Greer Murphy

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. doi request reprint BDNF and CREB1 genetic variants interact to affect antidepressant treatment outcomes in geriatric depression
    Greer M Murphy
    Neuroscience Research Laboratories, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California, USA
    Pharmacogenet Genomics 23:301-13. 2013
  2. ncbi request reprint Sleep/wake disruption in Alzheimer's disease: APOE status and longitudinal course
    Jerome A Yesavage
    National Institute of Aging Alzheimer s Disease Core Center, Palo Alto VA Health Care System 151Y, 3801 Miranda Avenue, Palo Alto, CA 94304, USA
    J Geriatr Psychiatry Neurol 17:20-4. 2004
  3. doi request reprint Extended cognitive behavior therapy for cigarette smoking cessation
    Joel D Killen
    Stanford University School of Medicine, Stanford, CA 94305 5705, USA
    Addiction 103:1381-90. 2008
  4. ncbi request reprint Slower speed-of-processing of cognitive tasks is associated with presence of the apolipoprotein epsilon4 allele
    Ruth O'Hara
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford University, Stanford, CA 94305 5550, United States
    J Psychiatr Res 42:199-204. 2008
  5. ncbi request reprint Application of microarray technology in psychotropic drug trials
    Greer M Murphy
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305 5485, USA
    J Psychopharmacol 20:72-8. 2006
  6. ncbi request reprint Extended treatment with bupropion SR for cigarette smoking cessation
    Joel D Killen
    Stanford University School of Medicine, Stanford, CA 94305 5705, USA
    J Consult Clin Psychol 74:286-94. 2006
  7. ncbi request reprint Effects of the serotonin transporter gene promoter polymorphism on mirtazapine and paroxetine efficacy and adverse events in geriatric major depression
    Greer M Murphy
    Neuroscience Research Laboratories, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, Calif, USA
    Arch Gen Psychiatry 61:1163-9. 2004
  8. ncbi request reprint Pharmacogenetics of psychotropic drug response
    Anil K Malhotra
    Department of Psychiatry Research, Zucker Hillside Hospital, 75 59 263rd St, Glen Oaks, NY 11004, USA
    Am J Psychiatry 161:780-96. 2004
  9. ncbi request reprint Pharmacogenetics of antidepressant medication intolerance
    Greer M Murphy
    Neruroscience Research Laboratories Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford CA 94305 5548, USA
    Am J Psychiatry 160:1830-5. 2003
  10. ncbi request reprint The apolipoprotein E epsilon4 allele and antidepressant efficacy in cognitively intact elderly depressed patients
    Greer M Murphy
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California 94305, USA
    Biol Psychiatry 54:665-73. 2003

Collaborators

Detail Information

Publications15

  1. doi request reprint BDNF and CREB1 genetic variants interact to affect antidepressant treatment outcomes in geriatric depression
    Greer M Murphy
    Neuroscience Research Laboratories, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California, USA
    Pharmacogenet Genomics 23:301-13. 2013
    ..Previous studies reported that the Met variant results in enhanced response to antidepressant medications. These findings may be at odds with studies indicating that on a cellular level the Met variant impairs the secretion of BDNF...
  2. ncbi request reprint Sleep/wake disruption in Alzheimer's disease: APOE status and longitudinal course
    Jerome A Yesavage
    National Institute of Aging Alzheimer s Disease Core Center, Palo Alto VA Health Care System 151Y, 3801 Miranda Avenue, Palo Alto, CA 94304, USA
    J Geriatr Psychiatry Neurol 17:20-4. 2004
    ..In these data, APOE status was associated with the progression of sleep/wake disturbances in AD. Overall, there was greater deterioration on sleep parameters in patients negative for the epsilon4 allele...
  3. doi request reprint Extended cognitive behavior therapy for cigarette smoking cessation
    Joel D Killen
    Stanford University School of Medicine, Stanford, CA 94305 5705, USA
    Addiction 103:1381-90. 2008
    ..PRIMARY AIM: Examine the effectiveness of extended cognitive behavior therapy (CBT) in promoting longer-term smoking abstinence...
  4. ncbi request reprint Slower speed-of-processing of cognitive tasks is associated with presence of the apolipoprotein epsilon4 allele
    Ruth O'Hara
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford University, Stanford, CA 94305 5550, United States
    J Psychiatr Res 42:199-204. 2008
    ..These findings provide continued support for the negative impact of the epsilon4 allele on cognition and further suggest that speed-of-processing during memory tasks may have the potential to detect subtle cognitive deficits...
  5. ncbi request reprint Application of microarray technology in psychotropic drug trials
    Greer M Murphy
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305 5485, USA
    J Psychopharmacol 20:72-8. 2006
    ..Yet, there is controversy as to whether genome-wide studies designed to detect millions of genotypes with microarrays will lead to new pharmacogenetic discoveries, or whether a more focused, hypothesis-driven approach is better...
  6. ncbi request reprint Extended treatment with bupropion SR for cigarette smoking cessation
    Joel D Killen
    Stanford University School of Medicine, Stanford, CA 94305 5705, USA
    J Consult Clin Psychol 74:286-94. 2006
    ..001; week 25: 48% vs. 31%, p = .001; week 52: 39% vs. 27%, p = .01). Because most smokers suffer relapse with any current cessation treatment, the comparatively high abstinence percentages achieved in this trial are of interest...
  7. ncbi request reprint Effects of the serotonin transporter gene promoter polymorphism on mirtazapine and paroxetine efficacy and adverse events in geriatric major depression
    Greer M Murphy
    Neuroscience Research Laboratories, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, Calif, USA
    Arch Gen Psychiatry 61:1163-9. 2004
    ..Some but not all studies have found that the short form of 5HTTLPR (S allele) results in decreased efficacy of selective serotonin reuptake inhibitors...
  8. ncbi request reprint Pharmacogenetics of psychotropic drug response
    Anil K Malhotra
    Department of Psychiatry Research, Zucker Hillside Hospital, 75 59 263rd St, Glen Oaks, NY 11004, USA
    Am J Psychiatry 161:780-96. 2004
    ..These pharmacogenetic strategies offer the prospect of identifying biological predictors of psychotropic drug response and could provide the means of determining the molecular substrates of drug efficacy and drug-induced adverse events...
  9. ncbi request reprint Pharmacogenetics of antidepressant medication intolerance
    Greer M Murphy
    Neruroscience Research Laboratories Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford CA 94305 5548, USA
    Am J Psychiatry 160:1830-5. 2003
    ..However, variation in genes encoding serotonin receptors could also explain antidepressant side effects (pharmacodynamic effect)...
  10. ncbi request reprint The apolipoprotein E epsilon4 allele and antidepressant efficacy in cognitively intact elderly depressed patients
    Greer M Murphy
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California 94305, USA
    Biol Psychiatry 54:665-73. 2003
    ..We hypothesized that epsilon4 carriers would show impaired antidepressant response...
  11. ncbi request reprint Double-blind, randomized comparison of mirtazapine and paroxetine in elderly depressed patients
    Alan F Schatzberg
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 401 Quarry Road, Rm 300, Stanford, CA 94305 5548, USA
    Am J Geriatr Psychiatry 10:541-50. 2002
    ..Authors studied the efficacy and tolerability of mirtazapine and paroxetine in elderly patients with major depression during an acute phase (8 weeks) and an extension phase (16 weeks)...
  12. ncbi request reprint Single nucleotide polymorphisms and their characterization with oligonucleotide microarrays
    Dennise D Dalma-Weiszhausz
    Affymetrix, Santa Clara, California 95051, USA
    Psychiatr Genet 12:97-107. 2002
    ....
  13. ncbi request reprint The brain-derived neurotrophic factor Val66Met polymorphism and rate of decline in Alzheimer's disease
    Jenny Y J Chuu
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305 5485, and the VA Sierra Pacific Mental Illness Research Education and Clinical Center, Palo Alto, CA, USA
    J Alzheimers Dis 9:43-9. 2006
    ..These findings suggest that the functional BDNF Val66Met variant is not a major determinant of rate of cognitive decline in AD...
  14. ncbi request reprint Analysis of neuronal gene expression with laser capture microdissection
    Valerie A M Vincent
    Neuroscience Research Laboratories, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California 94305 5485, USA
    J Neurosci Res 69:578-86. 2002
    ..As an example, gene expression was quantified in hippocampal neurons from the Tg2576 mouse model for Alzheimer's disease...
  15. ncbi request reprint Cardiac gene expression profile and lipid accumulation in response to starvation
    Jinya Suzuki
    Third Department of Internal Medicine, Fukui Medical University, Fukui 910 1193, Japan
    Am J Physiol Endocrinol Metab 283:E94-E102. 2002
    ..These data provide a broad perspective of the molecular events occurring physiologically in the heart in response to starvation...

Research Grants14

  1. Pharmacogenetics of the Antidepressant Response in Geriatric Major Depression
    Greer M Murphy; Fiscal Year: 2010
    ..Many patients are resistant to antidepressant medication treatment. A method for identifying patients likely to benefit from antidepressant treatment would decrease patient distress and save health care dollars. ..
  2. Pharmacogenetics of the Antidepressant Response in Geriatric Major Depression
    Greer Murphy; Fiscal Year: 2009
    ..Many patients are resistant to antidepressant medication treatment. A method for identifying patients likely to benefit from antidepressant treatment would decrease patient distress and save health care dollars. ..
  3. Pharmacogenetics of the Antidepressant Response in Geriatric Major Depression
    Greer Murphy; Fiscal Year: 2007
    ..Many patients are resistant to antidepressant medication treatment. A method for identifying patients likely to benefit from antidepressant treatment would decrease patient distress and save health care dollars. ..
  4. Microglial Neuroprotection and Neurotoxicity
    Greer Murphy; Fiscal Year: 2007
    ..Although microglial neurotoxicity undoubtedly occurs in many disease states, it is important to understand how microglia might be induced to clear abnormal proteins from the brain or provide neuroprotection. ..
  5. Pharmacogenetics of the Antidepressant Response in Geriatric Major Depression
    Greer Murphy; Fiscal Year: 2006
    ..Many patients are resistant to antidepressant medication treatment. A method for identifying patients likely to benefit from antidepressant treatment would decrease patient distress and save health care dollars. ..
  6. Microglial Neuroprotection and Neurotoxicity
    Greer Murphy; Fiscal Year: 2006
    ..Although microglial neurotoxicity undoubtedly occurs in many disease states, it is important to understand how microglia might be induced to clear abnormal proteins from the brain or provide neuroprotection. ..
  7. Microglial Neuroprotection and Neurotoxicity
    Greer Murphy; Fiscal Year: 2005
    ..Although microglial neurotoxicity undoubtedly occurs in many disease states, it is important to understand how microglia might be induced to clear abnormal proteins from the brain or provide neuroprotection. ..
  8. Microglial Neuroprotection and Neurotoxicity
    Greer Murphy; Fiscal Year: 2004
    ..Although microglial neurotoxicity undoubtedly occurs in many disease states, it is important to understand how microglia might be induced to clear abnormal proteins from the brain or provide neuroprotection. ..
  9. Microglial Neuroprotection and Neurotoxicity
    Greer Murphy; Fiscal Year: 2003
    ..Although microglial neurotoxicity undoubtedly occurs in many disease states, it is important to understand how microglia might be induced to clear abnormal proteins from the brain or provide neuroprotection. ..
  10. Pharmacogenetics of the Antidepressant Response in Geriatric Major Depression
    Greer M Murphy; Fiscal Year: 2010
    ..Many patients are resistant to antidepressant medication treatment. A method for identifying patients likely to benefit from antidepressant treatment would decrease patient distress and save health care dollars. ..