PANKAJ PASRICHA

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. pmc Transient gastric irritation in the neonatal rats leads to changes in hypothalamic CRF expression, depression- and anxiety-like behavior as adults
    Liansheng Liu
    Division of Gastroenterology and Hepatology, Stanford University Medical Center, Stanford, California, United States of America
    PLoS ONE 6:e19498. 2011
  2. pmc Divergent fate and origin of neurosphere-like bodies from different layers of the gut
    Laren Becker
    Department of Medicine, Division of Gastroenterology and Hepatology, Stanford University, Stanford, California 94305, USA
    Am J Physiol Gastrointest Liver Physiol 302:G958-65. 2012
  3. doi Unraveling the mystery of pain in chronic pancreatitis
    Pankaj Jay Pasricha
    Stanford University School of Medicine, 300 Pasteur Drive, M211 Alway Building, Stanford, CA 94305, USA
    Nat Rev Gastroenterol Hepatol 9:140-51. 2012
  4. doi Stem cell transplantation in neurodegenerative disorders of the gastrointestinal tract: future or fiction?
    Subhash Kulkarni
    Division of Gastroenterology and Hepatology, Stanford University, School of Medicine, Stanford, CA 94305, USA
    Gut 61:613-21. 2012
  5. pmc The endogenous hydrogen sulfide producing enzyme cystathionine-beta synthase contributes to visceral hypersensitivity in a rat model of irritable bowel syndrome
    Guang Yin Xu
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas 77555 0655, USA
    Mol Pain 5:44. 2009
  6. pmc Computational prediction and experimental validation associating FABP-1 and pancreatic adenocarcinoma with diabetes
    Ravi N Sharaf
    Department of Gastroenterology and Hepatology, Stanford University School of Medicine, Alway Building, Room M211, 300 Pasteur Drive, MC 5187, Stanford, CA 94305 5187, USA
    BMC Gastroenterol 11:5. 2011
  7. doi NOTES and other emerging trends in gastrointestinal endoscopy and surgery: the change that we need and the change that is real
    Pankaj Jay Pasricha
    Division of Gastroenterology and Hepatology, Stanford University Medical Center, Alway Building, Room M211, 300 Pasteur Drive, MC 5187, Stanford, California 94305, USA
    Am J Gastroenterol 104:2384-6. 2009
  8. pmc Characteristics of patients with chronic unexplained nausea and vomiting and normal gastric emptying
    Pankaj J Pasricha
    Division of Gastroenterology and Hepatology, Stanford University School of Medicine, 300 Pasteur Drive, Palo Alto, California 94305 5187, USA
    Clin Gastroenterol Hepatol 9:567-76.e1-4. 2011
  9. pmc Systemic administration of anti-NGF increases A-type potassium currents and decreases pancreatic nociceptor excitability in a rat model of chronic pancreatitis
    Yaohui Zhu
    Department of Medicine, Division of Gastroenterology and Hepatology, Stanford University School of Medicine, Stanford, California 94305, USA
    Am J Physiol Gastrointest Liver Physiol 302:G176-81. 2012
  10. pmc Changes in the gastric enteric nervous system and muscle: a case report on two patients with diabetic gastroparesis
    Pankaj J Pasricha
    Division of Gastroenterology, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA
    BMC Gastroenterol 8:21. 2008

Research Grants

Collaborators

  • Jiande Dz Chen
  • Robert Sapolsky
  • Qian Li
  • Thomas M Krummel
  • Guang Yin Xu
  • Henry P Parkman
  • Kenneth L Koch
  • Thomas L Abell
  • Hui Ouyang
  • SUSHIL SARNA
  • Zhishun Wang
  • G Farrugia
  • B E Lacy
  • Paul Swain
  • Subhash Kulkarni
  • Liansheng Liu
  • Laren Becker
  • Maria Adelaide Micci
  • Yaohui Zhu
  • Jinsong Liu
  • Kshama Mehta
  • Mohan Shenoy
  • Gunjan Tiwari
  • Ravi N Sharaf
  • Pankaj Jay Pasricha
  • Weihong Sha
  • Sergey V Kantsevoy
  • Xiaohong Xu
  • Xuan Zheng Shi
  • Harsha Vittal
  • Lee L Swanstrom
  • Xiaohua Hou
  • Nischita K Reddy
  • Tugba Colak
  • Cuiping Li
  • Min Liao
  • Atul J Butte
  • Martin Kaiser
  • JESSE HANSON
  • Bende Zou
  • Kelli D Montgomery
  • Aditi Bhargava
  • Reetesh Pai
  • Joel T Dudley
  • Xinmin Simon Xie
  • Anthony N Kalloo
  • Peter B Cotton
  • Christopher J Gostout
  • Nina V Isakovich
  • Sanjay B Jagannath
  • Guillermo Gomez
  • Hideaki Niiyama
  • Sydney S C Chung
  • Robert H Hawes
  • Barun K Choudhury
  • Yochai Birnbaum
  • Jieyun Yin
  • Richard Kozarek
  • Nonko D Pehlivanov
  • Richard Ewers
  • Desmond Birkett
  • David L Ware
  • Per Ola Park
  • Ramanna Merla
  • Steven Gross
  • Vahid Saadat
  • Xian Qiao

Detail Information

Publications24

  1. pmc Transient gastric irritation in the neonatal rats leads to changes in hypothalamic CRF expression, depression- and anxiety-like behavior as adults
    Liansheng Liu
    Division of Gastroenterology and Hepatology, Stanford University Medical Center, Stanford, California, United States of America
    PLoS ONE 6:e19498. 2011
    ..We hypothesized that psychological morbidity in these conditions may result from gastrointestinal problems, rather than causing them...
  2. pmc Divergent fate and origin of neurosphere-like bodies from different layers of the gut
    Laren Becker
    Department of Medicine, Division of Gastroenterology and Hepatology, Stanford University, Stanford, California 94305, USA
    Am J Physiol Gastrointest Liver Physiol 302:G958-65. 2012
    ..NLBs from the myenteric plexus layer contain more neural crest-derived ENSCs while those from submucosal plexus appear more heterogeneous, likely containing a population of mesenchymal stem cells...
  3. doi Unraveling the mystery of pain in chronic pancreatitis
    Pankaj Jay Pasricha
    Stanford University School of Medicine, 300 Pasteur Drive, M211 Alway Building, Stanford, CA 94305, USA
    Nat Rev Gastroenterol Hepatol 9:140-51. 2012
    ..Studies have also indicated novel therapeutic targets for this condition...
  4. doi Stem cell transplantation in neurodegenerative disorders of the gastrointestinal tract: future or fiction?
    Subhash Kulkarni
    Division of Gastroenterology and Hepatology, Stanford University, School of Medicine, Stanford, CA 94305, USA
    Gut 61:613-21. 2012
    ..This review summarises the current status of research in this field, identifies the major gaps in our knowledge and discusses the potential opportunities and hurdles for clinical application...
  5. pmc The endogenous hydrogen sulfide producing enzyme cystathionine-beta synthase contributes to visceral hypersensitivity in a rat model of irritable bowel syndrome
    Guang Yin Xu
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas 77555 0655, USA
    Mol Pain 5:44. 2009
    ..Dorsal root ganglion (DRG) neurons innervating the colon were labeled by injection of DiI (1,1'-dioleyl-3,3,3',3-tetramethylindocarbocyanine methanesulfonate) into the colon wall...
  6. pmc Computational prediction and experimental validation associating FABP-1 and pancreatic adenocarcinoma with diabetes
    Ravi N Sharaf
    Department of Gastroenterology and Hepatology, Stanford University School of Medicine, Alway Building, Room M211, 300 Pasteur Drive, MC 5187, Stanford, CA 94305 5187, USA
    BMC Gastroenterol 11:5. 2011
    ..We identified fatty acid binding protein-1 (FABP-1) as one of several candidates. The primary aim of this pilot study was to experimentally validate the predicted association between FABP-1 with PaC and PaC with diabetes...
  7. doi NOTES and other emerging trends in gastrointestinal endoscopy and surgery: the change that we need and the change that is real
    Pankaj Jay Pasricha
    Division of Gastroenterology and Hepatology, Stanford University Medical Center, Alway Building, Room M211, 300 Pasteur Drive, MC 5187, Stanford, California 94305, USA
    Am J Gastroenterol 104:2384-6. 2009
    ..In this piece, we discuss the circumstances that led to the development of NOTES and other innovative procedures, the peril that lies in ignoring them, and the true promise that they hold for our specialties...
  8. pmc Characteristics of patients with chronic unexplained nausea and vomiting and normal gastric emptying
    Pankaj J Pasricha
    Division of Gastroenterology and Hepatology, Stanford University School of Medicine, 300 Pasteur Drive, Palo Alto, California 94305 5187, USA
    Clin Gastroenterol Hepatol 9:567-76.e1-4. 2011
    ..Chronic nausea and vomiting with normal gastric emptying is a poorly understood syndrome; we analyzed its characteristics...
  9. pmc Systemic administration of anti-NGF increases A-type potassium currents and decreases pancreatic nociceptor excitability in a rat model of chronic pancreatitis
    Yaohui Zhu
    Department of Medicine, Division of Gastroenterology and Hepatology, Stanford University School of Medicine, Stanford, California 94305, USA
    Am J Physiol Gastrointest Liver Physiol 302:G176-81. 2012
    ..No significant differences were seen among those. These findings emphasize a key role for NGF in maintaining neuronal excitability in CP specifically via downregulation of I(A) by as yet unknown mechanisms...
  10. pmc Changes in the gastric enteric nervous system and muscle: a case report on two patients with diabetic gastroparesis
    Pankaj J Pasricha
    Division of Gastroenterology, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA
    BMC Gastroenterol 8:21. 2008
    ..The aim of this study was to use modern analytical methods to determine morphological and molecular changes in the gastric wall in patients with diabetic gastroparesis...
  11. ncbi In vivo gastric and intestinal slow waves in W/WV mice
    Xiaohua Hou
    Division of Gastroenterology, University of Texas Medical Branch, Galveston, Texas 77555 0764, USA
    Dig Dis Sci 50:1335-41. 2005
    ..There may be some abnormality of smooth muscle cells in W/WV mice that causes a reduction in the frequency, rhythmicity, and antegrade propagation of slow waves...
  12. doi Rhythmic and spatial abnormalities of gastric slow waves in patients with functional dyspepsia
    Weihong Sha
    Division of Gastroenterology, University of Texas Medical Branch, Galveston, TX, USA
    J Clin Gastroenterol 43:123-9. 2009
    ..The objectives of this study were to assess differences in gastric slow waves measured by a newly approved multichannel electrogastrogram (EGG) device between patients with functional dyspepsia (FD) and healthy controls...
  13. pmc Gut-derived factors promote neurogenesis of CNS-neural stem cells and nudge their differentiation to an enteric-like neuronal phenotype
    Subhash Kulkarni
    Div of Gastroenterology and Hepatology, Stanford Univ School of Medicine, CA 94305, USA
    Am J Physiol Gastrointest Liver Physiol 301:G644-55. 2011
    ..Our results show that the gut microenvironment induces CNS-NSC to produce neurons that share some of the characteristics of classical enteric neurons, further supporting the therapeutic use of these cells for gastrointestinal disorders...
  14. ncbi Substance P and calcitonin gene related peptide mediate pain in chronic pancreatitis and their expression is driven by nerve growth factor
    Liansheng Liu
    Division of Gastroenterology and Hepatology, Stanford University Medical Center, Stanford, CA, USA
    JOP 12:389-94. 2011
    ..Calcitonin gene-related peptide (CGRP), substance P and nerve growth factor play an important role in inflammatory pain in various somatic pain models but their role in chronic pancreatitis has not been well studied...
  15. ncbi Improvement of gastric motility with gastric electrical stimulation in STZ-induced diabetic rats
    Jinsong Liu
    Division of Gastroenterology, University of Texas Medical Branch, Galveston, Tex, USA
    Digestion 70:159-66. 2004
    ..The aims of this study were to observe whether gastric motility was impaired in streptozotocin (STZ)-induced diabetic rats and whether gastric electrical stimulation was able to restore the impaired motility...
  16. ncbi Electroacupuncture accelerates gastric emptying in association with changes in vagal activity
    Hui Ouyang
    Division of Gastroenterology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555 0632, USA
    Am J Physiol Gastrointest Liver Physiol 282:G390-6. 2002
    ..The effect may be attributed to improvement in gastric slow-wave rhythmicity and antral contractile (spike) activity and may possibly involve the vagal pathway...
  17. ncbi A novel safe approach to the peritoneal cavity for per-oral transgastric endoscopic procedures
    Sergey V Kantsevoy
    Division of Gastroenterology, Johns Hopkins Hospital, 1550 Orleans Street, Baltimore, MD 21231, USA
    Gastrointest Endosc 65:497-500. 2007
    ..We have previously reported the feasibility and safety of per-oral transgastric endoscopic procedures in a porcine model...
  18. ncbi A novel role of VIP in colonic motility function: induction of excitation-transcription coupling in smooth muscle cells
    Xuan Zheng Shi
    Department of Internal Medicine, Enteric Neuromuscular Disorders and Visceral Pain Center, Division of Gastroenterology, The University of Texas Medical Branch at Galveston, Galveston, Texas 77555, USA
    Gastroenterology 132:1388-400. 2007
    ..The aim of this study was to investigate whether the phosphorylation of CREB induces gene expression of the pore-forming alpha(1C) subunit of Ca(v)1.2 channels (L-type calcium channels), whose promoter has 2 binding sites for CREB...
  19. ncbi Feasibility of gastric electrical stimulation by use of endoscopically placed electrodes
    Xiaohong Xu
    Division of Gastroenterology, University of Texas Medical Branch, Galveston, Texas, USA
    Gastrointest Endosc 66:981-6. 2007
    ..New methods are needed for implanting GES electrodes in a safer and more feasible way...
  20. ncbi The treatment of diabetic gastroparesis with botulinum toxin injection of the pylorus
    Brian E Lacy
    Marvin M Schuster Center for Digestive and Motility Disorders, Johns Hopkins University, School of Medicine, Baltimore, MD, USA
    Diabetes Care 27:2341-7. 2004
    ....
  21. ncbi Development of a new access device for transgastric surgery
    Lee L Swanstrom
    Department of Minimally Invasive Surgery, Legacy Health System, Portland, Oregon 97210, USA
    J Gastrointest Surg 9:1129-36; discussion 1136-7. 2005
    ..This technology may serve as the needed platform for transgastric cholecystectomy, gastric reduction, fundoplication, hiatus hernia repair, or other advanced endosurgical procedures...
  22. ncbi An unusual electrocardiogram artifact: what is its source?
    Nischita K Reddy
    Department of Neurology, The University of Texas Medical Branch, Galveston, TX 77555 0553, USA
    J Electrocardiol 38:337-9. 2005
    ..The patient had an implanted gastric electrical stimulation system for treating her diabetic gastroparesis. Recent DC shock for ventricular fibrillation during coronary angiography caused malfunction of the gastric pacemaker...
  23. ncbi Mechanisms of disease: the pathological basis of gastroparesis--a review of experimental and clinical studies
    Harsha Vittal
    Maine Medical Center, University of Texas Medical Branch, Galveston, TX 77555 0764, USA
    Nat Clin Pract Gastroenterol Hepatol 4:336-46. 2007
    ..Future studies should focus on understanding the molecular pathways that lead to gastric dysfunction, in animal models and in humans, and pave the way for the development of rational therapies...
  24. doi Beyond gastric emptying: a "toxic" lesson about gastroparesis
    Pankaj J Pasricha
    Am J Gastroenterol 103:424-6. 2008
    ....

Research Grants16

  1. Molecular Approaches to Pathogenesis and Therapy in Human Gastroparesis
    PANKAJ PASRICHA; Fiscal Year: 2007
    ..These studies will provide insight into the underlying mechanism of gastroparesis and eventually lead to new and more effective forms of therapy ..
  2. Molecular Mechanisms of Pain in Chronic Pancreatitis
    Pankaj J Pasricha; Fiscal Year: 2010
    ..This study will provide important information on the neurobiology of chronic pancreatitis and identify potentially novel therapeutic targets. ..
  3. Genes, Environment & Neural Stem Cell Transplantation in the Gut
    PANKAJ PASRICHA; Fiscal Year: 2009
    ..It is the purpose of this proposal to study this approach experimentally and determine the biological factors that can optimize the use of neural stem cells for the treatment and perhaps cure of these diseases. ..
  4. Molecular Mechanisms of Pain in Chronic Pancreatitis
    PANKAJ PASRICHA; Fiscal Year: 2009
    ..This study will provide important information on the neurobiology of chronic pancreatitis and identify potentially novel therapeutic targets. ..
  5. Molecular Approaches to Pathogenesis and Therapy in Hum*
    PANKAJ PASRICHA; Fiscal Year: 2007
    ..These studies will provide insight into the underlying mechanism of gastroparesis and eventually lead to new and more effective forms of therapy. ..
  6. TRYPSIN, PAR-2 AND THE PAIN OF PANCREATITIS
    PANKAJ PASRICHA; Fiscal Year: 2002
    ..These studies will provide insight into the underlying mechanism of pancreatic pain that may eventually lead to new and more effective forms of therapy. ..
  7. Molecular Mechanisms of Pain in Chronic Pancreatitis
    PANKAJ PASRICHA; Fiscal Year: 2007
    ..This study will provide important information on the neurobiology of chronic pancreatitis and identify potentially novel therapeutic targets. ..
  8. TRYPSIN, PAR-2 AND THE PAIN OF PANCREATITIS
    PANKAJ PASRICHA; Fiscal Year: 2004
    ..These studies will provide insight into the underlying mechanism of pancreatic pain that may eventually lead to new and more effective forms of therapy. ..
  9. TRYPSIN, PAR-2 AND THE PAIN OF PANCREATITIS
    PANKAJ PASRICHA; Fiscal Year: 2003
    ..These studies will provide insight into the underlying mechanism of pancreatic pain that may eventually lead to new and more effective forms of therapy. ..
  10. NEURAL STEM CELL TRANSPLANTATION IN THE GUT
    PANKAJ PASRICHA; Fiscal Year: 2003
    ..e. embryonic stem cells, neural crest stem cells or human neural stem ceils) for cellular replacement therapy in the gastrointestinal tract. ..
  11. Genes, Environment & Neural Stem Cell Transplantation in the Gut
    Pankaj J Pasricha; Fiscal Year: 2010
    ..It is the purpose of this proposal to study this approach experimentally and determine the biological factors that can optimize the use of neural stem cells for the treatment and perhaps cure of these diseases. ..