ANTHONY ORO

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. pmc Somatic correction of junctional epidermolysis bullosa by a highly recombinogenic AAV variant
    Sandra P Melo
    Program in Epithelial Biology, Stanford University, School of Medicine, Stanford, California, USA
    Mol Ther 22:725-33. 2014
  2. pmc GLI activation by atypical protein kinase C ι/λ regulates the growth of basal cell carcinomas
    Scott X Atwood
    Program in Epithelial Biology, Stanford University School of Medicine, Stanford, California 94305, USA
    Nature 494:484-8. 2013
  3. pmc Hedgehog pathway inhibition and the race against tumor evolution
    Scott X Atwood
    Program in Epithelial Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Cell Biol 199:193-7. 2012
  4. pmc I-BAR protein antagonism of endocytosis mediates directional sensing during guided cell migration
    Gabriel A Quinones
    Program in Epithelial Biology and Cancer Biology Graduate Program, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Cell Biol 189:353-67. 2010
  5. pmc Translocation affecting sonic hedgehog genes in Basal-cell carcinoma
    Natalia Gomez-Ospina
    Stanford University School of Medicine, Stanford, CA
    N Engl J Med 366:2233-4. 2012
  6. pmc The primary cilia, a 'Rab-id' transit system for hedgehog signaling
    Anthony E Oro
    Stanford University, School of Medicine, Stanford, CA 94305, USA
    Curr Opin Cell Biol 19:691-6. 2007
  7. pmc A new role for an old friend: NFAT and stem cell quiescence
    Anthony E Oro
    Program in Epithelial Biology, School of Medicine, Stanford University, CCSR 2145, 269 Campus Drive, Stanford, CA 94305, USA
    Cell Stem Cell 2:104-6. 2008
  8. pmc Laminin-511 and integrin beta-1 in hair follicle development and basal cell carcinoma formation
    Mindy C DeRouen
    Cancer Biology Graduate Program, 251 Campus Drive, MSOB X234, Stanford, CA 94305 5173, USA
    BMC Dev Biol 10:112. 2010
  9. pmc Dual degradation signals control Gli protein stability and tumor formation
    Erik G Huntzicker
    Program in Epithelial Biology, Stanford University, Stanford, California 94305, USA
    Genes Dev 20:276-81. 2006
  10. pmc In vivo imaging of human and mouse skin with a handheld dual-axis confocal fluorescence microscope
    Hyejun Ra
    James H Clark Center for Biomedical Engineering and Sciences, Department of Pediatrics, Stanford University, Stanford, California 94305, USA
    J Invest Dermatol 131:1061-6. 2011

Collaborators

  • P A Coulombe
  • Jeffrey H Miner
  • Scott X Atwood
  • Mindy C DeRouen
  • M Peter Marinkovich
  • Erik G Huntzicker
  • Hanson H Zhen
  • Jing Gao
  • Sandra P Melo
  • Natalia Gomez-Ospina
  • Anne Lynn S Chang
  • Mischa Li
  • Hyejun Ra
  • Gabriel A Quinones
  • Marina Bershteyn
  • Douglas R Keene
  • Hanson Zhen
  • Julie B Sneddon
  • Ngon T Nguyen
  • Kavita Y Sarin
  • Rosa Gonzalez-Quevedo
  • Lily Horng
  • Christopher A Callahan
  • David Beynet
  • Jie Li
  • Leszek Lisowski
  • Mark A Kay
  • Kirk Chu
  • Elizaveta Bashkirova
  • Alex Lee
  • Jean Y Tang
  • Kun Qu
  • Wibool Piyawattanametha
  • Emilio Gonzalez-Gonzalez
  • Gordon S Kino
  • Michael J Mandella
  • Devin Leake
  • Christopher H Contag
  • Olav Solgaard
  • Roger L Kaspar
  • Si Hui Tan
  • Janet Jin
  • Wei Meng Woo
  • Samantha Williams
  • Kiyotoshi Sekiguchi
  • Bruce A Morgan
  • Hiroyuki Ido
  • Michael Nguyen
  • Kenji Harada
  • Chih Hsin Chen
  • Aaron D Tward
  • Kelli Montgomery
  • Hayes Gladstone
  • Ludmila A Lokteva
  • Robert West
  • Ivette S Estay
  • Matt van de Rijn
  • Patrick O Brown
  • Peter K Jackson
  • Howard Y Chang
  • Greg S Morganroth
  • Eunice Lee
  • Peggie Cheung
  • Steven E Artandi
  • Daniel Gilison
  • Maja K Artandi
  • Ruth I Tennen
  • Marina Shoffer
  • Estee Wang
  • Tyler Ofstad
  • Jordon K Wang
  • Julia Tzu
  • Yan Ping Zhang
  • Maria Bradley
  • Yi Chen

Detail Information

Publications23

  1. pmc Somatic correction of junctional epidermolysis bullosa by a highly recombinogenic AAV variant
    Sandra P Melo
    Program in Epithelial Biology, Stanford University, School of Medicine, Stanford, California, USA
    Mol Ther 22:725-33. 2014
    ....
  2. pmc GLI activation by atypical protein kinase C ι/λ regulates the growth of basal cell carcinomas
    Scott X Atwood
    Program in Epithelial Biology, Stanford University School of Medicine, Stanford, California 94305, USA
    Nature 494:484-8. 2013
    ..These results demonstrate that aPKC-ι/λ is critical for HH-dependent processes and implicates aPKC-ι/λ as a new, tumour-selective therapeutic target for the treatment of SMO-inhibitor-resistant cancers...
  3. pmc Hedgehog pathway inhibition and the race against tumor evolution
    Scott X Atwood
    Program in Epithelial Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Cell Biol 199:193-7. 2012
    ..Here, we summarize the effectiveness of Hedgehog pathway inhibitors and highlight promising areas for the development of next generation drug antagonists for Hedgehog-dependent cancers...
  4. pmc I-BAR protein antagonism of endocytosis mediates directional sensing during guided cell migration
    Gabriel A Quinones
    Program in Epithelial Biology and Cancer Biology Graduate Program, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Cell Biol 189:353-67. 2010
    ..These studies demonstrate that DMIM antagonizes pro-endocytic components to facilitate polarity and localized guidance cue sensing during directional cell migration...
  5. pmc Translocation affecting sonic hedgehog genes in Basal-cell carcinoma
    Natalia Gomez-Ospina
    Stanford University School of Medicine, Stanford, CA
    N Engl J Med 366:2233-4. 2012
    ..This study uncovers a translocation involving the SHH promoter in a person with holoprosencephaly and basal-cell carcinomas...
  6. pmc The primary cilia, a 'Rab-id' transit system for hedgehog signaling
    Anthony E Oro
    Stanford University, School of Medicine, Stanford, CA 94305, USA
    Curr Opin Cell Biol 19:691-6. 2007
    ..New data indicate that ligand and signaling lipids help regulate small GTPase-dependent accumulation and activity of signaling components...
  7. pmc A new role for an old friend: NFAT and stem cell quiescence
    Anthony E Oro
    Program in Epithelial Biology, School of Medicine, Stanford University, CCSR 2145, 269 Campus Drive, Stanford, CA 94305, USA
    Cell Stem Cell 2:104-6. 2008
    ..A recent paper in Cell (Horsley et al., 2008) demonstrates a role of the calcineurin-NFAT-CDK4 pathway in maintaining hair follicle stem cell quiescence...
  8. pmc Laminin-511 and integrin beta-1 in hair follicle development and basal cell carcinoma formation
    Mindy C DeRouen
    Cancer Biology Graduate Program, 251 Campus Drive, MSOB X234, Stanford, CA 94305 5173, USA
    BMC Dev Biol 10:112. 2010
    ..Previous reports have implicated laminins in hair follicle epithelial invagination...
  9. pmc Dual degradation signals control Gli protein stability and tumor formation
    Erik G Huntzicker
    Program in Epithelial Biology, Stanford University, Stanford, California 94305, USA
    Genes Dev 20:276-81. 2006
    ..These data argue that control of Gli protein accumulation underlies tumorigenesis and suggest a new avenue for antitumor therapy...
  10. pmc In vivo imaging of human and mouse skin with a handheld dual-axis confocal fluorescence microscope
    Hyejun Ra
    James H Clark Center for Biomedical Engineering and Sciences, Department of Pediatrics, Stanford University, Stanford, California 94305, USA
    J Invest Dermatol 131:1061-6. 2011
    ..These results suggest that in vivo confocal microscopy may provide an informative clinical end point to evaluate the efficacy of experimental molecular therapeutics...
  11. ncbi request reprint Hair cycle regulation of Hedgehog signal reception
    Anthony E Oro
    Program in Epithelial Biology, CCSR 2145c, 269 Campus Drive, Stanford University School of Medicine, Stanford, CA 94305, USA
    Dev Biol 255:238-48. 2003
    ..Delivery and reception of growth signals among multipotent cells are restricted in time and space to facilitate cyclic pattern formation...
  12. ncbi request reprint Mammalian variations on a theme: a Smo and Sufu surprise
    Anthony E Oro
    Program in Epithelial Biology, Stanford University School of Medicine, CCSR 2145c, 269 Campus Drive, Stanford, CA 94305, USA
    Dev Cell 10:156-8. 2006
    ....
  13. pmc Conditional telomerase induction causes proliferation of hair follicle stem cells
    Kavita Y Sarin
    Department of Medicine, Division of Hematology, Stanford School of Medicine, Stanford, California 94305, USA
    Nature 436:1048-52. 2005
    ..These data indicate that, in addition to its established role in extending telomeres, TERT can promote proliferation of resting stem cells through a non-canonical pathway...
  14. pmc MIM/BEG4, a Sonic hedgehog-responsive gene that potentiates Gli-dependent transcription
    Christopher A Callahan
    Program in Epithelial Biology and Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA
    Genes Dev 18:2724-9. 2004
    ..These data define MIM as both a Shh-responsive gene and a new member of the pathway that modulates Gli responses during growth and tumorigenesis...
  15. pmc The primary cilium: a small yet mighty organelle
    Mindy C DeRouen
    Program in Epithelial Biology, Stanford University School of Medicine, Stanford, California 94305, USA
    J Invest Dermatol 129:264-5. 2009
    ..In this issue, Lehman et al. describe the necessity of Ift88 and intraflagellar transport for signal reception of the sonic hedgehog pathway in the dermal papilla of developing hair follicles...
  16. pmc Laminin-10 is crucial for hair morphogenesis
    Jie Li
    Program in Epithelial Biology, Stanford University School of Medicine, 269 Campus Drive, Room 2145, CA 94305, USA
    EMBO J 22:2400-10. 2003
    ..We conclude that laminin-10 is required for hair follicle development and report the first use of exogenous protein to correct a cutaneous developmental defect...
  17. pmc MIM and cortactin antagonism regulates ciliogenesis and hedgehog signaling
    Marina Bershteyn
    Stanford University, CA 94305, USA
    Dev Cell 19:270-83. 2010
    ....
  18. pmc Receptor tyrosine phosphatase-dependent cytoskeletal remodeling by the hedgehog-responsive gene MIM/BEG4
    Rosa Gonzalez-Quevedo
    Program in Epithelial Biology, School of Medicine, Stanford University, Stanford, CA 94305, USA
    J Cell Biol 168:453-63. 2005
    ..MIM-dependent cytoskeletal changes can be inhibited using a soluble RPTPdelta-D2 domain. Our data suggest that the hedgehog-responsive gene MIM cooperates with RPTP to induce cytoskeletal changes...
  19. pmc Laminin-511 is an epithelial message promoting dermal papilla development and function during early hair morphogenesis
    Jing Gao
    Program in Epithelial Biology, Stanford University School of Medicine, Stanford, California 94305, USA
    Genes Dev 22:2111-24. 2008
    ..These studies show that epithelial-derived laminin-511 is a critical early signal that directs ciliary function and DP maintenance as a requirement for hair follicle downgrowth...
  20. pmc Bone morphogenetic protein antagonist gremlin 1 is widely expressed by cancer-associated stromal cells and can promote tumor cell proliferation
    Julie B Sneddon
    Department of Biochemistry, Stanford University Medical Center, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 103:14842-7. 2006
    ..Our data suggest that BMP antagonists may be important constituents of tumor stroma, providing a favorable microenvironment for cancer cell survival and expansion in many cancers...
  21. pmc Controlling hair follicle signaling pathways through polyubiquitination
    Erik G Huntzicker
    Program in Epithelial Biology, Stanford University, Stanford, California 94305, USA
    J Invest Dermatol 128:1081-7. 2008
    ..Here we review how polyubiquitination regulates the stability and interaction of key signaling components that control hair follicle development and regeneration...
  22. ncbi request reprint Leukemia cutis presenting as a Sister Mary Joseph nodule
    David Beynet
    Arch Dermatol 140:1170-1. 2004

Research Grants21

  1. BEG4/MIM Function in Epithelial Neoplasia
    ANTHONY ORO; Fiscal Year: 2009
    ..The funding of this proposal will lead to a greater understanding of the mechanisms of epithelial growth and invasion by Shh signaling and may lead to new targets for therapeutic intervention. ..
  2. STROMAL REGULATION OF BASAL CELL CARCINOMA FORMATION
    ANTHONY ORO; Fiscal Year: 2002
    ..Their studies should give insight into how the growth of other epithelial tumors are regulated by their stroma and may lead to the development of new anti-tumor agents. ..
  3. REGULATING GLI FUNCTION IN HAIR FOLLICLE PROGENITORS
    ANTHONY ORO; Fiscal Year: 2009
    ..2 mutant mice, and measure the differences in amount of calcium in stem cells from wild type and Cav1.2 mutants. These studies will provide new insights into the timing mechanisms used during organogenesis. ..
  4. STROMAL REGULATION OF BASAL CELL CARCINOMA FORMATION
    ANTHONY ORO; Fiscal Year: 2004
    ..Their studies should give insight into how the growth of other epithelial tumors are regulated by their stroma and may lead to the development of new anti-tumor agents. ..
  5. REGULATING GLI FUNCTION IN HAIR FOLLICLE PROGENITORS
    ANTHONY ORO; Fiscal Year: 2007
    ..This effort is based on the premise that understanding the regulation of Gli function will lead to new insights into hedgehog signaling, with a goal toward new therapeutics for skin regeneration and epithelial tumors. ..
  6. REGULATING GLI FUNCTION IN HAIR FOLLICLE PROGENITORS
    Anthony E Oro; Fiscal Year: 2010
    ..This effort is based on the premise that understanding the regulation of Gli function will lead to new insights into hedgehog signaling, with a goal toward new therapeutics for skin regeneration and epithelial tumors. ..
  7. STROMAL REGULATION OF BASAL CELL CARCINOMA FORMATION
    ANTHONY ORO; Fiscal Year: 2009
    ....
  8. BEG4/MIM Function in Epithelial Neoplasia
    ANTHONY ORO; Fiscal Year: 2009
    ....
  9. BEG4/MIM Function in Epithelial Neoplasia
    Anthony E Oro; Fiscal Year: 2010
    ..The funding of this proposal will lead to a greater understanding of the mechanisms of epithelial growth and invasion by Shh signaling and may lead to new targets for therapeutic intervention. ..
  10. STROMAL REGULATION OF BASAL CELL CARCINOMA FORMATION
    ANTHONY ORO; Fiscal Year: 2001
    ..Their studies should give insight into how the growth of other epithelial tumors are regulated by their stroma and may lead to the development of new anti-tumor agents. ..
  11. STROMAL REGULATION OF BASAL CELL CARCINOMA FORMATION
    Anthony E Oro; Fiscal Year: 2010
    ....
  12. Laser Capture Microdissection Instrument
    ANTHONY ORO; Fiscal Year: 2003
    ..abstract_text> ..
  13. STROMAL REGULATION OF BASAL CELL CARCINOMA FORMATION
    ANTHONY ORO; Fiscal Year: 2005
    ..Their studies should give insight into how the growth of other epithelial tumors are regulated by their stroma and may lead to the development of new anti-tumor agents. ..
  14. BEG4/MIM Function in Epithelial Neoplasia
    ANTHONY ORO; Fiscal Year: 2007
    ..The funding of this proposal will lead to a greater understanding of the mechanisms of epithelial growth and invasion by Shh signaling and may lead to new targets for therapeutic intervention. ..
  15. STROMAL REGULATION OF BASAL CELL CARCINOMA FORMATION
    ANTHONY ORO; Fiscal Year: 2007
    ..This effort is based on the premise that understanding Shh- dependent tumor-stroma interactions in the skin will lead to new insights into tumorigenesis, with a goal toward new therapeutics for human birth defects and epithelial tumors. ..
  16. STROMAL REGULATION OF BASAL CELL CARCINOMA FORMATION
    ANTHONY ORO; Fiscal Year: 2006
    ..This effort is based on the premise that understanding Shh- dependent tumor-stroma interactions in the skin will lead to new insights into tumorigenesis, with a goal toward new therapeutics for human birth defects and epithelial tumors. ..
  17. REGULATING GLI FUNCTION IN HAIR FOLLICLE PROGENITORS
    ANTHONY ORO; Fiscal Year: 2009
    ..This effort is based on the premise that understanding the regulation of Gli function will lead to new insights into hedgehog signaling, with a goal toward new therapeutics for skin regeneration and epithelial tumors. ..
  18. STROMAL REGULATION OF BASAL CELL CARCINOMA FORMATION
    ANTHONY ORO; Fiscal Year: 2003
    ..Their studies should give insight into how the growth of other epithelial tumors are regulated by their stroma and may lead to the development of new anti-tumor agents. ..