WILLIAM J NELSON

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. pmc Adaptation of core mechanisms to generate cell polarity
    W James Nelson
    Department of Molecular and Cellular Physiology, Beckman Center for Molecular and Genetic Medicine, Stanford University School of Medicine, Stanford, California 94305 5435, USA
    Nature 422:766-74. 2003
  2. pmc Convergence of Wnt, beta-catenin, and cadherin pathways
    W James Nelson
    Department of Molecular and Cellular Physiology, Beckman Center for Molecular and Genetic Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
    Science 303:1483-7. 2004
  3. pmc Regulation of cell-cell adhesion by the cadherin-catenin complex
    W James Nelson
    Department of Biological Sciences, The James H Clark Center E200 B, 318 Campus Drive, Stanford University, Stanford, CA 94305 5030, USA
    Biochem Soc Trans 36:149-55. 2008
  4. pmc Remodeling epithelial cell organization: transitions between front-rear and apical-basal polarity
    W James Nelson
    Department of Biology, Stanford University, Stanford, California 94305, USA
    Cold Spring Harb Perspect Biol 1:a000513. 2009
  5. pmc Tube morphogenesis: closure, but many openings remain
    W James Nelson
    Department of Molecular and Cellular Physiology, Beckman Center for Molecular and Genetic Medicine, Stanford University School of Medicine, Stanford, CA 94305 5435, USA
    Trends Cell Biol 13:615-21. 2003
  6. pmc Mum, this bud's for you: where do you want it? Roles for Cdc42 in controlling bud site selection in Saccharomyces cerevisiae
    W James Nelson
    Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305 5435, USA
    Bioessays 25:833-6. 2003
  7. ncbi request reprint Protein trafficking in the exocytic pathway of polarized epithelial cells
    W J Nelson
    Dept of Molecular and Cellular Physiology, Beckman Center for Molecular and Genetic Medicine, Stanford University School of Medicine, Stanford, CA 94305 5435, USA
    Trends Cell Biol 11:483-6. 2001
  8. pmc Transcriptional modulation of genes encoding structural characteristics of differentiating enterocytes during development of a polarized epithelium in vitro
    Jennifer M Halbleib
    Department of Molecular and Cellular Physiology, Stanford University, Stanford, CA 94305, USA
    Mol Biol Cell 18:4261-78. 2007
  9. pmc Adenomatous polyposis coli regulates endothelial cell migration independent of roles in beta-catenin signaling and cell-cell adhesion
    Elizabeth S Harris
    Department of Biology, The James H Clark Center, Bio X Program, Stanford University, Stanford, CA 94305, USA
    Mol Biol Cell 21:2611-23. 2010
  10. pmc A molecular mechanism directly linking E-cadherin adhesion to initiation of epithelial cell surface polarity
    Lene N Nejsum
    Department of Biological Sciences and Department of Molecular and Cellular Physiology, The James H Clark Center, Bio X Program, Stanford University, Stanford, CA 94305, USA
    J Cell Biol 178:323-35. 2007

Collaborators

Detail Information

Publications60

  1. pmc Adaptation of core mechanisms to generate cell polarity
    W James Nelson
    Department of Molecular and Cellular Physiology, Beckman Center for Molecular and Genetic Medicine, Stanford University School of Medicine, Stanford, California 94305 5435, USA
    Nature 422:766-74. 2003
    ....
  2. pmc Convergence of Wnt, beta-catenin, and cadherin pathways
    W James Nelson
    Department of Molecular and Cellular Physiology, Beckman Center for Molecular and Genetic Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
    Science 303:1483-7. 2004
    ..Here, we assemble evidence of possible interrelations between Wnt and other growth factor signaling, beta-catenin functions, and cadherin-mediated adhesion...
  3. pmc Regulation of cell-cell adhesion by the cadherin-catenin complex
    W James Nelson
    Department of Biological Sciences, The James H Clark Center E200 B, 318 Campus Drive, Stanford University, Stanford, CA 94305 5030, USA
    Biochem Soc Trans 36:149-55. 2008
    ..In the present article, in vitro protein assembly studies and live-cell studies of de novo cell-cell adhesion are discussed in the context of how the cadherin-catenin complex and the actin cytoskeleton regulate cell-cell adhesion...
  4. pmc Remodeling epithelial cell organization: transitions between front-rear and apical-basal polarity
    W James Nelson
    Department of Biology, Stanford University, Stanford, California 94305, USA
    Cold Spring Harb Perspect Biol 1:a000513. 2009
    ..The challenge is to understand how these regulators and effectors are adapted to regulate symmetry breaking processes that generate cell polarities that are specialized for different cellular activities and functions...
  5. pmc Tube morphogenesis: closure, but many openings remain
    W James Nelson
    Department of Molecular and Cellular Physiology, Beckman Center for Molecular and Genetic Medicine, Stanford University School of Medicine, Stanford, CA 94305 5435, USA
    Trends Cell Biol 13:615-21. 2003
    ..This review provides a summary of these pathways based upon articles published in the Tube Morphogenesis Series in Trends in Cell Biology...
  6. pmc Mum, this bud's for you: where do you want it? Roles for Cdc42 in controlling bud site selection in Saccharomyces cerevisiae
    W James Nelson
    Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305 5435, USA
    Bioessays 25:833-6. 2003
    ....
  7. ncbi request reprint Protein trafficking in the exocytic pathway of polarized epithelial cells
    W J Nelson
    Dept of Molecular and Cellular Physiology, Beckman Center for Molecular and Genetic Medicine, Stanford University School of Medicine, Stanford, CA 94305 5435, USA
    Trends Cell Biol 11:483-6. 2001
    ..The challenge now is to extend this knowledge to defining molecular mechanisms in detail in vitro and comprehending the development of complex epithelial structures in vivo...
  8. pmc Transcriptional modulation of genes encoding structural characteristics of differentiating enterocytes during development of a polarized epithelium in vitro
    Jennifer M Halbleib
    Department of Molecular and Cellular Physiology, Stanford University, Stanford, CA 94305, USA
    Mol Biol Cell 18:4261-78. 2007
    ..Coordinated expression of genes encoding components of functional cell structures were often observed indicating temporal control of expression and assembly of multiprotein complexes...
  9. pmc Adenomatous polyposis coli regulates endothelial cell migration independent of roles in beta-catenin signaling and cell-cell adhesion
    Elizabeth S Harris
    Department of Biology, The James H Clark Center, Bio X Program, Stanford University, Stanford, CA 94305, USA
    Mol Biol Cell 21:2611-23. 2010
    ..These results uncouple different APC functions and show that GSK3 beta/CKI phosphorylation regulates APC clusters and cell migration independently of cell-cell adhesion and beta-catenin transcriptional activity...
  10. pmc A molecular mechanism directly linking E-cadherin adhesion to initiation of epithelial cell surface polarity
    Lene N Nejsum
    Department of Biological Sciences and Department of Molecular and Cellular Physiology, The James H Clark Center, Bio X Program, Stanford University, Stanford, CA 94305, USA
    J Cell Biol 178:323-35. 2007
    ....
  11. pmc Fabrication of a dual substrate display to test roles of cell adhesion proteins in vesicle targeting to plasma membrane domains
    Stephen J Hunt
    Department of Biological Sciences, Stanford University, James H Clark Center, 318 Campus Drive, Room E200, Stanford, CA 94305 5430, United States
    FEBS Lett 581:4539-43. 2007
    ..These results support the hypothesis that E-cadherin adhesion initiates signaling at the PM resulting in targeted sites for exocytosis...
  12. pmc Deconstructing the cadherin-catenin-actin complex
    Soichiro Yamada
    Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Cell 123:889-901. 2005
    ..These results suggest that the linkage between the cadherin-catenin complex and actin filaments is more dynamic than previously appreciated...
  13. pmc Localized zones of Rho and Rac activities drive initiation and expansion of epithelial cell-cell adhesion
    Soichiro Yamada
    Department of Molecular and Cellular Physiology, Stanford University, Stanford, CA 94305, USA
    J Cell Biol 178:517-27. 2007
    ..We show that zones of Rac1 and lamellipodia activity and of RhoA and actomyosin contractility are restricted to the periphery of contacting membranes and together drive initiation, expansion, and completion of cell-cell adhesion...
  14. pmc Adenomatous polyposis coli and EB1 localize in close proximity of the mother centriole and EB1 is a functional component of centrosomes
    Ryan K Louie
    Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Cell Sci 117:1117-28. 2004
    ..In summary, our data indicate that APC and EB1 are functional components of mammalian centrosomes and that EB1 is important for anchoring cytoplasmic MT minus ends to the subdistal appendages of the mother centriole...
  15. pmc Immediate-early signaling induced by E-cadherin engagement and adhesion
    Tomas D Perez
    Department of Molecular and Cellular Physiology, Stanford University, Stanford, California 94305 5430, USA
    J Biol Chem 283:5014-22. 2008
    ....
  16. pmc AlphaE-catenin regulates actin dynamics independently of cadherin-mediated cell-cell adhesion
    Jacqueline M Benjamin
    Cancer Biology Program, Stanford University, Stanford, CA 94305, USA
    J Cell Biol 189:339-52. 2010
    ..In contrast, sequestration of cytosolic alphaE-catenin to the plasma membrane reduces membrane dynamics. These results demonstrate that the cytosolic pool of alphaE-catenin regulates actin dynamics independently of cell-cell adhesion...
  17. pmc Alpha-catenin is a molecular switch that binds E-cadherin-beta-catenin and regulates actin-filament assembly
    Frauke Drees
    Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Cell 123:903-15. 2005
    ..These results indicate a new role for alpha-catenin in local regulation of actin assembly and organization at sites of cadherin-mediated cell-cell adhesion...
  18. pmc Forchlorfenuron alters mammalian septin assembly, organization, and dynamics
    Qicong Hu
    Department of Biology, Stanford University, Stanford, California 94305, USA
    J Biol Chem 283:29563-71. 2008
    ..We conclude that FCF is a promising tool to study mammalian septin organization and functions...
  19. pmc A mitotic septin scaffold required for Mammalian chromosome congression and segregation
    Elias T Spiliotis
    Department of Molecular and Cellular Physiology, Beckman Center for Molecular and Genetic Medicine, Stanford University School of Medicine, Stanford, CA 94305 5435, USA
    Science 307:1781-5. 2005
    ..Mammalian septins may thus form a mitotic scaffold for CENP-E and other effectors to coordinate cytokinesis with chromosome congression and segregation...
  20. pmc Spatio-temporal regulation of Rac1 localization and lamellipodia dynamics during epithelial cell-cell adhesion
    Jason S Ehrlich
    Department of Molecular and Cellular Physiology, Stanford University School of Medicine, California 94305, USA
    Dev Cell 3:259-70. 2002
    ..These results define a role for Rac1 in regulating the rates of initiation and strengthening of cell-cell adhesion...
  21. pmc Parallels between global transcriptional programs of polarizing Caco-2 intestinal epithelial cells in vitro and gene expression programs in normal colon and colon cancer
    Annika M Sääf
    Department of Biochemistry, Stanford University, Stanford, CA 94305, USA
    Mol Biol Cell 18:4245-60. 2007
    ..The full data set is available at http://microarray-pubs.stanford.edu/CACO2...
  22. pmc Two distinct modes of myosin assembly and dynamics during epithelial wound closure
    Masako Tamada
    Department of Biological Sciences, Columbia University, New York, NY 10027, USA
    J Cell Biol 176:27-33. 2007
    ..Thus, we suggest that tight junctions serve as attachment points for the actomyosin ring during wound closure and that Rho-kinase is required for localization and activation of the contractile ring...
  23. pmc Adherens and tight junctions: structure, function and connections to the actin cytoskeleton
    Andrea Hartsock
    Departments of Molecular and Cellular Physiology, Stanford University, Stanford, CA 94305 5430, USA
    Biochim Biophys Acta 1778:660-9. 2008
    ....
  24. pmc Bench to bedside and back again: molecular mechanisms of alpha-catenin function and roles in tumorigenesis
    Jacqueline M Benjamin
    Department of Biological Sciences, Stanford University, 318 Campus Drive, Stanford, CA 94305 5430, USA
    Semin Cancer Biol 18:53-64. 2008
    ..This analysis identifies alpha-catenin as a prognostic factor in cancer progression...
  25. pmc Biochemical and structural analysis of alpha-catenin in cell-cell contacts
    Sabine Pokutta
    Department of Structural Biology, D100 Fairchild Science Building, Stanford University School of Medicine, Stanford, CA 94305 5126, U S A
    Biochem Soc Trans 36:141-7. 2008
    ..Thus alpha-catenin appears to play a central role in cell-cell contact formation...
  26. pmc Regulation of cell motile behavior by crosstalk between cadherin- and integrin-mediated adhesions
    Nicolas Borghi
    Department of Biology, Cancer Biology Program, Stanford University, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 107:13324-9. 2010
    ..These results demonstrate that there is crosstalk between E-cadherin- and integrin-based adhesion complexes and that E-cadherin regulates lamellipodia activity and cell migration directionality, but not cell migration rate...
  27. pmc Fractionation of the epithelial apical junctional complex: reassessment of protein distributions in different substructures
    Roger Vogelmann
    Department of Molecular and Cellular Physiology, Beckman Center for Molecular and Genetic Medicine, Stanford University School of Medicine, Stanford, CA 94305 5435, USA
    Mol Biol Cell 16:701-16. 2005
    ....
  28. pmc APC is a component of an organizing template for cortical microtubule networks
    Amy Reilein
    Department of Molecular and Cellular Physiology, Beckman Center for Molecular and Genetic Medicine B121, 279 Campus Drive, Stanford University School of Medicine, Stanford, CA 94305 5435, USA
    Nat Cell Biol 7:463-73. 2005
    ..Thus, APC is a component of a cortical template that guides microtubule network formation...
  29. pmc Self-organization of an acentrosomal microtubule network at the basal cortex of polarized epithelial cells
    Amy Reilein
    Department of Biological Sciences, Beckman Center for Molecular and Genetic Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Cell Biol 171:845-55. 2005
    ..These results define minimal parameters for the self-organization of an acentrosomal microtubule network...
  30. pmc Molecular mechanism for orienting membrane and actin dynamics to nascent cell-cell contacts in epithelial cells
    Marc D H Hansen
    Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, California 94305 5426, USA
    J Biol Chem 277:45371-6. 2002
    ..This shift may reflect a diffusion trapping mechanism by which these Rac1 complexes are localized to cadherin-mediated cell-cell contacts through an interaction with annexin II...
  31. pmc Cell-adhesion assays: fabrication of an E-cadherin substratum and isolation of lateral and Basal membrane patches
    Frauke Drees
    Department of Molecular and Cellular Physiology, Beckman Center for Molecular and Genetic Medicine, Stanford University School of Medicine, Stanford, CA, USA
    Methods Mol Biol 294:303-20. 2005
    ..These membrane patches provide direct access to protein complexes formed on the membrane following cell-cell or cell-ECM adhesion...
  32. ncbi request reprint Interaction of cadherin with the actin cytoskeleton
    W James Nelson
    Department of Molecular and Cellular Physiology, Beckman Center for Molecular and Genetic Medicine, Stanford University School of Medicine, CA 94305 5435, USA
    Novartis Found Symp 269:159-68; discussion 168-77, 223-30. 2005
    ..Here, we describe these protein interactions, and examine critically the evidence that they link cadherins to the actin cytoskeleton...
  33. pmc Role of adenomatous polyposis coli (APC) and microtubules in directional cell migration and neuronal polarization
    Angela I M Barth
    Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA
    Semin Cell Dev Biol 19:245-51. 2008
    ..This review will summarize these results and then focus on the role of microtubule-binding protein adenomatous polyposis coli (APC) in neuronal polarization and directed migration, and on its regulation by GSK3beta...
  34. pmc Epithelial cell surface polarity: the early steps
    Lene N Nejsum
    Departments of Biology, and Molecular and Cellular Physiology, The James H Clark Center, Bio X Program, Stanford University, 318 Campus Drive E200, Stanford, CA 94305 5430, USA
    Front Biosci (Landmark Ed) 14:1088-98. 2009
    ..Shortly hereafter, components of the lateral targeting patch, the Exocyst and the lateral SNARE complex, co-localize with E-cadherin at the forming contact, where they function in specifying the delivery of basal-lateral...
  35. pmc What can humans learn from flies about adenomatous polyposis coli?
    Angela I M Barth
    Department of Molecular and Cellular Physiology, Stanford University School of Medicine, CA 94305 5435, USA
    Bioessays 24:771-4. 2002
    ....
  36. pmc Cell autonomous defects in cortical development revealed by two-color chimera analysis
    Adam V Kwiatkowski
    Department of Biology, Stanford University, Stanford, CA 94305, USA
    Mol Cell Neurosci 41:44-50. 2009
    ..This technique could be applied to determine other cell autonomous functions in different stages of cortical development...
  37. pmc Here come the septins: novel polymers that coordinate intracellular functions and organization
    Elias T Spiliotis
    Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA
    J Cell Sci 119:4-10. 2006
    ..Hence, studies of these molecules might provide new insights not only into how cells coordinate their functions, but also into the pathogenesis of cancer and other diseases in which septins are abnormally expressed...
  38. pmc Role of APC and its binding partners in regulating microtubules in mitosis
    Shirin Bahmanyar
    Department of Biological Sciences and Molecular Cellular Physiology, Stanford University, Stanford, California 94305 5430, USA
    Adv Exp Med Biol 656:65-74. 2009
    ..APC localizes to three key locations in mitosis: kinetochores, the cortex and centrosomes. Here, we discuss possible mechanisms for APC function at these sites and suggest new pathways by which APC mutations promote tumorigenesis...
  39. pmc Disruption of the epithelial apical-junctional complex by Helicobacter pylori CagA
    Manuel R Amieva
    Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Science 300:1430-4. 2003
    ..CagA appears to target H. pylori to host cell intercellular junctions and to disrupt junction-mediated functions...
  40. pmc Catenins: playing both sides of the synapse
    Adam V Kwiatkowski
    Department of Biological Sciences, Stanford University, Stanford, CA 94305, United States
    Curr Opin Cell Biol 19:551-6. 2007
    ..Here we review the role of catenins in regulating the development of pre- and postsynaptic compartments and function in synaptic plasticity, with particular focus on their role in regulating the actin cytoskeleton...
  41. pmc In vitro and in vivo reconstitution of the cadherin-catenin-actin complex from Caenorhabditis elegans
    Adam V Kwiatkowski
    Department of Biology, Stanford University, 318 Campus Drive, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 107:14591-6. 2010
    ..Our study defines evolutionarily conserved properties of alpha-catenin and suggests that multiple mechanisms regulate alpha-catenin binding to F-actin...
  42. pmc VE-cadherin: at the front, center, and sides of endothelial cell organization and function
    Elizabeth S Harris
    Department of Biology, The James H Clark Center, Bio X Program, Stanford University, Stanford, CA 94305, USA
    Curr Opin Cell Biol 22:651-8. 2010
    ..Here we highlight recent work that has advanced our understanding of multiple regulatory and signaling mechanisms that converge on VE-cadherin and have consequences for endothelial barrier function and angiogenic remodeling...
  43. pmc Epithelial polarity requires septin coupling of vesicle transport to polyglutamylated microtubules
    Elias T Spiliotis
    Department of Biology, Stanford University, Stanford, CA 94305, USA
    J Cell Biol 180:295-303. 2008
    ..We suggest that septin coupling of the microtubule cytoskeleton to post-Golgi vesicle transport is required for the morphogenesis of polarized epithelia...
  44. pmc Mechanism of recruiting Sec6/8 (exocyst) complex to the apical junctional complex during polarization of epithelial cells
    Charles Yeaman
    Department of Molecular and Cellular Physiology, Beckman Center for Molecular and Genetic Medicine, Stanford University School of Medicine, Stanford, CA 94305 5345, USA
    J Cell Sci 117:559-70. 2004
    ....
  45. pmc Characterization of mammalian Par 6 as a dual-location protein
    Erin G Cline
    Department of Biological Sciences, The James A Clark Center, Stanford University, Stanford, CA 94305 5430, USA
    Mol Cell Biol 27:4431-43. 2007
    ..Therefore, we hypothesize that Par 6 in the nucleus acts as a scaffolding protein in nuclear speckle complexes, similar to its role in the cytoplasm...
  46. pmc Dissecting interactions between EB1, microtubules and APC in cortical clusters at the plasma membrane
    Angela I M Barth
    Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305 5435, USA
    J Cell Sci 115:1583-90. 2002
    ..These results show that localization of APC in cortical clusters is different from that of EB1 at MT plus ends and appears to be independent of EB1...
  47. pmc Re-solving the cadherin-catenin-actin conundrum
    William I Weis
    Department of Structural Biology, Stanford University, Stanford, California 94305, USA
    J Biol Chem 281:35593-7. 2006
  48. pmc Wingless signaling modulates cadherin-mediated cell adhesion in Drosophila imaginal disc cells
    Andreas Wodarz
    Howard Hughes Medical Institute and Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Cell Sci 119:2425-34. 2006
    ....
  49. pmc Separation of cell-cell adhesion complexes by differential centrifugation
    Roger Vogelmann
    Department of Molecular and Cellular Physiology, Beckman Center for Molecular and Genetic Medicine, Stanford University of Medicine, Stanford, CA, USA
    Methods Mol Biol 370:11-22. 2007
    ....
  50. pmc Resolving cadherin interactions and binding cooperativity at the single-molecule level
    Yunxiang Zhang
    Department of Physics, Stanford University, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 106:109-14. 2009
    ..We could not detect the formation of cadherin cis dimers, but found that increasing the density of cadherin monomers cooperatively increased the probability of trans adhesive binding...
  51. ncbi request reprint Cadherins in development: cell adhesion, sorting, and tissue morphogenesis
    Jennifer M Halbleib
    Department of Biological Sciences, Stanford University, Stanford, California 94305, USA
    Genes Dev 20:3199-214. 2006
    ..Here we examine how different members of the cadherin family act in different developmental contexts, and discuss the mechanisms involved...
  52. pmc Biochemical and structural definition of the l-afadin- and actin-binding sites of alpha-catenin
    Sabine Pokutta
    Department of Structural Biology, Stanford University School of Medicine, Stanford, California 94305, USA
    J Biol Chem 277:18868-74. 2002
    ..alpha-Catenin and the actin-binding protein vinculin share sequence and most likely structural similarity within their actin-binding domains. Despite this homology, actin binding requires additional sequences adjacent to this region...
  53. pmc A septin diffusion barrier at the base of the primary cilium maintains ciliary membrane protein distribution
    Qicong Hu
    Department of Biology, Stanford University, Stanford, CA 94305, USA
    Science 329:436-9. 2010
    ..Thus, SEPT2 is part of a diffusion barrier at the base of the ciliary membrane and is essential for retaining receptor-signaling pathways in the primary cilium...
  54. pmc Formation of extra centrosomal structures is dependent on beta-catenin
    Shirin Bahmanyar
    Department of Biology, Stanford University, Stanford, CA 94305, USA
    J Cell Sci 123:3125-35. 2010
    ..These results indicate that beta-catenin is required for centrosome amplification, and mutations in beta-catenin might contribute to the formation of abnormal centrosomes observed in cancers...
  55. pmc Epithelial cell polarity from the outside looking in
    W James Nelson
    Department of Molecular and Cellular Physiology, Beckman Center for Molecular and Genetic Medicine, Stanford University School of Medicine, Stanford, California 94305 5435, USA
    News Physiol Sci 18:143-6. 2003
    ....
  56. pmc Spatial control of exocytosis
    Elias T Spiliotis
    Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305 5435, USA
    Curr Opin Cell Biol 15:430-7. 2003
    ..Furthermore, local activation of signaling pathways reinforces formation of these patches and might effect global repositioning of the secretory pathway toward sites of localized exocytosis...
  57. pmc Breaking into the epithelial apical-junctional complex--news from pathogen hackers
    Roger Vogelmann
    Department of Molecular and Cellular Physiology, Beckman Center B121, Stanford University School of Medicine, 279 Campus Drive, Stanford, CA 94305 5435, USA
    Curr Opin Cell Biol 16:86-93. 2004
    ....
  58. pmc beta-Catenin is a Nek2 substrate involved in centrosome separation
    Shirin Bahmanyar
    Department of Biological Sciences, Stanford University, Stanford, California 94305, USA
    Genes Dev 22:91-105. 2008
    ..These results identify beta-catenin as a component of the intercentrosomal linker and define a new function for beta-catenin as a key regulator of mitotic centrosome separation...
  59. pmc Urinary excretion of viable podocytes in health and renal disease
    Stefanie U Vogelmann
    Division of Nephrology, Department of Medicine, Stanford University School of Medicine, CA 94305, USA
    Am J Physiol Renal Physiol 285:F40-8. 2003
    ....
  60. pmc Neurite outgrowth involves adenomatous polyposis coli protein and beta-catenin
    Violet Votin
    Department of Biological Sciences, Stanford University, Beckman Center B121, Stanford, CA 94305, USA
    J Cell Sci 118:5699-708. 2005
    ..These results indicate that APC is involved in both early neurite outgrowth and increased growth of the future axon, and that beta-catenin has a structural role in inhibiting APC function in neurite growth...

Research Grants26

  1. TOPOGENESIS OF NA/K-ATPASE IN POLARIZED EPITHELIAL CELLS
    W Nelson; Fiscal Year: 2002
    ....
  2. Cytoskeleton Coordination in Neuronal Morphogenesis
    W Nelson; Fiscal Year: 2005
    ....
  3. TOPOGENESIS OF NA/K-ATPASE IN POLARIZED EPITHELIAL CELLS
    William Nelson; Fiscal Year: 2007
    ....
  4. Regulation of Cell Migration by the APC-Microtubule Complex
    W Nelson; Fiscal Year: 2007
    ....
  5. SYNAPSE STRUCTURE AND DEVELOPMENT
    W Nelson; Fiscal Year: 2001
    ..This research will aid in the prevention of psychiatric illness and the development of therapies for afflicted individuals. ..
  6. TOGENESIS OF NA+,K+-ATPASE IN POLARIZED MDCK EPITHELIAL
    W Nelson; Fiscal Year: 1993
    ....
  7. Regulation of Cell Migration by the APC-Microtubule Complex
    William Nelson; Fiscal Year: 2009
    ..abstract_text> ..