Anthony E Oro

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. pmc Dual degradation signals control Gli protein stability and tumor formation
    Erik G Huntzicker
    Program in Epithelial Biology, Stanford University, Stanford, California 94305, USA
    Genes Dev 20:276-81. 2006
  2. pmc Bone morphogenetic protein antagonist gremlin 1 is widely expressed by cancer-associated stromal cells and can promote tumor cell proliferation
    Julie B Sneddon
    Department of Biochemistry, Stanford University Medical Center, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 103:14842-7. 2006
  3. ncbi request reprint Mammalian variations on a theme: a Smo and Sufu surprise
    Anthony E Oro
    Program in Epithelial Biology, Stanford University School of Medicine, CCSR 2145c, 269 Campus Drive, Stanford, CA 94305, USA
    Dev Cell 10:156-8. 2006
  4. pmc Receptor tyrosine phosphatase-dependent cytoskeletal remodeling by the hedgehog-responsive gene MIM/BEG4
    Rosa Gonzalez-Quevedo
    Program in Epithelial Biology, School of Medicine, Stanford University, Stanford, CA 94305, USA
    J Cell Biol 168:453-63. 2005
  5. ncbi request reprint Hair cycle regulation of Hedgehog signal reception
    Anthony E Oro
    Program in Epithelial Biology, CCSR 2145c, 269 Campus Drive, Stanford University School of Medicine, Stanford, CA 94305, USA
    Dev Biol 255:238-48. 2003
  6. pmc MIM/BEG4, a Sonic hedgehog-responsive gene that potentiates Gli-dependent transcription
    Christopher A Callahan
    Program in Epithelial Biology and Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA
    Genes Dev 18:2724-9. 2004
  7. pmc MIM and cortactin antagonism regulates ciliogenesis and hedgehog signaling
    Marina Bershteyn
    Stanford University, CA 94305, USA
    Dev Cell 19:270-83. 2010
  8. pmc Shh maintains dermal papilla identity and hair morphogenesis via a Noggin-Shh regulatory loop
    Wei Meng Woo
    Program in Epithelial Biology, Stanford University School of Medicine, Stanford, California 94305, USA
    Genes Dev 26:1235-46. 2012
  9. pmc GLI activation by atypical protein kinase C ι/λ regulates the growth of basal cell carcinomas
    Scott X Atwood
    Program in Epithelial Biology, Stanford University School of Medicine, Stanford, California 94305, USA
    Nature 494:484-8. 2013
  10. pmc Laminin-511 is an epithelial message promoting dermal papilla development and function during early hair morphogenesis
    Jing Gao
    Program in Epithelial Biology, Stanford University School of Medicine, Stanford, California 94305, USA
    Genes Dev 22:2111-24. 2008

Collaborators

Detail Information

Publications28

  1. pmc Dual degradation signals control Gli protein stability and tumor formation
    Erik G Huntzicker
    Program in Epithelial Biology, Stanford University, Stanford, California 94305, USA
    Genes Dev 20:276-81. 2006
    ..These data argue that control of Gli protein accumulation underlies tumorigenesis and suggest a new avenue for antitumor therapy...
  2. pmc Bone morphogenetic protein antagonist gremlin 1 is widely expressed by cancer-associated stromal cells and can promote tumor cell proliferation
    Julie B Sneddon
    Department of Biochemistry, Stanford University Medical Center, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 103:14842-7. 2006
    ..Our data suggest that BMP antagonists may be important constituents of tumor stroma, providing a favorable microenvironment for cancer cell survival and expansion in many cancers...
  3. ncbi request reprint Mammalian variations on a theme: a Smo and Sufu surprise
    Anthony E Oro
    Program in Epithelial Biology, Stanford University School of Medicine, CCSR 2145c, 269 Campus Drive, Stanford, CA 94305, USA
    Dev Cell 10:156-8. 2006
    ....
  4. pmc Receptor tyrosine phosphatase-dependent cytoskeletal remodeling by the hedgehog-responsive gene MIM/BEG4
    Rosa Gonzalez-Quevedo
    Program in Epithelial Biology, School of Medicine, Stanford University, Stanford, CA 94305, USA
    J Cell Biol 168:453-63. 2005
    ..MIM-dependent cytoskeletal changes can be inhibited using a soluble RPTPdelta-D2 domain. Our data suggest that the hedgehog-responsive gene MIM cooperates with RPTP to induce cytoskeletal changes...
  5. ncbi request reprint Hair cycle regulation of Hedgehog signal reception
    Anthony E Oro
    Program in Epithelial Biology, CCSR 2145c, 269 Campus Drive, Stanford University School of Medicine, Stanford, CA 94305, USA
    Dev Biol 255:238-48. 2003
    ..Delivery and reception of growth signals among multipotent cells are restricted in time and space to facilitate cyclic pattern formation...
  6. pmc MIM/BEG4, a Sonic hedgehog-responsive gene that potentiates Gli-dependent transcription
    Christopher A Callahan
    Program in Epithelial Biology and Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA
    Genes Dev 18:2724-9. 2004
    ..These data define MIM as both a Shh-responsive gene and a new member of the pathway that modulates Gli responses during growth and tumorigenesis...
  7. pmc MIM and cortactin antagonism regulates ciliogenesis and hedgehog signaling
    Marina Bershteyn
    Stanford University, CA 94305, USA
    Dev Cell 19:270-83. 2010
    ....
  8. pmc Shh maintains dermal papilla identity and hair morphogenesis via a Noggin-Shh regulatory loop
    Wei Meng Woo
    Program in Epithelial Biology, Stanford University School of Medicine, Stanford, California 94305, USA
    Genes Dev 26:1235-46. 2012
    ..Our findings suggest that dermal Shh signaling regulates specific DP signatures to maintain DP maturation while maintaining a reciprocal Shh-Noggin signaling loop to drive hair follicle morphogenesis...
  9. pmc GLI activation by atypical protein kinase C ι/λ regulates the growth of basal cell carcinomas
    Scott X Atwood
    Program in Epithelial Biology, Stanford University School of Medicine, Stanford, California 94305, USA
    Nature 494:484-8. 2013
    ..These results demonstrate that aPKC-ι/λ is critical for HH-dependent processes and implicates aPKC-ι/λ as a new, tumour-selective therapeutic target for the treatment of SMO-inhibitor-resistant cancers...
  10. pmc Laminin-511 is an epithelial message promoting dermal papilla development and function during early hair morphogenesis
    Jing Gao
    Program in Epithelial Biology, Stanford University School of Medicine, Stanford, California 94305, USA
    Genes Dev 22:2111-24. 2008
    ..These studies show that epithelial-derived laminin-511 is a critical early signal that directs ciliary function and DP maintenance as a requirement for hair follicle downgrowth...
  11. pmc Laminin-511 and integrin beta-1 in hair follicle development and basal cell carcinoma formation
    Mindy C DeRouen
    Cancer Biology Graduate Program, 251 Campus Drive, MSOB X234, Stanford, CA 94305 5173, USA
    BMC Dev Biol 10:112. 2010
    ..Previous reports have implicated laminins in hair follicle epithelial invagination...
  12. doi request reprint "Atypical" regulation of Hedgehog-dependent cancers
    Scott X Atwood
    Program in Epithelial Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Cancer Cell 25:133-4. 2014
    ....
  13. pmc Neuropilins are positive regulators of Hedgehog signal transduction
    R Tyler Hillman
    Department of Genetics, Stanford University School of Medicine, California 94305, USA
    Genes Dev 25:2333-46. 2011
    ..These findings enhance our knowledge of Hh pathway regulation and provide evidence for a conserved nexus between Nrps and this important developmental signaling system...
  14. pmc The primary cilium: a small yet mighty organelle
    Mindy C DeRouen
    Program in Epithelial Biology, Stanford University School of Medicine, Stanford, California 94305, USA
    J Invest Dermatol 129:264-5. 2009
    ..In this issue, Lehman et al. describe the necessity of Ift88 and intraflagellar transport for signal reception of the sonic hedgehog pathway in the dermal papilla of developing hair follicles...
  15. doi request reprint Somatic Correction of Junctional Epidermolysis Bullosa by a Highly Recombinogenic AAV Variant
    Sandra P Melo
    Program in Epithelial Biology, Stanford University, School of Medicine, Stanford, California, USA
    Mol Ther 22:725-33. 2014
    ....
  16. doi request reprint Partial proteasome inhibitors induce hair follicle growth by stabilizing β-catenin
    Gozde Yucel
    Program in Epithelial Biology, Stanford University, School of Medicine, Stanford, California, USA
    Stem Cells 32:85-92. 2014
    ..PaPIs thus represent a novel class of hair growth agents that act through transiently modifying the balance of stem cell activation and quiescence pathways...
  17. pmc Hedgehog pathway inhibition and the race against tumor evolution
    Scott X Atwood
    Program in Epithelial Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Cell Biol 199:193-7. 2012
    ..Here, we summarize the effectiveness of Hedgehog pathway inhibitors and highlight promising areas for the development of next generation drug antagonists for Hedgehog-dependent cancers...
  18. pmc Controlling hair follicle signaling pathways through polyubiquitination
    Erik G Huntzicker
    Program in Epithelial Biology, Stanford University, Stanford, California 94305, USA
    J Invest Dermatol 128:1081-7. 2008
    ..Here we review how polyubiquitination regulates the stability and interaction of key signaling components that control hair follicle development and regeneration...
  19. pmc Conditional telomerase induction causes proliferation of hair follicle stem cells
    Kavita Y Sarin
    Department of Medicine, Division of Hematology, Stanford School of Medicine, Stanford, California 94305, USA
    Nature 436:1048-52. 2005
    ..These data indicate that, in addition to its established role in extending telomeres, TERT can promote proliferation of resting stem cells through a non-canonical pathway...
  20. pmc BAR domain competition during directional cellular migration
    Gabriel A Quinones
    Program in Epithelial Biology and Cancer Biology Graduate Program, Stanford University School of Medicine, Stanford, CA, USA
    Cell Cycle 9:2522-8. 2010
    ....
  21. pmc I-BAR protein antagonism of endocytosis mediates directional sensing during guided cell migration
    Gabriel A Quinones
    Program in Epithelial Biology and Cancer Biology Graduate Program, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Cell Biol 189:353-67. 2010
    ..These studies demonstrate that DMIM antagonizes pro-endocytic components to facilitate polarity and localized guidance cue sensing during directional cell migration...
  22. pmc Laminin-10 is crucial for hair morphogenesis
    Jie Li
    Program in Epithelial Biology, Stanford University School of Medicine, 269 Campus Drive, Room 2145, CA 94305, USA
    EMBO J 22:2400-10. 2003
    ..We conclude that laminin-10 is required for hair follicle development and report the first use of exogenous protein to correct a cutaneous developmental defect...
  23. doi request reprint "Patch"ing up our tumor signaling knowledge
    Scott X Atwood
    Department of Dermatology, Program in Epithelial Biology, Stanford University School of Medicine, Stanford, California 94305, USA
    J Invest Dermatol 133:1131-3. 2013
    ..The study reveals new roles for Ptch1 that lie at the nexus between BCC and SCC formation...
  24. pmc State-dependent signaling by Cav1.2 regulates hair follicle stem cell function
    Gozde Yucel
    Program in Epithelial Biology, Stanford University, School of Medicine, Stanford, California 94305, USA
    Genes Dev 27:1217-22. 2013
    ..Our findings show how channels act in nonexcitable tissues to regulate stem cells and may lead to novel therapeutics for tissue regeneration...
  25. pmc The primary cilia, a 'Rab-id' transit system for hedgehog signaling
    Anthony E Oro
    Stanford University, School of Medicine, Stanford, CA 94305, USA
    Curr Opin Cell Biol 19:691-6. 2007
    ..New data indicate that ligand and signaling lipids help regulate small GTPase-dependent accumulation and activity of signaling components...
  26. pmc A new role for an old friend: NFAT and stem cell quiescence
    Anthony E Oro
    Program in Epithelial Biology, School of Medicine, Stanford University, CCSR 2145, 269 Campus Drive, Stanford, CA 94305, USA
    Cell Stem Cell 2:104-6. 2008
    ..A recent paper in Cell (Horsley et al., 2008) demonstrates a role of the calcineurin-NFAT-CDK4 pathway in maintaining hair follicle stem cell quiescence...
  27. pmc Augmenting endogenous Wnt signaling improves skin wound healing
    Jemima L Whyte
    Division of Plastic and Reconstructive Surgery, Department of Surgery, Stanford School of Medicine, Stanford University, Stanford, California, United States of America
    PLoS ONE 8:e76883. 2013
    ..Given the importance of Wnt signaling in the maintenance and repair of skin, liposomal Wnt3a may have widespread application in clinical practice. ..
  28. ncbi request reprint Leukemia cutis presenting as a Sister Mary Joseph nodule
    David Beynet
    Arch Dermatol 140:1170-1. 2004