Jason W Myers

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. doi request reprint The MAPK kinase kinase-1 is essential for stress-induced pancreatic islet cell death
    Dariush Mokhtari
    Department of Medical Cell Biology, Uppsala University, Biomedicum, S 751 23 Uppsala, Sweden
    Endocrinology 149:3046-53. 2008
  2. pmc Minimizing off-target effects by using diced siRNAs for RNA interference
    Jason W Myers
    Stanford University School of Medicine, Department of Molecular Pharmacology, 269 West Campus Drive, CCSR Room 3155, Stanford CA 94305 5174, USA
    J RNAi Gene Silencing 2:181-94. 2006
  3. ncbi request reprint Recombinant Dicer efficiently converts large dsRNAs into siRNAs suitable for gene silencing
    Jason W Myers
    Department of Molecular Pharmacology, 269 Campus Drive, Stanford University School of Medicine, Stanford, CA 94305 5174, USA
    Nat Biotechnol 21:324-8. 2003
  4. pmc siRNA screen of the human signaling proteome identifies the PtdIns(3,4,5)P3-mTOR signaling pathway as a primary regulator of transferrin uptake
    Thierry Galvez
    Department of Chemical and Systems Biology and Bio X Program, Stanford University School of Medicine, Stanford, CA 94305, USA
    Genome Biol 8:R142. 2007
  5. pmc Cyclin A2 regulates nuclear-envelope breakdown and the nuclear accumulation of cyclin B1
    Delquin Gong
    Department of Chemical and Systems Biology, CCSR, MC 5174, Stanford University School of Medicine, Stanford, California 94305, USA
    Curr Biol 17:85-91. 2007
  6. ncbi request reprint Silencing gene expression with Dicer-generated siRNA pools
    Jason W Myers
    Department of Molecular Pharmacology, Stanford University Medical School, CA, USA
    Methods Mol Biol 309:93-196. 2005
  7. pmc STIM is a Ca2+ sensor essential for Ca2+-store-depletion-triggered Ca2+ influx
    Jen Liou
    Department of Molecular Pharmacology, Stanford University Medical School, California 94305, USA
    Curr Biol 15:1235-41. 2005
  8. ncbi request reprint Probing the precision of the mitotic clock with a live-cell fluorescent biosensor
    Joshua T Jones
    Department of Molecular Pharmacology, W200 Clark, 318 Campus Drive, Stanford University Medical School, Stanford, California 94305, USA
    Nat Biotechnol 22:306-12. 2004
  9. ncbi request reprint Selective regulation of neurite extension and synapse formation by the beta but not the alpha isoform of CaMKII
    Charles C Fink
    Department of Molecular Pharmacology, Stanford University Medical School, Stanford, CA 94305, USA
    Neuron 39:283-97. 2003
  10. pmc Concordant regulation of translation and mRNA abundance for hundreds of targets of a human microRNA
    David G Hendrickson
    Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, California, USA
    PLoS Biol 7:e1000238. 2009

Collaborators

Detail Information

Publications14

  1. doi request reprint The MAPK kinase kinase-1 is essential for stress-induced pancreatic islet cell death
    Dariush Mokhtari
    Department of Medical Cell Biology, Uppsala University, Biomedicum, S 751 23 Uppsala, Sweden
    Endocrinology 149:3046-53. 2008
    ..Increased understanding of the signaling pathways that augment or diminish beta-cell MEKK-1 activity may aid in the generation of novel therapeutic strategies in the treatment of type 1 diabetes...
  2. pmc Minimizing off-target effects by using diced siRNAs for RNA interference
    Jason W Myers
    Stanford University School of Medicine, Department of Molecular Pharmacology, 269 West Campus Drive, CCSR Room 3155, Stanford CA 94305 5174, USA
    J RNAi Gene Silencing 2:181-94. 2006
    ..elegans and D. melanogaster, where gene suppression is mediated by endogenously-generated diced siRNA pools, and provide a strategy for improving the specificity of RNA interference experiments and screens in mammalian cells...
  3. ncbi request reprint Recombinant Dicer efficiently converts large dsRNAs into siRNAs suitable for gene silencing
    Jason W Myers
    Department of Molecular Pharmacology, 269 Campus Drive, Stanford University School of Medicine, Stanford, CA 94305 5174, USA
    Nat Biotechnol 21:324-8. 2003
    ..Dicer-generated siRNAs (d-siRNAs) are effective in silencing transiently transfected reporter genes and endogenous genes, making in vitro dicing a useful, practical alternative for the production of siRNAs...
  4. pmc siRNA screen of the human signaling proteome identifies the PtdIns(3,4,5)P3-mTOR signaling pathway as a primary regulator of transferrin uptake
    Thierry Galvez
    Department of Chemical and Systems Biology and Bio X Program, Stanford University School of Medicine, Stanford, CA 94305, USA
    Genome Biol 8:R142. 2007
    ..Signaling pathways that regulate transferrin uptake have not yet been identified...
  5. pmc Cyclin A2 regulates nuclear-envelope breakdown and the nuclear accumulation of cyclin B1
    Delquin Gong
    Department of Chemical and Systems Biology, CCSR, MC 5174, Stanford University School of Medicine, Stanford, California 94305, USA
    Curr Biol 17:85-91. 2007
    ..Nevertheless cyclin B1 translocates to the nucleus just prior to NEB in a cyclin A2-dependent fashion and is capable of supporting NEB if rendered constitutively nuclear...
  6. ncbi request reprint Silencing gene expression with Dicer-generated siRNA pools
    Jason W Myers
    Department of Molecular Pharmacology, Stanford University Medical School, CA, USA
    Methods Mol Biol 309:93-196. 2005
  7. pmc STIM is a Ca2+ sensor essential for Ca2+-store-depletion-triggered Ca2+ influx
    Jen Liou
    Department of Molecular Pharmacology, Stanford University Medical School, California 94305, USA
    Curr Biol 15:1235-41. 2005
    ..Our study suggests that STIM proteins function as Ca(2+) store sensors in the signaling pathway connecting Ca(2+) store depletion to Ca(2+) influx...
  8. ncbi request reprint Probing the precision of the mitotic clock with a live-cell fluorescent biosensor
    Joshua T Jones
    Department of Molecular Pharmacology, W200 Clark, 318 Campus Drive, Stanford University Medical School, Stanford, California 94305, USA
    Nat Biotechnol 22:306-12. 2004
    ..Inactivation of the spindle checkpoint by targeting the regulator Mad2 with RNAi consistently shortened mitosis, providing direct evidence that the internal mitotic timing mechanism is much faster in cells that lack the checkpoint...
  9. ncbi request reprint Selective regulation of neurite extension and synapse formation by the beta but not the alpha isoform of CaMKII
    Charles C Fink
    Department of Molecular Pharmacology, Stanford University Medical School, Stanford, CA 94305, USA
    Neuron 39:283-97. 2003
    ..These results show that the two main neuronal CaMKII isoforms have markedly different roles in neuronal plasticity, with CaMKIIalpha regulating synaptic strength and CaMKIIbeta controlling the dendritic morphology and number of synapses...
  10. pmc Concordant regulation of translation and mRNA abundance for hundreds of targets of a human microRNA
    David G Hendrickson
    Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, California, USA
    PLoS Biol 7:e1000238. 2009
    ....
  11. ncbi request reprint Restriction enzyme-generated siRNA (REGS) vectors and libraries
    George Sen
    Department of Molecular Pharmacology, 269 Campus Drive, CCSR 4225A Stanford University School of Medicine, Stanford, California 94305, USA
    Nat Genet 36:183-9. 2004
    ..REGS enabled us to create enzymatically a complex siRNA library (>4 x 10(5) clones) from double-stranded cDNA encompassing known and unknown genes with 96% of the clones containing inserts of the appropriate size...
  12. ncbi request reprint siRNA produced by recombinant dicer mediates efficient gene silencing in islet cells
    Robert Hägerkvist
    Department of Medical Cell Biology, Uppsala University Biomedicum, Sweden
    Ann N Y Acad Sci 1040:114-22. 2005
    ..The approach described here using d-siRNA provides an important tool for elucidating gene function in further studies of pancreatic islets and diabetes pathophysiology...
  13. pmc MAPK kinase kinase-1 is essential for cytokine-induced c-Jun NH2-terminal kinase and nuclear factor-kappaB activation in human pancreatic islet cells
    Dariush Mokhtari
    Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden
    Diabetes 57:1896-904. 2008
    ..The aim of the present investigation was to elucidate a putative role of the MAPK kinase kinase-1 (MEKK-1) in cytokine-induced signaling...
  14. ncbi request reprint Transforming growth factor-beta-activated protein kinase 1-binding protein (TAB)-1alpha, but not TAB1beta, mediates cytokine-induced p38 mitogen-activated protein kinase phosphorylation and cell death in insulin-producing cells
    Natalia Makeeva
    Department of Medical Cell Biology, Uppsala University, S 75123 Uppsala, Sweden
    Endocrinology 149:302-9. 2008
    ..We conclude that TAB1alpha, but not TAB1beta, plays an important role in the activation of p38 in insulin-producing cells and therefore also in cytokine-induced beta-cell death...