M Bishr Omary

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. pmc The pancreatic stellate cell: a star on the rise in pancreatic diseases
    M Bishr Omary
    Department of Medicine, VA Palo Alto Health Care System, Palo Alto, California 94304, USA
    J Clin Invest 117:50-9. 2007
  2. ncbi request reprint "Heads and tails" of intermediate filament phosphorylation: multiple sites and functional insights
    M Bishr Omary
    Department of Medicine, Palo Alto VA Medical Center and Stanford University School of Medicine, 3801 Miranda Avenue, Palo Alto, CA 94304, USA
    Trends Biochem Sci 31:383-94. 2006
  3. pmc Keratin overexpression levels correlate with the extent of spontaneous pancreatic injury
    Diana M Toivola
    Department of Medicine, Veterans Administration Palo Alto Health Care System, Palo Alto, CA, USA
    Am J Pathol 172:882-92. 2008
  4. ncbi request reprint Transglutaminase 2 regulates mallory body inclusion formation and injury-associated liver enlargement
    Pavel Strnad
    Department of Medicine, Palo Alto VA Medical Center, Palo Alto, California, USA
    Gastroenterology 132:1515-26. 2007
  5. pmc A disease- and phosphorylation-related nonmechanical function for keratin 8
    Nam On Ku
    Department of Medicine, Palo Alto VA Medical Center and Stanford University School of Medicine, Palo Alto, CA 94304, USA
    J Cell Biol 174:115-25. 2006
  6. pmc Keratins modulate the shape and function of hepatocyte mitochondria: a mechanism for protection from apoptosis
    Guo Zhong Tao
    Department of Surgery, Stanford University, Palo Alto, CA 94305, USA
    J Cell Sci 122:3851-5. 2009
  7. doi request reprint The genetic background modulates susceptibility to mouse liver Mallory-Denk body formation and liver injury
    Shinichiro Hanada
    Department of Medicine, Veterans Administration Palo Alto Health Care System and Stanford University, Palo Alto, CA, USA
    Hepatology 48:943-52. 2008
  8. ncbi request reprint Human Ran cysteine 112 oxidation by pervanadate regulates its binding to keratins
    Guo Zhong Tao
    Palo Alto Veterans Affairs Medical Center, Palo Alto, California 94304, USA
    J Biol Chem 280:12162-7. 2005
  9. pmc Reg-II is an exocrine pancreas injury-response product that is up-regulated by keratin absence or mutation
    Bihui Zhong
    Department of Medicine, Palo Alto Veterans Affairs Medical Center, Palo Alto, CA 94304, USA
    Mol Biol Cell 18:4969-78. 2007
  10. ncbi request reprint Keratin 18 overexpression but not phosphorylation or filament organization blocks mouse Mallory body formation
    Masaru Harada
    Department of Medicine, Veterans Affairs Palo Alto Health Care System, Palo Alto, CA 94304, USA
    Hepatology 45:88-96. 2007

Collaborators

Detail Information

Publications62

  1. pmc The pancreatic stellate cell: a star on the rise in pancreatic diseases
    M Bishr Omary
    Department of Medicine, VA Palo Alto Health Care System, Palo Alto, California 94304, USA
    J Clin Invest 117:50-9. 2007
    ..Therefore, understanding the biology of PaSCs offers potential therapeutic targets for the treatment and prevention of these diseases...
  2. ncbi request reprint "Heads and tails" of intermediate filament phosphorylation: multiple sites and functional insights
    M Bishr Omary
    Department of Medicine, Palo Alto VA Medical Center and Stanford University School of Medicine, 3801 Miranda Avenue, Palo Alto, CA 94304, USA
    Trends Biochem Sci 31:383-94. 2006
    ....
  3. pmc Keratin overexpression levels correlate with the extent of spontaneous pancreatic injury
    Diana M Toivola
    Department of Medicine, Veterans Administration Palo Alto Health Care System, Palo Alto, CA, USA
    Am J Pathol 172:882-92. 2008
    ..Keratin absence or mutation is well tolerated after pancreatic but not liver injury, whereas excessive overexpression is toxic to the pancreas but not the liver when induced under basal conditions...
  4. ncbi request reprint Transglutaminase 2 regulates mallory body inclusion formation and injury-associated liver enlargement
    Pavel Strnad
    Department of Medicine, Palo Alto VA Medical Center, Palo Alto, California, USA
    Gastroenterology 132:1515-26. 2007
    ..We hypothesized that protein transamidation is essential for MB formation...
  5. pmc A disease- and phosphorylation-related nonmechanical function for keratin 8
    Nam On Ku
    Department of Medicine, Palo Alto VA Medical Center and Stanford University School of Medicine, Palo Alto, CA 94304, USA
    J Cell Biol 174:115-25. 2006
    ....
  6. pmc Keratins modulate the shape and function of hepatocyte mitochondria: a mechanism for protection from apoptosis
    Guo Zhong Tao
    Department of Surgery, Stanford University, Palo Alto, CA 94305, USA
    J Cell Sci 122:3851-5. 2009
    ..The effects of keratin mutation on mitochondria are likely to contribute to hepatocyte predisposition to apoptosis and oxidative injury, and to play a pathogenic role in keratin-mutation-related human liver disease...
  7. doi request reprint The genetic background modulates susceptibility to mouse liver Mallory-Denk body formation and liver injury
    Shinichiro Hanada
    Department of Medicine, Veterans Administration Palo Alto Health Care System and Stanford University, Palo Alto, CA, USA
    Hepatology 48:943-52. 2008
    ..The extent of steatosis correlated with the total (large+small) number of MDBs, and there was a limited correlation between large MDBs and acidophil bodies...
  8. ncbi request reprint Human Ran cysteine 112 oxidation by pervanadate regulates its binding to keratins
    Guo Zhong Tao
    Palo Alto Veterans Affairs Medical Center, Palo Alto, California 94304, USA
    J Biol Chem 280:12162-7. 2005
    ..In cells, stabilization of oxidized Ran by proteasome inhibition promotes Ran-keratin interaction. Keratin sequestration of oxidized Ran may provide a back-up protective mechanism in some cases of oxidative injury...
  9. pmc Reg-II is an exocrine pancreas injury-response product that is up-regulated by keratin absence or mutation
    Bihui Zhong
    Department of Medicine, Palo Alto Veterans Affairs Medical Center, Palo Alto, CA 94304, USA
    Mol Biol Cell 18:4969-78. 2007
    ..Thus, Reg-II is a likely mouse exocrine pancreas cytoprotective candidate protein whose expression is regulated by keratin filament organization and phosphorylation...
  10. ncbi request reprint Keratin 18 overexpression but not phosphorylation or filament organization blocks mouse Mallory body formation
    Masaru Harada
    Department of Medicine, Veterans Affairs Palo Alto Health Care System, Palo Alto, CA 94304, USA
    Hepatology 45:88-96. 2007
    ..DDC feeding induced MBs in nontransgenic livers, but MBs were rarely seen in any of the K18 transgenic mice. Wild-type K18 overexpression protected mice from DDC-induced liver injury...
  11. ncbi request reprint Studying simple epithelial keratins in cells and tissues
    Nam On Ku
    Department of Medicine, Palo Alto VA Medical Center and Stanford University, Palo Alto, California 94304, USA
    Methods Cell Biol 78:489-517. 2004
  12. ncbi request reprint Bispecific and human disease-related anti-keratin rabbit monoclonal antibodies
    Guo Zhong Tao
    Palo Alto VA Medical Center and Stanford University School of Medicine, 3801 Miranda Avenue, Mail code 154J, Palo Alto, CA 94304, USA
    Exp Cell Res 312:411-22. 2006
    ..Therefore, a reverse immunologic and biochemical approach is a viable tool for generating versatile rabbit MAb for a variety of cell biologic applications including the potential identification of physiologic phosphorylation sites...
  13. ncbi request reprint Actin overexpression parallels severity of pancreatic injury
    Bihui Zhong
    Department of Medicine, VA Palo Alto Health Care System, Palo Alto, CA 94304, USA
    Exp Cell Res 299:404-14. 2004
    ..Keratin and actin induction may serve protective roles in pancreatic injury...
  14. pmc Keratin mutation predisposes to mouse liver fibrosis and unmasks differential effects of the carbon tetrachloride and thioacetamide models
    Pavel Strnad
    Department of Medicine, Palo Alto VA Medical Center, Palo Alto, California, USA
    Gastroenterology 134:1169-79. 2008
    ..We sought direct evidence for a keratin mutation-related predisposition to liver fibrosis using transgenic mouse models because the relationship between keratin mutations and cirrhosis is based primarily on human association studies...
  15. ncbi request reprint Protein phosphatase-2A associates with and dephosphorylates keratin 8 after hyposmotic stress in a site- and cell-specific manner
    Guo Zhong Tao
    Department of Medicine, Palo Alto VA Medical Center, 3801 Miranda Avenue, Mail code 154J, Palo Alto, CA 94304, USA
    J Cell Sci 119:1425-32. 2006
    ..The divergent hyposmosis versus hyperosmosis K8 Ser431 phosphorylation changes in HT29 cells suggest that there are unique signaling responses to osmotic stress...
  16. pmc Gene expression changes associated with Barrett's esophagus and Barrett's-associated adenocarcinoma cell lines after acid or bile salt exposure
    Ying Hao
    Department of Medicine, Stanford University, Stanford, CA, USA
    BMC Gastroenterol 7:24. 2007
    ..In this study, we determined whether similar exposure to acid or bile salts results in gene expression changes that provide insights into malignant transformation...
  17. ncbi request reprint Analysis of keratin polypeptides 8 and 19 variants in inflammatory bowel disease
    Guo Zhong Tao
    Department of Medicine, Palo Alto Veterans Affairs Medical Center and Stanford University Digestive Disease Center, Palo Alto, California 94304, USA
    Clin Gastroenterol Hepatol 5:857-64. 2007
    ..We asked whether mutations in KRT8 or KRT19, the major intestinal keratins, are associated with UC/CD...
  18. pmc Keratin 8 overexpression promotes mouse Mallory body formation
    Ikuo Nakamichi
    Department of Medicine, Stanford University, and Veterans Affairs Palo Alto Health Care System, CA 94305, USA
    J Cell Biol 171:931-7. 2005
    ..K8 overexpression is sufficient to form pre-MB and primes animals to accumulate MBs upon DDC challenge, which may help explain MB formation in human liver diseases...
  19. doi request reprint Autophagy activation by rapamycin eliminates mouse Mallory-Denk bodies and blocks their proteasome inhibitor-mediated formation
    Masaru Harada
    Department of Medicine, Veterans Affairs Palo Alto Health Care System, Palo Alto, CA 94304, USA
    Hepatology 47:2026-35. 2008
    ..Rap also led to resorption of spontaneously formed MDBs in aging K8-overexpressing mice. Immune EM demonstrated K8-positive and ubiquitin-positive structures in autophagic vacuoles in the mouse liver...
  20. doi request reprint "Toxic memory" via chaperone modification is a potential mechanism for rapid Mallory-Denk body reinduction
    Pavel Strnad
    Department of Medicine, Palo Alto VA Medical Center, Palo Alto, CA, USA
    Hepatology 48:931-42. 2008
    ..MDB reinduction parallels the rapid increase in p62 and Hsp25 levels as well as keratin 8 cross-linking that is normally associated with MDB formation...
  21. pmc Raf-1 activation disrupts its binding to keratins during cell stress
    Nam On Ku
    Department of Medicine, VA Palo Alto Medical Center, 3801 Miranda Ave, 154J, Palo Alto, CA 94304, USA
    J Cell Biol 166:479-85. 2004
    ..Keratin-bound Raf kinase is released upon Raf hyperphosphorylation and activation during oxidative and other stresses...
  22. ncbi request reprint Keratin 8 and 18 hyperphosphorylation is a marker of progression of human liver disease
    Diana M Toivola
    Department of Medicine, Palo Alto VA Medical Center, Stanford University School of Medicine Digestive Disease Center, Palo Alto, CA 94304, USA
    Hepatology 40:459-66. 2004
    ..In conclusion, site-specific keratin phosphorylation in liver disease is a progression marker when increased and a likely regression marker when decreased...
  23. ncbi request reprint Keratins let liver live: Mutations predispose to liver disease and crosslinking generates Mallory-Denk bodies
    Nam On Ku
    Department of Medicine, Palo Alto VA Medical Center and Stanford University Digestive Disease Center, Palo Alto, CA
    Hepatology 46:1639-49. 2007
    ..Keratin involvement in liver disease is multi-faceted and includes modulating disease progression upon mutation, formation of MDBs in response to unique forms of injury, and serving as markers of epithelial cell death...
  24. ncbi request reprint Organ-specific stress induces mouse pancreatic keratin overexpression in association with NF-kappaB activation
    Bihui Zhong
    VA Palo Alto Health Care System, Department of Medicine, 3801 Miranda Avenue, 154J, Palo Alto, CA 94304, USA
    J Cell Sci 117:1709-19. 2004
    ..Pancreatic keratin overexpression is associated with NF-kappaB activation and may serve unique functions in acinar or ductal cell response to injury...
  25. ncbi request reprint Keratin-8-deficient mice develop chronic spontaneous Th2 colitis amenable to antibiotic treatment
    Aida Habtezion
    Department of Medicine, Palo Alto VA Medical Center, 3801 Miranda Avenue, 154J, Palo Alto, CA 94304, USA
    J Cell Sci 118:1971-80. 2005
    ..These mice provide a model to investigate epithelial-leukocyte and epithelial-microbial cross-talk...
  26. ncbi request reprint Keratin 20 serine 13 phosphorylation is a stress and intestinal goblet cell marker
    Qin Zhou
    Department of Medicine, Veterans Affairs Palo Alto Health Care System, 3801 Miranda Avenue, Palo Alto, CA 94304, USA
    J Biol Chem 281:16453-61. 2006
    ..Therefore, K20 Ser(13) is a highly dynamic protein kinase C-related phosphorylation site that is induced during apoptosis and tissue injury. K20 Ser(13) phosphorylation also serves as a unique marker of small intestinal goblet cells...
  27. ncbi request reprint Keratins as susceptibility genes for end-stage liver disease
    Nam On Ku
    Department of Medicine, Palo Alto VA Medical Center, Palo Alto, California 94304, USA
    Gastroenterology 129:885-93. 2005
    ..Keratin 8 and 18 variants in 17 of 467 liver disease explants and 2 of 349 blood bank controls were previously reported in 5 analyzed exonic regions. We asked whether mutations were present in the remaining 10 exons of keratins 8 and 18...
  28. ncbi request reprint Keratin variants associate with progression of fibrosis during chronic hepatitis C infection
    Pavel Strnad
    Department of Medicine, Palo Alto VA Medical Center, Palo Alto, CA 94304, USA
    Hepatology 43:1354-63. 2006
    ..The unique 100% segregation of the most common K8 variant, R341H, with an intronic deletion suggests that one of these two genetic changes might lead to the other...
  29. pmc Hemin-activated macrophages home to the pancreas and protect from acute pancreatitis via heme oxygenase-1 induction
    Ikuo Nakamichi
    Department of Medicine, VA Palo Alto Health Care System, Palo Alto, California, USA
    J Clin Invest 115:3007-14. 2005
    ..Therefore, hemin-like compounds or hemin-activated macrophages may offer novel therapeutic approaches for preventing acute pancreatitis and its pulmonary complication via upregulation of HO-1...
  30. ncbi request reprint Denaturing temperature selection may underestimate keratin mutation detection by DHPLC
    Pavel Strnad
    Department of Medicine, Palo Alto Veterus Affairs Medical Center, Palo Alto, California 94304, USA
    Hum Mutat 27:444-52. 2006
    ..1138G>A (K8 p.V380I). Therefore, although DHPLC offers a robust and high throughput means for mutation analysis, assessment of denaturing temperature ranges, and possible inclusion of control mutants should be considered...
  31. ncbi request reprint Cellular integrity plus: organelle-related and protein-targeting functions of intermediate filaments
    Diana M Toivola
    Palo Alto VA Medical Center, 3801 Miranda Avenue, Palo Alto, CA 94304, USA
    Trends Cell Biol 15:608-17. 2005
    ..The IF-related organelle-specific and protein-targeting roles, which are likely interrelated, provide functions beyond cell scaffolding and integrity and contribute to the cytoprotective and tissue-specific functions of IF proteins...
  32. ncbi request reprint Keratin-8 null mice have different gallbladder and liver susceptibility to lithogenic diet-induced injury
    Guo Zhong Tao
    Palo Alto VA Medical Center, Palo Alto, Mail code 154J, 3801 Miranda Avenue, Palo Alto, CA 94304 and Stanford University School of Medicine Digestive Disease Center, Stanford, CA 94305, USA
    J Cell Sci 116:4629-38. 2003
    ..Differences between K8-null mouse gallbladder and hepatocyte susceptibility to injury may be related to their minimal versus absent keratin expression, respectively...
  33. pmc Keratin 8 and 18 mutations are risk factors for developing liver disease of multiple etiologies
    Nam On Ku
    Department of Medicine, Palo Alto Veterans Affairs Medical Center, 3801 Miranda Avenue, 154J, Palo Alto, CA 94304, USA
    Proc Natl Acad Sci U S A 100:6063-8. 2003
    ..03). Therefore, K8K18 are likely susceptibility genes for developing cryptogenic and noncryptogenic forms of liver disease...
  34. ncbi request reprint Pharmacologic transglutaminase inhibition attenuates drug-primed liver hypertrophy but not Mallory body formation
    Pavel Strnad
    Department of Medicine, Palo Alto VA Medical Center, Palo Alto, CA 94304, USA
    FEBS Lett 580:2351--2357. 2006
    ..Hence, TG2 is a potential mediator of injury-induced hepatomegaly via modulation of hepatocyte hypertrophy, and KCC009-mediated TG2 inhibition does not affect mouse MB formation...
  35. ncbi request reprint Keratin mutation in transgenic mice predisposes to Fas but not TNF-induced apoptosis and massive liver injury
    Nam On Ku
    Department of Medicine, Palo Alto VA Medical Center and Stanford University Digestive Disease Center, CA, USA
    Hepatology 37:1006-14. 2003
    ..This supports the association of keratin mutations with cirrhosis in patients with liver disease and suggests that keratins modulate apoptosis induced by Fas but not TNF...
  36. pmc Characterization of in vivo keratin 19 phosphorylation on tyrosine-391
    Qin Zhou
    Department of Medicine, Stanford University School of Medicine, Palo Alto, California, United States of America
    PLoS ONE 5:e13538. 2010
    ..Although K19 is known to be phosphorylated on tyrosine residue(s), conclusive site-specific characterization of these residue(s) and identification potential kinases that may be involved has not been reported...
  37. pmc Keratin 20 helps maintain intermediate filament organization in intestinal epithelia
    Qin Zhou
    Department of Medicine, VA Palo Alto Health Care System, Palo Alto, California 94304, USA
    Mol Biol Cell 14:2959-71. 2003
    ..Our data suggest the presence of unique regulatory domains for pancreatic and gastric K20 expression and support a significant role for K20 in maintaining keratin filaments in intestinal epithelia...
  38. ncbi request reprint Keratin mutation primes mouse liver to oxidative injury
    Qin Zhou
    Department of Medicine, Palo Alto Veterans Affairs Medical Center and Stanford University Digestive Disease Center, Palo Alto, CA, USA
    Hepatology 41:517-25. 2005
    ..Hence keratin mutations may prime hepatocytes to oxidative injury, which provides a new potential mechanism for how keratin mutations may predispose patients to cirrhosis...
  39. pmc Keratin binding to 14-3-3 proteins modulates keratin filaments and hepatocyte mitotic progression
    Nam On Ku
    Department of Medicine, Veterans Affairs Palo Alto Health Care System, 3801 Miranda Avenue, 154J, Palo Alto, CA 94304, USA
    Proc Natl Acad Sci U S A 99:4373-8. 2002
    ..Keratin binding to 14-3-3 may partially modulate hepatocyte mitotic progression, in association with nuclear redistribution of 14-3-3 proteins during mitosis...
  40. pmc Reciprocal keratin 18 Ser48 O-GlcNAcylation and Ser52 phosphorylation using peptide analysis
    Guo Zhong Tao
    Palo Alto VA Medical Center, Stanford University, Palo Alto, CA 94304, USA
    Biochem Biophys Res Commun 351:708-12. 2006
    ..Therefore, regulation of protein Ser/Thr phosphorylation and glycosylation at proximal sites can be interdependent and provides a potential mechanism of counter regulation...
  41. pmc Keratins modulate colonocyte electrolyte transport via protein mistargeting
    Diana M Toivola
    Palo Alto VA Medical Center, 3801 Miranda Ave, Mail code 154J, Palo Alto, CA 94304, USA
    J Cell Biol 164:911-21. 2004
    ..Therefore, colonic keratins have a novel function in regulating electrolyte transport, likely by targeting ion transporters to their cellular compartments...
  42. ncbi request reprint Hyposmotic stress induces cell growth arrest via proteasome activation and cyclin/cyclin-dependent kinase degradation
    Guo Zhong Tao
    Department of Medicine, Palo Alto Veterans Affairs Medical Center, Palo Alto, California 94034, USA
    J Biol Chem 277:19295-303. 2002
    ..The growth arrest is due to decreased protein synthesis and proteasome activation, with subsequent degradation of several cyclins and Cdks...
  43. ncbi request reprint Keratins: guardians of the liver
    M Bishr Omary
    Department of Medicine, VA Palo Alto Health Care System, Palo Alto, CA 94304, USA
    Hepatology 35:251-7. 2002
  44. pmc Type II keratins are phosphorylated on a unique motif during stress and mitosis in tissues and cultured cells
    Diana M Toivola
    Department of Medicine, Veterans Affairs Palo Alto Health Care System, Palo Alto, California 94304, USA
    Mol Biol Cell 13:1857-70. 2002
    ..In conclusion, type II keratins of proliferating epithelia undergo phosphorylation at a unique and conserved motif as part of physiological mitotic and stress-related signals...
  45. pmc Gene expression profiling reveals stromal genes expressed in common between Barrett's esophagus and adenocarcinoma
    Ying Hao
    Department of Medicine, Stanford University, Stanford, California 94305 5187, USA
    Gastroenterology 131:925-33. 2006
    ....
  46. doi request reprint Epidemiology of alcohol-related liver and pancreatic disease in the United States
    Alice L Yang
    Department of Medicine, Division of Gastroenterology and Hepatology, Veterans Affairs Palo Alto Health Care System and Stanford University, 3801 Miranda Ave 154J, Palo Alto, CA, USA
    Arch Intern Med 168:649-56. 2008
    ..To better understand alcohol-related liver and pancreas effects on and associations with different ethnic groups and sexes, we analyzed the trends of AP, CP, AH, CH, AP plus AH, and CP plus CH in the United States...
  47. ncbi request reprint Intermediate filament proteins and their associated diseases
    M Bishr Omary
    From the Department of Medicine, Palo Alto Veterans Affairs Medical Center and Stanford University, Palo Alto, Calif 94304, USA
    N Engl J Med 351:2087-100. 2004
  48. ncbi request reprint Keratin 8 phosphorylation by p38 kinase regulates cellular keratin filament reorganization: modulation by a keratin 1-like disease causing mutation
    Nam On Ku
    Department of Medicine, and Geriatric Research, Education and Clinical Center, Veterans Affairs Palo Alto Health Care System, Palo Alto, California 94304, USA
    J Biol Chem 277:10775-82. 2002
    ..The Ser-73 --> Ala-associated filament reorganization defect is rescued by a Ser-73 --> Asp mutation. Also, disease-causing keratin mutations can modulate keratin phosphorylation and organization, which may affect disease pathogenesis...
  49. ncbi request reprint Our new President--Emmet B. Keeffe, M.D
    M Bishr Omary
    Departments of Medicine and Surgery, Palo Alto VA Health Care System, 3801 Miranda Avenue, Palo Alto, CA 94304, USA
    Gastroenterology 126:1454-60. 2004
  50. ncbi request reprint Aggregation and loss of cytokeratin filament networks inhibit golgi organization in liver-derived epithelial cell lines
    Hiroto Kumemura
    Second Department of Medicine and Research Center for Innovative Cancer Therapy, Kurume University School of Medicine, Asahi machi, Kurume, Japan
    Cell Motil Cytoskeleton 57:37-52. 2004
    ..The original intact intermediate filament network is necessary for the organization of Golgi apparatus...
  51. ncbi request reprint Keratin 8 phosphorylation by protein kinase C delta regulates shear stress-mediated disassembly of keratin intermediate filaments in alveolar epithelial cells
    Karen M Ridge
    Division of Pulmonary and Critical Care Medicine, Northwestern University Medical School, Chicago, Illinois 60611, USA
    J Biol Chem 280:30400-5. 2005
    ..Importantly, these data provided clues regarding a molecular link between mechanically induced signal transduction and alterations in cytoskeletal IF...
  52. ncbi request reprint 'Hard' and 'soft' principles defining the structure, function and regulation of keratin intermediate filaments
    Pierre A Coulombe
    Department of Biological Chemistry, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA
    Curr Opin Cell Biol 14:110-22. 2002
    ..Keratin filaments undergo complex regulation involving post-translational modifications and interactions with self and with various classes of associated proteins...
  53. ncbi request reprint The intermediate filament protein keratin 8 is a novel cytoplasmic substrate for c-Jun N-terminal kinase
    Tao He
    Turku Centre for Biotechnology, University of Turku and Abo Akademi University, the Department of Biochemistry and Pharmacy, Abo Akademi University, FIN 20521, Turku, Finland
    J Biol Chem 277:10767-74. 2002
    ..Taken together, K8 is a new cytoplasmic target for JNK in Fas receptor-mediated signaling. The functional significance of this phosphorylation could relate to regulation of JNK signaling and/or regulation of keratin dynamics...
  54. ncbi request reprint Keratin 8/18 breakdown and reorganization during apoptosis
    Bert Schutte
    Department of Molecular Cell Biology Box 17, Research Institute Growth and Development GROW, University of Maastricht, The Netherlands
    Exp Cell Res 297:11-26. 2004
    ..At later stages of the apoptotic process, that is, when the integrity of the cytoplasmic membrane becomes compromised, keratin aggregates are shed from the cells...
  55. ncbi request reprint A mutation of keratin 18 within the coil 1A consensus motif causes widespread keratin aggregation but cell type-restricted lethality in mice
    Michael Hesse
    Institut fur Physiologische Chemie, Abteilung für Zellbiochemie, Bonner Forum Biomedizin and LIMES, Rheinische Friedrich Wilhelms Universitaet, Nussallee 11, 53115 Bonn, Germany
    Exp Cell Res 313:3127-40. 2007
    ..This has important implications for therapy approaches of keratinopathies, suggesting that suppressing the mutant allele is not necessary in vivo...
  56. ncbi request reprint From Mallory to Mallory-Denk bodies: what, how and why?
    Kurt Zatloukal
    Institute of Pathology, Medical University of Graz, Auenbruggerplatz 25, A 8036 Graz, Austria
    Exp Cell Res 313:2033-49. 2007
    ..Although it remains unclear whether MDBs serve a bystander, protective or injury promoting function, they do serve an important role as histological and potential progression markers in several liver diseases...
  57. pmc Extracellular transglutaminase 2 is catalytically inactive, but is transiently activated upon tissue injury
    Matthew Siegel
    Department of Chemical Engineering, Stanford University, Stanford, California, United States of America
    PLoS ONE 3:e1861. 2008
    ..Our findings provide a new basis for understanding the role of TG2 in physiology and disease...
  58. ncbi request reprint Identification of cytokeratins as accessory mediators of Salmonella entry into eukaryotic cells
    Steve A Carlson
    Preharvest Food Safety and Enteric Disease Research Unit, National Animal Disease Center, USDA, Agricultural Research Service, Ames, IA 50010, USA
    Life Sci 70:1415-26. 2002
    ..These results suggest that an interaction between SipC and cytokeratin-18 may occur as part of Salmonella invasion...
  59. ncbi request reprint Keratin-containing inclusions affect cell morphology and distribution of cytosolic cellular components
    Shinichiro Hanada
    Second Department of Medicine, Kurume University School of Medicine, Liver Cancer Division, Research Center for Innovative Cancer Therapy, Kurume University, 67 Asahi Machi, Kurume 830 0011, Japan jp
    Exp Cell Res 304:471-82. 2005
    ..01) and sometimes their morphology was significantly altered. Our data indicate that CK aggregates affect not only cell morphology but also the localization of various cytosolic components, which may affect the cellular function...
  60. ncbi request reprint Proteasome inhibition induces inclusion bodies associated with intermediate filaments and fragmentation of the Golgi apparatus
    Masaru Harada
    Second Department of Medicine and Research Center for Innovative Cancer Therapy, Kurume University School of Medicine, 67 Asahi Machi, Kurume 830 0011, Japan
    Exp Cell Res 288:60-9. 2003
    ..The IF inclusions disappeared by restoring proteasome function, and autophagy and lysosomal degradation might be, at least in part, associated with the elimination of inclusion bodies...
  61. pmc Functional analysis of the human papillomavirus type 16 E1=E4 protein provides a mechanism for in vivo and in vitro keratin filament reorganization
    Qian Wang
    Division of Virology, National Institute for Medical Research, London, United Kingdom
    J Virol 78:821-33. 2004
    ..The increase in avidity associated with multimeric binding may contribute to the ability of 16E1=E4 to sequester its cellular targets in the cytoplasm...
  62. ncbi request reprint Sphingosylphosphorylcholine regulates keratin network architecture and visco-elastic properties of human cancer cells
    Michael Beil
    Department of Internal Medicine I, University of Ulm, 89071 Ulm, Germany
    Nat Cell Biol 5:803-11. 2003
    ..We propose that reorganization of keratin by SPC may facilitate biological phenomena that require a high degree of elasticity, such as squeezing of cells through membranous pores during metastasis...

Research Grants4

  1. Feasibility of Hemin-Based Therapy in Experimental Acute Pancreatitis
    M Omary; Fiscal Year: 2006
    ....
  2. Pathogenesis of Keratin-Containing Inclusions in Liver Disease
    M Omary; Fiscal Year: 2007
    ..Frank Mallory, and may also impact on other inclusions that are found in association with several other neurological and neuromuscular human diseases whose pathogenesis is unknown. ..
  3. 2004 Intermediate Filaments Gordon Conference
    M Omary; Fiscal Year: 2004
    ..abstract_text> ..
  4. 2006 Gordon Research Conference on Intermediate Filaments
    M Omary; Fiscal Year: 2006
    ....