Marino S, Romelfanger C, Yokota Y, Nusse R. Wnt1 is epistatic to Id2 in inducing mammary hyperplasia, ductal side-branching, and tumors in the mouse. BMC Cancer. 2004;4:91 pubmed
..We also show that Wnt1 expression is able to cause mammary tumors in an Id2 mutant background. We conclude that functional Id2 expression is not required for Wnt1 to induce mammary hyperplasia and mammary tumors. ..
Nusse R. WNT targets. Repression and activation. Trends Genet. 1999;15:1-3 pubmed
..Recent work sheds light on how this switch between repression and activation is regulated. ..
Nusse R. Wnts and Hedgehogs: lipid-modified proteins and similarities in signaling mechanisms at the cell surface. Development. 2003;130:5297-305 pubmed
..Several other aspects of Wnt and Hedgehog transport and signaling are discussed, as well as the possible origin of these pathways. ..