Jayakumar Rajadas

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. doi request reprint A strategy for analyzing bond strength and interaction kinetics between Pleckstrin homology domains and PI(4,5)P2 phospholipids using force distance spectroscopy and surface plasmon resonance
    A V Malkovskiy
    Stanford BioADD Laboratory, Stanford, California 94305, USA
    Analyst 140:4558-65. 2015
  2. pmc Enhanced Aβ(1-40) production in endothelial cells stimulated with fibrillar Aβ(1-42)
    Jayakumar Rajadas
    Biomaterials and Advanced Drug Delivery Laboratory, Stanford University School of Medicine, Stanford, California, United States of America
    PLoS ONE 8:e58194. 2013
  3. pmc Synergistic photothermal ablative effects of functionalizing carbon nanotubes with a POSS-PCU nanocomposite polymer
    Aaron Tan
    Centre for Nanotechnology and Regenerative Medicine, UCL Division of Surgery and Interventional Science, University College London, London, NW3 2QG, UK
    J Nanobiotechnology 10:34. 2012
  4. pmc Engineered pullulan-collagen composite dermal hydrogels improve early cutaneous wound healing
    Victor W Wong
    Department of Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA
    Tissue Eng Part A 17:631-44. 2011
  5. pmc Pullulan hydrogels improve mesenchymal stem cell delivery into high-oxidative-stress wounds
    Victor W Wong
    Hagey Laboratory for Pediatric Regenerative Medicine, Department of Surgery, Stanford University School of Medicine, Stanford, CA, USA
    Macromol Biosci 11:1458-66. 2011
  6. pmc Small molecule, non-peptide p75 ligands inhibit Abeta-induced neurodegeneration and synaptic impairment
    Tao Yang
    Department of Neurology and Neurological Science, Stanford University, Stanford, California, USA
    PLoS ONE 3:e3604. 2008
  7. pmc Promotion of airway anastomotic microvascular regeneration and alleviation of airway ischemia by deferoxamine nanoparticles
    Xinguo Jiang
    Division of Pulmonary Critical Care, Department of Medicine, VA Palo Alto Health Care System Stanford University School of Medicine, Stanford, CA, USA
    Biomaterials 35:803-13. 2014
  8. doi request reprint [Pyr1]-Apelin-13 delivery via nano-liposomal encapsulation attenuates pressure overload-induced cardiac dysfunction
    Vahid Serpooshan
    Stanford University, Department of Pediatrics, 300 Pasteur Dr, Stanford, CA 94305, USA Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA
    Biomaterials 37:289-98. 2015
  9. pmc Small molecule BDNF mimetics activate TrkB signaling and prevent neuronal degeneration in rodents
    Stephen M Massa
    Department of Neurology and Laboratory for Computational Neurochemistry and Drug Discovery, UCSF, San Francisco, California, USA
    J Clin Invest 120:1774-85. 2010
  10. doi request reprint Transdermal Delivery of Functional Collagen Via Polyvinylpyrrolidone Microneedles
    Wenchao Sun
    Biomaterials and Advanced Drug Delivery Laboratory, Stanford University School of Medicine, 1050 Arastradero Road, Building A, Room A148, Palo Alto, CA, 94304, USA
    Ann Biomed Eng 43:2978-90. 2015

Collaborators

Detail Information

Publications25

  1. doi request reprint A strategy for analyzing bond strength and interaction kinetics between Pleckstrin homology domains and PI(4,5)P2 phospholipids using force distance spectroscopy and surface plasmon resonance
    A V Malkovskiy
    Stanford BioADD Laboratory, Stanford, California 94305, USA
    Analyst 140:4558-65. 2015
    ..We confirm the FDS findings of a high bond strength of ∼0.19 ± 0.04 nN by Surface Plasmon Resonance (SPR) data analysis, segregating non-specific interactions, which show a significantly lower K(D) suggesting tight binding...
  2. pmc Enhanced Aβ(1-40) production in endothelial cells stimulated with fibrillar Aβ(1-42)
    Jayakumar Rajadas
    Biomaterials and Advanced Drug Delivery Laboratory, Stanford University School of Medicine, Stanford, California, United States of America
    PLoS ONE 8:e58194. 2013
    ..Immunofluorescence staining further corroborates these observations. Cellular responses to fibrillar Aβ(1-42) treatment involving eNOS upregulation and increased autophagy are also reported...
  3. pmc Synergistic photothermal ablative effects of functionalizing carbon nanotubes with a POSS-PCU nanocomposite polymer
    Aaron Tan
    Centre for Nanotechnology and Regenerative Medicine, UCL Division of Surgery and Interventional Science, University College London, London, NW3 2QG, UK
    J Nanobiotechnology 10:34. 2012
    ..POSS-PCU displays excellent biocompatibility and has been used in making artificial organs as well as protective coatings for medical devices...
  4. pmc Engineered pullulan-collagen composite dermal hydrogels improve early cutaneous wound healing
    Victor W Wong
    Department of Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA
    Tissue Eng Part A 17:631-44. 2011
    ..These novel biomatrices can potentially serve as a structured delivery template for cells and biomolecules in regenerative skin applications...
  5. pmc Pullulan hydrogels improve mesenchymal stem cell delivery into high-oxidative-stress wounds
    Victor W Wong
    Hagey Laboratory for Pediatric Regenerative Medicine, Department of Surgery, Stanford University School of Medicine, Stanford, CA, USA
    Macromol Biosci 11:1458-66. 2011
    ..The results suggest that glucan hydrogel systems may prove beneficial for progenitor-cell-based approaches to skin regeneration...
  6. pmc Small molecule, non-peptide p75 ligands inhibit Abeta-induced neurodegeneration and synaptic impairment
    Tao Yang
    Department of Neurology and Neurological Science, Stanford University, Stanford, California, USA
    PLoS ONE 3:e3604. 2008
    ....
  7. pmc Promotion of airway anastomotic microvascular regeneration and alleviation of airway ischemia by deferoxamine nanoparticles
    Xinguo Jiang
    Division of Pulmonary Critical Care, Department of Medicine, VA Palo Alto Health Care System Stanford University School of Medicine, Stanford, CA, USA
    Biomaterials 35:803-13. 2014
    ..This approach may be an effective topical transplant-conditioning therapy for preventing airway complications following clinical lung transplantation. ..
  8. doi request reprint [Pyr1]-Apelin-13 delivery via nano-liposomal encapsulation attenuates pressure overload-induced cardiac dysfunction
    Vahid Serpooshan
    Stanford University, Department of Pediatrics, 300 Pasteur Dr, Stanford, CA 94305, USA Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA
    Biomaterials 37:289-98. 2015
    ..We concluded that this engineered nanocarrier system can serve as a delivery platform for treating heart injuries through sustained bioavailability of cardioprotective therapeutics...
  9. pmc Small molecule BDNF mimetics activate TrkB signaling and prevent neuronal degeneration in rodents
    Stephen M Massa
    Department of Neurology and Laboratory for Computational Neurochemistry and Drug Discovery, UCSF, San Francisco, California, USA
    J Clin Invest 120:1774-85. 2010
    ..We propose that these compounds constitute a novel group of tools for the study of TrkB signaling and may provide leads for developing new therapeutic agents for neurodegenerative diseases...
  10. doi request reprint Transdermal Delivery of Functional Collagen Via Polyvinylpyrrolidone Microneedles
    Wenchao Sun
    Biomaterials and Advanced Drug Delivery Laboratory, Stanford University School of Medicine, 1050 Arastradero Road, Building A, Room A148, Palo Alto, CA, 94304, USA
    Ann Biomed Eng 43:2978-90. 2015
    ..Since the technique presented in this paper is quick, safe, effective and easy, it can be considered as a new collagen delivery method for cosmetic and therapeutic applications. ..
  11. pmc Rationally designed turn promoting mutation in the amyloid-β peptide sequence stabilizes oligomers in solution
    Jayakumar Rajadas
    Biomaterials and Advanced Drug Delivery Laboratory, Stanford University, Stanford, California, United States of America
    PLoS ONE 6:e21776. 2011
    ..The biophysical information obtained in this work could aid in the development of structural models for toxic oligomer formation that could facilitate the development of therapeutic approaches to AD...
  12. pmc A critical role for the PAR-1/MARK-tau axis in mediating the toxic effects of Aβ on synapses and dendritic spines
    Wendou Yu
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Hum Mol Genet 21:1384-90. 2012
    ..Our results reveal a critical role for PAR-1/MARK kinases in AD pathogenesis and suggest PAR-1/MARK inhibitors as potential therapeutics for AD and possibly other tauopathies where aberrant tau hyperphosphorylation is involved...
  13. pmc Transdermal deferoxamine prevents pressure-induced diabetic ulcers
    Dominik Duscher
    Hagey Laboratory for Pediatric Regenerative Medicine, Division of Plastic and Reconstructive Surgery, Department of Surgery, Stanford University School of Medicine, Stanford, CA 94305
    Proc Natl Acad Sci U S A 112:94-9. 2015
    ..These findings suggest that transdermal delivery of DFO provides a targeted means to both prevent ulcer formation and accelerate diabetic wound healing with the potential for rapid clinical translation. ..
  14. pmc Polyvinylpyrrolidone microneedles enable delivery of intact proteins for diagnostic and therapeutic applications
    Wenchao Sun
    Biomaterials and Advanced Drug Delivery Laboratory, Stanford University, Stanford, CA 94305, USA
    Acta Biomater 9:7767-74. 2013
    ..These microneedles can serve as a broadly useful platform for delivering protein antigens and therapeutic proteins to the skin, for example for allergen skin testing or immunotherapy. ..
  15. doi request reprint Abeta peptide conformation determines uptake and interleukin-1alpha expression by primary microglial cells
    Saravanapavan Parvathy
    Neuroscience Research Laboratories, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305 5485, United States
    Neurobiol Aging 30:1792-804. 2009
    ..The uptake of oligomeric and protofibrillar Abeta by microglia merits further investigation as a potential means for removing these neurotoxic species from the brain...
  16. pmc Solvent microenvironments and copper binding alters the conformation and toxicity of a prion fragment
    Mohammed Inayathullah
    Biomaterials and Advanced Drug Delivery Laboratory, Stanford University School of Medicine, Stanford, California, United States of America
    PLoS ONE 8:e85160. 2013
    ..The toxicity of PrP(111-126) to cultured astrocytes was reduced following the addition of Cu(2+) ions, owing to binding affinity of copper towards histidine moiety present in the peptide. ..
  17. doi request reprint Nanotechnology and regenerative therapeutics in plastic surgery: The next frontier
    Aaron Tan
    UCL Medical School, University College London UCL, London, England, UK Biomaterials and Advanced Drug Delivery Laboratory BioADD, Stanford University School of Medicine, Stanford University, Stanford, CA, USA Electronic address
    J Plast Reconstr Aesthet Surg 69:1-13. 2016
    ..This study presents a review of nanotechnology and regenerative therapeutics, with focus on its applications and implications in plastic surgery. ..
  18. pmc Efficient gene delivery of primary human cells using peptide linked polyethylenimine polymer hybrid
    Devaveena Dey
    Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305 5111, USA
    Biomaterials 32:4647-58. 2011
    ..This was further corroborated with global gene expression analysis which showed upregulation of multiple genes and pathways involved in regulating intracellular oxidative stress...
  19. pmc Borreliacidal activity of Borrelia metal transporter A (BmtA) binding small molecules by manganese transport inhibition
    Dhananjay Wagh
    Biomaterials and Advanced Drug Delivery Laboratory, Stanford Cardiovascular Pharmacology Division, Cardiovascular Institute, Stanford University School of Medicine, Palo Alto, CA, USA
    Drug Des Devel Ther 9:805-16. 2015
    ..Our results support the possibility of developing a novel, targeted therapy to treat Lyme disease by targeting specific metabolic needs of Borrelia. ..
  20. pmc The effect of bioengineered acellular collagen patch on cardiac remodeling and ventricular function post myocardial infarction
    Vahid Serpooshan
    Stanford University, Department of Pediatrics, 300 Pasteur Dr, Stanford, CA 94305, USA
    Biomaterials 34:9048-55. 2013
    ..In summary, an acellular biomaterial with specific biomechanical properties promotes the endogenous capacity of the infarcted myocardium to attenuate remodeling and improve heart function following myocardial infarction. ..
  21. pmc Enhancement of mesenchymal stem cell angiogenic capacity and stemness by a biomimetic hydrogel scaffold
    Kristine C Rustad
    Department of Surgery, Stanford University, GK 201, Stanford, CA 94305, USA
    Biomaterials 33:80-90. 2012
    ..Our data suggest that biomimetic hydrogels provide a functional niche capable of augmenting MSC regenerative potential and enhancing wound healing...
  22. pmc Adipose tissue-derived stem cells display a proangiogenic phenotype on 3D scaffolds
    Evgenios A Neofytou
    Department of Cardiothoracic Surgery, Stanford University School of Medicine, California, USA
    J Biomed Mater Res A 98:383-93. 2011
    ..This can potentially help us to surpass the tissue thickness limitations faced by the tissue engineering community today...
  23. pmc The p75 neurotrophin receptor promotes amyloid-beta(1-42)-induced neuritic dystrophy in vitro and in vivo
    JULIET K KNOWLES
    Department of Neurology and Neurological Science, Stanford University, Stanford, California 94305, USA
    J Neurosci 29:10627-37. 2009
    ....
  24. pmc A Thermo-Sensitive Delivery Platform for Topical Administration of Inflammatory Bowel Disease Therapies
    Sidhartha R Sinha
    Division of Gastroenterology and Hepatology, Stanford University School of Medicine, Stanford, California Electronic address
    Gastroenterology 149:52-55.e2. 2015
    ..Image analysis showed that enemas delivered with and without the platform reached similar distances in the colons of mice, but greater colonic retention was achieved by using the platform. ..
  25. pmc Chaperone activity of small heat shock proteins underlies therapeutic efficacy in experimental autoimmune encephalomyelitis
    Michael P Kurnellas
    Department Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California 94305 5316, USA
    J Biol Chem 287:36423-34. 2012
    ..The linkage of the three activities was further established by demonstrating individual substitutions of critical hydrophobic amino acids in the peptide resulted in the loss of all of the functions...