLUSIONS: A glucose-induced impairment of DDAH causes ADMA accumulation and may contribute to endothelial vasodilator dysfunction in DM... - Prevalence of insulin resistance and the metabolic syndrome with alternative definitions of impaired fasting glucoseEarl S Ford
Division of Adult and Community Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
Atherosclerosis 181:143-8. 2005..The clinical and public health implications of the new IFG definition remain to be elucidated... - Relationship between fasting and day-long plasma glucose concentrations in diet-treated patients with type 2 diabetesF Abbasi
Department of Medicine, Stanford University, School of Medicine Stanford, CA 94305-5406, USA
Metabolism 51:457-9. 2002.... - Beyond type 2 diabetes: the need for a clinically useful way to identify insulin resistanceTracey L McLaughlin
Am J Med 114:501-2. 2003 - Relationship between plasma nitric oxide concentration and insulin resistance in essential hypertensionIvana Zavaroni
Department of Internal Medicine and Biomedical Sciences, Parma University, Parma, Italy
Am J Hypertens 17:549-52. 2004..This study was initiated to determine whether these inconsistent findings were related to differences in insulin resistance... - Relative effects of insulin resistance and protease inhibitor treatment on lipid and lipoprotein metabolism in HIV-infected patientsGeorge Beatty
Department of Medicine, University of California San Francisco at San Francisco General Hospital, San Francisco, California 94110, USA
HIV Clin Trials 5:383-91. 2004..The relationship between insulin resistance, dyslipidemia, HIV infection, and antiretroviral therapy remains unclear, and the atherogenic nature of lipid and lipoprotein profiles in HIV-infected patients has not been fully characterized... - Relative impact of low-density lipoprotein-cholesterol concentration and insulin resistance on carotid wall thickening in nondiabetic, normotensive volunteersPei-Wen Wang
Department of Internal Medicine, Chang Gung Memorial Hospital, Kaohsiung, Taiwan, ROC
Metabolism 51:255-9. 2002..These results provide evidence that insulin resistance is as significant a predictor of degree of atherogenesis (estimated by IMT) of the common carotid artery as a high LDL-C concentration... - American College of Endocrinology position statement on the insulin resistance syndromeDaniel Einhorn
American College of Endocrinology
Endocr Pract 9:237-52. 2003 - Effect of a high-carbohydrate versus a high--cis-monounsaturated fat diet on blood pressure in patients with type 2 diabetesMeena Shah
Division of Nutrition and Metabolic Diseases, Center for Human Nutrition, University of Texas Southwestern Medical Center, Dallas, TX 75235-9052, USA
Diabetes Care 28:2607-12. 2005.... - A novel peroxisome proliferator-activated gamma (PPAR gamma) agonist, CLX-0921, has potent antihyperglycemic activity with low adipogenic potentialDebendranath Dey
Department of Biochemistry, Clinical Development, and Research Development, Calyx Therapeutics Inc. Hayward, CA 94085, USA
Metabolism 52:1012-8. 2003..CLX-0921 also increases glycogen synthesis, an activity not typically associated with rosiglitazone or pioglitazone. Thus CLX-0921 appears to have a distinct spectrum of activity relative to other TZDs... - Improvements in insulin resistance with weight loss, in contrast to rosiglitazone, are not associated with changes in plasma adiponectin or adiponectin multimeric complexesFahim Abbasi
Division of Endocrinology and Metabolism, Deptartment of Medicine, Carl T. Hayden Veterans Affairs Medical Center, 650 East Indian School Road, Phoenix, AZ 85012, USA
Am J Physiol Regul Integr Comp Physiol 290:R139-44. 2006.... - Insulin resistance/compensatory hyperinsulinemia predict carotid intimal medial thickness in patients with essential hypertensionIvana Zavaroni
Department of Internal Medicine and Biomedical Sciences, Parma University, Via Gramsci 14, 43100 Parma, Italy
Nutr Metab Cardiovasc Dis 16:22-7. 2006..To test this hypothesis, we attempted to see if there was a link between insulin resistance (IR) and carotid intimal medial thickness (IMT), an early index of CVD, in patients with essential hypertension... - Quantification of insulin-mediated glucose disposal in HIV-infected individuals: comparison of patients treated and untreated with protease inhibitorsGeorge Beatty
Department of Medicine, University of California San Francisco, San Francisco General Hospital, San Francisco, California 94110, USA
J Acquir Immune Defic Syndr 33:34-40. 2003..Finally, PI treatment may have an inhibitory effect on insulin secretion... - Relation of plasma insulin levels to forearm flow-mediated dilatation in healthy volunteersDiego Ardigo
Department of Internal Medicine and Biomedical Sciences, Parma University, Parma, Italy
Am J Cardiol 97:1250-4. 2006..In conclusion, IR/CH is an independent predictor of decreases in endothelial-dependent vasodilation in apparently healthy individuals, in the absence of traditional risk factors for atherosclerosis... - Trends in hyperinsulinemia among nondiabetic adults in the U.SChaoyang Li
Centers for Disease Control and Prevention, 4770 Buford Hwy, MS K66, Atlanta, GA 30341, USA
Diabetes Care 29:2396-402. 2006..Our aim was to assess the trends in the mean concentrations of fasting serum insulin and the prevalence of hyperinsulinemia among nondiabetic adults during the periods of 1988-1994 and 1999-2002 in the U.S... - Relationship between obesity and several cardiovascular disease risk factors in apparently healthy Korean individuals: comparison of body mass index and waist circumferenceKi Chul Sung
Division of Cardiology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul 110 746, South Korea
Metabolism 56:297-303. 2007.... - Relationships between estimates of adiposity, insulin resistance, and nonalcoholic fatty liver disease in a large group of nondiabetic Korean adultsKi Chul Sung
Division of Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University, Pyung Dong, Jongro Ku, Seoul, Korea 110 746
Diabetes Care 30:2113-8. 2007..Insulin resistance and abdominal and overall adiposity are closely associated with NAFLD; however, the interplay between them in the relationship with NAFLD is unclear, especially in nondiabetic individuals... - Relationship among alcohol, body weight, and cardiovascular risk factors in 27,030 Korean menKi Chul Sung
Department of Medicine, Sungkyunkwan University, Kangbuk Samsung Hospital, Seoul, Korea
Diabetes Care 30:2690-4. 2007..However, the validity of this relationship and its impact on the putative benefits of alcohol consumption on cardiovascular disease (CVD) risk has not been well evaluated... - Does the association of the triglyceride to high-density lipoprotein cholesterol ratio with fasting serum insulin differ by race/ethnicity?Chaoyang Li
National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
Cardiovasc Diabetol 7:4. 2008..However, conflicting findings exist for the association of the TG/HDL-C ratio with FSI by race/ethnicity... - Hyperinsulinemia and impaired leptin-adiponectin ratio associate with endothelial nitric oxide synthase polymorphisms in subjects with in-stent restenosisElena Galluccio
Scientific Institute San Raffaele, Milan, Italy
Am J Physiol Endocrinol Metab 294:E978-86. 2008..Hyperinsulinemia, endothelial dysfunction, and a more atherogenic profile seem to be peculiar features of subjects with asymptomatic CAD and restenosis carrying NOS3 gene variants... - Relationship to insulin resistance of the adult treatment panel III diagnostic criteria for identification of the metabolic syndromeKaren L Cheal
Department of Psychiatry, Brigham and Women's Hospital, Boston, Massachusetts, USA
Diabetes 53:1195-200. 2004..The individual components vary both in terms of their utility in making a diagnosis of the metabolic syndrome and their relationship to insulin resistance, with the obesity and lipid criteria being most useful...