S Pfeffer

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. doi request reprint WHAMMing into the Golgi
    Garret L Hayes
    Department of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305 5307, USA
    Dev Cell 15:171-2. 2008
  2. doi request reprint A prize for membrane magic
    Suzanne R Pfeffer
    Department of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305 5307, USA Electronic address
    Cell 155:1203-6. 2013
  3. pmc Rab GTPase regulation of membrane identity
    Suzanne R Pfeffer
    Department of Biochemistry, Stanford University School of Medicine, 279 Campus Drive B400, Stanford, CA 94305 5307, USA
    Curr Opin Cell Biol 25:414-9. 2013
  4. pmc Hopping rim to rim through the Golgi
    Suzanne R Pfeffer
    an eLife reviewing editor, is at Stanford University, Stanford, United States
    elife 2:e00903. 2013
  5. doi request reprint A nexus for receptor recycling
    Suzanne R Pfeffer
    Department of Biochemistry, Stanford University School of Medicine, Stanford, California 94305 5307, USA
    Nat Cell Biol 15:446-8. 2013
  6. doi request reprint Rab GTPase localization and Rab cascades in Golgi transport
    Suzanne R Pfeffer
    Department of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305 5307, USA
    Biochem Soc Trans 40:1373-7. 2012
  7. pmc Cargo carriers from the Golgi to the cell surface
    Suzanne R Pfeffer
    Department of Biochemistry, Stanford University School of Medicine, Stanford, CA, USA
    EMBO J 31:3954-5. 2012
  8. pmc Unconventional secretion by autophagosome exocytosis
    Suzanne R Pfeffer
    Department of Biochemistry, School of Medicine, Stanford University, Stanford, CA 94305, USA
    J Cell Biol 188:451-2. 2010
  9. ncbi request reprint Two Rabs for exosome release
    Suzanne R Pfeffer
    Suzanne Pfeffer is at the Department of Biochemistry, Stanford University School of Medicine, 279 Campus Drive B400, Stanford, CA 94305 5307, USA
    Nat Cell Biol 12:3-4. 2010
  10. ncbi request reprint Unsolved mysteries in membrane traffic
    Suzanne R Pfeffer
    Department of Biochemistry, Stanford University School of Medicine, Stanford, California 94305 5307, USA
    Annu Rev Biochem 76:629-45. 2007

Research Grants

  1. INTRACELLULAR TRANSPORT--THE MANNOSE-PHOSPHATE RECEPTOR
    Suzanne Pfeffer; Fiscal Year: 2007
  2. Molecular Analysis of the CCC185 Golgin
    Suzanne Pfeffer; Fiscal Year: 2007
  3. Molecular Analysis of the CCC185 Golgin
    Suzanne Pfeffer; Fiscal Year: 2009
  4. Intracellular Transport: The Mannose Phosphate Receptor
    Suzanne Pfeffer; Fiscal Year: 2009
  5. Molecular Analysis of the CCC185 Golgin
    Suzanne R Pfeffer; Fiscal Year: 2010
  6. Intracellular Transport: The Mannose Phosphate Receptor
    Suzanne R Pfeffer; Fiscal Year: 2010
  7. LOCALIZATION OF THE GOLGI COMPLEX
    Suzanne Pfeffer; Fiscal Year: 2001
  8. LOCALIZATION OF THE GOLGI COMPLEX
    Suzanne Pfeffer; Fiscal Year: 1993
  9. Intracellular Transport: The Mannose Phosphate Receptor
    Suzanne R Pfeffer; Fiscal Year: 2010

Collaborators

  • AXEL BRUNGER
  • Jennifer J Kohler
  • Francis Barr
  • J S Glenn
  • Ian G Ganley
  • Alondra Schweizer Burguete
  • Garret L Hayes
  • Ryan M Nottingham
  • Jonathan V Reddy
  • Ulf Sivars
  • Eric J Espinosa
  • Peter L Lee
  • Khambhampaty Sridevi
  • Ella H Sklan
  • Paul M Sincock
  • John Hanna
  • Pierre Barbero
  • Alexander K Haas
  • Monica Calero
  • Frank C Brown
  • Eric Espinosa
  • Timothy D Fenn
  • Shirit Einav
  • Ramon L Serrano
  • David G Lambright
  • Pehr B Harbury
  • F Schimmöller
  • Li Ding
  • Sven Diederichs
  • Jeffrey P Krise
  • Brian O'Connor
  • Dikran Aivazian
  • Lenka Bittova
  • Kate Carroll
  • C Itin

Detail Information

Publications33

  1. doi request reprint WHAMMing into the Golgi
    Garret L Hayes
    Department of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305 5307, USA
    Dev Cell 15:171-2. 2008
    ..WHAMM's membrane localization at the entry face of the Golgi complex is novel for an actin nucleation-promoting factor, and highlights the importance of the cytoskeleton in organizing the secretory pathway...
  2. doi request reprint A prize for membrane magic
    Suzanne R Pfeffer
    Department of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305 5307, USA Electronic address
    Cell 155:1203-6. 2013
    ..I present a personal view of the membrane trafficking field, highlighting the contributions of these three Nobel laureates in a historical context...
  3. pmc Rab GTPase regulation of membrane identity
    Suzanne R Pfeffer
    Department of Biochemistry, Stanford University School of Medicine, 279 Campus Drive B400, Stanford, CA 94305 5307, USA
    Curr Opin Cell Biol 25:414-9. 2013
    ..Thus, in addition to determining compartment identity and functionality, Rab GTPases are likely able to order the events of membrane trafficking. This review will highlight recent advances in our understanding of Rabs and Rab cascades. ..
  4. pmc Hopping rim to rim through the Golgi
    Suzanne R Pfeffer
    an eLife reviewing editor, is at Stanford University, Stanford, United States
    elife 2:e00903. 2013
    ..A novel approach based on tracking the fate of proteins that become 'stapled' to the walls of the Golgi yields insights into the long-sought mechanism of transport through this organelle. ..
  5. doi request reprint A nexus for receptor recycling
    Suzanne R Pfeffer
    Department of Biochemistry, Stanford University School of Medicine, Stanford, California 94305 5307, USA
    Nat Cell Biol 15:446-8. 2013
    ..A global proteomics analysis reveals a collection of cell surface proteins that rely on SNX27 and the retromer complex for their cell surface localization at steady state...
  6. doi request reprint Rab GTPase localization and Rab cascades in Golgi transport
    Suzanne R Pfeffer
    Department of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305 5307, USA
    Biochem Soc Trans 40:1373-7. 2012
    ..Finally, I describe how Rab cascades may establish the distinct compartments of the Golgi complex to permit ordered processing, sorting and secretion of secretory cargoes...
  7. pmc Cargo carriers from the Golgi to the cell surface
    Suzanne R Pfeffer
    Department of Biochemistry, Stanford University School of Medicine, Stanford, CA, USA
    EMBO J 31:3954-5. 2012
    ..CARTS appear to be basolateral membrane-directed carriers that use myosin for their motility but not for their formation...
  8. pmc Unconventional secretion by autophagosome exocytosis
    Suzanne R Pfeffer
    Department of Biochemistry, School of Medicine, Stanford University, Stanford, CA 94305, USA
    J Cell Biol 188:451-2. 2010
    ..Medium-chain acyl CoAs are also required and may be important for substrate routing to this pathway...
  9. ncbi request reprint Two Rabs for exosome release
    Suzanne R Pfeffer
    Suzanne Pfeffer is at the Department of Biochemistry, Stanford University School of Medicine, 279 Campus Drive B400, Stanford, CA 94305 5307, USA
    Nat Cell Biol 12:3-4. 2010
    ..Rab27A and Rab27B GTPases and two of their cognate effector proteins seem to be needed to drive the physiologically important exosome-release process in certain cell types...
  10. ncbi request reprint Unsolved mysteries in membrane traffic
    Suzanne R Pfeffer
    Department of Biochemistry, Stanford University School of Medicine, Stanford, California 94305 5307, USA
    Annu Rev Biochem 76:629-45. 2007
    ..But much remains to be learned. This review highlights underlying themes in membrane traffic to help us refocus and solve many remaining and newly emerging issues that are fundamental to mammalian cell biology and human physiology...
  11. ncbi request reprint A model for Rab GTPase localization
    S Pfeffer
    Department of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305 5307, USA
    Biochem Soc Trans 33:627-30. 2005
    ..Our data suggest that these complex interactions are important for the cellular localization of Rab proteins at steady state...
  12. pmc How the Golgi works: a cisternal progenitor model
    Suzanne R Pfeffer
    Department of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305 5307, USA
    Proc Natl Acad Sci U S A 107:19614-8. 2010
    ....
  13. ncbi request reprint Structural clues to Rab GTPase functional diversity
    Suzanne R Pfeffer
    Department of Biochemistry, Stanford University School of Medicine, Stanford, California 94305 5307, USA
    J Biol Chem 280:15485-8. 2005
    ..This review will highlight what we have learned from crystallographic analysis of this important protein family...
  14. ncbi request reprint Targeting Rab GTPases to distinct membrane compartments
    Suzanne Pfeffer
    Department of Biochemistry, Stanford University School of Medicine, Stanford, California 94305 5307, USA
    Nat Rev Mol Cell Biol 5:886-96. 2004
    ..The further discovery of an integral membrane protein that can dissociate prenylated Rab proteins from GDP-dissociation inhibitor gives new insights into the mechanisms of Rab localization...
  15. ncbi request reprint Membrane domains in the secretory and endocytic pathways
    Suzanne Pfeffer
    Department of Biochemistry, Stanford University, Stanford, CA 94305, USA
    Cell 112:507-17. 2003
    ..Thus, functionally distinct specializations of a given organelle are physically segregated to a greater extent than previously believed...
  16. pmc Multiple routes of protein transport from endosomes to the trans Golgi network
    Suzanne R Pfeffer
    Department of Biochemistry, 279 Campus Drive B400, Stanford University School of Medicine, Stanford, CA 94305 5307, USA
    FEBS Lett 583:3811-6. 2009
    ..The identification of distinct molecular requirements for each of these pathways makes it clear that mammalian cells have evolved more complex targeting mechanisms and routes than previously anticipated...
  17. pmc Cholesterol accumulation sequesters Rab9 and disrupts late endosome function in NPC1-deficient cells
    Ian G Ganley
    Department of Biochemistry, Stanford University School of Medicine, 279 Campus Drive, Stanford, CA 94305 5307, USA
    J Biol Chem 281:17890-9. 2006
    ..We conclude that cholesterol contributes directly to the sequestration of Rab9 on Niemann-Pick type C cell membranes, which in turn, disrupts mannose 6-phosphate receptor trafficking...
  18. ncbi request reprint Vesicle traffic: get your coat!
    F Schimmöller
    Department of Biochemistry, Stanford University School of Medicine, Stanford, California 94305 5307, USA
    Curr Biol 7:R235-7. 1997
    ....
  19. ncbi request reprint Vesicle tethering factors united
    S Pfeffer
    Department of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305, USA
    Mol Cell 8:729-30. 2001
    ....
  20. pmc A syntaxin 10-SNARE complex distinguishes two distinct transport routes from endosomes to the trans-Golgi in human cells
    Ian G Ganley
    Department of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Cell Biol 180:159-72. 2008
    ..Importantly, our data provide a clear molecular distinction between the transport of MPRs and TGN46 to the trans-Golgi...
  21. pmc Visualization of Rab9-mediated vesicle transport from endosomes to the trans-Golgi in living cells
    Pierre Barbero
    Department of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Cell Biol 156:511-8. 2002
    ..Our data suggest that Rab9 remains vesicle associated until docking with the Golgi complex and is rapidly removed concomitant with or just after membrane fusion...
  22. pmc Rab and Arl GTPase family members cooperate in the localization of the golgin GCC185
    Alondra Schweizer Burguete
    Department of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305, USA
    Cell 132:286-98. 2008
    ....
  23. pmc Multiple Rab GTPase binding sites in GCC185 suggest a model for vesicle tethering at the trans-Golgi
    Garret L Hayes
    Department of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305, USA
    Mol Biol Cell 20:209-17. 2009
    ..Golgi-Rab binding sites may permit GCC185 to contribute to stacking and lateral interactions of Golgi cisternae as well as help it function as a vesicle tether...
  24. pmc A functional role for the GCC185 golgin in mannose 6-phosphate receptor recycling
    Jonathan V Reddy
    Department of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305 5307, USA
    Mol Biol Cell 17:4353-63. 2006
    ..These data assign a specific pathway to an interesting, TGN-localized protein and suggest that GCC185 may participate in the docking of late endosome-derived, Rab9-bearing transport vesicles at the TGN...
  25. pmc Identification of residues in TIP47 essential for Rab9 binding
    John Hanna
    Department of Biochemistry, Stanford University School of Medicine, 279 Campus Drive, Stanford, CA 94305 5307, USA
    Proc Natl Acad Sci U S A 99:7450-4. 2002
    ..These experiments reveal distinct binding domains for the Rab9 GTPase and MPR cytoplasmic domains in the cargo selection protein TIP47...
  26. ncbi request reprint Yip3 catalyses the dissociation of endosomal Rab-GDI complexes
    Ulf Sivars
    Department of Biochemistry, Stanford University School of Medicine, Stanford, California 94305 5307, USA
    Nature 425:856-9. 2003
    ..We propose that the conserved Yip proteins serve as GDI-displacement factors for the targeting of Rab GTPases in eukaryotic cells...
  27. pmc Clues to neuro-degeneration in Niemann-Pick type C disease from global gene expression profiling
    Jonathan V Reddy
    Department of Biochemistry, Stanford University School of Medicine, California, United States of America
    PLoS ONE 1:e19. 2006
    ..The majority of NPC cases are due to mutations in the NPC1 gene. The precise function of this gene is not yet known...
  28. ncbi request reprint TBC1D20 is a Rab1 GTPase-activating protein that mediates hepatitis C virus replication
    Ella H Sklan
    Department of Medicine, Division of Gastroenterology and Hepatology, Stanford University School of Medicine, Palo Alto, CA 94305 5187, USA
    J Biol Chem 282:36354-61. 2007
    ..These results highlight a novel mechanism by which viruses can hijack host cell machinery and suggest an attractive model whereby the NS5A-TBC1D20 interaction may promote viral membrane-associated RNA replication...
  29. doi request reprint Team effort by TRAPP forces a nucleotide fumble
    Ryan M Nottingham
    Department of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305 5307, USA
    Cell 133:1141-3. 2008
    ..Cai et al. (2008) now present structural and biochemical analyses of yeast TRAPPI in a complex with Ypt1p revealing a unique mechanism by which TRAPPI catalyzes guanine nucleotide exchange...
  30. ncbi request reprint Self-assembly is important for TIP47 function in mannose 6-phosphate receptor transport
    Paul M Sincock
    Department of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305 5307, USA
    Traffic 4:18-25. 2003
    ..However, oligomerization is required for TIP47 stimulation of mannose 6-phosphate receptor transport from endosomes to the trans-Golgi in vivo...
  31. pmc RhoBTB3: a Rho GTPase-family ATPase required for endosome to Golgi transport
    Eric J Espinosa
    Department of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305 5307, USA
    Cell 137:938-48. 2009
    ..Because RhoBTB3 interacts with TIP47 on membranes, we propose that it may function to release this cargo selection protein from vesicles to permit their efficient docking and fusion at the Golgi...
  32. pmc Association of beta-1,3-N-acetylglucosaminyltransferase 1 and beta-1,4-galactosyltransferase 1, trans-Golgi enzymes involved in coupled poly-N-acetyllactosamine synthesis
    Peter L Lee
    Department of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305, USA
    Glycobiology 19:655-64. 2009
    ..These results demonstrate that B3GNT1 and B4GALT1 physically associate in vitro and in cultured cells, providing insight into possible mechanisms for regulation of polyLacNAc production...
  33. ncbi request reprint In vitro selection and prediction of TIP47 protein-interaction interfaces
    Alondra Schweizer Burguete
    Department of Biochemistry, Stanford University School of Medicine, Stanford, California 94305 5307, USA
    Nat Methods 1:55-60. 2004
    ..These methods were validated in comparison with the protein's crystal structure, and provide a powerful means to predict protein-protein interaction interfaces...

Research Grants20

  1. INTRACELLULAR TRANSPORT--THE MANNOSE-PHOSPHATE RECEPTOR
    Suzanne Pfeffer; Fiscal Year: 2007
    ..These studies have important implications for our understanding of growth control and antigen processing, and will provide fundamental information regarding the mechanism of receptor trafficking in mammalian cells. ..
  2. Molecular Analysis of the CCC185 Golgin
    Suzanne Pfeffer; Fiscal Year: 2007
    ..This work has broad implications for our understanding of vesicle docking and fusion events within the secretory and endocytic pathways that are essential for normal human health and disease. ..
  3. Molecular Analysis of the CCC185 Golgin
    Suzanne Pfeffer; Fiscal Year: 2009
    ..This work has broad implications for our understanding of vesicle docking and fusion events within the secretory and endocytic pathways that are essential for normal human health and disease. ..
  4. Intracellular Transport: The Mannose Phosphate Receptor
    Suzanne Pfeffer; Fiscal Year: 2009
    ..By understanding the molecular events responsible for membrane traffic, we will be better able to intervene in a variety of disease states. ..
  5. Molecular Analysis of the CCC185 Golgin
    Suzanne R Pfeffer; Fiscal Year: 2010
    ..This work has broad implications for our understanding of vesicle docking and fusion events within the secretory and endocytic pathways that are essential for normal human health and disease. ..
  6. Intracellular Transport: The Mannose Phosphate Receptor
    Suzanne R Pfeffer; Fiscal Year: 2010
    ..By understanding the molecular events responsible for membrane traffic, we will be better able to intervene in a variety of disease states. ..
  7. LOCALIZATION OF THE GOLGI COMPLEX
    Suzanne Pfeffer; Fiscal Year: 2001
    ....
  8. LOCALIZATION OF THE GOLGI COMPLEX
    Suzanne Pfeffer; Fiscal Year: 1993
    ..This factor has the potential to represent a new class of proteins that can link a molecular motor to a specific membrane-bound organelle...
  9. Intracellular Transport: The Mannose Phosphate Receptor
    Suzanne R Pfeffer; Fiscal Year: 2010
    ..By understanding the molecular events responsible for membrane traffic, we will be better able to intervene in a variety of disease states. ..