Donna Peehl

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. ncbi request reprint Primary cell cultures as models of prostate cancer development
    D M Peehl
    Department of Urology, Stanford University School of Medicine, Stanford, California, USA
    Endocr Relat Cancer 12:19-47. 2005
  2. ncbi request reprint Molecular activity of 1,25-dihydroxyvitamin D3 in primary cultures of human prostatic epithelial cells revealed by cDNA microarray analysis
    Donna M Peehl
    Department of Urology, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Steroid Biochem Mol Biol 92:131-41. 2004
  3. pmc Anti-oncogenic and pro-differentiation effects of clorgyline, a monoamine oxidase A inhibitor, on high grade prostate cancer cells
    Hongjuan Zhao
    Department of Urology, Stanford University School of Medicine, Stanford, California, USA
    BMC Med Genomics 2:55. 2009
  4. pmc The significance of monoamine oxidase-A expression in high grade prostate cancer
    Donna M Peehl
    Department of Urology, Stanford University School of Medicine, Stanford, California, USA
    J Urol 180:2206-11. 2008
  5. doi request reprint Serum Mac-2BP does not distinguish men with high grade, large volume prostate cancer from men with benign prostatic hyperplasia
    Donna M Peehl
    Department of Urology, Stanford University School of Medicine, Stanford, California 94041, USA
    Prostate 71:26-31. 2011
  6. ncbi request reprint The role of vitamin D and retinoids in controlling prostate cancer progression
    D M Peehl
    Department of Urology, Stanford University School of Medicine, Stanford, California, USA
    Endocr Relat Cancer 10:131-40. 2003
  7. ncbi request reprint Are primary cultures realistic models of prostate cancer?
    Donna M Peehl
    Department of Urology, Stanford University School of Medicine, Stanford, California 94305 5118, USA
    J Cell Biochem 91:185-95. 2004
  8. ncbi request reprint Interaction of nuclear receptor ligands with the Vitamin D signaling pathway in prostate cancer
    Donna M Peehl
    Department of Urology, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Steroid Biochem Mol Biol 92:307-15. 2004
  9. ncbi request reprint Rationale for combination ketoconazole/ vitamin D treatment of prostate cancer
    D M Peehl
    Department of Urology, Stanford University School of Medicine, Stanford, California, USA
    Urology 58:123-6. 2001
  10. ncbi request reprint Characterization of cultured human prostatic epithelial cells by cluster designation antigen expression
    A Y Liu
    Department of Urology, University of Washington, Seattle, WA 98195, USA
    Cell Tissue Res 305:389-97. 2001

Research Grants

  1. A Serum Marker for Aggressive Prostate Cancer
    Donna Peehl; Fiscal Year: 2007
  2. A Serum Marker for Aggressive Prostate Cancer
    Donna M Peehl; Fiscal Year: 2010

Collaborators

Detail Information

Publications72

  1. ncbi request reprint Primary cell cultures as models of prostate cancer development
    D M Peehl
    Department of Urology, Stanford University School of Medicine, Stanford, California, USA
    Endocr Relat Cancer 12:19-47. 2005
    ....
  2. ncbi request reprint Molecular activity of 1,25-dihydroxyvitamin D3 in primary cultures of human prostatic epithelial cells revealed by cDNA microarray analysis
    Donna M Peehl
    Department of Urology, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Steroid Biochem Mol Biol 92:131-41. 2004
    ..The functions of other regulated genes suggest protection by 1,25(OH)(2)D(3) from oxidative stress. Overall, these results provide new insights into the molecular basis of antitumor activities of Vitamin D in prostate cells...
  3. pmc Anti-oncogenic and pro-differentiation effects of clorgyline, a monoamine oxidase A inhibitor, on high grade prostate cancer cells
    Hongjuan Zhao
    Department of Urology, Stanford University School of Medicine, Stanford, California, USA
    BMC Med Genomics 2:55. 2009
    ..CONCLUSION: Our results suggest that inhibitors of MAO-A, already in clinical use to treat depression, may have potential application as therapeutic PCa drugs by inhibiting oncogenic pathway activity and promoting differentiation...
  4. pmc The significance of monoamine oxidase-A expression in high grade prostate cancer
    Donna M Peehl
    Department of Urology, Stanford University School of Medicine, Stanford, California, USA
    J Urol 180:2206-11. 2008
    ..We investigated whether monoamine oxidase-A expression correlates with another basal cell protein, CD44, in high grade cancer and whether either is associated with an aggressive phenotype...
  5. doi request reprint Serum Mac-2BP does not distinguish men with high grade, large volume prostate cancer from men with benign prostatic hyperplasia
    Donna M Peehl
    Department of Urology, Stanford University School of Medicine, Stanford, California 94041, USA
    Prostate 71:26-31. 2011
    ..We investigated whether serum Mac-2BP could distinguish men with high grade, large volume prostate cancer from men with benign prostatic hyperplasia (BPH)...
  6. ncbi request reprint The role of vitamin D and retinoids in controlling prostate cancer progression
    D M Peehl
    Department of Urology, Stanford University School of Medicine, Stanford, California, USA
    Endocr Relat Cancer 10:131-40. 2003
    ....
  7. ncbi request reprint Are primary cultures realistic models of prostate cancer?
    Donna M Peehl
    Department of Urology, Stanford University School of Medicine, Stanford, California 94305 5118, USA
    J Cell Biochem 91:185-95. 2004
    ..of primary cultures, with special emphasis on two questions: are primary cultures from adenocarcinomas really comprised of cancer rather than normal cells, and do primary cultures faithfully retain characteristics of cells of origin?..
  8. ncbi request reprint Interaction of nuclear receptor ligands with the Vitamin D signaling pathway in prostate cancer
    Donna M Peehl
    Department of Urology, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Steroid Biochem Mol Biol 92:307-15. 2004
    ..In order to design the most effective strategies to use calcitriol to prevent or treat prostate cancer, the interactions of other nuclear receptors and their ligands with the Vitamin D signaling pathway need to be considered...
  9. ncbi request reprint Rationale for combination ketoconazole/ vitamin D treatment of prostate cancer
    D M Peehl
    Department of Urology, Stanford University School of Medicine, Stanford, California, USA
    Urology 58:123-6. 2001
    ..The detrimental consequences of vitamin D deficiency in these patients would also be alleviated by the addition of calcitriol to the therapeutic regimen...
  10. ncbi request reprint Characterization of cultured human prostatic epithelial cells by cluster designation antigen expression
    A Y Liu
    Department of Urology, University of Washington, Seattle, WA 98195, USA
    Cell Tissue Res 305:389-97. 2001
    ..We conclude that cells in culture retain expression of certain lineage-characteristic CD antigens. Furthermore, CD antigens can define subpopulations of cells with differential gene expression...
  11. ncbi request reprint Altered growth regulation and loss of response to retinoic acid accompany tumorigenic transformation of prostatic cells
    D M Peehl
    Department of Urology, Stanford University School of Medicine, CA 94305, USA
    Anticancer Res 19:3857-64. 1999
    ..129Nu5002-1 Tu cells, which do not have an altered ras gene, gained the same phenotype. This suggests that loss of inhibition by retinoic acid may be a critical element in the tumorigenic conversion of prostatic epithelial cells...
  12. ncbi request reprint Cultured stromal cells: an in vitro model of prostatic mesenchymal biology
    D M Peehl
    Department of Urology, Stanford University School of Medicine, Stanford, California 94305 5118, USA
    Prostate 45:115-23. 2000
    ..Initial efforts to develop in vitro models to study prostatic biology focused on the culture and characterization of epithelial cells. Recently, attention has turned towards inclusion of stromal cells in experimental systems...
  13. ncbi request reprint Vitamin D and prostate cancer risk
    D M Peehl
    Department of Urology, Stanford University School of Medicine, Stanford, Calif 94305, USA
    Eur Urol 35:392-4. 1999
    ..Evidence from diverse areas of study - epidemiologic, molecular, genetic, cellular, animal models, and clinical trials - suggests that vitamin D may be an effective preventive agent against prostate cancer...
  14. ncbi request reprint Basic FGF, EGF, and PDGF modify TGFbeta-induction of smooth muscle cell phenotype in human prostatic stromal cells
    D M Peehl
    Department of Urology, Stanford University School of Medicine, California 94305 5118, USA
    Prostate 35:125-34. 1998
    ..We investigated the ability of a variety of growth factors to regulate the differentiation of prostatic fibroblasts into smooth muscle cells...
  15. ncbi request reprint Vitamin A regulates proliferation and differentiation of human prostatic epithelial cells
    D M Peehl
    Department of Urology, Stanford University School of Medicine, CA 94305 5118
    Prostate 23:69-78. 1993
    ..The findings of this study indicate a role for vitamin A as a modulator of the growth and differentiation of prostatic epithelial cells...
  16. ncbi request reprint Glucocorticoids can promote androgen-independent growth of prostate cancer cells through a mutated androgen receptor
    X Y Zhao
    Department of Medicine, Stanford University School of Medicine, Stanford, California 94305, USA
    Nat Med 6:703-6. 2000
    ..Understanding this mechanism and recognizing the presence of glucocorticoid-responsive AR mutants are important for the development of new forms of therapy for the treatment of this subset of CaP...
  17. ncbi request reprint Tumor-selective killing by selenite in patient-matched pairs of normal and malignant prostate cells
    B Husbeck
    Department of Radiation Oncology, Stanford University, Stanford, California 94305, USA
    Prostate 66:218-25. 2006
    ..Selenite metabolism consumes glutathione (GSH) and produces superoxide. The generation of reactive oxygen species is an important mechanism in selenite-induced apoptosis...
  18. ncbi request reprint Reduced 1alpha-hydroxylase activity in human prostate cancer cells correlates with decreased susceptibility to 25-hydroxyvitamin D3-induced growth inhibition
    J Y Hsu
    Department of Medicine, Stanford University School of Medicine, California 94305, USA
    Cancer Res 61:2852-6. 2001
    ..This finding has ramifications for both the prevention and therapy of prostate cancer with vitamin D compounds...
  19. ncbi request reprint SMAD3 represses androgen receptor-mediated transcription
    S A Hayes
    Department of Surgery, Stanford University School of Medicine, California 94303, USA
    Cancer Res 61:2112-8. 2001
    ..These results provide fresh insight for understanding the mechanism by which TGF-beta regulates the androgen-signaling pathway in prostate cancer cells...
  20. ncbi request reprint Two mutations identified in the androgen receptor of the new human prostate cancer cell line MDA PCa 2a
    X Y Zhao
    Department of Medicine, Stanford University School of Medicine, California, USA
    J Urol 162:2192-9. 1999
    ..We have characterized the androgen receptor (AR) in a new human prostate cancer cell line, MDA PCa 2a, that has recently been established from a bone metastasis of a patient whose cancer exhibited androgen-independent growth...
  21. ncbi request reprint Role of glutathione depletion and reactive oxygen species generation in apoptotic signaling in a human B lymphoma cell line
    J S Armstrong
    Department of Radiation Oncology, Stanford University, Stanford, California, CA 94305 5105, USA
    Cell Death Differ 9:252-63. 2002
    ..Increased ROS production following mitochondrial GSH depletion, represents a crucial event, which irreversibly commits PW cells to apoptosis...
  22. ncbi request reprint Genetic polymorphisms in the androgen receptor and type II 5 alpha-reductase genes in prostate enlargement
    A Shibata
    Department of Health Research and Policy, Stanford University School of Medicine, Stanford, California, USA
    J Urol 166:1560-4. 2001
    ....
  23. ncbi request reprint Comparative gene and protein expression in primary cultures of epithelial cells from benign prostatic hyperplasia and prostate cancer
    Amy Rose
    Department of Urology, Stanford University School of Medicine, Stanford, CA 94305 5118, USA
    Cancer Lett 227:213-22. 2005
    ....
  24. ncbi request reprint Genistein potentiates the growth inhibitory effects of 1,25-dihydroxyvitamin D3 in DU145 human prostate cancer cells: role of the direct inhibition of CYP24 enzyme activity
    Srilatha Swami
    Department of Medicine, Division of Endocrinology, Stanford University School of Medicine, 300 Pasteur Dr, Stanford, CA 94305, USA
    Mol Cell Endocrinol 241:49-61. 2005
    ..Together these two effects lead to a substantial enhancement of the cellular responses to the growth inhibitory and pro-apoptotic signaling by 1,25(OH)2D3...
  25. ncbi request reprint Regulation of prostaglandin metabolism by calcitriol attenuates growth stimulation in prostate cancer cells
    Jacqueline Moreno
    Department of Medicine, Stanford University School of Medicine, Stanford, California 94305 5103, USA
    Cancer Res 65:7917-25. 2005
    ....
  26. ncbi request reprint Expression of CCL5 (RANTES) and CCR5 in prostate cancer
    Gayle G Vaday
    Department of Research, Northport Veterans Affairs Medical Center, Northport, New York 11768, USA
    Prostate 66:124-34. 2006
    ..Recently, CCL5 and CCR5 mRNA expression was reported in prostate cancer (PCa) tissues. Herein, we characterized CCL5 and CCR5 expression in cultures of PCa cells and explored possible functions of CCL5 in PCa progression...
  27. ncbi request reprint Redox modulation of human prostate carcinoma cells by selenite increases radiation-induced cell killing
    Bryan Husbeck
    Department of Radiation Oncology, Stanford University, Stanford, CA 94305, USA
    Free Radic Biol Med 38:50-7. 2005
    ..These data suggest that altering the redox environment of prostate cancer cells with selenite increases the apoptotic potential and sensitizes them to radiation-induced cell killing...
  28. ncbi request reprint Identification of the major oxidative 3alpha-hydroxysteroid dehydrogenase in human prostate that converts 5alpha-androstane-3alpha,17beta-diol to 5alpha-dihydrotestosterone: a potential therapeutic target for androgen-dependent disease
    David R Bauman
    Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6084, USA
    Mol Endocrinol 20:444-58. 2006
    ..The data show that the major oxidative 3alpha-HSD in normal human prostate is RL-HSD and may be a new therapeutic target for treating prostate diseases...
  29. ncbi request reprint Inhibition of p38 by vitamin D reduces interleukin-6 production in normal prostate cells via mitogen-activated protein kinase phosphatase 5: implications for prostate cancer prevention by vitamin D
    Larisa Nonn
    Department of Urology, Stanford University School of Medicine, Stanford, California 94305 5118, USA
    Cancer Res 66:4516-24. 2006
    ....
  30. doi request reprint Association of prostate-specific antigen promoter genotype with clinical and histopathologic features of prostate cancer
    Scott D Cramer
    Department of Cancer Biology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Cancer Epidemiol Biomarkers Prev 17:2451-7. 2008
    ..15-36.49], presence of any Gleason grade 4/5 cancer (OR, 4.26; 95% CI, 1.30-14.00), presence of any intraductal cancer (OR, 1.03; 95% CI, 1.00-1.04), and serum PSA at diagnosis (OR, 2.04; 95% CI, 1.50-2.77)...
  31. pmc Centrosomal PKCbetaII and pericentrin are critical for human prostate cancer growth and angiogenesis
    Jeewon Kim
    Department of Chemical and Systems Biology, Stanford University, School of Medicine, Stanford, California 94305 5174, USA
    Cancer Res 68:6831-9. 2008
    ..Our results suggest that a PKCbetaII inhibitor such as betaIIV5-3 may be used to reduce prostate cancer growth by targeting both angiogenesis and tumor cell growth...
  32. pmc Inhibition of monoamine oxidase A promotes secretory differentiation in basal prostatic epithelial cells
    Hongjuan Zhao
    Department of Urology Stanford University School of Medicine 300 Pasteur Drive, Grant Building S227 MC 5118, Stanford, CA 94305, USA
    Differentiation 76:820-30. 2008
    ....
  33. ncbi request reprint Mechanisms of vitamin D-mediated growth inhibition in prostate cancer cells: inhibition of the prostaglandin pathway
    Jacqueline Moreno
    Department of Medicine, Stanford University School of Medicine, Stanford, California 94305, USA
    Anticancer Res 26:2525-30. 2006
    ..We also propose that calcitriol can be combined with non-steroidal anti-inflammatory drugs (NSAIDs) that inhibit COX enzyme activity, as a potential therapeutic strategy in PCa...
  34. ncbi request reprint Vitamin D inhibition of the prostaglandin pathway as therapy for prostate cancer
    David Feldman
    Department of Medicine Endocrinology, Stanford University School of Medicine, 300 Pasteur Drive, Room S 025, Stanford, CA 94305 5103, USA
    Nutr Rev 65:S113-5. 2007
  35. pmc Human prostate epithelium lacks Wee1A-mediated DNA damage-induced checkpoint enforcement
    Taija M Kiviharju-af Hällström
    Molecular Cancer Biology Program, Biomedicum Helsinki and Haartman Institute, University of Helsinki, P O Box 63, FIN 00014 Helsinki, Finland
    Proc Natl Acad Sci U S A 104:7211-6. 2007
    ..The findings show that prostate epithelium has a surprising inability to control checkpoint arrest, the lack of which may predispose to accrual of DNA lesions...
  36. ncbi request reprint Calcitriol and genistein actions to inhibit the prostaglandin pathway: potential combination therapy to treat prostate cancer
    Srilatha Swami
    Department of Medicine, Division of Endocrinology, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Nutr 137:205S-210S. 2007
    ..Both calcitriol and genistein are relatively safe and have little toxicity associated with their intake. We postulate that the combination of calcitriol and genistein is an attractive therapeutic option for the treatment of PCa...
  37. pmc Distinctive gene expression of prostatic stromal cells cultured from diseased versus normal tissues
    Hongjuan Zhao
    Department of Urology, Stanford University, Stanford, California 94305, USA
    J Cell Physiol 210:111-21. 2007
    ..Our results support the hypothesis that prostatic stromal cells of different origin have unique transcriptional programs and point towards genes involved in actions of stromal cells in BPH and CA...
  38. ncbi request reprint Transcript profiling of the androgen signal in normal prostate, benign prostatic hyperplasia, and prostate cancer
    David R Bauman
    Department of Pharmacology, Center of Excellence in Environmental Toxicology, University of Pennsylvania School of Medicine, 130C John Morgan Building, 3620 Hamilton Walk, Philadelphia, Pennsylvania 19104 6084, USA
    Endocrinology 147:5806-16. 2006
    ..280 in normal PSC) were maintained in PEC and PSC in diseased prostate. These data suggest that CaP may be more responsive to an ERbeta agonist and BPH may be more responsive to androgen ablation...
  39. ncbi request reprint Potentiation of the growth-inhibitory effects of vitamin D in prostate cancer by genistein
    Aruna V Krishnan
    Department of Medicine, Division of Endocrinology, Stanford University School of Medicine, 300 Pasteur Drive, Grant Building, S 025, Stanford, CA 94305, USA
    Nutr Rev 65:S121-3. 2007
  40. ncbi request reprint Molecular targets of doxazosin in human prostatic stromal cells
    Hongjuan Zhao
    Department of Urology, Stanford University School of Medicine, Stanford, California 94305 5118, USA
    Prostate 62:400-10. 2005
    ..We used cDNA microarray analysis to obtain insights into the mechanisms of action of doxazosin, an alpha(1)-adrenergic receptor antagonist used to treat benign prostatic hyperplasia (BPH)...
  41. ncbi request reprint Antiproliferative and proapoptotic activities of triptolide (PG490), a natural product entering clinical trials, on primary cultures of human prostatic epithelial cells
    Taija M Kiviharju
    Department of Urology, Stanford University School of Medicine, Stanford, California 94305 5118, USA
    Clin Cancer Res 8:2666-74. 2002
    ..Our preclinical studies suggest that triptolide might be an effective preventive as well as therapeutic agent against prostate cancer and that triptolide may activate a functional p53 pathway in prostate cells...
  42. ncbi request reprint Primary culture model of peroxisome proliferator-activated receptor gamma activity in prostate cancer cells
    Yue Xu
    Department of Urology, Stanford University School of Medicine, Stanford, California, USA
    J Cell Physiol 196:131-43. 2003
    ....
  43. ncbi request reprint Novel stimulatory role for insulin-like growth factor binding protein-2 in prostate cancer cells
    Michael G Moore
    Division of Pediatric Endocrinology, University of California at Los Angeles Medical Center, Los Angeles, CA, USA
    Int J Cancer 105:14-9. 2003
    ....
  44. ncbi request reprint Vitamin D receptor start codon polymorphism (FokI) and prostate cancer progression
    Yue Xu
    Department of Urology, Stanford University School of Medicine, Stanford, California 94305, USA
    Cancer Epidemiol Biomarkers Prev 12:23-7. 2003
    ..Additional studies with a larger sample size and investigation of the functional significance of the FokI polymorphism in prostate cancer cells are warranted...
  45. ncbi request reprint Leptomycin B stabilizes and activates p53 in primary prostatic epithelial cells and induces apoptosis in the LNCaP cell line
    Philip S Lecane
    Department of Urology, Stanford University School of Medicine, Stanford, California 94305, USA
    Prostate 54:258-67. 2003
    ..We investigated the ability of LMB to activate p53 in prostatic epithelial cells...
  46. ncbi request reprint Expression of matrix metalloproteinase-2 and -9 and their inhibitors, tissue inhibitor of metalloproteinase-1 and -2, in primary cultures of human prostatic stromal and epithelial cells
    Michael J Wilson
    Minneapolis VA Medical Center, Minnesota 55417, USA
    J Cell Physiol 191:208-16. 2002
    ..Our results suggest that the elevated levels of MMP-2 and -9 observed in prostate development and cancer may be due to the elevated TGF-beta associated with these tissues...
  47. ncbi request reprint Inhibition of prostate cancer growth by vitamin D: Regulation of target gene expression
    Aruna V Krishnan
    Department of Medicine, Stanford University School of Medicine, Stanford, California 94305, USA
    J Cell Biochem 88:363-71. 2003
    ..Further investigation of the role of calcitriol and its analogs for the therapy or chemoprevention of PCa is currently being pursued...
  48. ncbi request reprint Preclinical activity of ketoconazole in combination with calcitriol or the vitamin D analogue EB 1089 in prostate cancer cells
    Donna M Peehl
    Department of Urology, Stanford University School of Medicine, California 94305 5118, USA
    J Urol 168:1583-8. 2002
    ..We tested the growth inhibitory activity of ketoconazole combined with 1,25-dihydroxyvitamin D3 (calcitriol) and with the vitamin D analogue EB 1089 in a preclinical model of prostate cancer...
  49. ncbi request reprint Polymorphisms in the androgen receptor and type II 5 alpha-reductase genes and prostate cancer prognosis
    Atsuko Shibata
    Department of Health Research and Policy, Stanford University School of Medicine, Stanford, California 94305 5405, USA
    Prostate 52:269-78. 2002
    ..Cytosine-adenine-guanine repeat length of the androgen receptor gene and the A49T and V89L polymorphisms of the 5 alpha-reductase (SRD5A2) gene have been associated with prostate cancer...
  50. ncbi request reprint Silencing of pi-class glutathione S-transferase in MDA PCa 2a and MDA PCa 2b cells
    Genevieve M Vidanes
    Department of Urology, Stanford University Medical Center, Pasteur Drive, Stanford, California 94305 5118, USA
    Prostate 51:225-30. 2002
    ..Of the available human prostate cancer cell lines, only LNCaP mirrors this phenotype. We investigated whether the prostate cancer cell lines MDA PCa 2a and MDA PCa 2b share this phenotype...
  51. ncbi request reprint Human type 3 3alpha-hydroxysteroid dehydrogenase (aldo-keto reductase 1C2) and androgen metabolism in prostate cells
    Tea Lanisnik Rizner
    Department of Pharmacology, University of Pennsylvania School of Medicine, 3620 Hamilton Walk, Philadelphia, PA 19104 6084, USA
    Endocrinology 144:2922-32. 2003
    ..Neither AKR1C2, retinol dehydrogenase/3alpha-HSD nor 11-cis-retinol dehydrogenase is a source of 5alpha-DHT in PC-3 cells...
  52. ncbi request reprint Pathways mediating the growth-inhibitory actions of vitamin D in prostate cancer
    Donna M Peehl
    Department of Urology, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Nutr 133:2461S-2469S. 2003
    ..Our research is directed at understanding the mechanisms of vitamin D action in prostate cells with the goal of developing chemoprevention and treatment strategies to improve prostate cancer therapy...
  53. ncbi request reprint Expression of transforming growth factor-beta 1 and growth in soft agar differentiate prostate carcinoma-associated fibroblasts from normal prostate fibroblasts
    Ignacio F San Francisco
    Division of Urologic Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Int J Cancer 112:213-8. 2004
    ..Increased capability of CAF as compared to NHPF to form colonies in soft agar may be due to a higher expression of TGF-beta1 and correlates with the ability of CAF to promote malignant progression of prostate epithelial cells...
  54. ncbi request reprint Cadmium-induced neoplastic transformation of human prostate epithelial cells
    Keiichiro Nakamura
    Center for Prostate Disease Research, Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    Int J Oncol 20:543-7. 2002
    ..1 and cytokeratin 8 (CK8). These findings provide evidence of malignant transformation of human prostate epithelial cells exposed to this environmentally important chemical...
  55. ncbi request reprint Altered SMRT levels disrupt vitamin D3 receptor signalling in prostate cancer cells
    Farhat L Khanim
    Division of Medical Sciences, Institute of Biomedical Research, University of Birmingham Medical School, Edgbaston, Birmingham B15 2TH, UK
    Oncogene 23:6712-25. 2004
    ..This can be targeted therapeutically by combination treatments with HDAC inhibitors...
  56. ncbi request reprint Retinol metabolism and lecithin:retinol acyltransferase levels are reduced in cultured human prostate cancer cells and tissue specimens
    Xiaojia Guo
    Department of Pharmacology, Weill Medical College of Cornell University, New York, New York 10021, USA
    Cancer Res 62:1654-61. 2002
    ..Collectively, these data implicate aberrant retinoid metabolism in the process of prostatic carcinogenesis...
  57. ncbi request reprint Mechanisms of decreased Vitamin D 1alpha-hydroxylase activity in prostate cancer cells
    Jian Feng Ma
    Department of Urology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Mol Cell Endocrinol 221:67-74. 2004
    ..We conclude that diminished 1alpha(OH)ase activity in prostate cancer cell lines is through decreased gene expression, whereas decreased activity in primary cultures and tissues is post-translational...
  58. ncbi request reprint Analysis of vitamin D-regulated gene expression in LNCaP human prostate cancer cells using cDNA microarrays
    Aruna V Krishnan
    Department of Medicine, Stanford University School of Medicine, Stanford, California 94305 5103, USA
    Prostate 59:243-51. 2004
    ..To better understand the molecular mechanisms underlying these actions, we employed cDNA microarrays to study 1,25(OH)2D3-regulated gene expression in the LNCaP human prostate cancer cells...
  59. ncbi request reprint Oxidative 3alpha-hydroxysteroid dehydrogenase activity of human type 10 17beta-hydroxysteroid dehydrogenase
    Xue Ying He
    Department of Pharmacology, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY 10314, USA
    J Steroid Biochem Mol Biol 87:191-8. 2003
    ..The experimental results lead to the conclusion that mitochondrial 17beta-HSD10 plays a significant part in a non-classical androgen synthesis pathway along with microsomal retinol dehydrogenases...
  60. ncbi request reprint A glucocorticoid-responsive mutant androgen receptor exhibits unique ligand specificity: therapeutic implications for androgen-independent prostate cancer
    Aruna V Krishnan
    Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
    Endocrinology 143:1889-900. 2002
    ..Triamcinolone, by itself, would not activate the AR(ccr) or promote tumor growth but would provide glucocorticoid activity essential for survival...
  61. ncbi request reprint Calcitriol as a chemopreventive and therapeutic agent in prostate cancer: role of anti-inflammatory activity
    Aruna V Krishnan
    Department of Medicine, Division of Endocrinology, Stanford University School of Medicine, Stanford, California, USA
    J Bone Miner Res 22:V74-80. 2007
    ..We conclude that calcitriol exerts several anti-inflammatory actions in prostate cells, which contribute to its potential as a chemopreventive and therapeutic agent in PCa...
  62. pmc Topology of NGEP, a prostate-specific cell:cell junction protein widely expressed in many cancers of different grade level
    Sudipto Das
    Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892 4264, USA
    Cancer Res 68:6306-12. 2008
    ..Our findings on the expression and the orientation of the NGEP protein serve as an important framework for the development of mAb targeting the extracellular regions of NGEP that could be used for prostate cancer immunotherapy...
  63. ncbi request reprint Molecular and cellular pathogenesis of benign prostatic hyperplasia
    Keith L Lee
    Department of Urology, Stanford University School of Medicine, Stanford, California 94305 5118, USA
    J Urol 172:1784-91. 2004
    ..However, the basic science literature is often conflicting and confusing, without a unified voice. We report the current state of knowledge of the molecular and cellular basis of BPH...
  64. pmc The current state of preclinical prostate cancer animal models
    Kenneth J Pienta
    University of Michigan, Department of Internal Medicine, Ann Arbor, MI, USA
    Prostate 68:629-39. 2008
    ..It should be possible to apply the knowledge gained molecular and epigenetic studies to develop new cell lines and models that mimic progressive and fatal prostate cancer and ultimately improve interventions...
  65. ncbi request reprint Novel pathways that contribute to the anti-proliferative and chemopreventive activities of calcitriol in prostate cancer
    Aruna V Krishnan
    Department of Medicine, Division of Endocrinology, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Steroid Biochem Mol Biol 103:694-702. 2007
    ..Thus, we conclude that calcitriol regulates myriad pathways that contribute to the potential chemopreventive and therapeutic utility of calcitriol in PCa...
  66. ncbi request reprint Chemopreventive anti-inflammatory activities of curcumin and other phytochemicals mediated by MAP kinase phosphatase-5 in prostate cells
    Larisa Nonn
    Department of Urology, Stanford University, Stanford, CA 94305 5118, USA
    Carcinogenesis 28:1188-96. 2007
    ..In summary, our findings show direct anti-inflammatory activity of MKP5 in prostate cells and suggest that up-regulation of MKP5 by phytochemicals may contribute to their chemopreventive actions by decreasing prostatic inflammation...
  67. ncbi request reprint Growth of prostatic epithelial and stromal cells in vitro
    Donna M Peehl
    Department of Urology, Stanford University School of Medicine, Stanford, CA, USA
    Methods Mol Med 81:41-57. 2003
  68. ncbi request reprint Aldo-keto reductase (AKR) 1C3: role in prostate disease and the development of specific inhibitors
    Trevor M Penning
    Department of Pharmacology, University of Pennsylvania, Philadelphia, PA 19104 6084, USA
    Mol Cell Endocrinol 248:182-91. 2006
    ..These compounds can now be used to determine the role of AKR1C3 in producing two proliferative signals in the prostate namely testosterone and 9alpha,11beta-PGF2...
  69. ncbi request reprint The role of vitamin D in prostate cancer
    Aruna V Krishnan
    Department of Medicine, Division of Endocrinology, Stanford University School of Medicine, Stanford, CA 94305 5103, USA
    Recent Results Cancer Res 164:205-21. 2003
    ..Current research involves further investigation of the role of 1,25(OH)2D3 and its analogs for the therapy or chemoprevention of PCa...
  70. ncbi request reprint Epigenetic repression of transcription by the Vitamin D3 receptor in prostate cancer cells
    Lyndon M Gommersall
    Department of Medicine, Division of Medical Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TH, UK
    J Steroid Biochem Mol Biol 89:251-6. 2004
    ..These data demonstrate that prostate cancer cells utilise a mechanism involving deacetylation to suppress the responsiveness of VDR target genes and thus ablate the antiproliferative action of 1alpha,25(OH)(2)D(3)...
  71. ncbi request reprint CXCR4 and CXCL12 (SDF-1) in prostate cancer: inhibitory effects of human single chain Fv antibodies
    Gayle G Vaday
    Department of Research, Veterans Affairs Medical Center, Northport, New York 11768, USA
    Clin Cancer Res 10:5630-9. 2004
    ..In this study, we examined the inhibitory effects of anti-CXCR4 antibodies on CXCL12-mediated PCa cell activities...
  72. ncbi request reprint High resolution regional elasticity mapping of the human prostate
    Yoshinobu Murayama
    College of Engineering, Nihon University, Koriyama, Fukushima, 9638642 Japan
    Conf Proc IEEE Eng Med Biol Soc 2007:5803-6. 2007
    ..Using this methodology we mapped the elasticity of human prostate cancer (CaP) and it was obviously observed that the node was significantly harder than surrounding normal tissues and had some textures...

Research Grants5

  1. A Serum Marker for Aggressive Prostate Cancer
    Donna Peehl; Fiscal Year: 2007
    ....
  2. A Serum Marker for Aggressive Prostate Cancer
    Donna M Peehl; Fiscal Year: 2010
    ....