Research Topics
Species | Ruth O'HaraSummaryAffiliation: Stanford University Country: USA Publications
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Publications
5-HTTLPR short allele, resilience, and successful aging in older adultsRuth Oʼhara
Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford University, CA 94305, USA
Am J Geriatr Psychiatry 20:452-6. 2012..We examined whether the presence of the short allele was associated with poorer emotional resilience in older adults...
Long-term effects of mnemonic training in community-dwelling older adultsRuth O'Hara
Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford University, Stanford, CA 94305 5550, United States
J Psychiatr Res 41:585-90. 2007..Our findings suggest that mnemonic training has long-term benefits for some older adults, particularly those who continue to employ the mnemonic...- Serotonin transporter polymorphism, memory and hippocampal volume in the elderly: association and interaction with cortisolR O'HARA
Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford University, Stanford, CA 94305 5550, USA
Mol Psychiatry 12:544-55. 2007.... 
Increasing the ranks of academic researchers in mental health: a multisite approach to postdoctoral fellowship trainingRuth O'Hara
Sierra Pacific MIRECC, VA Palo Alto Health Care System, Palo Alto, California 94304, USA
Acad Med 85:41-7. 2010..The VA's multisite fellowship program plays a valuable role in preparing substantial numbers of psychiatry and psychology trainees for a range of academic clinical research and leadership positions in the field of mental health...- Serotonin transporter polymorphism and stress: a view across the lifespanJoachim F Hallmayer
Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, C 305, Stanford, CA 94305-5550, USA
Curr Psychiatry Rep 9:173-5. 2007 - Sleep apnea, apolipoprotein epsilon 4 allele, and TBI: mechanism for cognitive dysfunction and development of dementiaRuth O'Hara
Sierra Pacific Mental Illness Research, Education, and Clinical Center MIRECC, 151 Y, 3801 Miranda Avenue, Palo Alto, CA 94304, USA
J Rehabil Res Dev 46:837-50. 2009..Increased understanding of the relationships among sleep apnea, the APOE epsilon 4 allele, and cognition could improve our ability to ameliorate one significant source of cognitive impairment and risk for dementia associated with TBI... - Slower speed-of-processing of cognitive tasks is associated with presence of the apolipoprotein epsilon4 alleleRuth O'Hara
Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford University, Stanford, CA 94305 5550, United States
J Psychiatr Res 42:199-204. 2008..These findings provide continued support for the negative impact of the epsilon4 allele on cognition and further suggest that speed-of-processing during memory tasks may have the potential to detect subtle cognitive deficits... - Factors in choosing atypical antipsychotics: toward understanding the bases of physicians' prescribing decisionsJennifer Hoblyn
Palo Alto Veterans Affairs Health Care System, Sierra Pacific Mental Illness Research, Education, and Clinical Center, Palo Alto, CA 94304, USA
J Psychiatr Res 40:160-6. 2006..Off-label prescribing of medications, polypharmacy, and other questionable prescribing practices have led investigators to examine a large VA pharmacy database to determine if physician prescribing decisions appear reasonable... - Which Alzheimer patients are at risk for rapid cognitive decline?Ruth O'Hara
Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford University, Stanford, California 94305 5550, USA
J Geriatr Psychiatry Neurol 15:233-8. 2002..This information could help clinicians target these patients for pharmacologic interventions, facilitate long-term care planning, and potentially create savings by delaying or stabilizing the course of the disease... - Relating medial temporal lobe volume to frontal fMRI activation for memory encoding in older adultsAllyson C Rosen
Department of Psychology, Stanford University, Stanford, CA, USA
Cortex 41:595-602. 2005..These findings indicate a positive association between MTL volume and right frontal-lobe function that may underlie variability in memory performance among the elderly, and also suggest a two-stage model of memory decline in aging... - Cognitive ability, expertise, and age differences in following air-traffic control instructionsJoy L Taylor
Psychiatry Service, Sierra Pacific Mental Illness Research, Education and Clinical Center, Department of Veterans Affairs, Palo Alto, CA 94304 1207, USA
Psychol Aging 20:117-33. 2005..Results are discussed within frameworks of deliberate practice and cognitive mediation of age differences... - Circadian clock gene polymorphisms and sleep-wake disturbance in Alzheimer diseaseJerome A Yesavage
Department of Veterans Affairs Health Care System, Stanford University School of Medicine, Palo Alto, California
Am J Geriatr Psychiatry 19:635-43. 2011..The goal of this study is to report indices of sleep-wake function collected from individuals with AD in relation to relevant polymorphisms in circadian clock-related genes... - Sleep/wake disruption in Alzheimer's disease: APOE status and longitudinal courseJerome A Yesavage
National Institute of Aging Alzheimer s Disease Core Center, Palo Alto VA Health Care System 151Y, 3801 Miranda Avenue, Palo Alto, CA 94304, USA
J Geriatr Psychiatry Neurol 17:20-4. 2004..In these data, APOE status was associated with the progression of sleep/wake disturbances in AD. Overall, there was greater deterioration on sleep parameters in patients negative for the epsilon4 allele... - Differential associations between entorhinal and hippocampal volumes and memory performance in older adultsAllyson C Rosen
Department of Psychology, Stanford University, Stanford, California 94305, USA
Behav Neurosci 117:1150-60. 2003..57) with delayed paragraph recall. These results suggest that entorhinal and hippocampal volumes are related to individual differences in dissociable kinds of memory performance among healthy older adults... - Should one use medications in combination with cognitive training? If so, which ones?Jerome Yesavage
Palo Alto Veterans Affairs Health Care System, Palo Alto, CA 94304, USA
J Gerontol B Psychol Sci Soc Sci 62:11-8. 2007..As the number of cognitively impaired older adults grows, it is likely that there will be pressure to treat more broadly with both medications and cognitive training... - COMT genotype, gender and cognition in community-dwelling, older adultsRuth O'Hara
Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford University, Stanford, CA 94305 5550, USA
Neurosci Lett 409:205-9. 2006..Further, when gender is taken into consideration, any negative impact of COMT genotype may extend to cognitive domains other than those associated with prefrontal regions... - The association of anxiety and depressive symptoms with cognitive performance in community-dwelling older adultsSherry A Beaudreau
Sierra Pacific Mental Illness, Research, Education, and Clinical Center MIRECC at the Veterans Affairs Palo Alto Health Care System, Palo Alto, California 94304, USA
Psychol Aging 24:507-12. 2009..Findings suggest an excess cognitive load on inhibitory ability in normal older adults reporting mild anxiety... - Age and disease severity predict choice of atypical neuroleptic: a signal detection approach to physicians' prescribing decisionsJerome A Yesavage
Palo Alto Veterans Affairs Health Care System, MC 151Y, Palo Alto, CA, USA
J Psychiatr Res 37:535-8. 2003.... - Insomnia in the context of traumatic brain injuryJamie M Zeitzer
VA Palo Alto Health Care System, 3801 Miranda Avenue 151Y, Palo Alto, CA 94304, USA
J Rehabil Res Dev 46:827-36. 2009.... - Modeling the effects of obstructive sleep apnea and hypertension in Vietnam veterans with PTSDLisa M Kinoshita
Department of Veterans Affairs, VA Palo Alto Health Care System, 3801 Miranda Avenue, Palo Alto, CA 94304, USA
Sleep Breath 16:1201-9. 2012..We hypothesized that in addition to indices of OSA severity, hypertension is associated with worse cognitive performance in such adults... - Gender differences in sexual behaviors of AD patients and their relationship to spousal caregiver well-beingHelen D Davies
Veterans Affairs Palo Alto Health Care System, Palo Alto, CA, USA
Aging Ment Health 16:89-101. 2012..This study evaluated the impact of gender differences on intimacy and sexual satisfaction in marital relationships in which one partner has AD... - Hormone replacement therapy and longitudinal cognitive performance in postmenopausal womenRuth O'Hara
Dept of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305 5550, USA
Am J Geriatr Psychiatry 13:1107-10. 2005..The authors examined the impact of hormone replacement therapy (HRT) on longitudinal cognitive performance (controlling for mood state) in 69 community-dwelling, postmenopausal women... - Underreporting of behavioral problems in older hospitalized patientsHelen D Davies
Veterans Affairs Palo Alto Health Care System, 3801 Miranda Avenue, 116F, Palo Alto, CA 94304, USA
Gerontologist 45:535-8. 2005..Such underreporting may have clinical and administrative implications... - Modeling the prevalence and incidence of Alzheimer's disease and mild cognitive impairmentJerome A Yesavage
Palo Alto Veterans Affairs Health Care System, 3801 Miranda Avenue, MC 151Y, Palo Alto, CA 94304, USA
J Psychiatr Res 36:281-6. 2002..Due to its substantial prevalence, MCI may be an important target for screening and possible intervention... - Late-life anxiety and cognitive impairment: a reviewSherry A Beaudreau
Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Veterans Affairs Palo Alto Health Care System, Clinical Center MIRECC, Palo Alto, CA 94304, USA
Am J Geriatr Psychiatry 16:790-803. 2008.... - Psychoactive drugs and pilot performance: a comparison of nicotine, donepezil, and alcohol effectsMartin S Mumenthaler
Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA
Neuropsychopharmacology 28:1366-73. 2003.... - Relationship of age and simulated flight performanceJ A Yesavage
Department of Veterans Affairs Health Care System, Palo Alto, California, USA
J Am Geriatr Soc 47:819-23. 1999..To determine the relationship between age and aviator performance on a flight simulator... - Spatial test for agricultural pesticide "blow-in" effect on prevalence of Parkinson's diseaseJ A Yesavage
Sierra Pacific Mental Illness Research, Education, and Clinical Center, Palo Alto Veterans Affairs Health Care System, Palo Alto, CA 94304, USA
J Geriatr Psychiatry Neurol 19:32-5. 2006..The results did not support the hypothesis of increasing prevalence of Parkinsonism attributable to wind drift... - Use of a VA pharmacy database to screen for areas at high risk for disease: Parkinson's disease and exposure to pesticidesJ A Yesavage
Sierra Pacific Mental Illness Research, Education, and Clinical Center, Palo Alto VA Health Care System, Palo Alto, CA 94304, USA
J Geriatr Psychiatry Neurol 17:36-8. 2004..However, a thorough exploration of alternative explanations is needed to reach definitive conclusions regarding the findings suggested by this method... - Epidemiology of restless legs syndrome: a synthesis of the literatureMaurice M Ohayon
Stanford Sleep Epidemiology Research Center, Stanford University, School of Medicine, 3430 West Bayshore Road, Palo Alto, CA 94303, USA
Sleep Med Rev 16:283-95. 2012..Future epidemiological studies should focus on systematically adding frequency and severity in the definition of the syndrome in order to minimize the inclusion of cases mimicking RLS... - Categorical versus dimensional approaches to diagnosis: methodological challengesHelena Chmura Kraemer
Department of Psychiatry and Behavioral Sciences, C305, 401 Quarry Road, Stanford University School of Medicine, Stanford University, Stanford, CA 94305 5717, USA
J Psychiatr Res 38:17-25. 2004..We argue that failure to utilize the correct approach under the appropriate circumstances can result in impaired clinical and research decision-making... - Prefrontal cortex and executive function impairments in primary breast cancerShelli R Kesler
Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 401 Quarry Rd, MC5795, Stanford, CA 94305 5795, USA
Arch Neurol 68:1447-53. 2011.... - Utility of the abbreviated Fuld Object Memory Evaluation and MMSE for detection of dementia and cognitive impairment not dementia in diverse ethnic groupsTiffany Rideaux
Pacific Graduate School of Psychology Stanford PsyD Consortium, Palo Alto University, Palo Alto, CA, USA
J Alzheimers Dis 31:371-86. 2012..Findings suggest that ethnicity is important in the selection of an appropriate cognitive screen and cut-score to use with older adults... - Immunology: hepatitis A virus link to atopic diseaseJennifer J McIntire
Division of Immunology and Allergy, Department of Pediatrics, Stanford University, Stanford, California 94305-5208, USA
Nature 425:576. 2003 - Psychiatric genetics: what to expectJoachim F Hallmayer
Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 1201 Welch Road, Room P112, Palo Alto, CA 94304, USA
Curr Psychiatry Rep 6:149-50. 2004 - Genetic evidence for a distinct subtype of schizophrenia characterized by pervasive cognitive deficitJoachim F Hallmayer
Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, CA, USA
Am J Hum Genet 77:468-76. 2005.... - Perinatal factors and the development of autism: a population studyEmma J Glasson
Schools of Population Health and Psychiatry and Clinical Neurosciences, University of Western Australia, Crawley, Australia
Arch Gen Psychiatry 61:618-27. 2004..Some investigations have shown an association with obstetric complications but findings have been inconsistent owing to differences in sampling and methods... - Brief report: effect of maternal age on severity of autismAlisa C Baxter
Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305 5719, USA
J Autism Dev Disord 37:976-82. 2007..Results indicate that there is no relationship between IQ or selected CBCL subtests and maternal age, suggesting that maternal age does not influence the severity of autism as measured by these indicators... - Abnormal cortical activation during response inhibition in 22q11.2 deletion syndromeDoron Gothelf
The Behavioral Neurogenetics Center, Child Psychiatry Department, Schneider Children s Medical Center of Israel, Petah Tiqwa, Israel
Hum Brain Mapp 28:533-42. 2007..2DS may recruit additional cingulate activation for tasks requiring attention and inhibition. 22q11.2DS is a unique model for learning about the deleterious effects of decreased dosage of the COMT gene on brain function...
Research Grants
- MCI, APOE and Sleep Apnea: Effects on CognitionRUTH O HARA; Fiscal Year: 2009..Reducing cognitive impairment and delaying the onset of AD has significant clinical and economic benefits. Thus, the answer to this question could significantly enhance our therapeutic approach to cognitive impairment in older adults. ..