Susumu Nakae

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. pmc Mast cell-derived TNF can promote Th17 cell-dependent neutrophil recruitment in ovalbumin-challenged OTII mice
    Susumu Nakae
    Department of Pathology L 235, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA
    Blood 109:3640-8. 2007
  2. ncbi Phenotypic differences between Th1 and Th17 cells and negative regulation of Th1 cell differentiation by IL-17
    Susumu Nakae
    Department of Pathology, L 235, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305 5324, USA
    J Leukoc Biol 81:1258-68. 2007
  3. ncbi IL-33 induces IL-13 production by mouse mast cells independently of IgE-FcepsilonRI signals
    Lien H Ho
    Department of Pathology, Stanford University School of Medicine, Stanford, California 94305 5324, USA
    J Leukoc Biol 82:1481-90. 2007
  4. ncbi Mast cell-derived TNF contributes to airway hyperreactivity, inflammation, and TH2 cytokine production in an asthma model in mice
    Susumu Nakae
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305 5324, USA
    J Allergy Clin Immunol 120:48-55. 2007
  5. ncbi RabGEF1, a negative regulator of Ras signalling, mast cell activation and skin inflammation
    See Ying Tam
    Departments of Pathology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305 5324, USA
    Novartis Found Symp 271:115-24; discussion 124-30, 145-51. 2005
  6. doi IL-17 contributes to the development of chronic rejection in a murine heart transplant model
    Satoshi Itoh
    Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Clin Immunol 30:235-40. 2010
  7. ncbi Mast cell-associated TNF promotes dendritic cell migration
    Hajime Suto
    Department of Pathology, Stanford University School of Medicine, CA 94305, USA
    J Immunol 176:4102-12. 2006
  8. pmc RabGEF1 regulates stem cell factor/c-Kit-mediated signaling events and biological responses in mast cells
    Janet Kalesnikoff
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305 5324, USA
    Proc Natl Acad Sci U S A 103:2659-64. 2006
  9. doi The role of recipient mast cells in acute and chronic cardiac allograft rejection in C57BL/6-KitW-sh/W-sh mice
    Satoshi Itoh
    Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, California 94305, USA
    J Heart Lung Transplant 29:401-9. 2010
  10. ncbi Mast cells enhance T cell activation: importance of mast cell costimulatory molecules and secreted TNF
    Susumu Nakae
    Department of Pathology, Stanford University School of Medicine, CA 94305, USA
    J Immunol 176:2238-48. 2006

Collaborators

Detail Information

Publications40

  1. pmc Mast cell-derived TNF can promote Th17 cell-dependent neutrophil recruitment in ovalbumin-challenged OTII mice
    Susumu Nakae
    Department of Pathology L 235, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA
    Blood 109:3640-8. 2007
    ....
  2. ncbi Phenotypic differences between Th1 and Th17 cells and negative regulation of Th1 cell differentiation by IL-17
    Susumu Nakae
    Department of Pathology, L 235, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305 5324, USA
    J Leukoc Biol 81:1258-68. 2007
    ..We also confirmed that IL-12 or IFN-gamma can negatively regulate Th17 cell differentiation. However, these cytokines could not modulate such effects on T cell differentiation in the absence of APC...
  3. ncbi IL-33 induces IL-13 production by mouse mast cells independently of IgE-FcepsilonRI signals
    Lien H Ho
    Department of Pathology, Stanford University School of Medicine, Stanford, California 94305 5324, USA
    J Leukoc Biol 82:1481-90. 2007
    ..These observations suggest potential roles for IL-33 in mast cell- and Th2 cytokine-associated immune responses and disorders...
  4. ncbi Mast cell-derived TNF contributes to airway hyperreactivity, inflammation, and TH2 cytokine production in an asthma model in mice
    Susumu Nakae
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305 5324, USA
    J Allergy Clin Immunol 120:48-55. 2007
    ..However, it is not clear to what extent mast cells represent a significant source of TNF in this mouse model...
  5. ncbi RabGEF1, a negative regulator of Ras signalling, mast cell activation and skin inflammation
    See Ying Tam
    Departments of Pathology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305 5324, USA
    Novartis Found Symp 271:115-24; discussion 124-30, 145-51. 2005
    ....
  6. doi IL-17 contributes to the development of chronic rejection in a murine heart transplant model
    Satoshi Itoh
    Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Clin Immunol 30:235-40. 2010
    ..This study illustrates that IL-17 contributes to the pathogenesis of chronic allograft rejection...
  7. ncbi Mast cell-associated TNF promotes dendritic cell migration
    Hajime Suto
    Department of Pathology, Stanford University School of Medicine, CA 94305, USA
    J Immunol 176:4102-12. 2006
    ..Our findings indicate that mast cell-associated TNF can contribute significantly to the initial stages of FITC-induced migration of cutaneous or airway DCs...
  8. pmc RabGEF1 regulates stem cell factor/c-Kit-mediated signaling events and biological responses in mast cells
    Janet Kalesnikoff
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305 5324, USA
    Proc Natl Acad Sci U S A 103:2659-64. 2006
    ..Thus, RabGEF1 plays a critical role in the regulation of SCF/c-Kit-mediated signaling events and biological responses in mast cells...
  9. doi The role of recipient mast cells in acute and chronic cardiac allograft rejection in C57BL/6-KitW-sh/W-sh mice
    Satoshi Itoh
    Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, California 94305, USA
    J Heart Lung Transplant 29:401-9. 2010
    ..We used C57BL/6-Kit(W-sh/W-sh) mast cell-deficient and corresponding wild-type mice to investigate possible contributions of recipient mast cells to acute or chronic cardiac allograft rejection...
  10. ncbi Mast cells enhance T cell activation: importance of mast cell costimulatory molecules and secreted TNF
    Susumu Nakae
    Department of Pathology, Stanford University School of Medicine, CA 94305, USA
    J Immunol 176:2238-48. 2006
    ..These results indicate that the secretion of soluble TNF and direct cell-cell interactions between mast cell OX40L and T cell OX40 contribute to the ability of IgE- and Ag-stimulated mouse mast cells to enhance T cell activation...
  11. pmc Mast cell-derived tumor necrosis factor can promote nerve fiber elongation in the skin during contact hypersensitivity in mice
    Maki Kakurai
    Department of Pathology, L 235, Stanford University School of Medicine, 300 Pasteur Dr, Stanford, CA 94305 5324, USA
    Am J Pathol 169:1713-21. 2006
    ..These observations show that mast cells, and mast cell-derived TNF, can promote the elongation of cutaneous nerve fibers during contact hypersensitivity in the mouse...
  12. doi Potential role of γδ T cell-derived IL-17 in acute cardiac allograft rejection
    Naoyuki Kimura
    Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, California 94305, USA
    Ann Thorac Surg 94:542-8. 2012
    ..We hypothesized that γδ T cells contribute to acute allograft rejection thru interleukin (IL)-17 production...
  13. doi Interleukin-16 deficiency suppresses the development of chronic rejection in murine cardiac transplantation model
    Naoyuki Kimura
    Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, California 94305, USA
    J Heart Lung Transplant 30:1409-17. 2011
    ..The precise role of IL-16 in transplant rejection remains unknown; therefore, the present study investigated the contribution of IL-16 to the development of chronic rejection in heart transplants...
  14. pmc Mast cells enhance T cell activation: Importance of mast cell-derived TNF
    Susumu Nakae
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305 5176, USA
    Proc Natl Acad Sci U S A 102:6467-72. 2005
    ..Finally, mast cells also can promote T cell activation by means of soluble factors. These findings identify multiple mechanisms by which mast cells can influence T cell proliferation and cytokine production...
  15. ncbi TNF can contribute to multiple features of ovalbumin-induced allergic inflammation of the airways in mice
    Susumu Nakae
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305 5324, USA
    J Allergy Clin Immunol 119:680-6. 2007
    ..However, studies with TNF-deficient or TNF receptor-deficient mice have not produced a clear picture of the role of TNF in the AHR associated with allergic inflammation in the mouse...
  16. pmc Mast cell-expressed orphan receptor CCRL2 binds chemerin and is required for optimal induction of IgE-mediated passive cutaneous anaphylaxis
    Brian A Zabel
    Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Exp Med 205:2207-20. 2008
    ..Rather, CCRL2 is able to bind the chemoattractant and increase local concentrations of bioactive chemerin, thus providing a link between CCRL2 expression and inflammation via the cell-signaling chemerin receptor CMKLR1...
  17. doi Interleukin-17 accelerates allograft rejection by suppressing regulatory T cell expansion
    Satoshi Itoh
    Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA
    Circulation 124:S187-96. 2011
    ..However, the precise role in allograft rejection remains uncertain. In the present study, we investigated the role of IL-17 in acute allograft rejection using IL-17-deficient mice...
  18. ncbi IL-33 can promote survival, adhesion and cytokine production in human mast cells
    Motoyasu Iikura
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305 5324, USA
    Lab Invest 87:971-8. 2007
    ..Our findings thus support the hypothesis that IL-33 may enhance mast cell function in allergic disorders and other settings, either in the presence or absence of co-stimulation of mast cells via IgE/antigen-FcepsilonRI signals...
  19. ncbi Mast cell-derived interleukin 10 limits skin pathology in contact dermatitis and chronic irradiation with ultraviolet B
    Michele A Grimbaldeston
    Department of Pathology, Stanford University School of Medicine, Stanford, California 94305 5176, USA
    Nat Immunol 8:1095-104. 2007
    ....
  20. ncbi Mast cells in the promotion and limitation of chronic inflammation
    Martin Metz
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305 5324, USA
    Immunol Rev 217:304-28. 2007
    ..Such work has confirmed that mast cells can significantly influence multiple features of chronic inflammatory responses, through diverse effects that can either promote or, perhaps more surprisingly, suppress aspects of these responses...
  21. ncbi Nonredundant function of phosphodiesterases 4D and 4B in neutrophil recruitment to the site of inflammation
    Miyako Ariga
    Division of Reproductive Biology, Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Immunol 173:7531-8. 2004
    ..These data demonstrate that PDE4B and PDE4D play complementary, but not redundant, roles in the control of neutrophil function...
  22. pmc TIM-1 and TIM-3 enhancement of Th2 cytokine production by mast cells
    Susumu Nakae
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305 5324, USA
    Blood 110:2565-8. 2007
    ..These observations suggest that TIM-1 and TIM-3 may be able to influence T-cell-mediated immune responses in part through effects on mast cells...
  23. ncbi Mast cells in the development of adaptive immune responses
    Stephen J Galli
    Department of Pathology, Stanford University School of Medicine, Stanford, California 94305 5324, USA
    Nat Immunol 6:135-42. 2005
    ..Thus, mast cells may influence the development, intensity and duration of adaptive immune responses that contribute to host defense, allergy and autoimmunity, rather than simply functioning as effector cells in these settings...
  24. ncbi Monomeric IgE enhances human mast cell chemokine production: IL-4 augments and dexamethasone suppresses the response
    Kentaro Matsuda
    Department of Pathology, Stanford University School of Medicine, CA 94305 5324, USA
    J Allergy Clin Immunol 116:1357-63. 2005
    ..Mouse monoclonal IgE antibodies can promote the survival of mouse bone marrow-derived cultured mast cells and induce the cells to secrete mediators in the absence of known specific antigen...
  25. ncbi Cardiomyocyte-specific Bcl-2 overexpression attenuates ischemia-reperfusion injury, immune response during acute rejection, and graft coronary artery disease
    Masashi Tanaka
    Department of Cardiothoracic Surgery, Falk Cardiovascular Research Center, 300 Pasteur Dr CVRB, Stanford University School of Medicine, Stanford, CA 94305 5407, USA
    Blood 104:3789-96. 2004
    ..In conclusion, our findings suggest that the modulation of Bcl-2 expression by pharmacologic up-regulation or gene transfer may be of clinical benefit in the short- and long-term function of cardiac allografts...
  26. ncbi RabGEF1 is a negative regulator of mast cell activation and skin inflammation
    See Ying Tam
    Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA
    Nat Immunol 5:844-52. 2004
    ..Thus, RabGEF1 is a negative regulator of Fc epsilon RI-dependent mast cell activation, and a lack of RabGEF1 results in the development of skin inflammation in vivo...
  27. pmc IL-17A produced by gammadelta T cells plays a critical role in innate immunity against listeria monocytogenes infection in the liver
    Satoru Hamada
    Molecular Microbiology Group, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan
    J Immunol 181:3456-63. 2008
    ..All the results suggest that IL-17A is a newly discovered effector molecule produced by TCR gammadelta T cells, which is important in innate immunity in the liver...
  28. doi Th17 and allergy
    Keisuke Oboki
    Department of Allergy and Immunology, National Research Institute for Child Health and Development, Toyko, Japan
    Allergol Int 57:121-34. 2008
    ..In this review, we summarize the current knowledge regarding IL-17 and Th17 cells and discuss their potential roles in the pathogenesis of allergic disorders...
  29. ncbi IL-17-mediated regulation of innate and acquired immune response against pulmonary Mycobacterium bovis bacille Calmette-Guerin infection
    Masayuki Umemura
    Molecular Microbiology Group, Center of Molecular Biosciences, University of the Ryukyus, 1 Senbaru, Nishihara, Okinawa 903 0213, Japan
    J Immunol 178:3786-96. 2007
    ..These data suggest that IL-17 is an important cytokine in the induction of optimal Th1 response and protective immunity against mycobacterial infection...
  30. ncbi IL-1-induced tumor necrosis factor-alpha elicits inflammatory cell infiltration in the skin by inducing IFN-gamma-inducible protein 10 in the elicitation phase of the contact hypersensitivity response
    Susumu Nakae
    Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Int Immunol 15:251-60. 2003
    ..Reduced CHS in TNF-alpha(-/-) mice was reversed by IP-10 injection during the elicitation phase. Thus, it was shown that the roles for IL-1 and TNF-alpha are different, although both cytokines are crucial for the development of CHS...
  31. pmc IL-17 production from activated T cells is required for the spontaneous development of destructive arthritis in mice deficient in IL-1 receptor antagonist
    Susumu Nakae
    Center for Experimental Medicine and Department of Cancer Biology, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Proc Natl Acad Sci U S A 100:5986-90. 2003
    ..These observations suggest that IL-17 plays a crucial role in T cell activation, downstream of IL-1, causing the development of autoimmune arthritis...
  32. ncbi Suppression of immune induction of collagen-induced arthritis in IL-17-deficient mice
    Susumu Nakae
    Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    J Immunol 171:6173-7. 2003
    ..Thus, these observations suggest that IL-17 plays a crucial role in the development of CIA by activating autoantigen-specific cellular and humoral immune responses...
  33. pmc TNF-alpha is crucial for the development of autoimmune arthritis in IL-1 receptor antagonist-deficient mice
    Reiko Horai
    Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    J Clin Invest 114:1603-11. 2004
    ..These findings suggest that IL-1 receptor antagonist deficiency in T cells disrupts homeostasis of the immune system and that TNF-alpha plays an important role in activating T cells through induction of OX40...
  34. ncbi IL-1beta, but not IL-1alpha, is required for antigen-specific T cell activation and the induction of local inflammation in the delayed-type hypersensitivity responses
    Aya Nambu
    Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, Shirokanedai, Tokyo 108 8639, Japan
    Int Immunol 18:701-12. 2006
    ..In addition, CD4+ T cell-derived IL-1 plays an important role in the activation of DCs during the elicitation phase, resulting in the production of TNF, that activate allergen-specific T cells...
  35. ncbi IL-17 plays an important role in the development of experimental autoimmune encephalomyelitis
    Yutaka Komiyama
    Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    J Immunol 177:566-73. 2006
    ..These observations indicate that IL-17 rather than IFN-gamma plays a crucial role in the development of EAE...
  36. ncbi Antigen-specific T cell sensitization is impaired in IL-17-deficient mice, causing suppression of allergic cellular and humoral responses
    Susumu Nakae
    Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo, Japan
    Immunity 17:375-87. 2002
    ..Our findings indicate that IL-17 plays an important role in activating T cells in allergen-specific T cell-mediated immune responses...
  37. ncbi Mast cells to the defense
    Stephen J Galli
    Nat Immunol 4:1160-2. 2003
  38. ncbi Abnormal T cell activation caused by the imbalance of the IL-1/IL-1R antagonist system is responsible for the development of experimental autoimmune encephalomyelitis
    Taizo Matsuki
    Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, Minato ku, Tokyo 108 8639, Japan
    Int Immunol 18:399-407. 2006
    ..These observations suggest that the IL-1/IL-1Ra system is crucial for auto-antigen-specific T cell induction and contributes to the development of EAE...
  39. ncbi Impaired selectin-ligand biosynthesis and reduced inflammatory responses in beta-1,4-galactosyltransferase-I-deficient mice
    Masahide Asano
    Department of Transgenic Animal Science, Graduate School of Medical Science, Kanazawa University, 13 1 Takaramachi, Kanazawa 920 8640, Japan
    Blood 102:1678-85. 2003
    ....
  40. ncbi IL-1 is required for allergen-specific Th2 cell activation and the development of airway hypersensitivity response
    Susumu Nakae
    Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Int Immunol 15:483-90. 2003
    ..These observations indicate that IL-1 plays important roles in the development of AHR...