Susana Ortiz Urda
Affiliation: Stanford University
- The plant lectin wheat germ agglutinin inhibits the binding of pemphigus foliaceus autoantibodies to desmoglein 1 in a majority of patients and prevents pathomechanisms of pemphigus foliaceus in vitro and in vivoSusana Ortiz-Urda
Department of Dermatology, University of Vienna, Vienna, Austria
J Immunol 171:6244-50. 2003..These findings suggest that WGA may interfere with autoantibody binding to dg1, preventing experimental PF without affecting the adhesive function of dg1. Our observations may provide a new approach to the therapy of PF...
- Stable nonviral genetic correction of inherited human skin diseaseSusana Ortiz-Urda
VA Palo Alto Healthcare System and the Program in Epithelial Biology, Stanford University School of Medicine, Stanford, California, USA
Nat Med 8:1166-70. 2002..These findings establish a practical approach to nonviral genetic correction of severe human genetic disorders requiring stable genomic integration of large DNA sequences...
- Injection of genetically engineered fibroblasts corrects regenerated human epidermolysis bullosa skin tissueSusana Ortiz-Urda
Veterans Affairs Palo Alto Healthcare System, Palo Alto, California, USA
J Clin Invest 111:251-5. 2003..This article was published online in advance of the print edition. The date of publication is available from the JCI website, http://www.jci.org...
- PhiC31 integrase-mediated nonviral genetic correction of junctional epidermolysis bullosaSusana Ortiz-Urda
VA Palo Alto Healthcare System and Program in Epithelial Biology, Stanford University School of Medicine, 269 Campus Drive, Stanford, CA 94305, USA
Hum Gene Ther 14:923-8. 2003..Furthermore, corrected JEB tissue restored hemidesmosome formation and abolished histologic evidence of subepidermal blistering. These findings provide an approach to durable nonviral correction of JEB...
- Type VII collagen is required for Ras-driven human epidermal tumorigenesisSusana Ortiz-Urda
VA Palo Alto Healthcare System, Palo Alto, CA 94304, USA
Science 307:1773-6. 2005..Tumor-stroma interactions mediated by collagen VII thus promote neoplasia, and retention of NC1 sequences in a subset of RDEB patients may contribute to their increased susceptibility to squamous cell carcinoma...