PETER R PARHAM

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. ncbi request reprint NK cell receptors of the orangutan (Pongo pygmaeus): a pivotal species for tracking the coevolution of killer cell Ig-like receptors with MHC-C
    Lisbeth A Guethlein
    Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305 5126, USA
    J Immunol 169:220-9. 2002
  2. ncbi request reprint Alloreactive killer cells: hindrance and help for haematopoietic transplants
    Peter Parham
    Department of Structural Biology, Stanford University, Stanford, California 94305, USA
    Nat Rev Immunol 3:108-22. 2003
  3. pmc Human-specific evolution and adaptation led to major qualitative differences in the variable receptors of human and chimpanzee natural killer cells
    Laurent Abi-Rached
    Department of Structural Biology, Stanford University School of Medicine, Stanford, California, United States of America
    PLoS Genet 6:e1001192. 2010
  4. doi request reprint Variable NK cell receptors and their MHC class I ligands in immunity, reproduction and human evolution
    Peter Parham
    Department of Structural Biology, Stanford University, Stanford, California 94305, USA
    Nat Rev Immunol 13:133-44. 2013
  5. pmc Human-specific evolution of killer cell immunoglobulin-like receptor recognition of major histocompatibility complex class I molecules
    Peter Parham
    Department of Structural Biology, Stanford University, Stanford, CA 94305, USA
    Philos Trans R Soc Lond B Biol Sci 367:800-11. 2012
  6. pmc Review: Immunogenetics of human placentation
    P Parham
    Department of Structural Biology, Stanford University School of Medicine, Stanford, CA, USA
    Placenta 33:S71-80. 2012
  7. pmc Characterization of killer immunoglobulin-like receptor genetics and comprehensive genotyping by pyrosequencing in rhesus macaques
    Anna J Moreland
    Department of Pathology and Laboratory Medicine, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    BMC Genomics 12:295. 2011
  8. ncbi request reprint Killer cell immunoglobulin-like receptor diversity: balancing signals in the natural killer cell response
    Peter Parham
    Department of Structural Biology, Stanford University School of Medicine, Stanford, CA, USA
    Immunol Lett 92:11-3. 2004
  9. pmc Primate-specific regulation of natural killer cells
    Peter Parham
    Department of Structural Biology, Stanford University School of Medicine, Stanford, CA, USA
    J Med Primatol 39:194-212. 2010
  10. ncbi request reprint Immunogenetics of killer cell immunoglobulin-like receptors
    Peter Parham
    Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305 5126, USA
    Mol Immunol 42:459-62. 2005

Collaborators

Detail Information

Publications60

  1. ncbi request reprint NK cell receptors of the orangutan (Pongo pygmaeus): a pivotal species for tracking the coevolution of killer cell Ig-like receptors with MHC-C
    Lisbeth A Guethlein
    Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305 5126, USA
    J Immunol 169:220-9. 2002
    ..The Popy-KIR2D include ones predicted to be specific for the C1 epitope of MHC-C, but none specific for C2. This correlates with the observation that all orangutan MHC-C allotypes examined have the C1 motif...
  2. ncbi request reprint Alloreactive killer cells: hindrance and help for haematopoietic transplants
    Peter Parham
    Department of Structural Biology, Stanford University, Stanford, California 94305, USA
    Nat Rev Immunol 3:108-22. 2003
    ..The alloreactions seem to be determined by the mismatched HLA class I ligands and their killer-cell immunoglobulin-like receptors...
  3. pmc Human-specific evolution and adaptation led to major qualitative differences in the variable receptors of human and chimpanzee natural killer cells
    Laurent Abi-Rached
    Department of Structural Biology, Stanford University School of Medicine, Stanford, California, United States of America
    PLoS Genet 6:e1001192. 2010
    ....
  4. doi request reprint Variable NK cell receptors and their MHC class I ligands in immunity, reproduction and human evolution
    Peter Parham
    Department of Structural Biology, Stanford University, Stanford, California 94305, USA
    Nat Rev Immunol 13:133-44. 2013
    ..We suggest that this compromise facilitated the development of the bigger brains that enabled archaic and modern humans to migrate out of Africa and populate other continents...
  5. pmc Human-specific evolution of killer cell immunoglobulin-like receptor recognition of major histocompatibility complex class I molecules
    Peter Parham
    Department of Structural Biology, Stanford University, Stanford, CA 94305, USA
    Philos Trans R Soc Lond B Biol Sci 367:800-11. 2012
    ..Correlating with their balance in human populations, B haplotypes favour reproductive success, whereas A haplotypes favour successful immune defence. Evolution of the B KIR haplotypes is thus unique to the human species...
  6. pmc Review: Immunogenetics of human placentation
    P Parham
    Department of Structural Biology, Stanford University School of Medicine, Stanford, CA, USA
    Placenta 33:S71-80. 2012
    ....
  7. pmc Characterization of killer immunoglobulin-like receptor genetics and comprehensive genotyping by pyrosequencing in rhesus macaques
    Anna J Moreland
    Department of Pathology and Laboratory Medicine, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    BMC Genomics 12:295. 2011
    ..Rhesus macaques serve as important animal models for many human diseases in which KIRs are implicated; however, the study of KIR activity in this model is hindered by incomplete characterization of KIR genetics...
  8. ncbi request reprint Killer cell immunoglobulin-like receptor diversity: balancing signals in the natural killer cell response
    Peter Parham
    Department of Structural Biology, Stanford University School of Medicine, Stanford, CA, USA
    Immunol Lett 92:11-3. 2004
    ..Such characteristics suggest that novel KIR variants provide competitive advantages in primate survival or reproduction, which are of short duration on the evolutionary time-scale...
  9. pmc Primate-specific regulation of natural killer cells
    Peter Parham
    Department of Structural Biology, Stanford University School of Medicine, Stanford, CA, USA
    J Med Primatol 39:194-212. 2010
    ....
  10. ncbi request reprint Immunogenetics of killer cell immunoglobulin-like receptors
    Peter Parham
    Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305 5126, USA
    Mol Immunol 42:459-62. 2005
    ..Consistent with this model are the results of several studies associating KIR differences with disease susceptibility, immune responsiveness and events following allogeneic transplantation...
  11. pmc NK cells and trophoblasts: partners in pregnancy
    Peter Parham
    Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305 5126, USA
    J Exp Med 200:951-5. 2004
    ..Recent research reveals that this process and human reproductive success are influenced by polymorphic HLA-C ligands and their killer cell immunoglobulin-like receptors (KIR)...
  12. ncbi request reprint Immunology. NK cells lose their inhibition
    Peter Parham
    Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Science 305:786-7. 2004
  13. ncbi request reprint Putting a face to MHC restriction
    Peter Parham
    Department of Structural Biology, Sherman Fairchild Building, 299 Campus Drive West, Stanford University School of Medicine, Stanford, CA 94305 5126, USA
    J Immunol 174:3-5. 2005
  14. pmc Pregnancy immunogenetics: NK cell education in the womb?
    Peter Parham
    Department of Structural Biology, Stanford University, Stanford, California, USA
    J Clin Invest 120:3801-4. 2010
    ..Equally important, they show that mothers with an activating receptor of similar specificity to the inhibitory receptor are less likely to suffer disordered pregnancy...
  15. ncbi request reprint MHC class I molecules and KIRs in human history, health and survival
    Peter Parham
    Departments of Structural Biology, and Microbiology and Immunology, Stanford University, Stanford, CA 94305, USA
    Nat Rev Immunol 5:201-14. 2005
    ..Such correlations raise the possibility that interplay between KIR and MHC class I polymorphisms has facilitated human survival in the presence of epidemic infections and has influenced both reproduction and population growth...
  16. pmc The genetic and evolutionary balances in human NK cell receptor diversity
    Peter Parham
    Department of Structural Biology, Stanford University School of Medicine, 299 Campus Drive West, Stanford, CA 94305, USA
    Semin Immunol 20:311-6. 2008
    ..Conserved and variable NK cell receptors produce structurally diverse NK cell receptor repertoires within a defined range of missing-self-response...
  17. pmc Donor-recipient combinations of group A and B KIR haplotypes and HLA class I ligand affect the outcome of HLA-matched, sibling donor hematopoietic cell transplantation
    Karina L McQueen
    Department of Structural Biology, Stanford University School of Medicine, Stanford, CA, USA
    Hum Immunol 68:309-23. 2007
    ..Analysis of the KIR genes individually revealed KIR2DS3 as a protective factor for chronic GVHD. The results suggest how simple assessments of KIR genotype might inform the selection of donors for hematopoietic cell transplantation...
  18. ncbi request reprint Genetic control of human NK cell repertoire
    Heather G Shilling
    Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305 5126, USA
    J Immunol 169:239-47. 2002
    ..Human NK cell repertoires are defined by combinations of variable KIR and HLA class I genes and conserved CD94:NKG2 genes...
  19. ncbi request reprint KIR3DL1 polymorphisms that affect NK cell inhibition by HLA-Bw4 ligand
    William Henry Carr
    Department of Structural Biology, Stanford University, Stanford, CA 94305 5126, USA
    J Immunol 175:5222-9. 2005
    ..Neither position 238 nor 320 is predicted to interact directly with HLA-Bw4 ligand. This study also revealed that KIR3DL1 and LILRB1 both contribute to developing an inhibitory response to HLA-Bw4 ligands...
  20. ncbi request reprint Conservation and variation in human and common chimpanzee CD94 and NKG2 genes
    Benny P Shum
    Department of Structural Biology, Stanford University School of Medicine, 299 Campus Drive West, Stanford, CA 94305, USA
    J Immunol 168:240-52. 2002
    ..Each species gave distinctive typing patterns, with NKG2A and CD94 being most conserved. Seven different NK complex genotypes within the panel of 48 common chimpanzees were due to differences in Pt-NKG2C and Pt-NKG2D genes...
  21. ncbi request reprint Allelic polymorphism synergizes with variable gene content to individualize human KIR genotype
    Heather G Shilling
    Department of Structural Biology and Microbiology, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Immunol 168:2307-15. 2002
    ..This level of diversity likely reflects strong pressure from pathogens on the human NK cell response...
  22. pmc KIR2DS4 is a product of gene conversion with KIR3DL2 that introduced specificity for HLA-A*11 while diminishing avidity for HLA-C
    Thorsten Graef
    Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Exp Med 206:2557-72. 2009
    ..Correlation between the worldwide distributions of functional KIR2DS4 and HLA-A*11 points to the physiological importance of their mutual interaction...
  23. ncbi request reprint Synergistic polymorphism at two positions distal to the ligand-binding site makes KIR2DL2 a stronger receptor for HLA-C than KIR2DL3
    Achim K Moesta
    Department of Structural Biology, School of Medicine, Stanford University, Stanford, CA 94305, USA
    J Immunol 180:3969-79. 2008
    ..This study demonstrates how allelic polymorphism at sites distal to the ligand-binding site of KIR2DL2/3 has diversified this receptor's interactions with HLA-C...
  24. pmc Dimorphic motifs in D0 and D1+D2 domains of killer cell Ig-like receptor 3DL1 combine to form receptors with high, moderate, and no avidity for the complex of a peptide derived from HIV and HLA-A*2402
    Deepti Sharma
    Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Immunol 183:4569-82. 2009
    ..A24nef was not bound by KIR3DS1, the activating counterpart of KIR3DL1. Moreover, introducing any one of three residues specific to KIR3DS1, serine 163, arginine 166, or leucine 199, into 3DL1*015, abrogated A24nef binding...
  25. ncbi request reprint Predominance of group A KIR haplotypes in Japanese associated with diverse NK cell repertoires of KIR expression
    Makoto Yawata
    Department of Structural Biology, Stanford University, School of Medicine, 299 Campus Drive West, Sherman Fairchild Building, Stanford, CA 94305 5126, USA
    Immunogenetics 54:543-50. 2002
    ..This diversity is likely due to allelic polymorphism in expressed genes of the A haplotype. In comparison to other populations, the Japanese appear less heterogeneous in KIR genotype as assessed by gene content...
  26. ncbi request reprint Reconstitution of NK cell receptor repertoire following HLA-matched hematopoietic cell transplantation
    Heather G Shilling
    Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Blood 101:3730-40. 2003
    ..These results demonstrate that a majority of HLA-matched hematopoietic cell transplantations involve KIR mismatch and reveal differences in NK cell repertoire having potential impact for immune responsiveness and transplantation outcome...
  27. pmc Co-evolution of KIR2DL3 with HLA-C in a human population retaining minimal essential diversity of KIR and HLA class I ligands
    Ketevan Gendzekhadze
    Department of Structural Biology and Microbiology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 106:18692-7. 2009
    ..That it contains all functional elements of KIR diversity worldwide, attests to the competitive advantage it provides, not only for surviving epidemic infections, but also for rebuilding populations once infection has passed...
  28. ncbi request reprint Single-cell analysis of the human NK cell response to missing self and its inhibition by HLA class I
    Monia Draghi
    Department of Structural Biology, Sherman Fairchild Building, 299 Campus Dr West, Stanford University School of Medicine, Stanford, CA 94305 5126, USA
    Blood 105:2028-35. 2005
    ..The single-cell assays developed here should facilitate future population study and clinical analysis of human NK cell regulation by MHC class I...
  29. pmc Natural selection drives recurrent formation of activating killer cell immunoglobulin-like receptor and Ly49 from inhibitory homologues
    Laurent Abi-Rached
    Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Exp Med 201:1319-32. 2005
    ....
  30. ncbi request reprint Episodes of natural selection shaped the interactions of IgA-Fc with FcalphaRI and bacterial decoy proteins
    Laurent Abi-Rached
    Department of Structural Biology and Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Immunol 178:7943-54. 2007
    ..A cluster of positively selected residues presents a putative binding site for unknown IgA-binding factors...
  31. ncbi request reprint The protein made from a common allele of KIR3DL1 (3DL1*004) is poorly expressed at cell surfaces due to substitution at positions 86 in Ig domain 0 and 182 in Ig domain 1
    Marcelo J Pando
    Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305 5126, USA
    J Immunol 171:6640-9. 2003
    ..This study demonstrates how a difference between KIR3DL1 allotypes in the D0 domain profoundly affects cell surface expression and function...
  32. ncbi request reprint Domain shuffling has been the main mechanism forming new hominoid killer cell Ig-like receptors
    Raja Rajalingam
    Department of Structural Biology, Stanford University, 299 Campus Drive West, Stanford, CA 94305, USA
    J Immunol 172:356-69. 2004
    ..Other KIR genes represent recombinant forms present in a minority of species, often only one, as exemplified by 8 of the 11 gorilla KIR genes...
  33. ncbi request reprint Evolution of killer cell Ig-like receptor (KIR) genes: definition of an orangutan KIR haplotype reveals expansion of lineage III KIR associated with the emergence of MHC-C
    Lisbeth A Guethlein
    Department of Structural Biology, and Department of Microbiology and Immunology, School of Medicine, Stanford University, 299 Campus Drive West, Stanford, CA 94305
    J Immunol 179:491-504. 2007
    ..Thus, expansion of lineage III KIR is associated with emergence of MHC-C...
  34. ncbi request reprint Unusual selection on the KIR3DL1/S1 natural killer cell receptor in Africans
    Paul J Norman
    Department of Structural Biology, Stanford University School of Medicine, Stanford, California 94305, USA
    Nat Genet 39:1092-9. 2007
    ..Natural killer cells express the dominant KIR3DL1 at a high frequency and with high surface density, providing strong responses to cells perturbed in Bw4 expression...
  35. pmc MHC class I-specific inhibitory receptors and their ligands structure diverse human NK-cell repertoires toward a balance of missing self-response
    Makoto Yawata
    Department of Structural Biology, Stanford University School of Medicine, CA 94305 5126, USA
    Blood 112:2369-80. 2008
    ..The analyses provide new perspective on how personalized human NK-cell repertoires are structured...
  36. pmc Polymorphic sites away from the Bw4 epitope that affect interaction of Bw4+ HLA-B with KIR3DL1
    Bharati Sanjanwala
    Department of Structural Biology, Stanford University, Stanford, CA 94305, USA
    J Immunol 181:6293-300. 2008
    ..This influence is likely mediated by changes in the peptides bound, which alter the conformation of the Bw4 epitope...
  37. pmc Meiotic recombination generates rich diversity in NK cell receptor genes, alleles, and haplotypes
    Paul J Norman
    Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Genome Res 19:757-69. 2009
    ..A consequence of such recombination is to blur the distinction between alleles and loci in the rapidly evolving human KIR gene family...
  38. pmc T cell-dependent production of IFN-gamma by NK cells in response to influenza A virus
    Xiao Song He
    Department of Medicine, Stanford University of School of Medicine, Stanford, California, USA
    J Clin Invest 114:1812-9. 2004
    ..Taken together, these results suggest that at an early stage of recurrent viral infection, NK-mediated innate immunity to the virus is enhanced by preexisting virus-specific T cells...
  39. ncbi request reprint The expanded cattle KIR genes are orthologous to the conserved single-copy KIR3DX1 gene of primates
    Lisbeth A Guethlein
    Department of Structural Biology, Fairchild D 159, 299 Campus Drive West, Stanford, CA 94305, USA
    Immunogenetics 59:517-22. 2007
    ....
  40. ncbi request reprint Distinctive KIR and HLA diversity in a panel of north Indian Hindus
    Raja Rajalingam
    Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305 5126, USA
    Immunogenetics 53:1009-19. 2002
    ..All 72 members of the north Indian panel have different HLA genotype and different KIR genotype...
  41. ncbi request reprint Variation within the human killer cell immunoglobulin-like receptor (KIR) gene family
    Makoto Yawata
    Stanford University, School of Medicine, Department of Structural Biology, 299 Campus Drive West, Stanford, CA 94305 5126, USA
    Crit Rev Immunol 22:463-82. 2002
    ....
  42. ncbi request reprint Stress management: MHC class I and class I-like molecules as reporters of cellular stress
    Michael Gleimer
    Program in Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Immunity 19:469-77. 2003
    ..Cellular immunity employs these indicators as a cue for elimination of damaged, infected, and malignant cells, promoting the health of the individual and the evolutionary success of the species...
  43. ncbi request reprint Complex interactions: the immunogenetics of human leukocyte antigen and killer cell immunoglobulin-like receptors
    Paul J Norman
    Departments of Structural Biology and Microbiology, Stanford University School of Medicine, 299 Campus Drive West, Stanford, CA 94305, USA
    Semin Hematol 42:65-75. 2005
    ..The functional variety of natural immune responses that are controlled by HLA and KIR interactions is genetically determined and maintained by natural selection...
  44. ncbi request reprint Influence of KIR diversity on human immunity
    Peter Parham
    Department of Structural Biology, Stanford University, Stanford, California, CA 994305, USA
    Adv Exp Med Biol 560:47-50. 2005
  45. ncbi request reprint Variable receptors controlling activation and inhibition of NK cells
    Karina L McQueen
    Department of Structural Biology, Stanford University, Fairchild Building D 157, 299 Campus Drive West, Stanford, CA 94305 5126, USA
    Curr Opin Immunol 14:615-21. 2002
    ..All known ligands for these diverse receptors are MHC class I molecules, or molecules of host or pathogen origin that are homologous to MHC class I...
  46. pmc Roles for HLA and KIR polymorphisms in natural killer cell repertoire selection and modulation of effector function
    Makoto Yawata
    Department of Structural Biology, School of Medicine, Stanford University, Stanford, CA 94305, USA, and Department of Haematology, The Royal Free Hospital, London, UK
    J Exp Med 203:633-45. 2006
    ..These findings show how KIR-HLA interactions shape the genetic and phenotypic KIR repertoires for both individual humans and the population...
  47. ncbi request reprint NKp46 and NKG2D recognition of infected dendritic cells is necessary for NK cell activation in the human response to influenza infection
    Monia Draghi
    Department of Structural Biology, 299 Campus Drive West, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Immunol 178:2688-98. 2007
    ..Poly(I:C)-treated DCs did not express the UL16-binding protein 3 ligand for NKG2D, and in the absence of the influenza hemagglutinin there was no involvement of NKp46...
  48. ncbi request reprint Taking license with natural killer cell maturation and repertoire development
    Peter Parham
    Department of Structural Biology, Stanford University, Stanford CA 94305, USA
    Immunol Rev 214:155-60. 2006
    ....
  49. pmc Evolution and survival of marine carnivores did not require a diversity of killer cell Ig-like receptors or Ly49 NK cell receptors
    John A Hammond
    Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Immunol 182:3618-27. 2009
    ..These results demonstrate that long-term survival of placental mammal species need not require a diverse system of either Ly49 or KIR NK cell receptors...
  50. ncbi request reprint Linkage of Patr-AL to Patr-A and- B in the major histocompatibility complex of the common chimpanzee (Pan troglodytes)
    Ron Geller
    Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305 5126, USA
    Immunogenetics 54:212-5. 2002
    ..The results demonstrate that Patr-AL is an MHC class I gene present on different MHC haplotypes as defined by their combination of Patr-A and B alleles...
  51. pmc The D0 domain of KIR3D acts as a major histocompatibility complex class I binding enhancer
    Salim I Khakoo
    Department of Structural Biology, Stanford University School of Medicine, CA 94305, USA
    J Exp Med 196:911-21. 2002
    ..This modulatory role for D0 is compatible with natural loss of expression of the D0 domain, a repeated event in the evolution of functional KIR genes...
  52. ncbi request reprint NK cell-mediated lysis of autologous HCMV-infected skin fibroblasts is highly variable among NK cell clones and polyclonal NK cell lines
    William H Carr
    Department of Structural Biology, Stanford University, California 94305 5126, USA
    Clin Immunol 105:126-40. 2002
    ..These results demonstrate that NK cell lysis of HCMV-infected autologous fibroblasts is more complex than a simple missing-self mechanism involving downregulation of HLA class I and failure to engage inhibitory self-specific KIR...
  53. pmc Chimpanzees use more varied receptors and ligands than humans for inhibitory killer cell Ig-like receptor recognition of the MHC-C1 and MHC-C2 epitopes
    Achim K Moesta
    Department of Structural Biology, and Department of Microbiology and Immunology, School of Medicine, Stanford University, Stanford, CA 94305
    J Immunol 182:3628-37. 2009
    ..Whereas human HLA-B allotypes that have functional C1 epitopes are either rare (HLA-B*73) or geographically localized (HLA-B*46), some 25% of Patr-B allotypes have the C1 epitope and are functional KIR ligands...
  54. ncbi request reprint Innate immunity: The unsung heroes
    Peter Parham
    Stanford University School of Medicine, 300 Pasteur Drive, Stanford, California 94305, USA
    Nature 423:20. 2003
  55. ncbi request reprint The beta 2-microglobulin locus of rainbow trout (Oncorhynchus mykiss) contains three polymorphic genes
    Katharine E Magor
    Department of Structural Biology, Stanford University, Stanford, CA 94305, USA
    J Immunol 172:3635-43. 2004
    ..Additional diversity in the trout beta2m genes appears to be due to somatic mutation that might be facilitated by the abundance of repetitive DNA elements within the 12 beta2m genes of an individual rainbow trout...
  56. pmc A small, variable, and irregular killer cell Ig-like receptor locus accompanies the absence of MHC-C and MHC-G in gibbons
    Laurent Abi-Rached
    Department of Structural Biology, Stanford University, Stanford, CA 94305, USA
    J Immunol 184:1379-91. 2010
    ..Our results indicate that the selective forces shaping the size and organization of the gibbon KIR locus differed from those acting upon the KIR of other hominoid species...
  57. ncbi request reprint High KIR diversity in Amerindians is maintained using few gene-content haplotypes
    Ketevan Gendzekhadze
    Department of Structural Biology, Stanford University School of Medicine, Sherman Fairchild Building, Stanford, CA, USA
    Immunogenetics 58:474-80. 2006
    ..Here is clear evidence for balancing selection on the KIR system and the biological importance of both A and B haplotypes for the survival of human populations...
  58. ncbi request reprint Structures of two major histocompatibility complex class I genes of the rainbow trout (Oncorhynchus mykiss)
    Benny P Shum
    Department of Structural Biology, Sherman Fairchild Building, Stanford University School of Medicine, Stanford, CA 94305 5126, USA
    Immunogenetics 54:193-9. 2002
    ..Clone GC41 also contains the 3' exons of the LMP7/ PSMB8 gene encoding the gamma-interferon-induced proteosome subunit of rainbow trout...
  59. pmc Humans differ from other hominids in lacking an activating NK cell receptor that recognizes the C1 epitope of MHC class I
    Achim K Moesta
    Department of Structural Biology, School of Medicine, Stanford University, Stanford, CA 94305, USA
    J Immunol 185:4233-7. 2010
    ..Supporting such elimination of activating C1-specific receptors as a uniquely human phenomenon is the presence of a high-avidity activating C1-specific receptor (Gg-KIR2DSa) in gorilla...
  60. pmc Coevolution of killer cell Ig-like receptors with HLA-C to become the major variable regulators of human NK cells
    Anastazia M Older Aguilar
    Immunology Program, School of Medicine, Stanford University, Stanford, CA 94305, USA
    J Immunol 185:4238-51. 2010
    ..This restriction frees most HLA-A and HLA-B variants to be dedicated TCR ligands, not subject to conflicting pressures from the NK cell and T cell arms of the immune response...

Research Grants65

  1. Human Population Diversity in Leukocyte Receptors
    PETER R PARHAM; Fiscal Year: 2010
    ..This project will determine the variability of these genes in the human population and how these differences affect their function. ..
  2. Origins of Diversity at Human Classical MHC Class I Genes
    PETER R PARHAM; Fiscal Year: 2010
    ..By studying these rapidly evolving immune system components in closely related species of non-human primate we will gain new insight and greater understanding of the human system and its contribution to human health and survival. ..
  3. EVOLUTION, SELECTION & ORIGINS OF CLASS I MHC MOLECULES
    Peter Parham; Fiscal Year: 2001
    ..The results to be obtained from these specific aims will provide new insights into different evolutionary pathways used by vertebrate populations to develop diversity in antigen presentation by MHC class I molecules. ..
  4. INTERACTIONS BETWEEN HLA CLASS I & CYTOLYTIC LYMPHOCYTES
    Peter Parham; Fiscal Year: 2000
    ....
  5. INTERACTIONS BETWEEN HLA CLASS I & CYTOLYTIC LYMPHOCYTES
    PETER R PARHAM; Fiscal Year: 2010
    ..The results will explain outstanding discrepancy and controversy in the literature and provide new illumination on the association of KIR and HLA factors in HIV disease. ..
  6. HUMAN DIVERSITY IN KILLER CELL INHIBITORY RECEPTOR GENES
    Peter Parham; Fiscal Year: 2007
    ..The approach will be piloted in the relatively simple Japanese KIR system and then extended to the more complex and highly mixed population of the US. ..
  7. NK Cell Receptor Evolution During Mammalian Radiation
    Peter Parham; Fiscal Year: 2006
    ..abstract_text> ..
  8. INTERACTIONS BETWEEN HLA CLASS I & CYTOLYTIC LYMPHOCYTES
    Peter Parham; Fiscal Year: 2006
    ..This research will provide fundamental knowledge essential for future assessment of the role and importance of NK-cell receptor variation in human disease susceptibility and clinical transplantation. ..
  9. EVOLUTION, SELECTION AND ORIGINS OF CLASS I MHC MOLECULE
    Peter Parham; Fiscal Year: 1993
    ..This information will enable strategies for the examination of invertebrate species for class I genes to be designed...
  10. MHC Class I and KIR Gene Evolution in Higher Primates
    Peter Parham; Fiscal Year: 2006
    ..This will test the hypothesis that orangutan is a species in which the HLA-C-mediated regulation of NK cells, which is dominant in humans, is at an intermediate stage of development. ..
  11. INTERACTIONS BETWEEN HLA-A, B & ANTIGEN RECEPTORS OF CTL
    Peter Parham; Fiscal Year: 1993
    ..This knowledge may contribute to the design of antigen- specific therapeutic intervention in transplant rejection and autoimmune diseases...
  12. THE NATURE AND FUNCTION OF HLA-A,B,C POLYMORPHISM
    Peter Parham; Fiscal Year: 1993
    ..It will also lay the foundation for absolute definition of class I HLA type, thereby facilitating development of accurate typing and more incisive analysis of human immunology, human genetics and of tissue match in transplantation...
  13. NATURE OF HLA-A, B, C POLYMORPHISM
    Peter Parham; Fiscal Year: 1990
    ..An exhaustive pairwise comparison of molecules will generate a set of evolutionary relationshps, reveal mutational hot spots and allow the contribution of various genetic mechanism to variability to be assessed...