Joanna L Mountain
Affiliation: Stanford University
- SNPSTRs: empirically derived, rapidly typed, autosomal haplotypes for inference of population history and mutational processesJoanna L Mountain
Department of Anthropological Sciences, Stanford, California 94305, USA
Genome Res 12:1766-72. 2002..Here, we illustrate the approach with two SNPSTR systems. Although even one system provides insight into population history, the power of the approach lies in combining results from multiple SNPSTR systems...
- Assessing genetic contributions to phenotypic differences among 'racial' and 'ethnic' groupsJoanna L Mountain
Department of Anthropological Sciences, Stanford University, Stanford, California 94305 2117, USA
Nat Genet 36:S48-53. 2004..Further, we suggest approaches and guidelines for assessing the contribution of genetic factors to between-group phenotypic differences, including studies of candidate genes and analyses of recently admixed populations...
- Impact of human population history on distributions of individual-level genetic distanceJoanna L Mountain
Department of Anthropological Sciences, Stanford University, Stanford, CA 94305 2117, USA
Hum Genomics 2:4-19. 2005..Analysis of short tandem repeat genotype data for over 1,000 individuals from 52 populations is consistent with dramatic differences in population histories across human groups...
- Y-chromosomal evidence of a pastoralist migration through Tanzania to southern AfricaBrenna M Henn
Department of Anthropology, Stanford University, Stanford, CA 94035 2117, USA
Proc Natl Acad Sci U S A 105:10693-8. 2008..Our Y-chromosomal evidence supports a demic diffusion model of pastoralism from eastern to southern Africa approximately 2,000 years ago...
- Characterizing the time dependency of human mitochondrial DNA mutation rate estimatesBrenna M Henn
Department of Anthropology, Stanford University, USA
Mol Biol Evol 26:217-30. 2009..Our findings suggest that human mtDNA estimates of dates of population and phylogenetic events should be adjusted in light of this time dependency of the mutation rate estimates...
- Hunter-gatherer genomic diversity suggests a southern African origin for modern humansBrenna M Henn
Department of Genetics, Stanford University, Stanford, CA 94305, USA
Proc Natl Acad Sci U S A 108:5154-62. 2011..However, African hunter-gatherer populations continue to maintain the highest levels of genetic diversity in the world...
- Detecting past population bottlenecks using temporal genetic dataUma Ramakrishnan
Department of Biological Sciences, Stanford University, Stanford, CA 94035 5020, USA
Mol Ecol 14:2915-22. 2005..Choice of genetic region is critical, as mutation rate heavily influences the extent to which temporal sampling yields novel information regarding the demographic history of populations...
- Precision and accuracy of divergence time estimates from STR and SNPSTR variationUma Ramakrishnan
Department of Anthropological Sciences, Stanford University, Stanford, California, USA
Mol Biol Evol 21:1960-71. 2004..Furthermore, the combination of estimates based separately on STR and SNPSTR variation provides insight into the age of the derived SNP alleles. In light of our simulations, we interpret estimates from data for human populations...
- REJECTOR: software for population history inference from genetic data via a rejection algorithmMatthew J Jobin
Department of Anthropology, Stanford University, Stanford, CA 94305, USA
Bioinformatics 24:2936-7. 2008..The tests demonstrate the precision and accuracy of estimation made possible using this approach...
- African Y chromosome and mtDNA divergence provides insight into the history of click languagesAlec Knight
Department of Anthropological Sciences, Stanford University, Stanford, CA 94305, USA
Curr Biol 13:464-73. 2003..Intriguingly, the language of the Hadzabe of eastern Africa, although not closely related to any other language, shares click consonants and accompaniments with languages of Khwe and San...
- Serial coalescent simulations suggest a weak genealogical relationship between Etruscans and modern TuscansElise M S Belle
Dipartimento di Biologia, Universita di Ferrara, Via Borsari, 46, 44100 Ferrara, Italy
Proc Natl Acad Sci U S A 103:8012-7. 2006..If neither proves to be the case, this study strongly suggests that either the mitochondrial mutation rate is much higher than currently believed or the Etruscans left very few modern mitochondrial descendants...
- History of click-speaking populations of Africa inferred from mtDNA and Y chromosome genetic variationSarah A Tishkoff
Department of Biology, University of Maryland, USA
Mol Biol Evol 24:2180-95. 2007....
- The importance of race and ethnic background in biomedical research and clinical practiceEsteban Gonzalez Burchard
Lung Biology Center, University of California, San Francisco, CA 94143 0833, USA
N Engl J Med 348:1170-5. 2003
- Diet and the evolution of human amylase gene copy number variationGeorge H Perry
School of Human Evolution and Social Change, Arizona State University, Tempe, Arizona 85287, USA
Nat Genet 39:1256-60. 2007..Higher AMY1 copy numbers and protein levels probably improve the digestion of starchy foods and may buffer against the fitness-reducing effects of intestinal disease...
- Toward resolution of the debate regarding purported crypto-Jews in a Spanish-American population: evidence from the Y chromosomeWesley K Sutton
Department of Anthropology, New York University, New York 10003, USA
Ann Hum Biol 33:100-11. 2006..Despite ethnographic criticisms, the notion of substantial crypto-Jewish ancestry among Spanish-Americans persists...