Jayakumar Rajadas

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. pmc Solvent microenvironments and copper binding alters the conformation and toxicity of a prion fragment
    Mohammed Inayathullah
    Biomaterials and Advanced Drug Delivery Laboratory, Stanford University School of Medicine, Stanford, California, United States of America
    PLoS ONE 8:e85160. 2013
  2. pmc Enhanced Aβ(1-40) production in endothelial cells stimulated with fibrillar Aβ(1-42)
    Jayakumar Rajadas
    Biomaterials and Advanced Drug Delivery Laboratory, Stanford University School of Medicine, Stanford, California, United States of America
    PLoS ONE 8:e58194. 2013
  3. pmc Synergistic photothermal ablative effects of functionalizing carbon nanotubes with a POSS-PCU nanocomposite polymer
    Aaron Tan
    Centre for Nanotechnology and Regenerative Medicine, UCL Division of Surgery and Interventional Science, University College London, London, NW3 2QG, UK
    J Nanobiotechnology 10:34. 2012
  4. doi request reprint Engineered pullulan-collagen composite dermal hydrogels improve early cutaneous wound healing
    Victor W Wong
    Department of Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA
    Tissue Eng Part A 17:631-44. 2011
  5. pmc Polyvinylpyrrolidone microneedles enable delivery of intact proteins for diagnostic and therapeutic applications
    Wenchao Sun
    Biomaterials and Advanced Drug Delivery Laboratory, Stanford University, Stanford, CA 94305, USA
    Acta Biomater 9:7767-74. 2013
  6. pmc Chaperone activity of small heat shock proteins underlies therapeutic efficacy in experimental autoimmune encephalomyelitis
    Michael P Kurnellas
    Department Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California 94305 5316, USA
    J Biol Chem 287:36423-34. 2012
  7. pmc Rationally designed turn promoting mutation in the amyloid-β peptide sequence stabilizes oligomers in solution
    Jayakumar Rajadas
    Biomaterials and Advanced Drug Delivery Laboratory, Stanford University, Stanford, California, United States of America
    PLoS ONE 6:e21776. 2011
  8. doi request reprint Pullulan hydrogels improve mesenchymal stem cell delivery into high-oxidative-stress wounds
    Victor W Wong
    Hagey Laboratory for Pediatric Regenerative Medicine, Department of Surgery, Stanford University School of Medicine, Stanford, CA, USA
    Macromol Biosci 11:1458-66. 2011
  9. pmc A critical role for the PAR-1/MARK-tau axis in mediating the toxic effects of Aβ on synapses and dendritic spines
    Wendou Yu
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Hum Mol Genet 21:1384-90. 2012

Collaborators

  • Victor W Wong
  • Geoffrey C Gurtner
  • Lawrence Steinman
  • Gary K Schoolnik
  • Joseph M Rifkind
  • Bingwei Lu
  • Robert Malenka
  • Mohammed Inayathullah
  • Wenchao Sun
  • Andrey V Malkovskiy
  • Aaron Tan
  • Wendou Yu
  • Michael P Kurnellas
  • K S Satheeshkumar
  • Zeynep Araci
  • Marc A Bruce
  • Senthilkumar Sivanesan
  • Antoine L Carre
  • Manish J Butte
  • Jasper O Hardesty
  • Alfred T Lane
  • M Peter Marinkovich
  • Xuexiang Zhang
  • Carlos Milla
  • Sathish Manickam
  • Giorgia Pastorin
  • Rachel A Becker
  • Jonathan Webster
  • Sara E Brownell
  • Leon Su
  • Raymond A Sobel
  • Seyed Yazdan Madani
  • Shalina S Ousman
  • Alexander M Seifalian
  • Sidharth Chopra
  • Dhananjay Wagh
  • Gregory Dolganov
  • Jonathan B Rothbard
  • Jai Polepalli

Detail Information

Publications9

  1. pmc Solvent microenvironments and copper binding alters the conformation and toxicity of a prion fragment
    Mohammed Inayathullah
    Biomaterials and Advanced Drug Delivery Laboratory, Stanford University School of Medicine, Stanford, California, United States of America
    PLoS ONE 8:e85160. 2013
    ..The toxicity of PrP(111-126) to cultured astrocytes was reduced following the addition of Cu(2+) ions, owing to binding affinity of copper towards histidine moiety present in the peptide. ..
  2. pmc Enhanced Aβ(1-40) production in endothelial cells stimulated with fibrillar Aβ(1-42)
    Jayakumar Rajadas
    Biomaterials and Advanced Drug Delivery Laboratory, Stanford University School of Medicine, Stanford, California, United States of America
    PLoS ONE 8:e58194. 2013
    ..Immunofluorescence staining further corroborates these observations. Cellular responses to fibrillar Aβ(1-42) treatment involving eNOS upregulation and increased autophagy are also reported...
  3. pmc Synergistic photothermal ablative effects of functionalizing carbon nanotubes with a POSS-PCU nanocomposite polymer
    Aaron Tan
    Centre for Nanotechnology and Regenerative Medicine, UCL Division of Surgery and Interventional Science, University College London, London, NW3 2QG, UK
    J Nanobiotechnology 10:34. 2012
    ..POSS-PCU displays excellent biocompatibility and has been used in making artificial organs as well as protective coatings for medical devices...
  4. doi request reprint Engineered pullulan-collagen composite dermal hydrogels improve early cutaneous wound healing
    Victor W Wong
    Department of Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA
    Tissue Eng Part A 17:631-44. 2011
    ..These novel biomatrices can potentially serve as a structured delivery template for cells and biomolecules in regenerative skin applications...
  5. pmc Polyvinylpyrrolidone microneedles enable delivery of intact proteins for diagnostic and therapeutic applications
    Wenchao Sun
    Biomaterials and Advanced Drug Delivery Laboratory, Stanford University, Stanford, CA 94305, USA
    Acta Biomater 9:7767-74. 2013
    ..These microneedles can serve as a broadly useful platform for delivering protein antigens and therapeutic proteins to the skin, for example for allergen skin testing or immunotherapy. ..
  6. pmc Chaperone activity of small heat shock proteins underlies therapeutic efficacy in experimental autoimmune encephalomyelitis
    Michael P Kurnellas
    Department Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California 94305 5316, USA
    J Biol Chem 287:36423-34. 2012
    ..The linkage of the three activities was further established by demonstrating individual substitutions of critical hydrophobic amino acids in the peptide resulted in the loss of all of the functions...
  7. pmc Rationally designed turn promoting mutation in the amyloid-β peptide sequence stabilizes oligomers in solution
    Jayakumar Rajadas
    Biomaterials and Advanced Drug Delivery Laboratory, Stanford University, Stanford, California, United States of America
    PLoS ONE 6:e21776. 2011
    ..The biophysical information obtained in this work could aid in the development of structural models for toxic oligomer formation that could facilitate the development of therapeutic approaches to AD...
  8. doi request reprint Pullulan hydrogels improve mesenchymal stem cell delivery into high-oxidative-stress wounds
    Victor W Wong
    Hagey Laboratory for Pediatric Regenerative Medicine, Department of Surgery, Stanford University School of Medicine, Stanford, CA, USA
    Macromol Biosci 11:1458-66. 2011
    ..The results suggest that glucan hydrogel systems may prove beneficial for progenitor-cell-based approaches to skin regeneration...
  9. pmc A critical role for the PAR-1/MARK-tau axis in mediating the toxic effects of Aβ on synapses and dendritic spines
    Wendou Yu
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Hum Mol Genet 21:1384-90. 2012
    ..Our results reveal a critical role for PAR-1/MARK kinases in AD pathogenesis and suggest PAR-1/MARK inhibitors as potential therapeutics for AD and possibly other tauopathies where aberrant tau hyperphosphorylation is involved...