R Nusse

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. pmc A transcriptional response to Wnt protein in human embryonic carcinoma cells
    Jennifer Willert
    Department of Developmental Biology, Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305 USA
    BMC Dev Biol 2:8. 2002
  2. pmc Wnt1 is epistatic to Id2 in inducing mammary hyperplasia, ductal side-branching, and tumors in the mouse
    Susan Marino
    Department of Developmental Biology, Howard Hughes Medical Institute, Beckman Center, Stanford University Medical School Stanford, CA 94305, USA
    BMC Cancer 4:91. 2004
  3. ncbi request reprint WNT targets. Repression and activation
    R Nusse
    Howard Hughes Medical Institute, Stanford University, CA 94305, USA
    Trends Genet 15:1-3. 1999
  4. ncbi request reprint Wnt signaling in disease and in development
    Roel Nusse
    Department of Developmental Biology, Howard Hughes Medical Institute Beckman Center, School of Medicine, Stanford University, Stanford, CA, USA
    Cell Res 15:28-32. 2005
  5. ncbi request reprint Wnts and Hedgehogs: lipid-modified proteins and similarities in signaling mechanisms at the cell surface
    Roel Nusse
    Howard Hughes Medical Institute, Department of Developmental Biology, Beckman Center, Stanford University, Stanford, CA 94305, USA
    Development 130:5297-305. 2003
  6. pmc Naked cuticle targets dishevelled to antagonize Wnt signal transduction
    R Rousset
    Department of Developmental Biology, Howard Hughes Medical Institute, Beckman Center B300, Stanford University School of Medicine, Stanford, California 94305, USA
    Genes Dev 15:658-71. 2001
  7. ncbi request reprint A Drosophila Axin homolog, Daxin, inhibits Wnt signaling
    K Willert
    Howard Hughes Medical Institute, Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Development 126:4165-73. 1999
  8. ncbi request reprint Cell culture and whole animal approaches to understanding signaling by Wnt proteins in Drosophila
    R Nusse
    Howard Hughes Medical Institute, Department of Developmental Biology, Beckman Center, Stanford University Medical Center, California 94305 5428, USA
    Cold Spring Harb Symp Quant Biol 62:185-90. 1997
  9. ncbi request reprint Signaling by wingless in Drosophila
    J Klingensmith
    Howard Hughes Medical Institute, Department of Developmental Biology, Stanford University School of Medicine, California 94305
    Dev Biol 166:396-414. 1994
  10. ncbi request reprint Wingless repression of Drosophila frizzled 2 expression shapes the Wingless morphogen gradient in the wing
    K M Cadigan
    Howard Hughes Medical Institute, Department of Developmental Biology, Stanford University Medical Center, California 94305, USA
    Cell 93:767-77. 1998

Collaborators

Detail Information

Publications90

  1. pmc A transcriptional response to Wnt protein in human embryonic carcinoma cells
    Jennifer Willert
    Department of Developmental Biology, Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305 USA
    BMC Dev Biol 2:8. 2002
    ..Wnt signaling is implicated in many developmental decisions, including stem cell control, as well as in cancer. There are relatively few target genes known of the Wnt pathway...
  2. pmc Wnt1 is epistatic to Id2 in inducing mammary hyperplasia, ductal side-branching, and tumors in the mouse
    Susan Marino
    Department of Developmental Biology, Howard Hughes Medical Institute, Beckman Center, Stanford University Medical School Stanford, CA 94305, USA
    BMC Cancer 4:91. 2004
    ..During pregnancy, the mammary glands from Id2 mutant animals are deficient in lobulo-alveolar development. This failure of development is believed to be due to a proliferation defect...
  3. ncbi request reprint WNT targets. Repression and activation
    R Nusse
    Howard Hughes Medical Institute, Stanford University, CA 94305, USA
    Trends Genet 15:1-3. 1999
    ..Recent work sheds light on how this switch between repression and activation is regulated...
  4. ncbi request reprint Wnt signaling in disease and in development
    Roel Nusse
    Department of Developmental Biology, Howard Hughes Medical Institute Beckman Center, School of Medicine, Stanford University, Stanford, CA, USA
    Cell Res 15:28-32. 2005
    ..It is also clear that Wnt signals are required for adult tissue maintenance. Perturbations in Wnt signaling cause human degenerative diseases as well as cancer...
  5. ncbi request reprint Wnts and Hedgehogs: lipid-modified proteins and similarities in signaling mechanisms at the cell surface
    Roel Nusse
    Howard Hughes Medical Institute, Department of Developmental Biology, Beckman Center, Stanford University, Stanford, CA 94305, USA
    Development 130:5297-305. 2003
    ..Several other aspects of Wnt and Hedgehog transport and signaling are discussed, as well as the possible origin of these pathways...
  6. pmc Naked cuticle targets dishevelled to antagonize Wnt signal transduction
    R Rousset
    Department of Developmental Biology, Howard Hughes Medical Institute, Beckman Center B300, Stanford University School of Medicine, Stanford, California 94305, USA
    Genes Dev 15:658-71. 2001
    ..Our results suggest that Nkd acts directly through Dsh to limit Wg activity and thus determines how efficiently Wnt signals stabilize Armadillo (Arm)/beta-catenin and activate downstream genes...
  7. ncbi request reprint A Drosophila Axin homolog, Daxin, inhibits Wnt signaling
    K Willert
    Howard Hughes Medical Institute, Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Development 126:4165-73. 1999
    ..The loss-of-function and overexpression phenotypes show that Daxin, like its mammalian counterpart, acts as a negative regulator of wg/Wnt signaling...
  8. ncbi request reprint Cell culture and whole animal approaches to understanding signaling by Wnt proteins in Drosophila
    R Nusse
    Howard Hughes Medical Institute, Department of Developmental Biology, Beckman Center, Stanford University Medical Center, California 94305 5428, USA
    Cold Spring Harb Symp Quant Biol 62:185-90. 1997
  9. ncbi request reprint Signaling by wingless in Drosophila
    J Klingensmith
    Howard Hughes Medical Institute, Department of Developmental Biology, Stanford University School of Medicine, California 94305
    Dev Biol 166:396-414. 1994
    ..Where appropriate, wingless signaling will be compared to the activity of vertebrate Wnt proteins...
  10. ncbi request reprint Wingless repression of Drosophila frizzled 2 expression shapes the Wingless morphogen gradient in the wing
    K M Cadigan
    Howard Hughes Medical Institute, Department of Developmental Biology, Stanford University Medical Center, California 94305, USA
    Cell 93:767-77. 1998
    ..In contrast to other ligand-receptor relationships where the receptor limits diffusion of the ligand, Dfz2 broadens the range of Wg action by protecting it from degradation...
  11. ncbi request reprint Pathway specificity by the bifunctional receptor frizzled is determined by affinity for wingless
    E J Rulifson
    Howard Hughes Medical Institute and Department of Developmental Biology, Stanford University, California 94305, USA
    Mol Cell 6:117-26. 2000
    ..This suggests that Fz has an intrinsic capacity for polarity signaling and that high-affinity interaction with Wg couples it to the Wnt pathway...
  12. pmc Casein kinase 2 associates with and phosphorylates dishevelled
    K Willert
    Howard Hughes Medical Institute and Department of Developmental Biology, Stanford University School of Medicine, CA 94305, USA
    EMBO J 16:3089-96. 1997
    ..Overexpression of Dfz2, a Wingless receptor, also stimulated phosphorylation of Dsh, Dsh-associated kinase activity, and association of CK2 with Dsh, thus suggesting a role for CK2 in the transduction of the Wg signal...
  13. ncbi request reprint Expression of wingless in the Drosophila embryo: a conserved cis-acting element lacking conserved Ci-binding sites is required for patched-mediated repression
    D Lessing
    Howard Hughes Medical Institute, Department of Developmental Biology, Beckman Center, Stanford University, Medical Center, Stanford, CA 94305, USA
    Development 125:1469-76. 1998
    ..We show that wg regulatory DNA can drive lacZ in a proper wg-like pattern without any conserved Ci-binding sites and suggest that Ci can not be the sole endpoint of the Hh pathway...
  14. ncbi request reprint The dishevelled protein is modified by wingless signaling in Drosophila
    S Yanagawa
    Howard Hughes Medical Institute, Department of Developmental Biology, Beckman Center, Stanford University, California 94305 5428, USA
    Genes Dev 9:1087-97. 1995
    ..We conclude that dsh, a highly conserved gene, is not merely a permissive factor in Wg signaling but encodes a novel signal transduction molecule, which may function between the Wg receptor and more downstream signaling molecules...
  15. ncbi request reprint A new secreted protein that binds to Wnt proteins and inhibits their activities
    J C Hsieh
    Department of Molecular Biology and Genetics, Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Nature 398:431-6. 1999
    ....
  16. ncbi request reprint Beta-catenin: a key mediator of Wnt signaling
    K Willert
    Howard Hughes Medical Institute, Department of Developmental Biology, Backman Center, Stanford University Medical Center, California 94305, USA
    Curr Opin Genet Dev 8:95-102. 1998
    ..Activating mutations in beta-catenin and in components regulating its stability can contribute to the formation of certain tumors...
  17. ncbi request reprint WNT signaling in the control of hair growth and structure
    S E Millar
    Howard Hughes Medical Institute, Stanford University, Stanford, California, 94305 5428, USA
    Dev Biol 207:133-49. 1999
    ....
  18. ncbi request reprint Wnt meeting 1996
    K M Cadigan
    Howard Hughes Medical Institute, Department of Developmental Biology, Beckman Center, Stanford University, CA, USA
    Biochim Biophys Acta 1332:R1-5. 1997
  19. ncbi request reprint wingless signaling in the Drosophila eye and embryonic epidermis
    K M Cadigan
    Howard Hughes Medical Institute, Stanford University School of Medicine, California 94305, USA
    Development 122:2801-12. 1996
    ..However, we present evidence that wingless signaling still occurs normally in the complete absence of Notch protein in the embryonic epidermis. Thus, in the simplest model for wingless signalling, a direct role for Notch is unlikely...
  20. ncbi request reprint A versatile transcriptional effector of Wingless signaling
    R Nusse
    Department of Developmental Biology, Beckman Center, Stanford University, Medical Center, California 94305 5428, USA
    Cell 89:321-3. 1997
  21. ncbi request reprint Wnt signaling: a common theme in animal development
    K M Cadigan
    Howard Hughes Medical Institute, Department of Developmental Biology, Beckman Center, Stanford University Medical Center, Stanford, California 94305 5323, USA
    Genes Dev 11:3286-305. 1997
  22. ncbi request reprint A novel human homologue of the Drosophila frizzled wnt receptor gene binds wingless protein and is in the Williams syndrome deletion at 7q11.23
    Y K Wang
    Howard Hughes Medical Institute, Stanford University Medical Center, CA 94305, USA
    Hum Mol Genet 6:465-72. 1997
    ..The potential function of FZD3 in transmitting a Wnt protein signal in the human brain and other tissues suggests that heterozygous deletion of the FZD3 gene could contribute to the WS phenotype...
  23. pmc The role of the cysteine-rich domain of Frizzled in Wingless-Armadillo signaling
    Michael Povelones
    Department of Developmental Biology, Beckman Center, Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305 5428, USA
    EMBO J 24:3493-503. 2005
    ..We propose that Fz activates signaling in two steps: Fz uses its CRD to capture Wg, and once bound Wg interacts with the membrane portion of the receptor to initiate signaling...
  24. ncbi request reprint Ligand receptor interactions in the Wnt signaling pathway in Drosophila
    Chi Hwa Wu
    Howard Hughes Medical Institute, Department of Developmental Biology, Stanford University Medical School, California 94305 5323, USA
    J Biol Chem 277:41762-9. 2002
    ..We have therefore examined whether a soluble form of the Arrow molecule can bind to Wingless and Frizzled, but no interactions were detected...
  25. ncbi request reprint Wnt signaling regulates B lymphocyte proliferation through a LEF-1 dependent mechanism
    T Reya
    Howard Hughes Medical Institute, Department of Microbiology and Immunology, University of California, San Francisco, 94143, USA
    Immunity 13:15-24. 2000
    ..Finally, we establish a link between Wnt signaling and normal B cell development by demonstrating that Wnt proteins are mitogenic for pro-B cells and that this effect is mediated by LEF-1...
  26. ncbi request reprint Biological activity of soluble wingless protein in cultured Drosophila imaginal disc cells
    F van Leeuwen
    Howard Hughes Medical Institute, Beckman Center, Stanford University, School of Medicine, California 94305
    Nature 368:342-4. 1994
    ..The protein in the medium acts fast and is inhibited by an antibody to wingless protein, demonstrating that Wnt products can act as soluble extracellular signalling molecules...
  27. pmc Mutations in the segment polarity genes wingless and porcupine impair secretion of the wingless protein
    M van den Heuvel
    Howard Hughes Medical Institute, Department of Developmental Biology, Beckman Center for Molecular and Genetic Medicine, Stanford University School of Medicine, CA 94305
    EMBO J 12:5293-302. 1993
    ..These data provide further evidence that wg acts as a secreted factor and suggest that porcupine provides an accessory function for wg protein secretion or transport...
  28. ncbi request reprint Differential requirements for segment polarity genes in wingless signaling
    J Noordermeer
    Howard Hughes Medical Institute, Stanford University, California 94305 5428, USA
    Mech Dev 51:145-55. 1995
    ..Signaling from engrailed cells to this novel wingless expression domain is dependent on hedgehog but also on porcupine. We further demonstrate a novel requirement for hedgehog in maintenance of expression of engrailed itself...
  29. pmc Developmental roles of the Mi-2/NURD-associated protein p66 in Drosophila
    Charlene Kon
    Department of Developmental Biology, Howard Hughes Medical Institute, Beckman Center, Stanford University School of Medicine, California 94305 5329, USA
    Genetics 169:2087-100. 2005
    ..By co-immunoprecipitation, p66 associates with dMi-2, a known NURD complex member...
  30. ncbi request reprint Wingless blocks bristle formation and morphogenetic furrow progression in the eye through repression of Daughterless
    Kenneth M Cadigan
    Howard Hughes Medical Institute and the Department of Developmental Biology, Stanford University School of Medicine, Beckman Center, Stanford, California 94305, USA
    Development 129:3393-402. 2002
    ..These results are summarized in a model where daughterless is a major, but probably not the only, target of wingless action in the eye...
  31. ncbi request reprint Maintenance of Wnt-3 expression in Purkinje cells of the mouse cerebellum depends on interactions with granule cells
    P C Salinas
    Department of Developmental Biology, Stanford University, CA 94305 5428
    Development 120:1277-86. 1994
    ..Our results show that Wnt-3 expression in Purkinje cells is modulated by their presynaptic granule cells at the time of neuronal maturation...
  32. pmc Wingless signaling modulates cadherin-mediated cell adhesion in Drosophila imaginal disc cells
    Andreas Wodarz
    Howard Hughes Medical Institute and Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Cell Sci 119:2425-34. 2006
    ....
  33. pmc Genetic evidence that Drosophila frizzled controls planar cell polarity and Armadillo signaling by a common mechanism
    Michael Povelones
    Howard Hughes Medical Institute, Department of Developmental Biology, Beckman Center, Stanford University School of Medicine, Stanford, CA 94305, USA
    Genetics 171:1643-54. 2005
    ..This suggests that fz controls these two different signaling activities by a common mechanism. In addition, this screen yielded a set of missense mutations that identify amino acids specifically required for fz signaling function...
  34. pmc WntD is a feedback inhibitor of Dorsal/NF-kappaB in Drosophila development and immunity
    Michael D Gordon
    Department of Developmental Biology, Howard Hughes Medical Institute, Beckman Center and
    Nature 437:746-9. 2005
    ..Furthermore, the wntD mutant phenotype is suppressed by loss of zygotic dorsal. These results describe the first secreted feedback antagonist of Toll signalling, and demonstrate a novel Wnt activity in the fly...
  35. ncbi request reprint Wnt proteins are lipid-modified and can act as stem cell growth factors
    Karl Willert
    Howard Hughes Medical Institute and Department of Developmental Biology, Stanford University School of Medicine, Stanford, California 94305, USA
    Nature 423:448-52. 2003
    ..The purified Wnt3a protein induces self-renewal of haematopoietic stem cells, signifying its potential use in tissue engineering...
  36. ncbi request reprint Expression of two members of the Wnt family during mouse development--restricted temporal and spatial patterns in the developing neural tube
    H Roelink
    Howard Hughes Medical Institute, Beckman Center, Stanford University, California 94305
    Genes Dev 5:381-8. 1991
    ..Characteristic expression patterns of these two closely related genes suggest that Wnt-3 and Wnt-3A play distinct roles in cell-cell signaling during morphogenesis of the developing neural tube...
  37. ncbi request reprint Molecular cloning and chromosomal localization to 17q21 of the human WNT3 gene
    H Roelink
    Howard Hughes Medical Institute, Department of Developmental Biology, Beckman Center, Stanford University, California 94305
    Genomics 17:790-2. 1993
    ..WNT3 is located on chromosome 17q21. The gene was not found to be amplified or rearranged in a collection of human breast tumors...
  38. ncbi request reprint Dishevelled 2 recruits beta-arrestin 2 to mediate Wnt5A-stimulated endocytosis of Frizzled 4
    Wei Chen
    Howard Hughes Medical Institute, Departments of Medicine and Biochemistry, Duke University Medical Center, Durham, NC 27710, USA
    Science 301:1391-4. 2003
    ..These findings provide a previously unrecognized mechanism for receptor recruitment of beta-arrestin and demonstrate that Dvl plays an important role in the endocytosis of frizzled, as well as in promoting signaling...
  39. ncbi request reprint The consequences of ubiquitous expression of the wingless gene in the Drosophila embryo
    J Noordermeer
    Howard Hughes Medical Institute, Stanford University, California 94305 5428
    Development 116:711-9. 1992
    ..For the development of the wild-type pattern, it is required that wingless is expressed in a subset of these cells...
  40. ncbi request reprint Isolation and expression of two novel Wnt/wingless gene homologues in Drosophila
    J Russell
    Howard Hughes Medical Institute, Stanford University, California 94305
    Development 115:475-85. 1992
    ..DWnt-3 is also expressed in mesodermal and neurogenic regions. The distribution of DWnt-3 transcripts in cells of the central nervous system (CNS) during Drosophila embryogenesis suggests that DWnt-3 could be involved in CNS development...
  41. pmc Essential requirement for Wnt signaling in proliferation of adult small intestine and colon revealed by adenoviral expression of Dickkopf-1
    Frank Kuhnert
    Department of Medicine, Stanford University School of Medicine, Center for Clinical Sciences Research 3100, 269 Campus Drive, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 101:266-71. 2004
    ....
  42. pmc A mutational analysis of dishevelled in Drosophila defines novel domains in the dishevelled protein as well as novel suppressing alleles of axin
    Andrea Penton
    Howard Hughes Medical Institute, Department of Developmental Biology, Stanford University Medical School, Stanford, California 94305 5323, USA
    Genetics 161:747-62. 2002
    ..We also recovered second-site-suppressing mutations in axin, mapping at a region that may specifically interact with overexpressed Dsh...
  43. ncbi request reprint Wnts as ligands: processing, secretion and reception
    A J Mikels
    Department of Developmental Biology, Stanford University, Stanford, CA, USA
    Oncogene 25:7461-8. 2006
    ..This review attempts to consolidate the current data regarding these essential processes...
  44. ncbi request reprint Bone regeneration is regulated by wnt signaling
    Jae Beom Kim
    Department of Surgery, Division of Plastic and Reconstructive Surgery, Stanford University, Stanford, CA 94305 5148, USA
    J Bone Miner Res 22:1913-23. 2007
    ..Herein, we studied the role of Wnt signaling in skeletal tissue regeneration...
  45. ncbi request reprint Creating transgenic Drosophila by microinjecting the site-specific phiC31 integrase mRNA and a transgene-containing donor plasmid
    Matthew P Fish
    Department of Developmental Biology and Howard Hughes Medical Institute, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, California 94305 5120, USA
    Nat Protoc 2:2325-31. 2007
    ..The whole procedure, from injection to established transgenic stocks, can be completed in three generations (approximately 1 month) and can be adapted for other types of transgenesis and mRNA injections in Drosophila...
  46. doi request reprint Wnt signaling and stem cell control
    Roel Nusse
    Howard Hughes Medical Institute, Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Cell Res 18:523-7. 2008
    ..In general, Wnt proteins act to maintain the undifferentiated state of stem cells, while other growth factors instruct the cells to proliferate. These other factors include FGF and EGF, signaling through tyrosine kinase pathways...
  47. ncbi request reprint A dedicated Wnt secretion factor
    Wendy Ching
    Department of Developmental Biology and Howard Hughes Medical Institute, Stanford University School of Medicine, Beckman Center, B271, Stanford, CA 94305, USA
    Cell 125:432-3. 2006
    ..In this issue of Cell, Bänziger et al. (2006) and Bartscherer et al. (2006) identify Wntless/Evi, a multipass transmembrane protein in the secretory pathway of Wnt-producing cells that promotes Wnt secretion...
  48. pmc A critical role for endocytosis in Wnt signaling
    Jeremy T Blitzer
    Howard Hughes Medical Institute and Department of Developmental Biology, Stanford University School of Medicine, Stanford, California 94305, USA
    BMC Cell Biol 7:28. 2006
    ..While numerous Wnts, their cognate receptors of the Frizzled and Arrow/LRP5/6 families and downstream pathway components have been identified, little is known about the initial events occurring directly after receptor activation...
  49. ncbi request reprint Cancer. Converging on beta-catenin in Wilms tumor
    Roel Nusse
    Department of Developmental Biology, Howard Hughes Medical Institute, Stanford University, School of Medicine, Stanford, CA 94305 5323, USA
    Science 316:988-9. 2007
  50. ncbi request reprint Wnt/beta-catenin signaling in murine hepatic transit amplifying progenitor cells
    Min Hu
    Department of Surgery, Stanford University School of Medicine, Stanford, California, USA
    Gastroenterology 133:1579-91. 2007
    ..Because Wnt/beta-catenin signaling is a known regulatory pathway for liver development and regeneration, we studied the role of Wnt signaling in oval cells using a mouse model of chronic liver injury...
  51. pmc Wnt proteins are self-renewal factors for mammary stem cells and promote their long-term expansion in culture
    Yi Arial Zeng
    Howard Hughes Medical Institute, Department of Developmental Biology, Stanford University, School of Medicine, Stanford, CA 94305 5323, USA
    Cell Stem Cell 6:568-77. 2010
    ..We conclude that Wnt proteins serve as rate-limiting self-renewal signals acting directly on mammary stem cells...
  52. pmc Construction of transgenic Drosophila by using the site-specific integrase from phage phiC31
    Amy C Groth
    Department of Genetics, Stanford University School of Medicine, Stanford, California 94305, USA
    Genetics 166:1775-82. 2004
    ..These experiments demonstrate the potential for precise genetic engineering of the Drosophila genome with the phiC31 integrase system and will likely benefit research in Drosophila and other insects...
  53. ncbi request reprint Wnt3a growth factor induces androgen receptor-mediated transcription and enhances cell growth in human prostate cancer cells
    Meletios Verras
    Department of Urology, Stanford University School of Medicine, Stanford, California, USA
    Cancer Res 64:8860-6. 2004
    ..Our findings demonstrate that Wnt3a plays an important role in androgen-mediated transcription and cell growth. These results suggest a novel mechanism for the progression of prostate cancer...
  54. pmc Wnt signaling mediates self-organization and axis formation in embryoid bodies
    Derk ten Berge
    Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305, USA
    Cell Stem Cell 3:508-18. 2008
    ..Our findings show that the Wnt pathway mediates the local execution of a gastrulation-like process in the embryoid body, which displays an unexpected degree of self-organization...
  55. ncbi request reprint Ablation of insulin-producing neurons in flies: growth and diabetic phenotypes
    Eric J Rulifson
    Department of Developmental Biology, Beckman Center B300, Stanford University, Stanford, CA 94305 5329, USA
    Science 296:1118-20. 2002
    ..Interestingly, the phenotype of flies lacking IPCs includes certain features of diabetes mellitus...
  56. pmc Convergence of Wnt, beta-catenin, and cadherin pathways
    W James Nelson
    Department of Molecular and Cellular Physiology, Beckman Center for Molecular and Genetic Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
    Science 303:1483-7. 2004
    ..Here, we assemble evidence of possible interrelations between Wnt and other growth factor signaling, beta-catenin functions, and cadherin-mediated adhesion...
  57. pmc Wnt and FGF signals interact to coordinate growth with cell fate specification during limb development
    Derk ten Berge
    Howard Hughes Medical Institute, Department of Developmental Biology, Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA
    Development 135:3247-57. 2008
    ....
  58. pmc Wnt-mediated self-renewal of neural stem/progenitor cells
    M Yashar S Kalani
    Howard Hughes Medical Institute, Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 105:16970-5. 2008
    ....
  59. ncbi request reprint The Wnt signaling pathway in development and disease
    Catriona Y Logan
    Department of Developmental Biology, Beckman Center, Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA
    Annu Rev Cell Dev Biol 20:781-810. 2004
    ..The next few years are likely to see novel therapeutic reagents aimed at controlling Wnt signaling in order to alleviate these conditions...
  60. doi request reprint Translating insights from development into regenerative medicine: the function of Wnts in bone biology
    P Leucht
    Department of Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA
    Semin Cell Dev Biol 19:434-43. 2008
    ..In this review we summarize recent data with a focus on the roles of Wnt signaling in mesenchymal stem cell fate, osteoprogenitor cell differentiation, chondrocyte maturation, bone remodeling, and bone regeneration...
  61. doi request reprint Wnt signaling and stem cell control
    R Nusse
    Howard Hughes Medical Institute, Department of Developmental Biology, Stanford University School of Medicine, Stanford, California 94305, USA
    Cold Spring Harb Symp Quant Biol 73:59-66. 2008
    ..We propose that these modifications control the range of Wnt signaling and have critical roles in establishing niches for stem cells in various tissues...
  62. doi request reprint Telomerase modulates Wnt signalling by association with target gene chromatin
    Jae Il Park
    Department of Medicine, Stanford University School of Medicine, Stanford, California 94305, USA
    Nature 460:66-72. 2009
    ..These data reveal an unanticipated role for telomerase as a transcriptional modulator of the Wnt/beta-catenin signalling pathway...
  63. pmc A dermal HOX transcriptional program regulates site-specific epidermal fate
    John L Rinn
    Program in Epithelial Biology, Stanford University School of Medicine, Stanford, California 94305, USA
    Genes Dev 22:303-7. 2008
    ..Thus, maintenance of appropriate HOX transcriptional program in adult fibroblasts may serve as a source of positional memory to differentially pattern the epithelia during homeostasis and regeneration...
  64. pmc Wnt signalling in development and disease. Max Delbrück Center for Molecular Medicine meeting on Wnt signaling in Development and Disease
    Christophe Fuerer
    Department of Developmental Biology, Howard Hughes Medical Institute, Stanford University, School of Medicine, Stanford, California 94305 5323, USA
    EMBO Rep 9:134-8. 2008
  65. pmc Lipid-independent secretion of a Drosophila Wnt protein
    Wendy Ching
    Howard Hughes Medical Institute and the Department of Developmental Biology, Stanford University School of Medicine, Stanford, California 94305, USA
    J Biol Chem 283:17092-8. 2008
    ..Our results show that not all Wnt family members require lipid modification, Porcupine, or Wntless/Evi/Sprinter for secretion and suggest that different modes of secretion may exist for different Wnt proteins...
  66. doi request reprint Wnt proteins promote bone regeneration
    Steven Minear
    Department of Surgery, Division of Plastic and Reconstructive Surgery, Stanford School of Medicine, Stanford, CA 94305, USA
    Sci Transl Med 2:29ra30. 2010
    ..The end result was faster bone regeneration. Because Wnt signaling is conserved in mammalian tissue repair, this protein-based approach may have widespread applications in regenerative medicine...
  67. pmc Asymmetric homotypic interactions of the atypical cadherin flamingo mediate intercellular polarity signaling
    Wei Shen Chen
    Department of Pathology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA
    Cell 133:1093-105. 2008
    ....
  68. ncbi request reprint Wnt signaling mediates regional specification in the vertebrate face
    Samantha A Brugmann
    Department of Plastic and Reconstructive Surgery, Stanford University, Stanford, CA 94305, USA
    Development 134:3283-95. 2007
    ..Collectively, these data elucidate a new role for Wnt signaling in regional specification of the vertebrate face, and suggest possible mechanisms whereby species-specific facial features are generated...
  69. ncbi request reprint Wnt signaling: multiple pathways, multiple receptors, and multiple transcription factors
    Michael D Gordon
    Howard Hughes Medical Institute and Department of Developmental Biology, Stanford University School of Medicine, Stanford, California 94305, USA
    J Biol Chem 281:22429-33. 2006
  70. pmc Purified Wnt5a protein activates or inhibits beta-catenin-TCF signaling depending on receptor context
    Amanda J Mikels
    Department of Developmental Biology, Stanford University School of Medicine, Stanford, California, United States of America
    PLoS Biol 4:e115. 2006
    ..In this model, signaling by different Wnt family members is not intrinsically regulated by the Wnt proteins themselves but by receptor availability...
  71. ncbi request reprint Regional expression of the Wnt-3 gene in the developing mouse forebrain in relationship to diencephalic neuromeres
    P C Salinas
    Howard Hughes Medical Institute, Stanford Medical School, Stanford University, CA 94305
    Mech Dev 39:151-60. 1992
    ..The continued expression of these genes in the adult mouse brain suggests a distinct role in the mature CNS...
  72. pmc Ror2 receptor requires tyrosine kinase activity to mediate Wnt5A signaling
    Amanda Mikels
    Department of Developmental Biology and Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, California 94305, USA
    J Biol Chem 284:30167-76. 2009
    ....
  73. pmc Transcriptional program induced by Wnt protein in human fibroblasts suggests mechanisms for cell cooperativity in defining tissue microenvironments
    Zach Klapholz-Brown
    Department of Biochemistry, Stanford University School of Medicine, Stanford, California, USA
    PLoS ONE 2:e945. 2007
    ..Given the multifaceted roles of Wnt signaling in these processes, its transcriptional effects on the stromal cells that make up the scaffold and infrastructure of epithelial tissues are of great interest...
  74. pmc Pathogenesis of listeria-infected Drosophila wntD mutants is associated with elevated levels of the novel immunity gene edin
    Michael D Gordon
    Department of Developmental Biology, Howard Hughes Medical Institute, Beckman Center, Stanford University School of Medicine, Stanford, California, United States of America
    PLoS Pathog 4:e1000111. 2008
    ..These results are consistent with a model in which the regulation of host factors, including edin, must be tightly controlled to avoid the detrimental consequences of having too much or too little activity...
  75. pmc Mutants in the mouse NuRD/Mi2 component P66alpha are embryonic lethal
    Susan Marino
    Howard Hughes Medical Institute, Department of Developmental Biology, Beckman Center, Stanford University School of Medicine, Stanford, California, United States of America
    PLoS ONE 2:e519. 2007
    ..There are two mouse and human p66 paralogs, p66alpha and p66beta. The functions of these genes are not clear, in part because there are no mutants available, except in invertebrate model systems...
  76. ncbi request reprint Identification of DCAP, a drosophila homolog of a glucose transport regulatory complex
    Hiroto Yamazaki
    Department of Developmental Biology, Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305, USA
    Mech Dev 119:115-9. 2002
    ..DCAP is predominantly expressed in the midgut and fat bodies of late-stage embryos, suggesting a role in insulin-mediated glucose transport in these organs...
  77. pmc Wnt signaling regulates pancreatic beta cell proliferation
    Ingrid C Rulifson
    Department of Developmental Biology, Oncology Division, Stanford University, Stanford, CA 94305 5329, USA
    Proc Natl Acad Sci U S A 104:6247-52. 2007
    ..Thus, Wnt signaling is both necessary and sufficient for islet beta cell proliferation, and our study provides previously unrecognized evidence of a mechanism governing endocrine pancreas growth and function...
  78. doi request reprint Alternative wnt signaling is initiated by distinct receptors
    Renée van Amerongen
    Howard Hughes Medical Institute, Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Sci Signal 1:re9. 2008
    ..Here, we discuss basic principles of signal transduction initiated at the cell membrane, with the Wnt pathway, which harbors a multitude of ligands and receptors, as an example...
  79. pmc Liposomal packaging generates Wnt protein with in vivo biological activity
    Nathan T Morrell
    Division of Plastic and Reconstructive Surgery, Department of Surgery, Stanford University, Stanford, California, United States of America
    PLoS ONE 3:e2930. 2008
    ..When delivered subcutaneously, Wnt3a liposomes induce hair follicle neogenesis, demonstrating their robust biological activity in a regenerative context...
  80. pmc Lentiviral vectors to probe and manipulate the Wnt signaling pathway
    Christophe Fuerer
    Howard Hughes Medical Institute, Department of Developmental Biology, Stanford University School of Medicine, Stanford, California, United States of America
    PLoS ONE 5:e9370. 2010
    ..Further understanding of the function of Wnt signaling in specific cell types could benefit from lentiviral vectors expressing reporters for the Wnt pathway or vectors interfering with signaling...
  81. doi request reprint Towards an integrated view of Wnt signaling in development
    Renée van Amerongen
    Department of Developmental Biology and Howard Hughes Medical Institute, Beckman Center, 279 Campus Drive, Stanford University, Stanford, CA 94305, USA
    Development 136:3205-14. 2009
    ....
  82. ncbi request reprint Direct flight muscles in Drosophila develop from cells with characteristics of founders and depend on DWnt-2 for their correct patterning
    Karen M Kozopas
    Department of Cell Biology, University of Alabama at Birmingham, Birmingham, AL 35294 0005, USA
    Dev Biol 243:312-25. 2002
    ..We conclude that DWnt-2 promotes the correct patterning of DFMs through a mechanism that is independent of the attachment site differentiation initiated by stripe...
  83. ncbi request reprint Wnt signalling sees spots
    Michael Povelones
    Nat Cell Biol 4:E249-50. 2002
  84. ncbi request reprint A role for Wnt signalling in self-renewal of haematopoietic stem cells
    Tannishtha Reya
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nature 423:409-14. 2003
    ..We conclude that the Wnt signalling pathway is critical for normal HSC homeostasis in vitro and in vivo, and provide insight into a potential molecular hierarchy of regulation of HSC development...
  85. pmc Illegitimate WNT signaling promotes proliferation of multiple myeloma cells
    Patrick W B Derksen
    Department of Pathology, Academic Medical Center, University of Amsterdam, 1105AZ, Amsterdam, The Netherlands
    Proc Natl Acad Sci U S A 101:6122-7. 2004
    ..We therefore suggest that MM cells are dependent on an active WNT signal, which may have important implications for the management of this incurable form of cancer...
  86. ncbi request reprint LRP5 and Wnt signaling: a union made for bone
    Mark L Johnson
    Osteoporosis Research Center, Creighton University School of Medicine, Omaha, Nebraska 68131, USA
    J Bone Miner Res 19:1749-57. 2004
  87. ncbi request reprint A proliferative role for Wnt-3a in chick somites
    Lisa M Galli
    Department of Biology, San Francisco State University, San Francisco, CA 94132, USA
    Dev Biol 269:489-504. 2004
    ..Furthermore, our results demonstrate that small changes in proliferation can dramatically influence patterning and morphogenesis...
  88. pmc Differential inhibition of Wnt-3a by Sfrp-1, Sfrp-2, and Sfrp-3
    Lisa M Galli
    Department of Biology, San Francisco State University, San Francisco, California 94132, USA
    Dev Dyn 235:681-90. 2006
    ..These results provide the framework for understanding how Sfrps function to regulate Wnt-3a activity in developing embryos and in cancer...
  89. doi request reprint Illegitimate WNT pathway activation by beta-catenin mutation or autocrine stimulation in T-cell malignancies
    Richard W J Groen
    Department of Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Cancer Res 68:6969-77. 2008
    ..Our data indicate that activation of the WNT pathway, either by CTNNB1 mutation or autocrine stimulation, plays a role in the pathogenesis of a subset of NHLs, in particular, those of T-cell origin...
  90. ncbi request reprint Cell biology: relays at the membrane
    Roel Nusse
    Nature 438:747-9. 2005