Matthew Porteus

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. pmc Design and Development of Artificial Zinc Finger Transcription Factors and Zinc Finger Nucleases to the hTERT Locus
    Kimberly A Wilson
    1 Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, USA 2 Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, USA
    Mol Ther Nucleic Acids 2:e87. 2013
  2. pmc Expanding the Repertoire of Target Sites for Zinc Finger Nuclease-mediated Genome Modification
    Kimberly A Wilson
    1 Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas, USA 2 Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Mol Ther Nucleic Acids 2:e88. 2013
  3. pmc Nuclease-mediated gene editing by homologous recombination of the human globin locus
    Richard A Voit
    Department of Pediatrics, Stanford University, 1291 Welch Rd Stanford, CA 94305, USA and Department of Pediatrics, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd Dallas, TX 75390, USA
    Nucleic Acids Res 42:1365-78. 2014
  4. pmc A survey of ex vivo/in vitro transduction efficiency of mammalian primary cells and cell lines with Nine natural adeno-associated virus (AAV1-9) and one engineered adeno-associated virus serotype
    Brian L Ellis
    Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390 9148, USA
    Virol J 10:74. 2013
  5. doi request reprint Homologous recombination-based gene therapy for the primary immunodeficiencies
    Matthew Porteus
    Department of Pediatrics, Divisions of Cancer Biology, Hematology Oncology, Human Gene Therapy, Stanford University, Stanford, California, USA
    Ann N Y Acad Sci 1246:131-40. 2011
  6. doi request reprint Design and testing of zinc finger nucleases for use in mammalian cells
    Matthew Porteus
    Department of Pediatrics and Biochemistry, UT Southwestern Medical Center, Dallas, TX, USA
    Methods Mol Biol 435:47-61. 2008
  7. doi request reprint Gene therapy for primary immunodeficiencies
    Eric Kildebeck
    Department of Pediatrics, Stanford University School of Medicine, California 94305, USA
    Curr Opin Pediatr 24:731-8. 2012

Collaborators

  • Kimberly A Wilson
  • Richard A Voit
  • Shondra M Pruett-Miller
  • Brian L Ellis
  • Eric Kildebeck
  • Ayal Hendel
  • Abbye E McEwen
  • Robert J Steininger
  • Matthew L Hirsch
  • Morgan L Chateau
  • Jon P Connelly
  • Eric J Kildebeck
  • Jiuli Zhang
  • Jenny C Barker
  • Josh Checketts

Detail Information

Publications7

  1. pmc Design and Development of Artificial Zinc Finger Transcription Factors and Zinc Finger Nucleases to the hTERT Locus
    Kimberly A Wilson
    1 Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, USA 2 Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, USA
    Mol Ther Nucleic Acids 2:e87. 2013
    ..Our work provides a foundation for using engineered ZF proteins (ZFPs) for modulation of the hTERT locus.Molecular Therapy - Nucleic Acids (2013) 2, e87; doi:10.1038/mtna.2013.12; published online 23 April 2013...
  2. pmc Expanding the Repertoire of Target Sites for Zinc Finger Nuclease-mediated Genome Modification
    Kimberly A Wilson
    1 Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas, USA 2 Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Mol Ther Nucleic Acids 2:e88. 2013
    ..These findings significantly expand the range of sites that can be potentially targeted by these custom-engineered proteins.Molecular Therapy - Nucleic Acids (2013) 2, e88; doi:10.1038/mtna.2013.13; published online 30 April 2013...
  3. pmc Nuclease-mediated gene editing by homologous recombination of the human globin locus
    Richard A Voit
    Department of Pediatrics, Stanford University, 1291 Welch Rd Stanford, CA 94305, USA and Department of Pediatrics, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd Dallas, TX 75390, USA
    Nucleic Acids Res 42:1365-78. 2014
    ....
  4. pmc A survey of ex vivo/in vitro transduction efficiency of mammalian primary cells and cell lines with Nine natural adeno-associated virus (AAV1-9) and one engineered adeno-associated virus serotype
    Brian L Ellis
    Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390 9148, USA
    Virol J 10:74. 2013
    ..Although transduction studies have been completed, the bulk of the studies have been done in vivo, and there has never been a comprehensive study of transduction ex vivo/in vitro...
  5. doi request reprint Homologous recombination-based gene therapy for the primary immunodeficiencies
    Matthew Porteus
    Department of Pediatrics, Divisions of Cancer Biology, Hematology Oncology, Human Gene Therapy, Stanford University, Stanford, California, USA
    Ann N Y Acad Sci 1246:131-40. 2011
    ..In this review, I discuss the development of nuclease-stimulated, homologous recombination-based approaches as a novel gene therapy strategy for the primary immunodeficiencies...
  6. doi request reprint Design and testing of zinc finger nucleases for use in mammalian cells
    Matthew Porteus
    Department of Pediatrics and Biochemistry, UT Southwestern Medical Center, Dallas, TX, USA
    Methods Mol Biol 435:47-61. 2008
    ..This chapter describes how to identify potential targets for ZFN cutting, to make ZFNs to cut this target site, and how to test whether the newly designed ZFNs are active in a mammalian cell culture-based system...
  7. doi request reprint Gene therapy for primary immunodeficiencies
    Eric Kildebeck
    Department of Pediatrics, Stanford University School of Medicine, California 94305, USA
    Curr Opin Pediatr 24:731-8. 2012
    ..In this review, we discuss recent advances in gene therapy with an emphasis on strategies to improve safety, including the emergence of gene targeting technologies for the treatment of PIDs...