Renee A Reijo Pera

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. pmc Enhanced generation of induced pluripotent stem cells from a subpopulation of human fibroblasts
    James A Byrne
    Center for Human Embryonic Stem Cell Research and Education, Institute for Stem Cell Biology and Regenerative Medicine, Department of Obstetrics and Gynecology, Stanford University, Palo Alto, California, United States of America
    PLoS ONE 4:e7118. 2009
  2. pmc Transplantation directs oocyte maturation from embryonic stem cells and provides a therapeutic strategy for female infertility
    Cory R Nicholas
    Department of Obstetrics and Gynecology, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Palo Alto, CA 94304, USA
    Hum Mol Genet 18:4376-89. 2009
  3. pmc Dazl functions in maintenance of pluripotency and genetic and epigenetic programs of differentiation in mouse primordial germ cells in vivo and in vitro
    Kelly M Haston
    Department of Obstetrics and Gynecology, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Palo Alto, California, United States of America
    PLoS ONE 4:e5654. 2009
  4. pmc NANOS3 function in human germ cell development
    Vanessa T Angeles Julaton
    Institute for Stem Cell Biology and Regenerative Medicine, Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford University, Palo Alto, CA 94305, USA
    Hum Mol Genet 20:2238-50. 2011
  5. pmc Human germ cell differentiation from fetal- and adult-derived induced pluripotent stem cells
    Sarita Panula
    Department of Obstetrics and Gynecology, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford University, Palo Alto, CA 94305, USA
    Hum Mol Genet 20:752-62. 2011
  6. pmc Dynamic blastomere behaviour reflects human embryo ploidy by the four-cell stage
    SHAWN L CHAVEZ
    Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, California 94305, USA
    Nat Commun 3:1251. 2012
  7. pmc SNCA triplication Parkinson's patient's iPSC-derived DA neurons accumulate α-synuclein and are susceptible to oxidative stress
    Blake Byers
    Department of Bioengineering, Stanford University, Stanford, California, United States of America
    PLoS ONE 6:e26159. 2011
  8. pmc Pumilio-2 function in the mouse nervous system
    Henrike Siemen
    Institute for Stem Cell Biology and Regenerative Medicine, Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, California, United States of America
    PLoS ONE 6:e25932. 2011
  9. ncbi request reprint More than just a matter of time
    Renee A Reijo Pera
    Stanford University School of Medicine, Stanford, CA 94305 5463, USA
    Reprod Biomed Online 27:113-4. 2013
  10. doi request reprint Status of human germ cell differentiation from pluripotent stem cells
    Renee A Reijo Pera
    Institute for Stem Cell Biology and Regenerative Medicine, Department of Obstetrics and Gynecology, Stanford University, Stanford, CA 94305 5463, USA
    Reprod Fertil Dev 25:396-404. 2013

Research Grants

  1. THE DAZ GENES AND EARLY GERM CELL DEVELOPMENT
    Renee Reijo Pera; Fiscal Year: 1999
  2. MEIOSIS IN MEN AND RISKS ASSOCIATED WITH ICSI
    Renee Reijo Pera; Fiscal Year: 2005
  3. Genetic Analysis of Germ Cell Formation
    Renee Reijo Pera; Fiscal Year: 2005
  4. Federally Registered Human Embryonic Stem Cell Center
    Renee Reijo Pera; Fiscal Year: 2005
  5. MEIOSIS IN MEN AND RISKS ASSOCIATED WITH ICSI
    Renee Reijo Pera; Fiscal Year: 2004
  6. Genetic Analysis of Germ Cell Formation
    Renee Reijo Pera; Fiscal Year: 2006
  7. MEIOSIS IN MEN AND RISKS ASSOCIATED WITH ICSI
    Renee Reijo Pera; Fiscal Year: 2005
  8. Genetic Analysis of Germ Cell Formation
    Renee Reijo Pera; Fiscal Year: 2007
  9. THE DAZ GENES AND EARLY GERM CELL DEVELOPMENT
    Renee Reijo Pera; Fiscal Year: 2003
  10. MEIOSIS IN MEN AND RISKS ASSOCIATED WITH ICSI
    Renee Reijo Pera; Fiscal Year: 2004

Collaborators

Detail Information

Publications28

  1. pmc Enhanced generation of induced pluripotent stem cells from a subpopulation of human fibroblasts
    James A Byrne
    Center for Human Embryonic Stem Cell Research and Education, Institute for Stem Cell Biology and Regenerative Medicine, Department of Obstetrics and Gynecology, Stanford University, Palo Alto, California, United States of America
    PLoS ONE 4:e7118. 2009
    ..Limitations, however, include our current lack of understanding regarding the underlying mechanisms and the inefficiency of reprogramming...
  2. pmc Transplantation directs oocyte maturation from embryonic stem cells and provides a therapeutic strategy for female infertility
    Cory R Nicholas
    Department of Obstetrics and Gynecology, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Palo Alto, CA 94304, USA
    Hum Mol Genet 18:4376-89. 2009
    ....
  3. pmc Dazl functions in maintenance of pluripotency and genetic and epigenetic programs of differentiation in mouse primordial germ cells in vivo and in vitro
    Kelly M Haston
    Department of Obstetrics and Gynecology, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Palo Alto, California, United States of America
    PLoS ONE 4:e5654. 2009
    ..Little is known of the genes that regulate quantitative and qualitative aspects of early mammalian germ cell development both in vivo, and during differentiation of germ cells from mouse embryonic stem cells (mESCs) in vitro...
  4. pmc NANOS3 function in human germ cell development
    Vanessa T Angeles Julaton
    Institute for Stem Cell Biology and Regenerative Medicine, Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford University, Palo Alto, CA 94305, USA
    Hum Mol Genet 20:2238-50. 2011
    ..Findings may contribute to our understanding of the basic biology of human germ cell development and may provide clinical insights regarding infertility...
  5. pmc Human germ cell differentiation from fetal- and adult-derived induced pluripotent stem cells
    Sarita Panula
    Department of Obstetrics and Gynecology, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford University, Palo Alto, CA 94305, USA
    Hum Mol Genet 20:752-62. 2011
    ..This system may provide a useful model for molecular genetic studies of human germline formation and pathology and a novel platform for clinical studies and potential therapeutical applications...
  6. pmc Dynamic blastomere behaviour reflects human embryo ploidy by the four-cell stage
    SHAWN L CHAVEZ
    Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, California 94305, USA
    Nat Commun 3:1251. 2012
    ....
  7. pmc SNCA triplication Parkinson's patient's iPSC-derived DA neurons accumulate α-synuclein and are susceptible to oxidative stress
    Blake Byers
    Department of Bioengineering, Stanford University, Stanford, California, United States of America
    PLoS ONE 6:e26159. 2011
    ....
  8. pmc Pumilio-2 function in the mouse nervous system
    Henrike Siemen
    Institute for Stem Cell Biology and Regenerative Medicine, Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, California, United States of America
    PLoS ONE 6:e25932. 2011
    ..These findings demonstrate that Pum2 serves key functions in the adult mammalian central nervous system encompassing neuronal excitability and behavioral response to environmental challenges...
  9. ncbi request reprint More than just a matter of time
    Renee A Reijo Pera
    Stanford University School of Medicine, Stanford, CA 94305 5463, USA
    Reprod Biomed Online 27:113-4. 2013
    ..A response to the editorial "On patenting time and other natural phenomenon" by Jacques Cohen. ..
  10. doi request reprint Status of human germ cell differentiation from pluripotent stem cells
    Renee A Reijo Pera
    Institute for Stem Cell Biology and Regenerative Medicine, Department of Obstetrics and Gynecology, Stanford University, Stanford, CA 94305 5463, USA
    Reprod Fertil Dev 25:396-404. 2013
    ..In the present paper, the current status of germ cell development from stem cells is reviewed in light of potential utility for basic science and clinical applications...
  11. pmc Modeling Parkinson's disease using induced pluripotent stem cells
    Blake Byers
    Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Palo Alto, CA, USA
    Curr Neurol Neurosci Rep 12:237-42. 2012
    ....
  12. ncbi request reprint Gene expression profiles of human inner cell mass cells and embryonic stem cells
    Renee A Reijo Pera
    Institute for Stem Cell Biology and Regenerative Medicine, Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, CA 94304 5542, USA
    Differentiation 78:18-23. 2009
    ....
  13. ncbi request reprint Non-invasive imaging of human embryos to predict developmental competence
    R A Reijo Pera
    Institute for Stem Cell Biology and Regenerative Medicine, Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, CA 94305 5463, USA
    Placenta 32:S264-7. 2011
    ....
  14. pmc Parthenogenic blastocysts derived from cumulus-free in vitro matured human oocytes
    Sohyun L McElroy
    Center for Human Embryonic Stem Cell Research and Education, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Palo Alto, California, United States of America
    PLoS ONE 5:e10979. 2010
    ..We aimed to improve maturation conditions for cumulus-free oocytes via culture with ovarian paracrine/autocrine factors identified by single cell analysis...
  15. pmc Novel missense mutations of the Deleted-in-AZoospermia-Like (DAZL) gene in infertile women and men
    Joyce Y Tung
    Human Embryonic Stem Cell Center, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California at San Francisco, San Francisco, CA 94143, USA
    Reprod Biol Endocrinol 4:40. 2006
    ..Recently, we showed that there are several common polymorphisms within the DAZL gene that are associated with age at ovarian failure/menopause and sperm count...
  16. ncbi request reprint A gene trap mutation of a murine homolog of the Drosophila stem cell factor Pumilio results in smaller testes but does not affect litter size or fertility
    Eugene Yujun Xu
    Division of Reproductive Biology Research, Department of Obstetrics and Gynecology, and Center for Genetic Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Mol Reprod Dev 74:912-21. 2007
    ..elegans where single members of the Pumilio gene family are dispensable for reproductive development and viability, this individual member of the Pumilio gene family in mice is also not essential for reproduction or viability...
  17. doi request reprint The road to pluripotence: the research response to the embryonic stem cell debate
    Christopher Thomas Scott
    Center for Biomedical Ethics, Program on Stem Cells in Society, Department of Obstetrics and Gynecology, Stanford University School of Medicine, CA 94304, USA
    Hum Mol Genet 17:R3-9. 2008
    ..Human embryonic stem cell research is barely a decade old. The recent pace of discovery--in spite of federal restrictions--is testament to the potential of these cells to uncover some of biology's most intractable mysteries...
  18. pmc Isolation and characterization of pluripotent human spermatogonial stem cell-derived cells
    Nina Kossack
    Institute for Stem Cell Biology and Regenerative Medicine, Department of Obstetrics and Gynecology, Stanford University School of Medicine, Palo Alto, California 94304 5542, USA
    Stem Cells 27:138-49. 2009
    ..Thus, these data suggest the potential to derive pluripotent cells from human testis biopsies but indicate a need for novel strategies to optimize hMGSC culture conditions and reprogramming...
  19. pmc Instructing an embryonic stem cell-derived oocyte fate: lessons from endogenous oogenesis
    Cory R Nicholas
    Department of Obstetrics and Gynecology, Stanford University School of Medicine, Palo Alto, California 94304, USA
    Endocr Rev 30:264-83. 2009
    ..Thus, ESC-derived oocytes could ultimately help to restore fertility in women. Here, we review endogenous and ESC-derived oocyte development, and we discuss the potential and challenges for differentiating functional oocytes from ESCs...
  20. pmc Characterization of a Dazl-GFP germ cell-specific reporter
    Cory R Nicholas
    Department of Obstetrics and Gynecology, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Palo Alto, CA, USA
    Genesis 47:74-84. 2009
    ....
  21. pmc Intact fetal ovarian cord formation promotes mouse oocyte survival and development
    Cory R Nicholas
    Institute for Stem Cell Biology and Regenerative Medicine, Department of Obstetrics and Gynecology, Stanford University, Palo Alto, CA, USA
    BMC Dev Biol 10:2. 2010
    ..Although germline cysts and testicular cords are required for spermatogenesis, the role of cyst and ovarian cord formation in mammalian oocyte development and female fertility has not been determined...
  22. doi request reprint Testicular germline stem cells
    Kehkooi Kee
    Center for Human Embryonic Stem Cell Research and Education, Institute for Stem Cell Biology and Regenerative Medicine, Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford University, Palo Alto, CA 94305, USA
    Nat Rev Urol 7:94-100. 2010
    ..To date, stem cells with embryonic-like potential have been created from adult testis germ cells. These cells could provide patient-specific, non-embryo-derived stem cells for men in the future...
  23. pmc Promotion of human early embryonic development and blastocyst outgrowth in vitro using autocrine/paracrine growth factors
    Kazuhiro Kawamura
    Program of Reproductive and Stem Cell Biology, Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, California, United States of America
    PLoS ONE 7:e49328. 2012
    ..This approach is valuable for infertility treatment and future derivation of patient-specific embryonic stem cells...
  24. pmc Human DAZL, DAZ and BOULE genes modulate primordial germ-cell and haploid gamete formation
    Kehkooi Kee
    Center for Human Embryonic Stem Cell Research and Education, Institute for Stem Cell Biology and Regenerative Medicine, Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford University, Palo Alto, California 94305, USA
    Nature 462:222-5. 2009
    ..These results are significant to the generation of gametes for future basic science and potential clinical applications...
  25. pmc Estrogen receptor beta-selective agonists stimulate calcium oscillations in human and mouse embryonic stem cell-derived neurons
    Lili Zhang
    Department of Obstetrics, Gynecology and Reproductive Sciences and Center for Reproductive Sciences, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 5:e11791. 2010
    ..Our results demonstrate that ERbeta signaling regulates nongenomic pathways in neurons derived from ES cells, and suggest that these cells might be useful to study the nongenomic mechanisms of estrogenic compounds...
  26. pmc Human primordial germ cell formation is diminished by exposure to environmental toxicants acting through the AHR signaling pathway
    Kehkooi Kee
    Department of Obstetrics and Gynecology, Center for Human Embryonic Stem Cell Research and Education, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford University, Palo Alto, California, USA
    Toxicol Sci 117:218-24. 2010
    ..This study demonstrates the utility of hESCs as a model system for direct examination of the molecular and genetic pathways of environmental toxicants on human germ cell development...
  27. pmc A novel and critical role for Oct4 as a regulator of the maternal-embryonic transition
    Kira Foygel
    Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, California, USA
    PLoS ONE 3:e4109. 2008
    ..We hypothesized that Oct4, an ESC pluripotency regulator that is also highly expressed at the 1- to 2-cell stages in embryos, may be a critical regulator of the earliest gene network in the embryo...
  28. ncbi request reprint Developmental competence of immature and failed/abnormally fertilized human oocytes in nuclear transfer
    Sohyun Lee McElroy
    Institute for Stem Cell Biology and Regenerative Medicine, Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, Palo Alto, CA 94304 5542, USA
    Reprod Biomed Online 16:684-93. 2008
    ..In light of these results, it is suggested that the discarded oocytes can be used to investigate new human nuclear transfer protocols for embryonic stem cell derivation...

Research Grants20

  1. THE DAZ GENES AND EARLY GERM CELL DEVELOPMENT
    Renee Reijo Pera; Fiscal Year: 1999
    ..abstract_text> ..
  2. MEIOSIS IN MEN AND RISKS ASSOCIATED WITH ICSI
    Renee Reijo Pera; Fiscal Year: 2005
    ..They propose to extend their findings and use their new technology in the genetics of human reproduction by using single sperm PCR to examine the germ cells of infertile men for DAZ deletions and defects in DNA repair and recombination. ..
  3. Genetic Analysis of Germ Cell Formation
    Renee Reijo Pera; Fiscal Year: 2005
    ..As such, this research is significant to our understanding of basic germ cell development in humans and has the direct potential to increase knowledge of germ cell defects in the 10-15% of couples who are infertile. ..
  4. Federally Registered Human Embryonic Stem Cell Center
    Renee Reijo Pera; Fiscal Year: 2005
    ..Thus, the extension of this program will support the utility of hES cells for both the research and clinical communities. ..
  5. MEIOSIS IN MEN AND RISKS ASSOCIATED WITH ICSI
    Renee Reijo Pera; Fiscal Year: 2004
    ..They propose to extend their findings and use their new technology in the genetics of human reproduction by using single sperm PCR to examine the germ cells of infertile men for DAZ deletions and defects in DNA repair and recombination. ..
  6. Genetic Analysis of Germ Cell Formation
    Renee Reijo Pera; Fiscal Year: 2006
    ..As such, this research is significant to our understanding of basic germ cell development in humans and has the direct potential to increase knowledge of germ cell defects in the 10-15% of couples who are infertile. ..
  7. MEIOSIS IN MEN AND RISKS ASSOCIATED WITH ICSI
    Renee Reijo Pera; Fiscal Year: 2005
    ..They propose to extend their findings and use their new technology in the genetics of human reproduction by using single sperm PCR to examine the germ cells of infertile men for DAZ deletions and defects in DNA repair and recombination. ..
  8. Genetic Analysis of Germ Cell Formation
    Renee Reijo Pera; Fiscal Year: 2007
    ..As such, this research is significant to our understanding of basic germ cell development in humans and has the direct potential to increase knowledge of germ cell defects in the 10-15% of couples who are infertile. ..
  9. THE DAZ GENES AND EARLY GERM CELL DEVELOPMENT
    Renee Reijo Pera; Fiscal Year: 2003
    ..abstract_text> ..
  10. MEIOSIS IN MEN AND RISKS ASSOCIATED WITH ICSI
    Renee Reijo Pera; Fiscal Year: 2004
    ..They propose to extend their findings and use their new technology in the genetics of human reproduction by using single sperm PCR to examine the germ cells of infertile men for DAZ deletions and defects in DNA repair and recombination. ..
  11. THE DAZ GENES AND EARLY GERM CELL DEVELOPMENT
    Renee Reijo Pera; Fiscal Year: 2000
    ..abstract_text> ..
  12. MEIOSIS IN MEN AND RISKS ASSOCIATED WITH ICSI
    Renee Reijo Pera; Fiscal Year: 2001
    ..They propose to extend their findings and use their new technology in the genetics of human reproduction by using single sperm PCR to examine the germ cells of infertile men for DAZ deletions and defects in DNA repair and recombination. ..
  13. THE DAZ GENES AND EARLY GERM CELL DEVELOPMENT
    Renee Reijo Pera; Fiscal Year: 2001
    ..abstract_text> ..
  14. THE DAZ GENES AND EARLY GERM CELL DEVELOPMENT
    Renee Reijo Pera; Fiscal Year: 2002
    ..abstract_text> ..
  15. MEIOSIS IN MEN AND RISKS ASSOCIATED WITH ICSI
    Renee Reijo Pera; Fiscal Year: 2002
    ..They propose to extend their findings and use their new technology in the genetics of human reproduction by using single sperm PCR to examine the germ cells of infertile men for DAZ deletions and defects in DNA repair and recombination. ..
  16. THE DAZ GENES AND EARLY GERM CELL DEVELOPMENT
    Renee Reijo Pera; Fiscal Year: 2003
    ..abstract_text> ..
  17. MEIOSIS IN MEN AND RISKS ASSOCIATED WITH ICSI
    Renee Reijo Pera; Fiscal Year: 2003
    ..They propose to extend their findings and use their new technology in the genetics of human reproduction by using single sperm PCR to examine the germ cells of infertile men for DAZ deletions and defects in DNA repair and recombination. ..
  18. THE DAZ GENES AND EARLY GERM CELL DEVELOPMENT
    Renee Reijo Pera; Fiscal Year: 2003
    ..abstract_text> ..
  19. Genetic Analysis of Germ Cell Formation
    Renee Reijo Pera; Fiscal Year: 2009
    ..As such, this research is significant to our understanding of basic germ cell development in humans and has the direct potential to increase knowledge of germ cell defects in the 10-15% of couples who are infertile. ..