Research Topics
Genomes and GenesSpecies | Jeffrey NortonSummaryAffiliation: Stanford University Country: USA Publications
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Publications
Value of surgery in patients with negative imaging and sporadic Zollinger-Ellison syndromeJeffrey A Norton
Stanford University Medical Center, Stanford, CA 94305, USA
Ann Surg 256:509-17. 2012..To address the value of surgery in patients with sporadic Zollinger-Ellison syndrome (ZES) with negative imaging studies...- Diagnostic accuracy of cyst fluid amphiregulin in pancreatic cystsMay T Tun
Department of Medicine, Stanford University, Stanford, CA 94305, USA
BMC Gastroenterol 12:15. 2012..This study evaluated the diagnostic utility of amphiregulin (AREG) as a pancreatic cyst fluid biomarker to differentiate non-mucinous, benign mucinous, and malignant mucinous cysts... - Role of factor VII in correcting dilutional coagulopathy and reducing re-operations for bleeding following non-traumatic major gastrointestinal and abdominal surgeryThomas C Tsai
Department of Surgery, Stanford University School of Medicine, Stanford, CA, USA
J Gastrointest Surg 14:1311-8. 2010..The objective of this study is to evaluate the effectiveness of rfVIIa in reducing blood product requirements and re-operation for postoperative bleeding after major abdominal surgery... - Resolved and unresolved controversies in the surgical management of patients with Zollinger-Ellison syndromeJeffrey A Norton
Department of Surgery, Stanford University Medical Center, Stanford, California 94305 5641, USA
Ann Surg 240:757-73. 2004..Highlight unresolved controversies in the management of Zollinger-Ellison syndrome (ZES)... - Does the use of routine duodenotomy (DUODX) affect rate of cure, development of liver metastases, or survival in patients with Zollinger-Ellison syndrome?Jeffrey A Norton
Surgical Oncology, Department of Surgery, Stanford University Medical Center, Room H 3591, 300 Pasteur Drive, Stanford, CA 94305 5641, USA
Ann Surg 239:617-25; discussion 626. 2004..To determine whether routine use of duodenotomy (DUODX) alters cure rate, survival, or development of liver metastases in 143 patients (162 operations) with Zollinger-Ellison syndrome (ZES) without MEN1... 
Role of surgery in Zollinger-Ellison syndromeJeffrey A Norton
Surgical Oncology, Department of Surgery, Stanford University, Palo Alto, California, USA
J Am Coll Surg 205:S34-7. 2007- Surgery for gastrinoma and insulinoma in multiple endocrine neoplasia type 1Jeffrey A Norton
Department of Surgery, Stanford University Medical Center, Room H 3591, 300 Pasteur Drive, Stanford, CA 94305 5641, USA
J Natl Compr Canc Netw 4:148-53. 2006..There is a high likelihood of cure when the insulinoma is excised surgically. However, recurrent hypoglycemia may occur, and careful follow-up is indicated... - Surgery for primary pancreatic neuroendocrine tumorsJeffrey A Norton
Stanford University School of Medicine, 300 Pasteur Drive, Stanford, California, USA
J Gastrointest Surg 10:327-31. 2006 - Surgery increases survival in patients with gastrinomaJeffrey A Norton
Department of Surgery, Stanford University Medical Center, Stanford, CA 94305 5641, USA
Ann Surg 244:410-9. 2006..To determine whether the routine use of surgical exploration for gastrinoma resection/cure in 160 patients with Zollinger-Ellison syndrome (ZES) altered survival compared with 35 ZES patients who did not undergo surgery... - CDH1 truncating mutations in the E-cadherin gene: an indication for total gastrectomy to treat hereditary diffuse gastric cancerJeffrey A Norton
Department of Surgery, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94035, USA
Ann Surg 245:873-9. 2007.... - Prospective study of surgery for primary hyperparathyroidism (HPT) in multiple endocrine neoplasia-type 1 and Zollinger-Ellison syndrome: long-term outcome of a more virulent form of HPTJeffrey A Norton
Department of Surgery, Stanford University Medical Center, Stanford, CA 94305, USA
Ann Surg 247:501-10. 2008..Surgery for parathyroid hyperplasia is tricky and difficult. Long-term outcome in ZES/MEN1/HPT is not well known... - Surgery and prognosis of duodenal gastrinoma as a duodenal neuroendocrine tumorJeffrey A Norton
Department of Surgery, Stanford University Medical Center, 300 Pasteur Drive, Room H3651, Stanford, CA 94305 5641, USA
Best Pract Res Clin Gastroenterol 19:699-704. 2005..However, it has not affected the rate of development of liver metastases. Duodenotomy is a critical method to find duodenal gastrinomas. It should be routinely performed in all surgery to find and remove gastrinoma for cure of ZES... - Pancreatic endocrine tumors with major vascular abutment, involvement, or encasement and indication for resectionJeffrey A Norton
Department of Surgery, Stanford University Medical Center, Stanford, CA 94305 5641, USA
Arch Surg 146:724-32. 2011..Surgery for pancreatic endocrine tumors (PETs) with blood vessel involvement is controversial... - Inhibition of host signal transducer and activator of transcription factor 6 results in cure with cyclophosphamide and interleukin 12 immunotherapyJeffrey A Norton
Department of Surgery, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, California, 94305 5641, USA
Ann Surg Oncol 13:118-24. 2006..It is not known whether this lack of a preexisting host antitumor immune response is a limiting factor for the lack of response to IL-12 therapy by nonimmunogenic tumors... 
Gemcitabine chemotherapy and single-fraction stereotactic body radiotherapy for locally advanced pancreatic cancerDevin Schellenberg
Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA, USA
Int J Radiat Oncol Biol Phys 72:678-86. 2008..This prospective trial evaluated the efficacy of a single fraction of 25 Gy stereotactic body radiotherapy (SBRT) delivered between Cycle 1 and 2 of gemcitabine chemotherapy...- Morbidity and mortality of aggressive resection in patients with advanced neuroendocrine tumorsJeffrey A Norton
Department of Surgery, University of California, San Francisco, CA 94143, USA
Arch Surg 138:859-66. 2003..Aggressive surgery remains a potentially efficacious antitumor therapy but is rarely performed because of its possible morbidity and mortality... - Surgical treatment and prognosis of gastrinomaJeffrey A Norton
Department of Surgery, Stanford University Medical Center, Room H3591, 300 Pasteur Drive, Stanford, CA 94305-5641, USA
Best Pract Res Clin Gastroenterol 19:799-805. 2005..However, the excellent long-term survival of these patients with lesser operations and the increased operative mortality and long-term morbidity of Whipple make its current role unclear until further studies are done... - Appendiceal mucinous neoplasms: clinicopathologic study of 116 cases with analysis of factors predicting recurrenceReetesh K Pai
Department of Pathology, Stanford University, Stanford, CA, USA
Am J Surg Pathol 33:1425-39. 2009..Appendiceal mucinous neoplasms can be stratified into 4 distinct risk groups on the basis of a careful histopathologic assessment of cytoarchitectural features and extent of disease at presentation... - Hereditary diffuse gastric cancer: surgery, surveillance and unanswered questionsRobin M Cisco
Stanford University School of Medicine, Department of Surgery, Stanford, CA 94305, USA
Future Oncol 4:553-9. 2008.... - Risk-reducing total gastrectomy for germline mutations in E-cadherin (CDH1): pathologic findings with clinical implicationsWilliam M Rogers
Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
Am J Surg Pathol 32:799-809. 2008..The observed site predilection suggests a possible role for geographically targeted endoscopic surveillance biopsy in patients who elect to delay surgical intervention... - Expression of p16(INK4A) but not hypoxia markers or poly adenosine diphosphate-ribose polymerase is associated with improved survival in patients with pancreatic adenocarcinomaDaniel T Chang
Department of Radiation Oncology, Stanford University, Stanford, CA, USA
Cancer 116:5179-87. 2010..This study investigates whether immunohistochemical expression of p16(INK4A) as well as hypoxia markers and poly adenosine diphosphate-ribose polymerase (PARP) correlates with survival in patients with resected pancreatic adenocarcinoma... - A national comparison of surgical versus percutaneous drainage of pancreatic pseudocysts: 1997-2001John M Morton
Department of Surgery, Stanford School of Medicine, Stanford, California 94305 5655, USA
J Gastrointest Surg 9:15-20; discussion 20-1. 2005.... - Phase II study to assess the efficacy of conventionally fractionated radiotherapy followed by a stereotactic radiosurgery boost in patients with locally advanced pancreatic cancerAlbert C Koong
Department of Radiation Oncology, Stanford University School of Medicine, 269 Campus Drive West, Stanford, CA 94305
Int J Radiat Oncol Biol Phys 63:320-3. 2005..To determine the efficacy of concurrent 5-fluorouracil (5-FU) and intensity-modulated radiotherapy (IMRT) followed by body stereotactic radiosurgery (SRS) in patients with locally advanced pancreatic cancer... - Possible primary lymph node gastrinoma: occurrence, natural history, and predictive factors: a prospective studyJeffrey A Norton
Department of Surgery, University of California San Francisco, 533 Parnassus Avenue, U 371, Box 0790, San Francisco, CA 94143, USA
Ann Surg 237:650-7; discussion 657-9. 2003..To analyze the results of a prospective study of 176 patients with Zollinger-Ellison syndrome (ZES) (138 sporadic, 38 MEN1) undergoing 207 operations over a 17-year period... - Computed tomography, endoscopic, laparoscopic, and intra-operative sonography for assessing resectability of pancreatic cancerEliza E Long
Department of Surgery, Stanford University School of Medicine, Stanford, CA, USA
Surg Oncol 14:105-13. 2005..With these modern imaging modalities, it is now possible to avoid major operations that only determine an inoperable tumor. With proper preoperative selection, surgery is able to remove tumor in the majority of patients... - Macrophages as effector cells in interleukin 12-induced T cell-dependent tumor rejectionKangla Tsung
Department of Surgery, University of California, San Francisco, San Francisco Veterans Affairs Medical Center, San Francisco, California 94121, USA
Cancer Res 62:5069-75. 2002.... - Hereditary diffuse gastric cancer: implications of genetic testing for screening and prophylactic surgeryRobin M Cisco
Department of Surgery, Stanford University School of Medicine, Stanford, California, USA
Cancer 113:1850-6. 2008..Because of the emergence of gene-directed gastrectomy for HDGC, today, a previously lethal disease is detected by molecular techniques, allowing curative surgery at an early stage... - Intraoperative radiation therapy for locally advanced and recurrent soft-tissue sarcomas in adultsPhuoc T Tran
Department of Radiation Oncology, Stanford Cancer Center, Stanford, CA 94305, USA
Int J Radiat Oncol Biol Phys 72:1146-53. 2008..To analyze the outcomes of and identify prognostic factors for patients treated with surgery and intraoperative radiotherapy (IORT) for locally advanced and recurrent soft-tissue sarcoma in adults from a single institution... - Gastric carcinoid tumors in multiple endocrine neoplasia-1 patients with Zollinger-Ellison syndrome can be symptomatic, demonstrate aggressive growth, and require surgical treatmentJeffrey A Norton
Department of Surgery, Stanford University Medical Center, 300 Pasteur Drive, Stanford, CA 94305-5651, USA
Surgery 136:1267-74. 2004..With increased long-term medical treatment and life expectancy, these tumors will become an important determinant of survival... - The role of IFN-gamma in rejection of established tumors by IL-12 : source of production and targetJennifer Gillary Segal
Department of Surgery, University of California, VA Medical Center, San Francisco, California 94121, USA
Cancer Res 62:4696-703. 2002..Our results indicate that the rejection of established tumors by IL-12/Cy+IL-12 is dependent on the induction of a Th1 response producing IFN-gamma that acts on host cells... - Surgery for gastrinomaRobin M Cisco
Department of Surgery, Stanford University Medical Center, 300 Pasteur Drive, Stanford, CA 94305 5641, USA
Adv Surg 41:165-76. 2007..More research also is needed to define the appropriate indications for pancreaticoduodenectomy in ZES and to determine whether proximal vagotomy should be performed at the time of surgical exploration... - Surgical management of Zollinger-Ellison syndrome; state of the artEllen H Morrow
Division of General Surgery, Department of Surgery, Stanford University School of Medicine, Stanford, CA 94305 5641, USA
Surg Clin North Am 89:1091-103. 2009..The role of Whipple procedure, especially for MEN-1 cases, should be explored further. Laparoscopic and endoscopic treatments are more experimental, but may have a role... - Current surgical management of Zollinger-Ellison syndrome (ZES) in patients without multiple endocrine neoplasia-type 1 (MEN1)Jeffrey A Norton
Department of Surgery, University of California San Francisco, 533 Parnassus Avenue, Room U-372, San Francisco, CA 94143-0790, USA
Surg Oncol 12:145-51. 2003..Postoperative evaluation should include secretin test because it is the most sensitive method to document cure and detect tumor recurrence... - Antitumor immunity induced by dendritic cell-based vaccination is dependent on interferon-gamma and interleukin-12Jade S Hiramoto
Department of Surgery, University of California, San Francisco, California 94143 0780, USA
J Surg Res 116:64-9. 2004..This study was conducted to determine whether dendritic cells (DCs) pulsed with a tumor cell lysate can effectively vaccinate against tumor cells and to establish which cytokines are necessary... - A novel PRKAR1A mutation associated with primary pigmented nodular adrenocortical disease and the Carney complexMarcia C Peck
Department of Medicine, Stanford University School of Medicine, Stanford, California 94305 5821, USA
Endocr Pract 16:198-204. 2010..To delineate the genetic and phenotypic features of Carney complex in a family with multiple cases of primary pigmented nodular adrenocortical disease (PPNAD)... - Aggressive surgery for metastatic liver neuroendocrine tumorsJeffrey A Norton
Department of Surgery, University of California-San Francisco, San Francisco, CA, USA
Surgery 134:1057-63; discussion 1063-5. 2003..It results in excellent long-term survival and amelioration of symptoms. Surgery should be the first-line therapy for patients with LNET... - Interfractional uncertainty in the treatment of pancreatic cancer with radiationPriya Jayachandran
Department of Radiation Oncology, Stanford University, Stanford, CA, USA
Int J Radiat Oncol Biol Phys 76:603-7. 2010..To compare the interfractional variation in pancreatic tumor position using bony anatomy and implanted fiducial markers... - Comparison of intensity-modulated radiotherapy and 3-dimensional conformal radiotherapy as adjuvant therapy for gastric cancerA Yuriko Minn
Department of Radiation Oncology, Stanford University, Stanford, California 94305 5847, USA
Cancer 116:3943-52. 2010.... - Multiple-gland disease in primary hyperparathyroidism: a function of operative approach?Natalie C Lee
Department of Surgery, University of California, San Francisco, USA
Arch Surg 137:896-9; discussion 899-900. 2002.... - Endocrine tumours of the gastrointestinal tract. Surgical treatment of neuroendocrine metastasesJeffrey A Norton
Stanford University Medical Center, CA 94305-5641, USA
Best Pract Res Clin Gastroenterol 19:577-83. 2005..Surgical resection appears to result in outstanding long-term survival and amelioration of symptoms. It should be the first-line therapy for patients with liver neuroendocrine tumors in whom the tumor can be completely removed... - Production of interferon-gamma by tumor-sensitized T cells is essential for interleukin-12-induced complete tumor eradicationNatalie C Lee
Department of Surgery, University of California, San Francisco, USA
Surgery 132:365-8. 2002..T cells are the source, but not the target, of IFN-gamma during tumor regression... - Total mesenteric excision in the treatment of rectal carcinoma: methods and outcomesTodd V Brennan
Department of Surgery, University of California, San Francisco 94143-0790, USA
Surg Oncol 10:171-6. 2002 - Lessons from Coley's ToxinKangla Tsung
Department of Surgery, Stanford University School of Medicine, Room H3591, 300 Pasteur Drive, Stanford, CA 94025, USA
Surg Oncol 15:25-8. 2006..The active molecule in Coley's Toxin is not tumor necrosis factor (TNF) or endotoxin (LPS), but interleukin-12 (IL-12). IL-12 holds the key to improved anti-tumor immuns response... - Evidence-based analysis: postoperative gastric bleeding: etiology and preventionJade S Hiramoto
Department of Surgery, University of California, 533 Parnassus Ave Room U-372, San Francisco, CA 94143-7088, USA
Surg Oncol 12:9-19. 2003..Intravenous proton pump inhibitors may be the drugs of choice for stress ulcer prophylaxis (SUP) in high-risk patients... - Hepatic artery embolization for treatment of patients with metastatic carcinoid tumors: a commentaryJeffrey A Norton
Department of Surgery, University of California San Francisco, San Francisco, California 94143, USA
Cancer J 9:241-3. 2003 - Management and outcome of patients with sporadic gastrinoma arising in the duodenumTheresa G Zogakis
Surgery Branch, Center for Cancer Research, National Cancer Institute/National Institutes of Health, Building 10, Room 2B07, 10 Center Drive, Bethesda, MD 20892-1502, USA
Ann Surg 238:42-8. 2003..Disease-free survival is lower for patients with regional lymph node metastases suggesting that a more systematic lymphadenectomy to extirpate occult disease may be indicated in this group... - A carrier of both MEN1 and BRCA2 mutations: case report and review of the literaturePavandeep Ghataorhe
School of Medicine, Oxford University, South Parks Road, Oxford OX1 3PL, UK
Cancer Genet Cytogenet 179:89-92. 2007..To our knowledge, this is the first report of a patient with both MEN1 and BRCA2 mutations and with a personal history of hyperparathyroidism and pancreatic neuroendocrine tumors... - Characterization of a recurrent germ line mutation of the E-cadherin gene: implications for genetic testing and clinical managementGianpaolo Suriano
Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada
Clin Cancer Res 11:5401-9. 2005..To identify germ line CDH1 mutations in hereditary diffuse gastric cancer (HDGC) families and develop guidelines for management of at risk individuals... - Results of initial operation for hyperparathyroidism in patients with multiple endocrine neoplasia type 1Dina M Elaraj
Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
Surgery 134:858-64; discussion 864-5. 2003..The high incidence of severe hypoparathyroidism after total PTx suggests that subtotal PTx is the initial operation of choice in this setting... - Cure of an established nonimmunogenic tumor, SCC VII, with a novel interleukin 12-based immunotherapy regimen in C3H miceAditi H Mandpe
Department of Otolaryngology-Head and Neck Surgery, University of California, San Francisco, and the Surgical Service Veterans Affairs Medical Center, San Francisco, 94143-0342, USA
Arch Otolaryngol Head Neck Surg 129:786-92. 2003..Additional treatment with cyclophosphamide plus interleukin 12 leads to complete regression in 75% of mice... - Inherited pancreatic endocrine tumor syndromes: advances in molecular pathogenesis, diagnosis, management, and controversiesRobert T Jensen
Digestive Diseases Branch, National Institutes of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA
Cancer 113:1807-43. 2008..In this article, these areas are reviewed briefly along with the current state of knowledge of the PETs in these disorders, and the controversies that exist in their management are summarized briefly and discussed...
Research Grants
- Influence of Tumor Immunogenicity to ImmunotherapyJeffrey Norton; Fiscal Year: 2006....