THOMAS RANDO

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. ncbi request reprint Stem cells, ageing and the quest for immortality
    Thomas A Rando
    Geriatric Research, Education and Clinical Center GRECC, VA Palo Alto Health Care System, Stanford, California 94305, USA
    Nature 441:1080-6. 2006
  2. ncbi request reprint Non-viral gene therapy for Duchenne muscular dystrophy: progress and challenges
    Thomas A Rando
    Department of Neurology and Neurological Sciences, SUMC, Room A 343, Stanford University School of Medicine, Stanford, CA 94305 5235, USA
    Biochim Biophys Acta 1772:263-71. 2007
  3. doi request reprint The ins and outs of aging and longevity
    Thomas A Rando
    Glenn Laboratories for the Biology of Aging, Stanford University School of Medicine, Stanford, CA 94305 5235, USA
    Annu Rev Physiol 75:617-9. 2013
  4. pmc Aging, rejuvenation, and epigenetic reprogramming: resetting the aging clock
    Thomas A Rando
    The Glenn Laboratories for the Biology of Aging, Stanford University School of Medicine, Stanford, CA 94305, USA
    Cell 148:46-57. 2012
  5. ncbi request reprint The immortal strand hypothesis: segregation and reconstruction
    Thomas A Rando
    Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA
    Cell 129:1239-43. 2007
  6. pmc Rescue of dystrophin expression in mdx mouse muscle by RNA/DNA oligonucleotides
    T A Rando
    Department of Neurology and Neurological Sciences, Palo Alto Veterans Affairs Medical Center and Stanford University School of Medicine, Palo Alto, CA 94305, USA
    Proc Natl Acad Sci U S A 97:5363-8. 2000
  7. doi request reprint Turning back time: reversing tissue pathology to enhance stem cell engraftment
    Thomas A Rando
    Department of Neurology and Neurological Sciences, Stanford University School of Medicine, VA Palo Alto Health Care Systems, Stanford, CA 94305 5235, USA
    Cell Stem Cell 3:232-4. 2008
  8. ncbi request reprint Oligonucleotide-mediated gene therapy for muscular dystrophies
    Thomas A Rando
    Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Room A 343, Stanford, CA 94305 5235, USA
    Neuromuscul Disord 12:S55-60. 2002
  9. ncbi request reprint Role of nitric oxide in the pathogenesis of muscular dystrophies: a "two hit" hypothesis of the cause of muscle necrosis
    T A Rando
    GRECC, Palo Alto VA Medical Center, Palo Alto, California 94304, USA
    Microsc Res Tech 55:223-35. 2001
  10. ncbi request reprint The dystrophin-glycoprotein complex, cellular signaling, and the regulation of cell survival in the muscular dystrophies
    T A Rando
    Department of Neurology and Neurological Sciences, Stanford University Medical Center, Room A 343, Stanford, California 94305 5235, USA
    Muscle Nerve 24:1575-94. 2001

Research Grants

  1. Cellular Signaling and Muscular Dystrophies
    THOMAS RANDO; Fiscal Year: 2005
  2. OXIDATIVE STRESS AND MUSCLE CELL DEATH
    THOMAS RANDO; Fiscal Year: 2005
  3. Notch Signaling and Satellite Cell Activation
    THOMAS RANDO; Fiscal Year: 2007
  4. FASEB Conference:Skeletal muscle satellite and stem cells
    THOMAS RANDO; Fiscal Year: 2007
  5. Notch Signaling and Satellite Cell Activation
    THOMAS RANDO; Fiscal Year: 2009
  6. OXIDATIVE STRESS AND MUSCLE CELL DEATH
    THOMAS RANDO; Fiscal Year: 2000
  7. Molecular Regulation of Myogenic Differentiation
    Thomas A Rando; Fiscal Year: 2010

Collaborators

Detail Information

Publications46

  1. ncbi request reprint Stem cells, ageing and the quest for immortality
    Thomas A Rando
    Geriatric Research, Education and Clinical Center GRECC, VA Palo Alto Health Care System, Stanford, California 94305, USA
    Nature 441:1080-6. 2006
    ....
  2. ncbi request reprint Non-viral gene therapy for Duchenne muscular dystrophy: progress and challenges
    Thomas A Rando
    Department of Neurology and Neurological Sciences, SUMC, Room A 343, Stanford University School of Medicine, Stanford, CA 94305 5235, USA
    Biochim Biophys Acta 1772:263-71. 2007
    ..Given the relative simplicity, safety, and cost-effectiveness of these methodologies, non-viral gene therapy continues to have great promise for future gene therapy approaches to the treatment of DMD...
  3. doi request reprint The ins and outs of aging and longevity
    Thomas A Rando
    Glenn Laboratories for the Biology of Aging, Stanford University School of Medicine, Stanford, CA 94305 5235, USA
    Annu Rev Physiol 75:617-9. 2013
    ..These experimental and evolutionary perspectives converge in the modern science of aging, and its curious cousin "longevity", in an attempt to unify extensive findings from diverse areas of biology...
  4. pmc Aging, rejuvenation, and epigenetic reprogramming: resetting the aging clock
    Thomas A Rando
    The Glenn Laboratories for the Biology of Aging, Stanford University School of Medicine, Stanford, CA 94305, USA
    Cell 148:46-57. 2012
    ..This Review focuses on the emerging biology of rejuvenation through the lens of epigenetic reprogramming. By defining youthfulness and senescence as epigenetic states, a framework for asking new questions about the aging process emerges...
  5. ncbi request reprint The immortal strand hypothesis: segregation and reconstruction
    Thomas A Rando
    Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA
    Cell 129:1239-43. 2007
    ..In this Essay, I explore evidence in support of the hypothesis, the biological implications, and the key questions that remain to be answered experimentally to address the fundamental tenets of the hypothesis...
  6. pmc Rescue of dystrophin expression in mdx mouse muscle by RNA/DNA oligonucleotides
    T A Rando
    Department of Neurology and Neurological Sciences, Palo Alto Veterans Affairs Medical Center and Stanford University School of Medicine, Palo Alto, CA 94305, USA
    Proc Natl Acad Sci U S A 97:5363-8. 2000
    ..These results provide the foundation for further studies of chimeraplast-mediated gene therapy as a therapeutic approach to muscular dystrophies and other genetic disorders of muscle...
  7. doi request reprint Turning back time: reversing tissue pathology to enhance stem cell engraftment
    Thomas A Rando
    Department of Neurology and Neurological Sciences, Stanford University School of Medicine, VA Palo Alto Health Care Systems, Stanford, CA 94305 5235, USA
    Cell Stem Cell 3:232-4. 2008
  8. ncbi request reprint Oligonucleotide-mediated gene therapy for muscular dystrophies
    Thomas A Rando
    Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Room A 343, Stanford, CA 94305 5235, USA
    Neuromuscul Disord 12:S55-60. 2002
    ....
  9. ncbi request reprint Role of nitric oxide in the pathogenesis of muscular dystrophies: a "two hit" hypothesis of the cause of muscle necrosis
    T A Rando
    GRECC, Palo Alto VA Medical Center, Palo Alto, California 94304, USA
    Microsc Res Tech 55:223-35. 2001
    ....
  10. ncbi request reprint The dystrophin-glycoprotein complex, cellular signaling, and the regulation of cell survival in the muscular dystrophies
    T A Rando
    Department of Neurology and Neurological Sciences, Stanford University Medical Center, Room A 343, Stanford, California 94305 5235, USA
    Muscle Nerve 24:1575-94. 2001
    ....
  11. doi request reprint [Proteasomal degradation of Pax3 in skeletal muscle progenitors: one ubiquitin does the trick!]
    Stéphane C Boutet
    Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA
    Med Sci (Paris) 24:31-3. 2008
  12. ncbi request reprint Late-onset distal muscular dystrophy affecting the posterior calves
    Jonathan S Katz
    Department of Neurology 127, Department of Veterans Affairs, Palo Alto VA Medical Center, 3801 Miranda Avenue, Palo Alto, California 94304, USA
    Muscle Nerve 28:443-8. 2003
    ..Most of these cases are sporadic, although the overall phenotype appears genetically heterogeneous and dysferlinopathy is uncommon...
  13. ncbi request reprint The regulation of Notch signaling controls satellite cell activation and cell fate determination in postnatal myogenesis
    Irina M Conboy
    Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA
    Dev Cell 3:397-409. 2002
    ....
  14. ncbi request reprint Artificial sweeteners--enhancing glycosylation to treat muscular dystrophies
    Thomas A Rando
    Department of Neurology and Neurological Sciences, Stanford University, and the Neurology Service, Veterans Affairs Palo Alto Health Care Systems, Palo Alto, California, USA
    N Engl J Med 351:1254-6. 2004
  15. ncbi request reprint Notch-mediated restoration of regenerative potential to aged muscle
    Irina M Conboy
    Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305 5235, USA
    Science 302:1575-7. 2003
    ..Thus, Notch signaling is a key determinant of muscle regenerative potential that declines with age...
  16. pmc Enhancement of plasmid-mediated gene therapy for muscular dystrophy by directed plasmid integration
    Carmen Bertoni
    Department of Neurology, Stanford University School of Medicine, Stanford, CA 94305 5235, USA
    Proc Natl Acad Sci U S A 103:419-24. 2006
    ..These data demonstrate the importance of both the level and distribution of dystrophin expression to achieve therapeutic efficacy, and that the efficacy can be enhanced by targeted plasmid integration...
  17. ncbi request reprint Dystrophin gene repair in mdx muscle precursor cells in vitro and in vivo mediated by RNA-DNA chimeric oligonucleotides
    Carmen Bertoni
    Department of Neurology and Neurological Sciences, Medical Center, Stanford University School of Medicine, Stanford, CA 94305, USA
    Hum Gene Ther 13:707-18. 2002
    ..These results, taken together, further demonstrate that chimeraplast-mediated gene repair may be effective as an approach to gene therapy for muscular dystrophies due to point mutations...
  18. ncbi request reprint Restoration of dystrophin expression in mdx muscle cells by chimeraplast-mediated exon skipping
    Carmen Bertoni
    Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305 5235, USA
    Hum Mol Genet 12:1087-99. 2003
    ..As such, chimeraplast-mediated exon skipping has the potential to be used to transform a severe DMD phenotype into a much milder BMD phenotype...
  19. pmc High incidence of non-random template strand segregation and asymmetric fate determination in dividing stem cells and their progeny
    Michael J Conboy
    Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California, United States of America corrected
    PLoS Biol 5:e102. 2007
    ....
  20. ncbi request reprint Intrinsic changes and extrinsic influences of myogenic stem cell function during aging
    Andrew S Brack
    Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305 5235, USA
    Stem Cell Rev 3:226-37. 2007
    ..Future studies that enhance our understanding of the interactions between stem cells and the environment in which they reside will offer promise for therapeutic applications in age-related diseases...
  21. ncbi request reprint Regulation of Pax3 by proteasomal degradation of monoubiquitinated protein in skeletal muscle progenitors
    Stéphane C Boutet
    Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA
    Cell 130:349-62. 2007
    ..These results reveal an important mechanism of Pax3 regulation in muscle progenitors and an unrecognized role of protein monoubiquitination in mediating proteasomal degradation...
  22. ncbi request reprint Increased Wnt signaling during aging alters muscle stem cell fate and increases fibrosis
    Andrew S Brack
    Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA
    Science 317:807-10. 2007
    ..These results indicate that the Wnt signaling pathway may play a critical role in tissue-specific stem cell aging and an increase in tissue fibrosis with age...
  23. doi request reprint Stem cell review series: aging of the skeletal muscle stem cell niche
    Suchitra D Gopinath
    Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305 5235, USA
    Aging Cell 7:590-8. 2008
    ....
  24. ncbi request reprint NF90 regulates cell cycle exit and terminal myogenic differentiation by direct binding to the 3'-untranslated region of MyoD and p21WAF1/CIP1 mRNAs
    Lingfang Shi
    Division of Pulmonary and Critical Care Medicine, Stanford University Medical Center, Stanford, California 94305 5236, USA
    J Biol Chem 280:18981-9. 2005
    ..NF90 regulates transcription factors and a cell cycle inhibitor essential for skeletal muscle differentiation and for survival...
  25. ncbi request reprint Aging, stem cells and tissue regeneration: lessons from muscle
    Irina M Conboy
    Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California 94305 5235, USA
    Cell Cycle 4:407-10. 2005
    ..Therefore, it may be that even very old stem cells may be capable of maintaining and repairing aged tissues if provided with optimal environmental cues...
  26. ncbi request reprint Oxidative stress and the pathogenesis of muscular dystrophies
    Thomas A Rando
    Neurology Service and GRECC, VA Palo Alto Health Care System, Palo Alto, California, USA
    Am J Phys Med Rehabil 81:S175-86. 2002
    ..This review focuses on the oxidative stress theory, which states that the final common pathway of muscle cell death in these diseases involves oxidative damage...
  27. ncbi request reprint Strand bias in oligonucleotide-mediated dystrophin gene editing
    Carmen Bertoni
    Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305 5235, USA
    Hum Mol Genet 14:221-33. 2005
    ....
  28. ncbi request reprint Rejuvenation of aged progenitor cells by exposure to a young systemic environment
    Irina M Conboy
    Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California 94305, USA
    Nature 433:760-4. 2005
    ..These results suggest that the age-related decline of progenitor cell activity can be modulated by systemic factors that change with age...
  29. doi request reprint Gene delivery to muscle
    Matthew L Springer
    Stanford University School of Medicine, Stanford, California, USA
    Curr Protoc Hum Genet . 2002
    ..A procedure describing the injection of plasmid DNA into muscle with or without electric charge is also included...
  30. pmc BCL9 is an essential component of canonical Wnt signaling that mediates the differentiation of myogenic progenitors during muscle regeneration
    Andrew S Brack
    Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305 5235, USA
    Dev Biol 335:93-105. 2009
    ..These results suggest a critical role of BCL9/9-2 in the Wnt-mediated regulation of adult, as opposed to embryonic, myogenic progenitors...
  31. ncbi request reprint Sequential activation of individual PKC isozymes in integrin-mediated muscle cell spreading: a role for MARCKS in an integrin signaling pathway
    Marie Helene Disatnik
    Department of Neurology and Neurological Sciences, Stanford University School of Medicine, CA 94305, USA
    J Cell Sci 115:2151-63. 2002
    ..The mechanism of PKC-mediated cell spreading may be via the phosphorylation of signaling proteins, such as MARCKS, that are involved in the reorganization of the actin cytoskeleton...
  32. ncbi request reprint A caveolin-3 mutant that causes limb girdle muscular dystrophy type 1C disrupts Src localization and activity and induces apoptosis in skeletal myotubes
    Gayle M Smythe
    Department of Neurology and Neurological Science, Stanford University School of Medicine, Stanford, California 94305 5235, USA
    J Cell Sci 116:4739-49. 2003
    ....
  33. ncbi request reprint The regulation of catalase gene expression in mouse muscle cells is dependent on the CCAAT-binding factor NF-Y
    Dan Luo
    Neurology Service and GRECC, VA Palo Alto Health Care System, Palo Alto, CA 94304, USA
    Biochem Biophys Res Commun 303:609-18. 2003
    ..These data provide the first examination of the regulation of the mouse catalase gene and indicate unique aspects of its regulation that may pertain to the tissue-specific patterns of expression...
  34. ncbi request reprint Long-term increase in mVEGF164 in mouse hindlimb muscle mediated by phage phiC31 integrase after nonviral DNA delivery
    Joylette L Portlock
    Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA
    Hum Gene Ther 17:871-6. 2006
    ..These results suggest the possible utility of the phiC31 integrase system to treat ischemic disease...
  35. ncbi request reprint The bi-directional translocation of MARCKS between membrane and cytosol regulates integrin-mediated muscle cell spreading
    Marie Helene Disatnik
    Department of Neurology and Neurological Sciences, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305 5235, USA
    J Cell Sci 117:4469-79. 2004
    ....
  36. ncbi request reprint Isolation of adult mouse myogenic progenitors: functional heterogeneity of cells within and engrafting skeletal muscle
    Richard I Sherwood
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Cell 119:543-54. 2004
    ..Together, these studies describe the clonal isolation of functional adult myogenic progenitors and demonstrate that these cells do not arise from hematopoietic or other bone marrow or circulating precursors...
  37. pmc Enhanced gene repair mediated by methyl-CpG-modified single-stranded oligonucleotides
    Carmen Bertoni
    Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA
    Nucleic Acids Res 37:7468-82. 2009
    ....
  38. ncbi request reprint Focal adhesion kinase is essential for costamerogenesis in cultured skeletal muscle cells
    Navaline L Quach
    Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA
    Dev Biol 293:38-52. 2006
    ..We present a model of costamerogenesis whereby signaling through FAK is essential for both normal costamerogenesis and normal myofibrillogenesis which are tightly coupled during skeletal myogenesis...
  39. ncbi request reprint Ageing: from stem to stern
    Anne Brunet
    Nature 449:288-91. 2007
  40. doi request reprint Get personal with gene therapy for muscular dystrophy
    Thomas A Rando
    Lancet Neurol 7:196-8. 2008
  41. doi request reprint Technology insight: therapy for Duchenne muscular dystrophy-an opportunity for personalized medicine?
    Leland E Lim
    Neurology Service at the Veterans Affairs Palo Alto Health Care System, CA, USA
    Nat Clin Pract Neurol 4:149-58. 2008
    ..This mutation-focused approach offers the opportunity for 'personalized' gene therapy for muscular dystrophy and might also be a logical strategy for the treatment of other genetic disorders...
  42. ncbi request reprint Remarkable preservation of undigested muscle tissue within a Late Cretaceous tyrannosaurid coprolite from Alberta, Canada
    Karen Chin
    Department of Geological Sciences and CU Museum, University of Colorado at Boulder, Boulder, CO 80309, USA
    Palaios 18:286-94. 2003
    ..Rapid burial of the feces probably was facilitated by a flood event on the ancient coastal lowland plain on which the fecal mass was deposited...
  43. ncbi request reprint The adult muscle stem cell comes of age
    Thomas A Rando
    Nat Med 11:829-31. 2005
  44. ncbi request reprint Stem cells in postnatal myogenesis: molecular mechanisms of satellite cell quiescence, activation and replenishment
    Jyotsna Dhawan
    Center for Cellular and Molecular Biology, Uppal Road, Hyderabad 500007, India
    Trends Cell Biol 15:666-73. 2005
    ..The molecular mechanisms of these transitions are considered in the context of the biology of the satellite cell niche, changes with age, and interactions with established pathways of myogenic commitment and differentiation...
  45. ncbi request reprint Prognostic value of telomere length: the long and short of it
    Thomas A Rando
    Ann Neurol 60:155-7. 2006
  46. ncbi request reprint Activation of an adipogenic program in adult myoblasts with age
    Jane M Taylor-Jones
    Department of Geriatrics, Donald W Reynolds Center on Aging, University of Arkansas for Medical Sciences, 629 South Elm Street, Little Rock, AR 72205, USA
    Mech Ageing Dev 123:649-61. 2002
    ..Whether this change in differentiation potential contributes to the increased adiposity in muscle with age remains to be determined...

Research Grants20

  1. Cellular Signaling and Muscular Dystrophies
    THOMAS RANDO; Fiscal Year: 2005
    ..We will study the mechanisms by which caveolin-3 deficiency lead to muscle cell death, and we will test whether these mechanisms involve the disruption of either normal integrin signaling or signaling through the DGC. ..
  2. OXIDATIVE STRESS AND MUSCLE CELL DEATH
    THOMAS RANDO; Fiscal Year: 2005
    ..Using this approach, we will test our specific hypothesis of the role of oxidative injury in the pathogenetic process and we will determine if the results of the expression array analysis suggest alternate hynotheses. ..
  3. Notch Signaling and Satellite Cell Activation
    THOMAS RANDO; Fiscal Year: 2007
    ....
  4. FASEB Conference:Skeletal muscle satellite and stem cells
    THOMAS RANDO; Fiscal Year: 2007
    ..We fully anticipate that progress in this field will pave the way for stem cell therapies for a variety of degenerative, inflammatory, and age-related disorders. ..
  5. Notch Signaling and Satellite Cell Activation
    THOMAS RANDO; Fiscal Year: 2009
    ..abstract_text> ..
  6. OXIDATIVE STRESS AND MUSCLE CELL DEATH
    THOMAS RANDO; Fiscal Year: 2000
    ....
  7. Molecular Regulation of Myogenic Differentiation
    Thomas A Rando; Fiscal Year: 2010
    ....