Jayakumar Rajadas

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. pmc Enhanced Aβ(1-40) production in endothelial cells stimulated with fibrillar Aβ(1-42)
    Jayakumar Rajadas
    Biomaterials and Advanced Drug Delivery Laboratory, Stanford University School of Medicine, Stanford, California, United States of America
    PLoS ONE 8:e58194. 2013
  2. pmc Synergistic photothermal ablative effects of functionalizing carbon nanotubes with a POSS-PCU nanocomposite polymer
    Aaron Tan
    Centre for Nanotechnology and Regenerative Medicine, UCL Division of Surgery and Interventional Science, University College London, London, NW3 2QG, UK
    J Nanobiotechnology 10:34. 2012
  3. pmc Engineered pullulan-collagen composite dermal hydrogels improve early cutaneous wound healing
    Victor W Wong
    Department of Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA
    Tissue Eng Part A 17:631-44. 2011
  4. pmc Transdermal deferoxamine prevents pressure-induced diabetic ulcers
    Dominik Duscher
    Hagey Laboratory for Pediatric Regenerative Medicine, Division of Plastic and Reconstructive Surgery, Department of Surgery, Stanford University School of Medicine, Stanford, CA 94305
    Proc Natl Acad Sci U S A 112:94-9. 2015
  5. doi request reprint [Pyr1]-Apelin-13 delivery via nano-liposomal encapsulation attenuates pressure overload-induced cardiac dysfunction
    Vahid Serpooshan
    Stanford University, Department of Pediatrics, 300 Pasteur Dr, Stanford, CA 94305, USA Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA
    Biomaterials 37:289-98. 2015
  6. pmc Borreliacidal activity of Borrelia metal transporter A (BmtA) binding small molecules by manganese transport inhibition
    Dhananjay Wagh
    Biomaterials and Advanced Drug Delivery Laboratory, Stanford Cardiovascular Pharmacology Division, Cardiovascular Institute, Stanford University School of Medicine, Palo Alto, CA, USA
    Drug Des Devel Ther 9:805-16. 2015
  7. pmc Polyvinylpyrrolidone microneedles enable delivery of intact proteins for diagnostic and therapeutic applications
    Wenchao Sun
    Biomaterials and Advanced Drug Delivery Laboratory, Stanford University, Stanford, CA 94305, USA
    Acta Biomater 9:7767-74. 2013
  8. pmc A Thermo-Sensitive Delivery Platform for Topical Administration of Inflammatory Bowel Disease Therapies
    Sidhartha R Sinha
    Division of Gastroenterology and Hepatology, Stanford University School of Medicine, Stanford, California Electronic address
    Gastroenterology 149:52-55.e2. 2015
  9. pmc Solvent microenvironments and copper binding alters the conformation and toxicity of a prion fragment
    Mohammed Inayathullah
    Biomaterials and Advanced Drug Delivery Laboratory, Stanford University School of Medicine, Stanford, California, United States of America
    PLoS ONE 8:e85160. 2013
  10. pmc Chaperone activity of small heat shock proteins underlies therapeutic efficacy in experimental autoimmune encephalomyelitis
    Michael P Kurnellas
    Department Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California 94305 5316, USA
    J Biol Chem 287:36423-34. 2012

Collaborators

  • Victor W Wong
  • Geoffrey C Gurtner
  • Morteza Mahmoudi
  • Melanie Rodrigues
  • Aida Habtezion
  • Lawrence Steinman
  • Gary K Schoolnik
  • Joseph M Rifkind
  • Bingwei Lu
  • Robert Malenka
  • Mohammed Inayathullah
  • Dhananjay Wagh
  • Andrey V Malkovskiy
  • Sidhartha R Sinha
  • Dominik Duscher
  • Vahid Serpooshan
  • Senthilkumar Sivanesan
  • Wenchao Sun
  • Aaron Tan
  • Michael P Kurnellas
  • Wendou Yu
  • Kwang Min Kim
  • Joseph C Wu
  • Graham G Walmsley
  • Arnetha J Whitmore
  • Xiaoran Huang
  • Daniel Bernstein
  • Robert C Rennert
  • Zeshaan N Maan
  • Andrey Malkovskiy
  • Mingming Zhao
  • Xuexiang J Zhang
  • Song Liu
  • Michael Januszyk
  • Venkata Raveendra Pothineni
  • Alexander J Whittam
  • Michael Brownlee
  • SCOTT METZLER
  • Michael G Galvez
  • Pilar Ruiz-Lozano
  • Linh P Nguyen
  • Frezghi Habte
  • Evgenios Neofytou
  • Antoine L Carre
  • Carlos Milla
  • Jasper O Hardesty
  • M Peter Marinkovich
  • Sathish Manickam
  • Manish J Butte
  • Marc A Bruce
  • Xuexiang Zhang
  • K S Satheeshkumar
  • Zeynep Araci
  • Alfred T Lane
  • Jai Polepalli
  • Rachel A Becker
  • Shalina S Ousman
  • Leon Su
  • Gregory Dolganov
  • Alexander M Seifalian
  • Jonathan B Rothbard
  • Sidharth Chopra
  • Giorgia Pastorin
  • Sara E Brownell
  • Jonathan Webster
  • Seyed Yazdan Madani
  • Raymond A Sobel

Detail Information

Publications13

  1. pmc Enhanced Aβ(1-40) production in endothelial cells stimulated with fibrillar Aβ(1-42)
    Jayakumar Rajadas
    Biomaterials and Advanced Drug Delivery Laboratory, Stanford University School of Medicine, Stanford, California, United States of America
    PLoS ONE 8:e58194. 2013
    ..Immunofluorescence staining further corroborates these observations. Cellular responses to fibrillar Aβ(1-42) treatment involving eNOS upregulation and increased autophagy are also reported...
  2. pmc Synergistic photothermal ablative effects of functionalizing carbon nanotubes with a POSS-PCU nanocomposite polymer
    Aaron Tan
    Centre for Nanotechnology and Regenerative Medicine, UCL Division of Surgery and Interventional Science, University College London, London, NW3 2QG, UK
    J Nanobiotechnology 10:34. 2012
    ..POSS-PCU displays excellent biocompatibility and has been used in making artificial organs as well as protective coatings for medical devices...
  3. pmc Engineered pullulan-collagen composite dermal hydrogels improve early cutaneous wound healing
    Victor W Wong
    Department of Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA
    Tissue Eng Part A 17:631-44. 2011
    ..These novel biomatrices can potentially serve as a structured delivery template for cells and biomolecules in regenerative skin applications...
  4. pmc Transdermal deferoxamine prevents pressure-induced diabetic ulcers
    Dominik Duscher
    Hagey Laboratory for Pediatric Regenerative Medicine, Division of Plastic and Reconstructive Surgery, Department of Surgery, Stanford University School of Medicine, Stanford, CA 94305
    Proc Natl Acad Sci U S A 112:94-9. 2015
    ..These findings suggest that transdermal delivery of DFO provides a targeted means to both prevent ulcer formation and accelerate diabetic wound healing with the potential for rapid clinical translation. ..
  5. doi request reprint [Pyr1]-Apelin-13 delivery via nano-liposomal encapsulation attenuates pressure overload-induced cardiac dysfunction
    Vahid Serpooshan
    Stanford University, Department of Pediatrics, 300 Pasteur Dr, Stanford, CA 94305, USA Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA
    Biomaterials 37:289-98. 2015
    ..We concluded that this engineered nanocarrier system can serve as a delivery platform for treating heart injuries through sustained bioavailability of cardioprotective therapeutics...
  6. pmc Borreliacidal activity of Borrelia metal transporter A (BmtA) binding small molecules by manganese transport inhibition
    Dhananjay Wagh
    Biomaterials and Advanced Drug Delivery Laboratory, Stanford Cardiovascular Pharmacology Division, Cardiovascular Institute, Stanford University School of Medicine, Palo Alto, CA, USA
    Drug Des Devel Ther 9:805-16. 2015
    ..Our results support the possibility of developing a novel, targeted therapy to treat Lyme disease by targeting specific metabolic needs of Borrelia. ..
  7. pmc Polyvinylpyrrolidone microneedles enable delivery of intact proteins for diagnostic and therapeutic applications
    Wenchao Sun
    Biomaterials and Advanced Drug Delivery Laboratory, Stanford University, Stanford, CA 94305, USA
    Acta Biomater 9:7767-74. 2013
    ..These microneedles can serve as a broadly useful platform for delivering protein antigens and therapeutic proteins to the skin, for example for allergen skin testing or immunotherapy. ..
  8. pmc A Thermo-Sensitive Delivery Platform for Topical Administration of Inflammatory Bowel Disease Therapies
    Sidhartha R Sinha
    Division of Gastroenterology and Hepatology, Stanford University School of Medicine, Stanford, California Electronic address
    Gastroenterology 149:52-55.e2. 2015
    ..Image analysis showed that enemas delivered with and without the platform reached similar distances in the colons of mice, but greater colonic retention was achieved by using the platform. ..
  9. pmc Solvent microenvironments and copper binding alters the conformation and toxicity of a prion fragment
    Mohammed Inayathullah
    Biomaterials and Advanced Drug Delivery Laboratory, Stanford University School of Medicine, Stanford, California, United States of America
    PLoS ONE 8:e85160. 2013
    ..The toxicity of PrP(111-126) to cultured astrocytes was reduced following the addition of Cu(2+) ions, owing to binding affinity of copper towards histidine moiety present in the peptide. ..
  10. pmc Chaperone activity of small heat shock proteins underlies therapeutic efficacy in experimental autoimmune encephalomyelitis
    Michael P Kurnellas
    Department Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California 94305 5316, USA
    J Biol Chem 287:36423-34. 2012
    ..The linkage of the three activities was further established by demonstrating individual substitutions of critical hydrophobic amino acids in the peptide resulted in the loss of all of the functions...
  11. pmc Rationally designed turn promoting mutation in the amyloid-β peptide sequence stabilizes oligomers in solution
    Jayakumar Rajadas
    Biomaterials and Advanced Drug Delivery Laboratory, Stanford University, Stanford, California, United States of America
    PLoS ONE 6:e21776. 2011
    ..The biophysical information obtained in this work could aid in the development of structural models for toxic oligomer formation that could facilitate the development of therapeutic approaches to AD...
  12. pmc Pullulan hydrogels improve mesenchymal stem cell delivery into high-oxidative-stress wounds
    Victor W Wong
    Hagey Laboratory for Pediatric Regenerative Medicine, Department of Surgery, Stanford University School of Medicine, Stanford, CA, USA
    Macromol Biosci 11:1458-66. 2011
    ..The results suggest that glucan hydrogel systems may prove beneficial for progenitor-cell-based approaches to skin regeneration...
  13. pmc A critical role for the PAR-1/MARK-tau axis in mediating the toxic effects of Aβ on synapses and dendritic spines
    Wendou Yu
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Hum Mol Genet 21:1384-90. 2012
    ..Our results reveal a critical role for PAR-1/MARK kinases in AD pathogenesis and suggest PAR-1/MARK inhibitors as potential therapeutics for AD and possibly other tauopathies where aberrant tau hyperphosphorylation is involved...