J R Pomerening

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. ncbi Emi2 at the crossroads: where CSF meets MPF
    David V Hansen
    Department of Tumor Biology and Angiogenesis, Genentech, Inc, South San Francisco, California 94080, USA
    Cell Cycle 6:732-8. 2007
  2. ncbi Mutation of a conserved CDK site converts a metazoan Elongation Factor 1Bbeta subunit into a replacement for yeast eEF1Balpha
    J R Pomerening
    Department of Molecular Pharmacology, Stanford University School of Medicine, 269 West Campus Drive, CCSR 3160, Stanford, CA 94305 5174, USA
    Mol Genet Genomics 269:776-88. 2003
  3. ncbi Systems-level dissection of the cell-cycle oscillator: bypassing positive feedback produces damped oscillations
    Joseph R Pomerening
    Department of Molecular Pharmacology, Stanford University School of Medicine, Stanford, California 94305, USA
    Cell 122:565-78. 2005
  4. ncbi Building a cell cycle oscillator: hysteresis and bistability in the activation of Cdc2
    Joseph R Pomerening
    Department of Molecular Pharmacology, Stanford University School of Medicine, Stanford, CA 94305-5174, USA
    Nat Cell Biol 5:346-51. 2003
  5. ncbi Cyclin A2 regulates nuclear-envelope breakdown and the nuclear accumulation of cyclin B1
    Delquin Gong
    Department of Chemical and Systems Biology, CCSR, MC 5174, Stanford University School of Medicine, Stanford, California 94305, USA
    Curr Biol 17:85-91. 2007
  6. ncbi Robust, tunable biological oscillations from interlinked positive and negative feedback loops
    Tony Yu Chen Tsai
    Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA 94305 5174, USA
    Science 321:126-9. 2008
  7. ncbi Uncovering mechanisms of bistability in biological systems
    Joseph R Pomerening
    Department of Biology and The Biocomplexity Institute, Indiana University, 212 South Hawthorne Drive, Simon Hall SI MSB, Room 043F, Bloomington, IN 47405 7003, United States
    Curr Opin Biotechnol 19:381-8. 2008

Collaborators

Detail Information

Publications7

  1. ncbi Emi2 at the crossroads: where CSF meets MPF
    David V Hansen
    Department of Tumor Biology and Angiogenesis, Genentech, Inc, South San Francisco, California 94080, USA
    Cell Cycle 6:732-8. 2007
    ..Finally, we propose that inactivation of Emi2 by Cdc2 permits mitotic progression during early embryonic cleavage cycles...
  2. ncbi Mutation of a conserved CDK site converts a metazoan Elongation Factor 1Bbeta subunit into a replacement for yeast eEF1Balpha
    J R Pomerening
    Department of Molecular Pharmacology, Stanford University School of Medicine, 269 West Campus Drive, CCSR 3160, Stanford, CA 94305 5174, USA
    Mol Genet Genomics 269:776-88. 2003
    ....
  3. ncbi Systems-level dissection of the cell-cycle oscillator: bypassing positive feedback produces damped oscillations
    Joseph R Pomerening
    Department of Molecular Pharmacology, Stanford University School of Medicine, Stanford, California 94305, USA
    Cell 122:565-78. 2005
    ..This work also underscores the fundamental similarity of cell-cycle oscillations in embryos to repetitive action potentials in pacemaker neurons, with both systems relying on a combination of negative and positive-feedback loops...
  4. ncbi Building a cell cycle oscillator: hysteresis and bistability in the activation of Cdc2
    Joseph R Pomerening
    Department of Molecular Pharmacology, Stanford University School of Medicine, Stanford, CA 94305-5174, USA
    Nat Cell Biol 5:346-51. 2003
    ..We also show that Cdc2 activation exhibits hysteresis, a property of bistable systems with particular relevance to biochemical oscillators. These findings help establish the basic systems-level logic of the mitotic oscillator...
  5. ncbi Cyclin A2 regulates nuclear-envelope breakdown and the nuclear accumulation of cyclin B1
    Delquin Gong
    Department of Chemical and Systems Biology, CCSR, MC 5174, Stanford University School of Medicine, Stanford, California 94305, USA
    Curr Biol 17:85-91. 2007
    ..Nevertheless cyclin B1 translocates to the nucleus just prior to NEB in a cyclin A2-dependent fashion and is capable of supporting NEB if rendered constitutively nuclear...
  6. ncbi Robust, tunable biological oscillations from interlinked positive and negative feedback loops
    Tony Yu Chen Tsai
    Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA 94305 5174, USA
    Science 321:126-9. 2008
    ..Positive-plus-negative oscillators also appear to be more robust and easier to evolve, rationalizing why they are found in contexts where an adjustable frequency is unimportant...
  7. ncbi Uncovering mechanisms of bistability in biological systems
    Joseph R Pomerening
    Department of Biology and The Biocomplexity Institute, Indiana University, 212 South Hawthorne Drive, Simon Hall SI MSB, Room 043F, Bloomington, IN 47405 7003, United States
    Curr Opin Biotechnol 19:381-8. 2008
    ..These will include the role of positive feedback loops, the potential function of dual phosphorylation cycles, and substrate competition as a means of generating ultrasensitivity...