Karen J Parker

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. ncbi request reprint Interaction of photoperiod and testes development is associated with paternal care in Microtus pennsylvanicus (meadow voles)
    Karen J Parker
    Department of Psychology and The Reproductive Sciences Program, University of Michigan, 525 East University Avenue, Ann Arbor, MI 48109 1109, USA
    Physiol Behav 75:91-5. 2002
  2. pmc Preliminary evidence that plasma oxytocin levels are elevated in major depression
    Karen J Parker
    Department of Psychiatry and Behavioral Sciences, School of Medicine, Stanford University, Stanford, CA 94305, USA
    Psychiatry Res 178:359-62. 2010
  3. pmc Identifying key features of early stressful experiences that produce stress vulnerability and resilience in primates
    Karen J Parker
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 1201 Welch Road MSLS P 104, Stanford, CA 94305 5485, USA
    Neurosci Biobehav Rev 35:1466-83. 2011
  4. pmc Somatic and neuroendocrine responses to standard and biologically salient acoustic startle stimuli in monkeys
    Karen J Parker
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, USA
    Psychoneuroendocrinology 36:547-56. 2011
  5. pmc Early life stress and novelty seeking behavior in adolescent monkeys
    Karen J Parker
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 1201 Welch Road, MSLS Room P104, Mail Code 5485, Stanford, CA 94305 5485, USA
    Psychoneuroendocrinology 32:785-92. 2007
  6. doi request reprint Effects of age on cerebrospinal fluid oxytocin levels in free-ranging adult female and infant rhesus macaques
    Karen J Parker
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305 5485, USA
    Behav Neurosci 124:428-33. 2010
  7. pmc Maternal mediation, stress inoculation, and the development of neuroendocrine stress resistance in primates
    Karen J Parker
    Department of Psychiatry and Behavioral Sciences, Stanford University, 1201 Welch Road, MSLS P104, Stanford, CA 94305 5485, USA
    Proc Natl Acad Sci U S A 103:3000-5. 2006
  8. ncbi request reprint Intranasal oxytocin administration attenuates the ACTH stress response in monkeys
    Karen J Parker
    Department of Psychiatry and Behavioral Sciences, Stanford University Medical School, CA 94305 5485, USA
    Psychoneuroendocrinology 30:924-9. 2005
  9. ncbi request reprint Neuroendocrine aspects of hypercortisolism in major depression
    Karen J Parker
    Department of Psychiatry and Behavioral Sciences, Stanford University Medical School, 1201 Welch Road, MSLS Room P104, Mail Code 5485, Stanford, CA 94305 5485, USA
    Horm Behav 43:60-6. 2003
  10. ncbi request reprint Female meadow voles (Microtus pennsylvanicus) demonstrate same-sex partner preferences
    Karen J Parker
    Department of Psychology and Reproductive Sciences Program, University of Michigan, MI, USA
    J Comp Psychol 117:283-9. 2003

Research Grants

Collaborators

Detail Information

Publications24

  1. ncbi request reprint Interaction of photoperiod and testes development is associated with paternal care in Microtus pennsylvanicus (meadow voles)
    Karen J Parker
    Department of Psychology and The Reproductive Sciences Program, University of Michigan, 525 East University Avenue, Ann Arbor, MI 48109 1109, USA
    Physiol Behav 75:91-5. 2002
    ..Collectively, these data suggest that photoperiod and fertility status may interact to exert both inhibitory and permissive control over the expression of paternal behavior in adult meadow voles...
  2. pmc Preliminary evidence that plasma oxytocin levels are elevated in major depression
    Karen J Parker
    Department of Psychiatry and Behavioral Sciences, School of Medicine, Stanford University, Stanford, CA 94305, USA
    Psychiatry Res 178:359-62. 2010
    ..Additional research is required to elucidate the role of OT in the pathophysiology of this psychiatric disorder...
  3. pmc Identifying key features of early stressful experiences that produce stress vulnerability and resilience in primates
    Karen J Parker
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 1201 Welch Road MSLS P 104, Stanford, CA 94305 5485, USA
    Neurosci Biobehav Rev 35:1466-83. 2011
    ..This article concludes by identifying gaps in our current knowledge, providing directions for future research, and discussing the translational implications of these primate models for human development and psychopathology...
  4. pmc Somatic and neuroendocrine responses to standard and biologically salient acoustic startle stimuli in monkeys
    Karen J Parker
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, USA
    Psychoneuroendocrinology 36:547-56. 2011
    ..The development of monkey startle methodology may further enhance the utility of this paradigm in translational studies of human stress-related psychiatric disorders...
  5. pmc Early life stress and novelty seeking behavior in adolescent monkeys
    Karen J Parker
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 1201 Welch Road, MSLS Room P104, Mail Code 5485, Stanford, CA 94305 5485, USA
    Psychoneuroendocrinology 32:785-92. 2007
    ..These trait-like differences in novelty seeking appear to reflect mild early stress-induced adaptations that enhance curiosity and resilience...
  6. doi request reprint Effects of age on cerebrospinal fluid oxytocin levels in free-ranging adult female and infant rhesus macaques
    Karen J Parker
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305 5485, USA
    Behav Neurosci 124:428-33. 2010
    ..Research is now required to examine CSF oxytocin levels in the context of social functioning in free-ranging rhesus monkeys...
  7. pmc Maternal mediation, stress inoculation, and the development of neuroendocrine stress resistance in primates
    Karen J Parker
    Department of Psychiatry and Behavioral Sciences, Stanford University, 1201 Welch Road, MSLS P104, Stanford, CA 94305 5485, USA
    Proc Natl Acad Sci U S A 103:3000-5. 2006
    ..Results from both experiments demonstrate that stress inoculation, rather than high levels of maternal care, promotes the development of primate stress resistance...
  8. ncbi request reprint Intranasal oxytocin administration attenuates the ACTH stress response in monkeys
    Karen J Parker
    Department of Psychiatry and Behavioral Sciences, Stanford University Medical School, CA 94305 5485, USA
    Psychoneuroendocrinology 30:924-9. 2005
    ..This primate model offers critical opportunities to improve our understanding of the anti-stress effects of OT and may lead to novel pharmacological treatments for stress-related psychiatric disorders...
  9. ncbi request reprint Neuroendocrine aspects of hypercortisolism in major depression
    Karen J Parker
    Department of Psychiatry and Behavioral Sciences, Stanford University Medical School, 1201 Welch Road, MSLS Room P104, Mail Code 5485, Stanford, CA 94305 5485, USA
    Horm Behav 43:60-6. 2003
    ..In considering the evidence for hypercortisolism in humans, studies of nonhuman primates are presented and their utility and limitations as comparative models of human depression are discussed...
  10. ncbi request reprint Female meadow voles (Microtus pennsylvanicus) demonstrate same-sex partner preferences
    Karen J Parker
    Department of Psychology and Reproductive Sciences Program, University of Michigan, MI, USA
    J Comp Psychol 117:283-9. 2003
    ..Data support the hypothesis that captive meadow voles develop selective and enduring same-sex social bonds that may, under free-living conditions, facilitate communal nesting and cooperative rearing of young...
  11. ncbi request reprint Prospective investigation of stress inoculation in young monkeys
    Karen J Parker
    Department of Psychiatry and Behavioral Sciences, Stanford University Medical School, Stanford, Calif 94305 5485, USA
    Arch Gen Psychiatry 61:933-41. 2004
    ..Retrospective studies in humans have identified characteristics that promote stress resistance, including childhood exposure to moderately stressful events (ie, stress inoculation)...
  12. ncbi request reprint Mild early life stress enhances prefrontal-dependent response inhibition in monkeys
    Karen J Parker
    Department of Psychiatry and Behavioral Sciences, Stanford University Medical School, Stanford, California 94305 5485, USA
    Biol Psychiatry 57:848-55. 2005
    ..e., stress inoculation) strengthens emotional and neuroendocrine resistance to subsequent stressors. Herein we extend this research to examine the effects of mild early life stress on cognition...
  13. pmc Animal models of early life stress: Implications for understanding resilience
    David M Lyons
    Department of Psychiatry and Behavioral Sciences, Stanford University, 1201 Welch Rd, MSLS P104, Stanford, CA 94305, USA
    Dev Psychobiol 52:402-10. 2010
    ..Implications for programs designed to enhance resilience in human development are discussed...
  14. pmc Preliminary evidence that hippocampal volumes in monkeys predict stress levels of adrenocorticotropic hormone
    David M Lyons
    Department of Psychiatry and Behavioral Sciences, Stanford University Medical Center, Stanford, California 94305 5485, USA
    Biol Psychiatry 62:1171-4. 2007
    ..Hippocampal volumes previously determined in monkeys by magnetic resonance imaging are used to test the hypothesis that small hippocampi predict increased stress levels of adrenocorticotropic hormone (ACTH)...
  15. ncbi request reprint Stress inoculation-induced indications of resilience in monkeys
    David M Lyons
    Department of Psychiatry and Behavioral Sciences, Stanford University Medical Center, Stanford, CA 94305 5485, USA
    J Trauma Stress 20:423-33. 2007
    ....
  16. ncbi request reprint Circadian and homeostatic regulation of hypocretin in a primate model: implications for the consolidation of wakefulness
    Jamie M Zeitzer
    Department of Psychiatry and Behavioral Sciences, Stanford University, Palo Alto, California 94304, USA
    J Neurosci 23:3555-60. 2003
    ..In the squirrel monkey, hypocretin-1 works in opposition to the accumulating sleep drive during the day to maintain a constant level of wake...
  17. ncbi request reprint Social stress-related behavior affects hippocampal cell proliferation in mice
    Rupshi Mitra
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305 5020, USA
    Physiol Behav 89:123-7. 2006
    ....
  18. pmc Prefrontal plasticity and stress inoculation-induced resilience
    Maor Katz
    Department of Psychiatry, Stanford University, Stanford, Calif, USA
    Dev Neurosci 31:293-9. 2009
    ..These findings suggest that the process of coping with early life stress increases prefrontal myelination and expands a region of cortex that broadly controls arousal regulation and resilience...
  19. pmc Effects of intranasal oxytocin on social anxiety in males with fragile X syndrome
    Scott S Hall
    Center for Interdisciplinary Brain Sciences Research, Department of Psychiatry and Behavioral Sciences, Stanford University, 401 Quarry Road, Stanford, CA 94305 5795, USA
    Psychoneuroendocrinology 37:509-18. 2012
    ..Further double-blind placebo-controlled studies of OT, conducted in combination with behavioral treatment programs, may be warranted...
  20. doi request reprint Animal models of early life stress: implications for understanding resilience
    David M Lyons
    Department of Psychiatry and Behavioral Sciences, Stanford University, CA 94305, USA
    Dev Psychobiol 52:616-24. 2010
    ..Implications for programs designed to enhance resilience in human development are discussed...
  21. pmc A novel form of oxytocin in New World monkeys
    Alex G Lee
    Department of Psychiatry and Behavioral Sciences, Stanford University, 1201 Welch Road, Palo Alto, CA 94305, USA
    Biol Lett 7:584-7. 2011
    ..These findings dispel the notion that all placental mammals possess a 'universal' oxytocin sequence, and highlight the need for research on the functional significance of this novel nonapeptide in New World monkeys...
  22. pmc Oxytocin receptor gene polymorphism (rs2254298) interacts with familial risk for psychopathology to predict symptoms of depression and anxiety in adolescent girls
    Renee J Thompson
    Department of Psychology, Stanford University, Stanford, CA, USA
    Psychoneuroendocrinology 36:144-7. 2011
    ..These findings highlight the potential importance of this OXTR gene polymorphism in the etiology of depression and anxiety disorders...
  23. pmc For better or worse? Stress inoculation effects for implicit but not explicit anxiety
    Michael D Edge
    Department of Psychology, Stanford University, Stanford, CA 94305, USA
    Depress Anxiety 26:831-7. 2009
    ..low) ELS is associated with greater self-reported anxiety. This study tested the hypothesis that stress inoculation effects are evident for implicit (nonconscious) but not explicit (conscious) aspects of anxiety...
  24. doi request reprint Neonatal CSF oxytocin levels are associated with parent report of infant soothability and sociability
    Catherine L Clark
    Department of Pediatrics, Division of Neonatal and Developmental Medicine, Stanford University School of Medicine, Stanford, CA 94305 5485, United States
    Psychoneuroendocrinology 38:1208-12. 2013
    ..This is the first study to link CSF OT levels to normative human social functioning. Research is now required to test whether early OT levels serve as a biomarker for subsequent social abnormalities...

Research Grants1

  1. Maternal Availability and Postnatal Brain Development
    Karen Parker; Fiscal Year: 2005
    ..This animal model provides valuable insights on a basic process in human development, insofar as early emotional challenges foster adaptations useful later in life. ..