Kari Nadeau

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. doi request reprint Exome sequencing and genome-wide copy number variant mapping reveal novel associations with sensorineural hereditary hearing loss
    Rajini R Haraksingh
    Department of Genetics, Stanford University School of Medicine, 300 Pasteur Dr, M 344A, Stanford, CA 94305, USA
    BMC Genomics 15:1155. 2014
  2. pmc In utero arsenic exposure and fetal immune repertoire in a US pregnancy cohort
    Kari C Nadeau
    Division of Immunology and Allergy, Stanford University, 730 Welch Road, Stanford, CA, USA Electronic address
    Clin Immunol 155:188-97. 2014
  3. pmc Epigenetically mediated pathogenic effects of phenanthrene on regulatory T cells
    Jing Liu
    Stanford University School of Medicine, Division of Immunology and Allergy, Grant Building, 3rd Floor, S370, MC5208, Stanford, CA 94305, USA
    J Toxicol 2013:967029. 2013
  4. pmc Asthma discordance in twins is linked to epigenetic modifications of T cells
    R Scott Runyon
    Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA
    PLoS ONE 7:e48796. 2012
  5. pmc The STAT5b Pathway Defect and Autoimmunity
    Takahiro Kanai
    Division of Immunology and Allergy, Department of Pediatrics, School of Medicine, Stanford University Stanford, CA, USA
    Front Immunol 3:234. 2012
  6. pmc Secondhand smoke in combination with ambient air pollution exposure is associated with increasedx CpG methylation and decreased expression of IFN-γ in T effector cells and Foxp3 in T regulatory cells in children
    Arunima Kohli
    Department of Pediatric Allergy and Immunology, Stanford University, 269 Campus Drive, Stanford, CA, 94305, USA
    Clin Epigenetics 4:17. 2012
  7. doi request reprint Ambient air pollution impairs regulatory T-cell function in asthma
    Kari Nadeau
    School of Medicine, Stanford University, Stanford, CA, USA
    J Allergy Clin Immunol 126:845-852.e10. 2010
  8. pmc Eotaxin and FGF enhance signaling through an Extracellular signal-related kinase (ERK)-dependent pathway in the pathogenesis of Eosinophilic Esophagitis
    Jennifer J Huang
    Stanford School of Medicine, Stanford, CA 94305, USA
    Allergy Asthma Clin Immunol 6:25. 2010
  9. pmc Idiopathic neutropenia of childhood is associated with Fas/FasL expression
    Kari C Nadeau
    Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305, USA
    Clin Immunol 129:438-47. 2008
  10. pmc TSLP directly impairs pulmonary Treg function: association with aberrant tolerogenic immunity in asthmatic airway
    Khoa D Nguyen
    Department of Pediatrics, Stanford University, Stanford, CA, USA
    Allergy Asthma Clin Immunol 6:4. 2010

Collaborators

  • Judy Fuentebella
  • Eric Sibley
  • Rachel L Miller
  • Jing Liu
  • Jillian W Wong
  • David Buchbinder
  • Anup J Patel
  • Kristina T Kudelko
  • Chen Dong
  • Shalini Pereira
  • Francois Haddad
  • Khoa D Nguyen
  • Arunima Kohli
  • Rajini R Haraksingh
  • Takahiro Kanai
  • R Scott Runyon
  • Jennifer J Huang
  • Christopher Vanichsarn
  • M Monica Gramatges
  • Grace P Yu
  • John S Oghalai
  • Juan Rodriguez-Paris
  • Fereshteh Jahanbani
  • Iris Schrijver
  • Joel Gelernter
  • Michael P Snyder
  • Gary E Swan
  • Marco Garcia
  • Olivier Humblet
  • Fred Lurmann
  • Marco A Garcia
  • Tessa Hunter
  • Ruth Krasnow
  • Jennifer Jenks
  • Regina Ahn
  • S Katharine Hammond
  • Nitya Rajeshuni
  • Lisa M Jack
  • Leslie M Cachola
  • Amanda C Jacobson
  • Christina Maher
  • Dorsey Bass
  • Anthony Quiros
  • Nadeau C Kari
  • William Berquist
  • Jae Won Joh
  • Christine Nguyen
  • Lisa Hoyte
  • Kenneth Cox
  • Scott Seki
  • Neha Reshamwala
  • John Kerner
  • Tammie Nguyen
  • Pauline Fani
  • Michael R Jeng
  • Elisabeth G Hoyte
  • Jennifer Huang
  • Steven J Song
  • David Chiang
  • Christopher Vanishsarn
  • Alan M Krensky
  • Jerome D Booker
  • Alison Fohner

Detail Information

Publications18

  1. doi request reprint Exome sequencing and genome-wide copy number variant mapping reveal novel associations with sensorineural hereditary hearing loss
    Rajini R Haraksingh
    Department of Genetics, Stanford University School of Medicine, 300 Pasteur Dr, M 344A, Stanford, CA 94305, USA
    BMC Genomics 15:1155. 2014
    ..To identify loci associated with predominantly non-syndromic sensorineural hearing loss, we performed exome sequencing of families and of single probands, as well as copy number variation (CNV) mapping in a case-control cohort...
  2. pmc In utero arsenic exposure and fetal immune repertoire in a US pregnancy cohort
    Kari C Nadeau
    Division of Immunology and Allergy, Stanford University, 730 Welch Road, Stanford, CA, USA Electronic address
    Clin Immunol 155:188-97. 2014
    ..03). These data provide evidence that relatively low-level arsenic exposure in utero may alter the fetal immune system and lead to immune dysregulation...
  3. pmc Epigenetically mediated pathogenic effects of phenanthrene on regulatory T cells
    Jing Liu
    Stanford University School of Medicine, Division of Immunology and Allergy, Grant Building, 3rd Floor, S370, MC5208, Stanford, CA 94305, USA
    J Toxicol 2013:967029. 2013
    ..These findings present a mechanism by which exposure to AhR-ligands mediates human T cell responses and begins to elucidate the relationship between environmental exposures, immune modulation, and initiation of human disease...
  4. pmc Asthma discordance in twins is linked to epigenetic modifications of T cells
    R Scott Runyon
    Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA
    PLoS ONE 7:e48796. 2012
    ..Our preliminary data suggest exposure to second hand smoke may augment the modified T cell responses associated with asthma...
  5. pmc The STAT5b Pathway Defect and Autoimmunity
    Takahiro Kanai
    Division of Immunology and Allergy, Department of Pediatrics, School of Medicine, Stanford University Stanford, CA, USA
    Front Immunol 3:234. 2012
    ..We will review the likely pathophysiological mechanisms associated with STAT5b deficiency...
  6. pmc Secondhand smoke in combination with ambient air pollution exposure is associated with increasedx CpG methylation and decreased expression of IFN-γ in T effector cells and Foxp3 in T regulatory cells in children
    Arunima Kohli
    Department of Pediatric Allergy and Immunology, Stanford University, 269 Campus Drive, Stanford, CA, 94305, USA
    Clin Epigenetics 4:17. 2012
    ..abstract:..
  7. doi request reprint Ambient air pollution impairs regulatory T-cell function in asthma
    Kari Nadeau
    School of Medicine, Stanford University, Stanford, CA, USA
    J Allergy Clin Immunol 126:845-852.e10. 2010
    ..Because AAP exposure can induce epigenetic changes, we hypothesized that Treg-cell function would be impaired by AAP, allowing amplification of an inflammatory response...
  8. pmc Eotaxin and FGF enhance signaling through an Extracellular signal-related kinase (ERK)-dependent pathway in the pathogenesis of Eosinophilic Esophagitis
    Jennifer J Huang
    Stanford School of Medicine, Stanford, CA 94305, USA
    Allergy Asthma Clin Immunol 6:25. 2010
    ..Moreover, blood cells, local tissue, and plasma from EoE and control subjects were studied to determine if the localized disease was associated with a systemic effect that correlated with presence of EoE disease...
  9. pmc Idiopathic neutropenia of childhood is associated with Fas/FasL expression
    Kari C Nadeau
    Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305, USA
    Clin Immunol 129:438-47. 2008
    ..Addition of anti-sFasL blocking antibodies to patient plasma caused a statistically significant decrease in neutrophil apoptosis. These studies show that the Fas/FasL pathway could be associated with neutrophil apoptosis in childhood IN...
  10. pmc TSLP directly impairs pulmonary Treg function: association with aberrant tolerogenic immunity in asthmatic airway
    Khoa D Nguyen
    Department of Pediatrics, Stanford University, Stanford, CA, USA
    Allergy Asthma Clin Immunol 6:4. 2010
    ..TSLP mediated inhibition of Treg function might present a novel pathologic mechanism to dampen tolerogenic immune responses in inflamed asthmatic airway...
  11. doi request reprint Increased number of regulatory T cells in children with eosinophilic esophagitis
    Judy Fuentebella
    Department of Pediatrics, Lucile Packard Children s Hospital, Stanford University Medical Center, Palo Alto, CA, USA
    J Pediatr Gastroenterol Nutr 51:283-9. 2010
    ..We tested the differences in Treg in subjects with EoE compared with those with gastroesophageal reflux disease (GERD) and healthy controls (HC)...
  12. pmc Epoprostenol-associated pneumonitis: diagnostic use of a T-cell proliferation assay
    Kristina T Kudelko
    Division of Pulmonary and Critical Care Medicine, Stanford University, Stanford, California, USA
    J Heart Lung Transplant 29:1071-5. 2010
    ..There was no significant proliferation to any drug in the healthy control. Hence, a drug T-cell proliferation assay confirmed that epoprostenol can rarely incite a profound inflammatory response in the pulmonary interstitium...
  13. doi request reprint Increased HLA-DR expression on tissue eosinophils in eosinophilic esophagitis
    Anup J Patel
    Lucile Packard Children s Hospital, Stanford University, Palo Alto, CA, USA
    J Pediatr Gastroenterol Nutr 51:290-4. 2010
    ..The aim of the study was to investigate whether eosinophils have increased human leukocyte antigen (HLA)-DR expression in subjects with eosinophilic esophagitis (EoE) compared with controls...
  14. doi request reprint Monozygotic twin pair showing discordant phenotype for X-linked thrombocytopenia and Wiskott-Aldrich syndrome: a role for epigenetics?
    David Buchbinder
    Division of Pediatric Hematology, Children s Hospital Orange County, University of California at Irvine, Orange, CA, USA
    J Clin Immunol 31:773-7. 2011
    ..Characterization of the potential epigenetic contribution to the spectrum of XLT and WAS is described and the implications of these findings are discussed...
  15. doi request reprint Neonatal alloimmune thrombocytopenia and neutropenia associated with maternal human leukocyte antigen antibodies
    M Monica Gramatges
    Department of Pediatrics, Stanford University School of Medicine, Palo Alto, California 94107, USA
    Pediatr Blood Cancer 53:97-9. 2009
    ....
  16. doi request reprint Regulatory T cell dysfunction in subjects with common variable immunodeficiency complicated by autoimmune disease
    Grace P Yu
    Stanford University School of Medicine, Immunology Program, Stanford, CA 94304, USA
    Clin Immunol 131:240-53. 2009
    ..These results suggest that attenuation of Treg function is associated with autoimmune disease in CVID subjects and may contribute to autoimmune pathogenesis...
  17. pmc XCL1 enhances regulatory activities of CD4+ CD25(high) CD127(low/-) T cells in human allergic asthma
    Khoa D Nguyen
    Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Immunol 181:5386-95. 2008
    ..Altogether, these results suggest an association between dysregulated XCL1 expression and reduced Treg activities in AA, as well as a potential role of XCL1 in reversing defective Treg function in the disease...
  18. doi request reprint Impaired IL-10-dependent induction of tolerogenic dendritic cells by CD4+CD25hiCD127lo/- natural regulatory T cells in human allergic asthma
    Khoa D Nguyen
    Department of Pediatrics, Stanford University, Stanford, California 94305, USA
    Am J Respir Crit Care Med 180:823-33. 2009
    ..However, the significance of the influence of natural regulatory T cells on tolerogenic dendritic cells in the disease has not been investigated...