THOMAS RANDO

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. van Velthoven C, Rando T. Stem Cell Quiescence: Dynamism, Restraint, and Cellular Idling. Cell Stem Cell. 2019;24:213-225 pubmed publisher
    ..In this Review, we discuss recent advances in our understanding of stem cell quiescence and techniques enabling more refined analyses of quiescence in vivo. ..
  2. Rando T. The ins and outs of aging and longevity. Annu Rev Physiol. 2013;75:617-9 pubmed publisher
    ..These experimental and evolutionary perspectives converge in the modern science of aging, and its curious cousin "longevity", in an attempt to unify extensive findings from diverse areas of biology. ..
  3. Liu L, Charville G, Cheung T, Yoo B, Santos P, Schroeder M, et al. Impaired Notch Signaling Leads to a Decrease in p53 Activity and Mitotic Catastrophe in Aged Muscle Stem Cells. Cell Stem Cell. 2018;23:544-556.e4 pubmed publisher
    ..Altogether, these findings illuminate a Notch-p53 signaling axis that plays an important role in MuSC survival during activation and is dysregulated during aging, contributing to the age-related decline in muscle regenerative potential. ..
  4. Filareto A, Maguire Nguyen K, Gan Q, Aldanondo G, Machado L, Chamberlain J, et al. Monitoring disease activity noninvasively in the mdx model of Duchenne muscular dystrophy. Proc Natl Acad Sci U S A. 2018;115:7741-7746 pubmed publisher
    ..Our data demonstrate the value of these noninvasive imaging modalities for monitoring disease progression and response to therapy in mouse models of muscular dystrophy. ..
  5. Wosczyna M, Rando T. A Muscle Stem Cell Support Group: Coordinated Cellular Responses in Muscle Regeneration. Dev Cell. 2018;46:135-143 pubmed publisher
    ..Understanding the complex interactions between and among these cell populations has the potential to lead to therapies that will help promote normal skeletal muscle regeneration under conditions in which this process is suboptimal. ..
  6. Charville G, Cheung T, Yoo B, Santos P, Lee G, Shrager J, et al. Ex Vivo Expansion and In Vivo Self-Renewal of Human Muscle Stem Cells. Stem Cell Reports. 2015;5:621-32 pubmed publisher
    ..These studies indicate characteristics of the huSC transcriptome that promote expansion ex vivo to allow enhanced functional engraftment of a defined population of self-renewing huSCs. ..
  7. Biressi S, Miyabara E, Gopinath S, Carlig P, Rando T. A Wnt-TGFβ2 axis induces a fibrogenic program in muscle stem cells from dystrophic mice. Sci Transl Med. 2014;6:267ra176 pubmed publisher
  8. Rando T, Ambrosio F. Regenerative Rehabilitation: Applied Biophysics Meets Stem Cell Therapeutics. Cell Stem Cell. 2018;22:306-309 pubmed publisher
    ..Here we highlight recent stem cell-based examples of the regenerative rehabilitation paradigm to promote tissue repair and regeneration, and we discuss remaining challenges and future directions for the field. ..
  9. Tang A, Rando T. Induction of autophagy supports the bioenergetic demands of quiescent muscle stem cell activation. EMBO J. 2014;33:2782-97 pubmed publisher
    ..These studies suggest that autophagy, regulated by SIRT1, may play an important role during SC activation to meet the high bioenergetic demands of the activation process. ..

More Information

Publications15

  1. Rando T, Chang H. Aging, rejuvenation, and epigenetic reprogramming: resetting the aging clock. Cell. 2012;148:46-57 pubmed publisher
    ..By defining youthfulness and senescence as epigenetic states, a framework for asking new questions about the aging process emerges. ..
  2. Rodgers J, Schroeder M, Ma C, Rando T. HGFA Is an Injury-Regulated Systemic Factor that Induces the Transition of Stem Cells into GAlert. Cell Rep. 2017;19:479-486 pubmed publisher
    ..Our data suggest that factors that induce GAlert will have broad therapeutic applications for regenerative medicine and wound healing. ..
  3. Rando T, Disatnik M, Zhou L. Rescue of dystrophin expression in mdx mouse muscle by RNA/DNA oligonucleotides. Proc Natl Acad Sci U S A. 2000;97:5363-8 pubmed
    ..These results provide the foundation for further studies of chimeraplast-mediated gene therapy as a therapeutic approach to muscular dystrophies and other genetic disorders of muscle...
  4. Luo D, de Morrée A, Boutet S, Quach N, Natu V, Rustagi A, et al. Deltex2 represses MyoD expression and inhibits myogenic differentiation by acting as a negative regulator of Jmjd1c. Proc Natl Acad Sci U S A. 2017;114:E3071-E3080 pubmed publisher
    ..These results reveal a mechanism by which a member of the Deltex family of proteins can inhibit cellular differentiation, and demonstrate a role of Deltex in the epigenetic regulation of myogenesis. ..
  5. de Morrée A, van Velthoven C, Gan Q, Salvi J, Klein J, Akimenko I, et al. Staufen1 inhibits MyoD translation to actively maintain muscle stem cell quiescence. Proc Natl Acad Sci U S A. 2017;114:E8996-E9005 pubmed publisher
    ..Conversely, blocking MyoD translation maintains the quiescent phenotype. Collectively, our data show that MuSCs express MyoD mRNA and actively repress its translation to remain quiescent yet primed for activation. ..
  6. van Velthoven C, de Morrée A, Egner I, Brett J, Rando T. Transcriptional Profiling of Quiescent Muscle Stem Cells In Vivo. Cell Rep. 2017;21:1994-2004 pubmed publisher