Research Topics
Genomes and GenesSpecies | Karen J ParkerSummaryAffiliation: Stanford University Country: USA Publications
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Detail Information
Publications
Interaction of photoperiod and testes development is associated with paternal care in Microtus pennsylvanicus (meadow voles)Karen J Parker
Department of Psychology and The Reproductive Sciences Program, University of Michigan, 525 East University Avenue, Ann Arbor, MI 48109 1109, USA
Physiol Behav 75:91-5. 2002..Collectively, these data suggest that photoperiod and fertility status may interact to exert both inhibitory and permissive control over the expression of paternal behavior in adult meadow voles...
Preliminary evidence that plasma oxytocin levels are elevated in major depressionKaren J Parker
Department of Psychiatry and Behavioral Sciences, School of Medicine, Stanford University, Stanford, CA 94305, USA
Psychiatry Res 178:359-62. 2010..Additional research is required to elucidate the role of OT in the pathophysiology of this psychiatric disorder...
Effects of age on cerebrospinal fluid oxytocin levels in free-ranging adult female and infant rhesus macaquesKaren J Parker
Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305 5485, USA
Behav Neurosci 124:428-33. 2010..Research is now required to examine CSF oxytocin levels in the context of social functioning in free-ranging rhesus monkeys...- Early life stress and novelty seeking behavior in adolescent monkeysKaren J Parker
Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 1201 Welch Road, MSLS Room P104, Mail Code 5485, Stanford, CA 94305 5485, USA
Psychoneuroendocrinology 32:785-92. 2007..These trait-like differences in novelty seeking appear to reflect mild early stress-induced adaptations that enhance curiosity and resilience... - Identifying key features of early stressful experiences that produce stress vulnerability and resilience in primatesKaren J Parker
Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 1201 Welch Road MSLS P 104, Stanford, CA 94305 5485, USA
Neurosci Biobehav Rev 35:1466-83. 2011..This article concludes by identifying gaps in our current knowledge, providing directions for future research, and discussing the translational implications of these primate models for human development and psychopathology... - Maternal mediation, stress inoculation, and the development of neuroendocrine stress resistance in primatesKaren J Parker
Department of Psychiatry and Behavioral Sciences, Stanford University, 1201 Welch Road, MSLS P104, Stanford, CA 94305 5485, USA
Proc Natl Acad Sci U S A 103:3000-5. 2006..Results from both experiments demonstrate that stress inoculation, rather than high levels of maternal care, promotes the development of primate stress resistance... - Intranasal oxytocin administration attenuates the ACTH stress response in monkeysKaren J Parker
Department of Psychiatry and Behavioral Sciences, Stanford University Medical School, CA 94305 5485, USA
Psychoneuroendocrinology 30:924-9. 2005..This primate model offers critical opportunities to improve our understanding of the anti-stress effects of OT and may lead to novel pharmacological treatments for stress-related psychiatric disorders... - Mild early life stress enhances prefrontal-dependent response inhibition in monkeysKaren J Parker
Department of Psychiatry and Behavioral Sciences, Stanford University Medical School, Stanford, California 94305 5485, USA
Biol Psychiatry 57:848-55. 2005..e., stress inoculation) strengthens emotional and neuroendocrine resistance to subsequent stressors. Herein we extend this research to examine the effects of mild early life stress on cognition... - Prospective investigation of stress inoculation in young monkeysKaren J Parker
Department of Psychiatry and Behavioral Sciences, Stanford University Medical School, Stanford, Calif 94305 5485, USA
Arch Gen Psychiatry 61:933-41. 2004..Retrospective studies in humans have identified characteristics that promote stress resistance, including childhood exposure to moderately stressful events (ie, stress inoculation)... - Female meadow voles (Microtus pennsylvanicus) demonstrate same-sex partner preferencesKaren J Parker
Department of Psychology and Reproductive Sciences Program, University of Michigan, MI, USA
J Comp Psychol 117:283-9. 2003..Data support the hypothesis that captive meadow voles develop selective and enduring same-sex social bonds that may, under free-living conditions, facilitate communal nesting and cooperative rearing of young... - Somatic and neuroendocrine responses to standard and biologically salient acoustic startle stimuli in monkeysKaren J Parker
Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, USA
Psychoneuroendocrinology 36:547-56. 2011..The development of monkey startle methodology may further enhance the utility of this paradigm in translational studies of human stress-related psychiatric disorders... - Neuroendocrine aspects of hypercortisolism in major depressionKaren J Parker
Department of Psychiatry and Behavioral Sciences, Stanford University Medical School, 1201 Welch Road, MSLS Room P104, Mail Code 5485, Stanford, CA 94305 5485, USA
Horm Behav 43:60-6. 2003..In considering the evidence for hypercortisolism in humans, studies of nonhuman primates are presented and their utility and limitations as comparative models of human depression are discussed... - Animal models of early life stress: Implications for understanding resilienceDavid M Lyons
Department of Psychiatry and Behavioral Sciences, Stanford University, 1201 Welch Rd, MSLS P104, Stanford, CA 94305, USA
Dev Psychobiol 52:402-10. 2010..Implications for programs designed to enhance resilience in human development are discussed... - Preliminary evidence that hippocampal volumes in monkeys predict stress levels of adrenocorticotropic hormoneDavid M Lyons
Department of Psychiatry and Behavioral Sciences, Stanford University Medical Center, Stanford, California 94305 5485, USA
Biol Psychiatry 62:1171-4. 2007..Hippocampal volumes previously determined in monkeys by magnetic resonance imaging are used to test the hypothesis that small hippocampi predict increased stress levels of adrenocorticotropic hormone (ACTH)... - Stress inoculation-induced indications of resilience in monkeysDavid M Lyons
Department of Psychiatry and Behavioral Sciences, Stanford University Medical Center, Stanford, CA 94305 5485, USA
J Trauma Stress 20:423-33. 2007.... - Social stress-related behavior affects hippocampal cell proliferation in miceRupshi Mitra
Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305 5020, USA
Physiol Behav 89:123-7. 2006.... - Circadian and homeostatic regulation of hypocretin in a primate model: implications for the consolidation of wakefulnessJamie M Zeitzer
Department of Psychiatry and Behavioral Sciences, Stanford University, Palo Alto, California 94304, USA
J Neurosci 23:3555-60. 2003..In the squirrel monkey, hypocretin-1 works in opposition to the accumulating sleep drive during the day to maintain a constant level of wake... - Prefrontal plasticity and stress inoculation-induced resilienceMaor Katz
Department of Psychiatry, Stanford University, Stanford, Calif, USA
Dev Neurosci 31:293-9. 2009..These findings suggest that the process of coping with early life stress increases prefrontal myelination and expands a region of cortex that broadly controls arousal regulation and resilience... - Effects of intranasal oxytocin on social anxiety in males with fragile X syndromeScott S Hall
Center for Interdisciplinary Brain Sciences Research, Department of Psychiatry and Behavioral Sciences, Stanford University, 401 Quarry Road, Stanford, CA 94305 5795, USA
Psychoneuroendocrinology 37:509-18. 2012..Further double-blind placebo-controlled studies of OT, conducted in combination with behavioral treatment programs, may be warranted... - Animal models of early life stress: implications for understanding resilienceDavid M Lyons
Department of Psychiatry and Behavioral Sciences, Stanford University, CA 94305, USA
Dev Psychobiol 52:616-24. 2010..Implications for programs designed to enhance resilience in human development are discussed... - A novel form of oxytocin in New World monkeysAlex G Lee
Department of Psychiatry and Behavioral Sciences, Stanford University, 1201 Welch Road, Palo Alto, CA 94305, USA
Biol Lett 7:584-7. 2011..These findings dispel the notion that all placental mammals possess a 'universal' oxytocin sequence, and highlight the need for research on the functional significance of this novel nonapeptide in New World monkeys... - Oxytocin receptor gene polymorphism (rs2254298) interacts with familial risk for psychopathology to predict symptoms of depression and anxiety in adolescent girlsRenee J Thompson
Department of Psychology, Stanford University, Stanford, CA, USA
Psychoneuroendocrinology 36:144-7. 2011..These findings highlight the potential importance of this OXTR gene polymorphism in the etiology of depression and anxiety disorders... - For better or worse? Stress inoculation effects for implicit but not explicit anxietyMichael D Edge
Department of Psychology, Stanford University, Stanford, CA 94305, USA
Depress Anxiety 26:831-7. 2009..low) ELS is associated with greater self-reported anxiety. This study tested the hypothesis that stress inoculation effects are evident for implicit (nonconscious) but not explicit (conscious) aspects of anxiety...
Research Grants
- Maternal Availability and Postnatal Brain DevelopmentKaren Parker; Fiscal Year: 2005..This animal model provides valuable insights on a basic process in human development, insofar as early emotional challenges foster adaptations useful later in life. ..