Greer M Murphy

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. ncbi request reprint Microglial overexpression of the M-CSF receptor augments phagocytosis of opsonized Abeta
    Olivera M Mitrasinovic
    Department of Psychiatry and Behavioral Sciences, Neuroscience Research Laboratories, Stanford University School of Medicine, Stanford, CA 94305, USA
    Neurobiol Aging 24:807-15. 2003
  2. ncbi request reprint Pharmacogenetics of antidepressant medication intolerance
    Greer M Murphy
    Neruroscience Research Laboratories Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford CA 94305 5548, USA
    Am J Psychiatry 160:1830-5. 2003
  3. pmc Expression of macrophage colony-stimulating factor receptor is increased in the AbetaPP(V717F) transgenic mouse model of Alzheimer's disease
    G M Murphy
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California 94305 5485, USA
    Am J Pathol 157:895-904. 2000
  4. ncbi request reprint Application of microarray technology in psychotropic drug trials
    Greer M Murphy
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305 5485, USA
    J Psychopharmacol 20:72-8. 2006
  5. ncbi request reprint Rate of cognitive decline in AD is accelerated by the interleukin-1 alpha -889 *1 allele
    G M Murphy
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, CA 94305, USA
    Neurology 56:1595-7. 2001
  6. ncbi request reprint CYP2D6 genotyping with oligonucleotide microarrays and nortriptyline concentrations in geriatric depression
    G M Murphy
    Department of Psychiatry and Behavioral Sciences, MSLS P 104, Stanford University School of Medicine, Stanford, CA 94305 5485, USA
    Neuropsychopharmacology 25:737-43. 2001
  7. ncbi request reprint Microglia overexpressing the macrophage colony-stimulating factor receptor are neuroprotective in a microglial-hippocampal organotypic coculture system
    Olivera M Mitrasinovic
    Neuroscience Research Laboratories, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California 94305, USA
    J Neurosci 25:4442-51. 2005
  8. doi request reprint Markers in the 15q24 nicotinic receptor subunit gene cluster (CHRNA5-A3-B4) predict severity of nicotine addiction and response to smoking cessation therapy
    Jane E Sarginson
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, California, 94305 5485, USA
    Am J Med Genet B Neuropsychiatr Genet 156:275-84. 2011
  9. doi request reprint BDNF and CREB1 genetic variants interact to affect antidepressant treatment outcomes in geriatric depression
    Greer M Murphy
    Neuroscience Research Laboratories, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California, USA
    Pharmacogenet Genomics 23:301-13. 2013
  10. ncbi request reprint Effects of the serotonin transporter gene promoter polymorphism on mirtazapine and paroxetine efficacy and adverse events in geriatric major depression
    Greer M Murphy
    Neuroscience Research Laboratories, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, Calif, USA
    Arch Gen Psychiatry 61:1163-9. 2004

Collaborators

Detail Information

Publications42

  1. ncbi request reprint Microglial overexpression of the M-CSF receptor augments phagocytosis of opsonized Abeta
    Olivera M Mitrasinovic
    Department of Psychiatry and Behavioral Sciences, Neuroscience Research Laboratories, Stanford University School of Medicine, Stanford, CA 94305, USA
    Neurobiol Aging 24:807-15. 2003
    ..Microglia in AD and in AD mouse models with increased expression of M-CSFR are likely to rapidly ingest opsonized Abeta after immunization, making high intracerebral antibody titers unnecessary...
  2. ncbi request reprint Pharmacogenetics of antidepressant medication intolerance
    Greer M Murphy
    Neruroscience Research Laboratories Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford CA 94305 5548, USA
    Am J Psychiatry 160:1830-5. 2003
    ..However, variation in genes encoding serotonin receptors could also explain antidepressant side effects (pharmacodynamic effect)...
  3. pmc Expression of macrophage colony-stimulating factor receptor is increased in the AbetaPP(V717F) transgenic mouse model of Alzheimer's disease
    G M Murphy
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California 94305 5485, USA
    Am J Pathol 157:895-904. 2000
    ..Because chronic activation of microglia is thought to result in neuronal injury, the M-CSF system may be a potential target for therapeutic intervention in AD...
  4. ncbi request reprint Application of microarray technology in psychotropic drug trials
    Greer M Murphy
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305 5485, USA
    J Psychopharmacol 20:72-8. 2006
    ..Yet, there is controversy as to whether genome-wide studies designed to detect millions of genotypes with microarrays will lead to new pharmacogenetic discoveries, or whether a more focused, hypothesis-driven approach is better...
  5. ncbi request reprint Rate of cognitive decline in AD is accelerated by the interleukin-1 alpha -889 *1 allele
    G M Murphy
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, CA 94305, USA
    Neurology 56:1595-7. 2001
    ..There was no difference in rate of decline between patients with and without the APOE epsilon 4 allele. These results support the hypothesis that inflammation is important in the clinical course of AD...
  6. ncbi request reprint CYP2D6 genotyping with oligonucleotide microarrays and nortriptyline concentrations in geriatric depression
    G M Murphy
    Department of Psychiatry and Behavioral Sciences, MSLS P 104, Stanford University School of Medicine, Stanford, CA 94305 5485, USA
    Neuropsychopharmacology 25:737-43. 2001
    ..These results demonstrate that CYP2D6 genotyping on a microarray platform can be used to predict plasma antidepressant concentrations despite advanced patient age and numerous concurrent medications...
  7. ncbi request reprint Microglia overexpressing the macrophage colony-stimulating factor receptor are neuroprotective in a microglial-hippocampal organotypic coculture system
    Olivera M Mitrasinovic
    Neuroscience Research Laboratories, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California 94305, USA
    J Neurosci 25:4442-51. 2005
    ....
  8. doi request reprint Markers in the 15q24 nicotinic receptor subunit gene cluster (CHRNA5-A3-B4) predict severity of nicotine addiction and response to smoking cessation therapy
    Jane E Sarginson
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, California, 94305 5485, USA
    Am J Med Genet B Neuropsychiatr Genet 156:275-84. 2011
    ..These results provide further support for the role of the CHRNA5/A3/B4 subunits in determining number of cigarettes smoked and response to smoking cessation therapy...
  9. doi request reprint BDNF and CREB1 genetic variants interact to affect antidepressant treatment outcomes in geriatric depression
    Greer M Murphy
    Neuroscience Research Laboratories, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California, USA
    Pharmacogenet Genomics 23:301-13. 2013
    ..Previous studies reported that the Met variant results in enhanced response to antidepressant medications. These findings may be at odds with studies indicating that on a cellular level the Met variant impairs the secretion of BDNF...
  10. ncbi request reprint Effects of the serotonin transporter gene promoter polymorphism on mirtazapine and paroxetine efficacy and adverse events in geriatric major depression
    Greer M Murphy
    Neuroscience Research Laboratories, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, Calif, USA
    Arch Gen Psychiatry 61:1163-9. 2004
    ..Some but not all studies have found that the short form of 5HTTLPR (S allele) results in decreased efficacy of selective serotonin reuptake inhibitors...
  11. ncbi request reprint Biolistic expression of the macrophage colony stimulating factor receptor in organotypic cultures induces an inflammatory response
    Olivera M Mitrasinovic
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California 94305 5485, USA
    J Neurosci Res 77:420-9. 2004
    ....
  12. doi request reprint Abeta peptide conformation determines uptake and interleukin-1alpha expression by primary microglial cells
    Saravanapavan Parvathy
    Neuroscience Research Laboratories, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305 5485, United States
    Neurobiol Aging 30:1792-804. 2009
    ..The uptake of oligomeric and protofibrillar Abeta by microglia merits further investigation as a potential means for removing these neurotoxic species from the brain...
  13. pmc FKBP5 polymorphisms and antidepressant response in geriatric depression
    Jane E Sarginson
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305 5485, USA
    Am J Med Genet B Neuropsychiatr Genet 153:554-60. 2010
    ..These results suggest that FKBP5 is unlikely to play a major role in determining antidepressant treatment outcomes in geriatric patients...
  14. ncbi request reprint Gene expression profile of the PDAPP mouse model for Alzheimer's disease with and without Apolipoprotein E
    Simon P Selwood
    Neuroscience Research Laboratories, Stanford University School of Medicine, Stanford, CA 94305 5485, USA
    Neurobiol Aging 30:574-90. 2009
    ..These results provide a global molecular profile of hippocampal and cortical gene expression during the initial and intermediate stages Abeta deposition, and the effects of APOE deletion on this process...
  15. ncbi request reprint Analysis of neuronal gene expression with laser capture microdissection
    Valerie A M Vincent
    Neuroscience Research Laboratories, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California 94305 5485, USA
    J Neurosci Res 69:578-86. 2002
    ..As an example, gene expression was quantified in hippocampal neurons from the Tg2576 mouse model for Alzheimer's disease...
  16. ncbi request reprint Macrophage colony stimulating factor promotes phagocytosis by murine microglia
    Olivera M Mitrasinovic
    Neuroscience Research Laboratories, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305 5485, USA
    Neurosci Lett 344:185-8. 2003
    ..These results suggest that M-CSF could be important in promoting microglial clearance of abnormal protein aggregates such as Abeta...
  17. doi request reprint ABCB1 (MDR1) polymorphisms and antidepressant response in geriatric depression
    Jane E Sarginson
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California 94305 5485, USA
    Pharmacogenet Genomics 20:467-75. 2010
    ..We sought to determine if ABCB1 polymorphisms predict response to antidepressant treatment in geriatric patients...
  18. ncbi request reprint The apolipoprotein E epsilon4 allele and antidepressant efficacy in cognitively intact elderly depressed patients
    Greer M Murphy
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California 94305, USA
    Biol Psychiatry 54:665-73. 2003
    ..We hypothesized that epsilon4 carriers would show impaired antidepressant response...
  19. pmc Failure to improve cigarette smoking abstinence with transdermal selegiline + cognitive behavior therapy
    Joel D Killen
    Departments of Medicine and Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, CA 94303 1334, USA
    Addiction 105:1660-8. 2010
    ..To examine the effectiveness of transdermal selegiline for producing cigarette smoking abstinence...
  20. ncbi request reprint Apolipoprotein E epsilon4 allele affects the relationship between stress and depression in caregivers of patients with Alzheimer's disease
    D Gallagher-Thompson
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, CA 94305 5485, USA
    J Geriatr Psychiatry Neurol 14:115-9. 2001
    ..This relationship was not observed in caregivers without the epsilon4 allele. These results suggest that carriers of the epsilon4 allele may respond differently to psychological stress than do individuals without the epsilon4 allele...
  21. ncbi request reprint Overexpression of macrophage colony-stimulating factor receptor on microglial cells induces an inflammatory response
    O M Mitrasinovic
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California 94305, USA
    J Biol Chem 276:30142-9. 2001
    ....
  22. ncbi request reprint Accelerated phagocytosis of amyloid-beta by mouse and human microglia overexpressing the macrophage colony-stimulating factor receptor
    Olivera M Mitrasinovic
    Neuroscience Research Laboratories, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California 94305 5485, USA
    J Biol Chem 277:29889-96. 2002
    ..These results suggest that overexpression of M-CSFR in APPV717F mice may prime microglia for phagocytosis of A beta after immunization...
  23. ncbi request reprint Macrophage colony stimulating factor prevents NMDA-induced neuronal death in hippocampal organotypic cultures
    Valerie A M Vincent
    Neuroscience Research Laboratories, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California 94305, USA
    J Neurochem 82:1388-97. 2002
    ..The role of M-CSF in neurological disease should be reevaluated as a microglial activator with potentially neuroprotective effects...
  24. ncbi request reprint Proinflammatory effects of M-CSF and A beta in hippocampal organotypic cultures
    Valerie A M Vincent
    Department of Psychiatry and Behavioral Sciences, Neuroscience Research Laboratories, Stanford University School of Medicine, Stanford, CA 94305 5485, USA
    Neurobiol Aging 23:349-62. 2002
    ..Treatment with M-CSF/Abeta did not result in neuronal death. These results demonstrate that combined M-CSF/Abeta treatment results in a strong inflammatory response in the organotypic environment without inducing neurotoxicity...
  25. pmc Initial cognitive performance predicts longitudinal aviator performance
    Jerome A Yesavage
    Stanford VA Aging Clinical Research Center, VA Palo Alto Health Care System, Palo Alto, CA 94304 1207, USA
    J Gerontol B Psychol Sci Soc Sci 66:444-53. 2011
    ..The goal of the study was to improve prediction of longitudinal flight simulator performance by studying cognitive factors that may moderate the influence of chronological age...
  26. pmc Apolipoprotein E epsilon4 influences on episodic recall and brain structures in aging pilots
    Maheen M Adamson
    Department of Veterans Affairs, Palo Alto, CA 94304, USA
    Neurobiol Aging 31:1059-63. 2010
    ..These findings point to basic memory testing as a sensitive tool for detecting APOE epsilon4-related influences on memory in aging workers...
  27. pmc Influences of APOE ε4 and expertise on performance of older pilots
    Joy L Taylor
    Psychiatry Service, Department of Veterans Affairs, Palo Alto Health Care System Palo Alto, CA 94304 1207, USA
    Psychol Aging 26:480-7. 2011
    ..Results suggest that relevant training and activity may help sustain middle-aged and older adults' real-world performance, especially among APOE ε4 carriers...
  28. ncbi request reprint No association between apolipoprotein E epsilon 4 allele and rate of decline in Alzheimer's disease
    G M Murphy
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, CA 94305 5485, USA
    Am J Psychiatry 154:603-8. 1997
    ..The relationship between number of apolipoprotein E epsilon 4 (APOE epsilon 4) alleles and the rate of cognitive decline in patients with Alzheimer's disease was examined...
  29. ncbi request reprint Rate of cognitive decline in Alzheimer's disease is not affected by the alpha-1-antichymotrypsin A allele or the CYP2D6 B mutant
    G M Murphy
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, CA 94305 5485, USA
    Neurosci Lett 217:200-2. 1996
    ..These findings suggest that any increased risk of developing AD or LBV conferred by these markers is not necessarily accompanied by a more rapid rate of decline...
  30. ncbi request reprint Macrophage colony-stimulating factor augments beta-amyloid-induced interleukin-1, interleukin-6, and nitric oxide production by microglial cells
    G M Murphy
    Neuroscience Research Laboratories, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California 94305 5485, USA
    J Biol Chem 273:20967-71. 1998
    ....
  31. ncbi request reprint Nocturnal sleep apnea/hypopnea is associated with lower memory performance in APOE epsilon4 carriers
    R O'HARA
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305 5550, USA
    Neurology 65:642-4. 2005
    ..This is the first study to provide preliminary evidence for a negative interaction of APOE epsilon4 and OSAH on memory in older adults, which may have important implications for treating cognitive decline and delaying dementia onset...
  32. ncbi request reprint Association between apolipoprotein E epsilon4 and sleep-disordered breathing in adults
    H Kadotani
    Center for Narcolepsy, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305 5485, USA
    JAMA 285:2888-90. 2001
    ..Sleep-disordered breathing occurs in Alzheimer disease patients and increases risks for cardiovascular disease. Complex interactions among sleep, brain pathology, and cardiovascular disease may occur in ApoE epsilon4 carriers...
  33. ncbi request reprint Double-blind, randomized comparison of mirtazapine and paroxetine in elderly depressed patients
    Alan F Schatzberg
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 401 Quarry Road, Rm 300, Stanford, CA 94305 5548, USA
    Am J Geriatr Psychiatry 10:541-50. 2002
    ..Authors studied the efficacy and tolerability of mirtazapine and paroxetine in elderly patients with major depression during an acute phase (8 weeks) and an extension phase (16 weeks)...
  34. ncbi request reprint The brain-derived neurotrophic factor Val66Met polymorphism and rate of decline in Alzheimer's disease
    Jenny Y J Chuu
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305 5485, and the VA Sierra Pacific Mental Illness Research Education and Clinical Center, Palo Alto, CA, USA
    J Alzheimers Dis 9:43-9. 2006
    ..These findings suggest that the functional BDNF Val66Met variant is not a major determinant of rate of cognitive decline in AD...
  35. ncbi request reprint Extended treatment with bupropion SR for cigarette smoking cessation
    Joel D Killen
    Stanford University School of Medicine, Stanford, CA 94305 5705, USA
    J Consult Clin Psychol 74:286-94. 2006
    ..001; week 25: 48% vs. 31%, p = .001; week 52: 39% vs. 27%, p = .01). Because most smokers suffer relapse with any current cessation treatment, the comparatively high abstinence percentages achieved in this trial are of interest...
  36. ncbi request reprint Sleep and circadian abnormalities in a transgenic mouse model of Alzheimer's disease: a role for cholinergic transmission
    J P Wisor
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, USA
    Neuroscience 131:375-85. 2005
    ..The Tg2576 model provides a uniquely powerful tool for studies on the pathophysiology of and treatments for sleep deficits and associated cholinergic abnormalities in AD...
  37. ncbi request reprint Pharmacogenetics of psychotropic drug response
    Anil K Malhotra
    Department of Psychiatry Research, Zucker Hillside Hospital, 75 59 263rd St, Glen Oaks, NY 11004, USA
    Am J Psychiatry 161:780-96. 2004
    ..These pharmacogenetic strategies offer the prospect of identifying biological predictors of psychotropic drug response and could provide the means of determining the molecular substrates of drug efficacy and drug-induced adverse events...
  38. ncbi request reprint Single nucleotide polymorphisms and their characterization with oligonucleotide microarrays
    Dennise D Dalma-Weiszhausz
    Affymetrix, Santa Clara, California 95051, USA
    Psychiatr Genet 12:97-107. 2002
    ....
  39. ncbi request reprint Cardiac gene expression profile and lipid accumulation in response to starvation
    Jinya Suzuki
    Third Department of Internal Medicine, Fukui Medical University, Fukui 910 1193, Japan
    Am J Physiol Endocrinol Metab 283:E94-E102. 2002
    ..These data provide a broad perspective of the molecular events occurring physiologically in the heart in response to starvation...
  40. ncbi request reprint Potential ethnic modifiers in the assessment and treatment of Alzheimer's disease: challenges for the future
    Warachal E Faison
    Alzheimer s Research and Clinical Programs, Neurosciences Department, Medical University of South Carolina, Charleston, South Carolina 29406, USA
    Int Psychogeriatr 19:539-58. 2007
    ..for AD to answer two questions: (1) what are the challenges to diagnose and treat AD across different ethnic groups, and (2) are there differences in response to pharmacologic interventions for AD across these different ethnic groups?..
  41. pmc A novel quantitative trait locus on mouse chromosome 18, "era1," modifies the entrainment of circadian rhythms
    Jonathan P Wisor
    Molecular Neurobiology Laboratory, SRI International, Menlo Park, CA 94025, USA
    Sleep 30:1255-63. 2007
    ..We now describe a novel circadian rhythm phenotype, and a locus influencing that phenotype, in a segregating population of mice...